Rattus norvegicus

168 known processes

Irs1

insulin receptor substrate 1

(Aliases: IRS1IRM)

Irs1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of locomotion GO:0040017 102 0.856
Mouse
regulation of cell proliferation GO:0042127 359 0.765
Mouse
transcription from rna polymerase ii promoter GO:0006366 252 0.764
enzyme linked receptor protein signaling pathway GO:0007167 116 0.722
tissue development GO:0009888 252 0.641
single organism biosynthetic process GO:0044711 342 0.593
Human
cellular response to hormone stimulus GO:0032870 247 0.571
protein phosphorylation GO:0006468 345 0.519
signal transduction by phosphorylation GO:0023014 144 0.514
positive regulation of cell migration GO:0030335 96 0.480
Mouse
cellular response to peptide hormone stimulus GO:0071375 120 0.475
positive regulation of signal transduction GO:0009967 175 0.474
cell migration GO:0016477 197 0.474
Mouse
regulation of cell motility GO:2000145 131 0.457
Mouse
insulin receptor signaling pathway GO:0008286 24 0.451
regulation of cellular protein metabolic process GO:0032268 267 0.450
response to peptide hormone GO:0043434 278 0.434
cellular response to endogenous stimulus GO:0071495 377 0.433
intracellular signal transduction GO:0035556 314 0.419
Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.414
positive regulation of signaling GO:0023056 270 0.414
cellular response to nitrogen compound GO:1901699 210 0.410
lipid biosynthetic process GO:0008610 128 0.407
cellular response to growth factor stimulus GO:0071363 162 0.402
regulation of cell migration GO:0030334 128 0.402
Mouse
positive regulation of phosphate metabolic process GO:0045937 262 0.402
locomotion GO:0040011 237 0.398
Mouse
anatomical structure morphogenesis GO:0009653 298 0.383
Fly
localization of cell GO:0051674 202 0.374
Mouse
cellular response to organonitrogen compound GO:0071417 197 0.372
response to glucocorticoid GO:0051384 223 0.370
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.369
response to peptide GO:1901652 292 0.367
aging GO:0007568 241 0.366
Fly
cellular metal ion homeostasis GO:0006875 172 0.340
regulation of anatomical structure morphogenesis GO:0022603 141 0.335
response to estradiol GO:0032355 164 0.333
positive regulation of cell motility GO:2000147 97 0.331
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.329
response to growth factor GO:0070848 189 0.328
single organism reproductive process GO:0044702 297 0.325
Fly
insulin like growth factor receptor signaling pathway GO:0048009 3 0.323
Human
regulation of mapk cascade GO:0043408 116 0.322
apoptotic process GO:0006915 381 0.307
negative regulation of cellular metabolic process GO:0031324 281 0.306
chemical homeostasis GO:0048878 292 0.305
cellular response to peptide GO:1901653 133 0.304
positive regulation of transcription dna templated GO:0045893 197 0.296
cell morphogenesis GO:0000902 142 0.296
Fly
positive regulation of developmental process GO:0051094 283 0.283
Fly
regulation of nucleic acid templated transcription GO:1903506 380 0.282
response to nutrient GO:0007584 248 0.280
cell motility GO:0048870 202 0.277
Mouse
positive regulation of biosynthetic process GO:0009891 319 0.276
Human
negative regulation of macromolecule metabolic process GO:0010605 260 0.274
positive regulation of phosphorus metabolic process GO:0010562 262 0.273
positive regulation of phosphorylation GO:0042327 177 0.272
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.265
Human
nucleic acid templated transcription GO:0097659 379 0.264
response to insulin GO:0032868 133 0.258
cellular component movement GO:0006928 248 0.254
Mouse
organophosphate biosynthetic process GO:0090407 143 0.253
calcium ion homeostasis GO:0055074 162 0.252
rna biosynthetic process GO:0032774 380 0.246
programmed cell death GO:0012501 392 0.244
negative regulation of metabolic process GO:0009892 331 0.242
cellular lipid metabolic process GO:0044255 208 0.241
cardiovascular system development GO:0072358 134 0.240
rna metabolic process GO:0016070 406 0.239
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.238
regulation of cellular component movement GO:0051270 150 0.237
Mouse
cellular response to oxygen containing compound GO:1901701 386 0.228
positive regulation of nucleic acid templated transcription GO:1903508 197 0.226
regulation of phosphorus metabolic process GO:0051174 349 0.225
positive regulation of rna biosynthetic process GO:1902680 197 0.223
macromolecular complex subunit organization GO:0043933 339 0.222
regulation of rna biosynthetic process GO:2001141 381 0.222
transcription dna templated GO:0006351 377 0.220
positive regulation of cell differentiation GO:0045597 217 0.219
regulation of protein modification process GO:0031399 194 0.217
regulation of rna metabolic process GO:0051252 391 0.215
regulation of programmed cell death GO:0043067 341 0.210
positive regulation of rna metabolic process GO:0051254 203 0.209
positive regulation of multicellular organismal process GO:0051240 387 0.205
Fly
negative regulation of cell proliferation GO:0008285 119 0.203
homeostatic process GO:0042592 331 0.202
Fly
muscle structure development GO:0061061 87 0.202
anatomical structure formation involved in morphogenesis GO:0048646 83 0.199
lipid metabolic process GO:0006629 283 0.198
positive regulation of cell communication GO:0010647 271 0.197
regulation of locomotion GO:0040012 148 0.196
Mouse
cellular ion homeostasis GO:0006873 184 0.193
cellular response to lipid GO:0071396 201 0.188
response to oxygen levels GO:0070482 265 0.184
Fly
cellular homeostasis GO:0019725 252 0.184
mapk cascade GO:0000165 140 0.182
reactive oxygen species metabolic process GO:0072593 37 0.179
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.177
cellular calcium ion homeostasis GO:0006874 160 0.177
positive regulation of cellular biosynthetic process GO:0031328 295 0.177
Human
regulation of cellular component organization GO:0051128 368 0.176
multicellular organism reproduction GO:0032504 233 0.174
Fly
urogenital system development GO:0001655 78 0.174
organic acid metabolic process GO:0006082 292 0.171
Human
response to corticosteroid GO:0031960 235 0.170
regulation of phosphorylation GO:0042325 248 0.169
cell adhesion GO:0007155 110 0.169
reproductive process GO:0022414 372 0.166
Fly
protein heterooligomerization GO:0051291 89 0.165
regulation of intracellular signal transduction GO:1902531 218 0.164
response to estrogen GO:0043627 232 0.161
response to purine containing compound GO:0014074 126 0.160
positive regulation of mapk cascade GO:0043410 92 0.156
regulation of mesenchymal cell proliferation GO:0010464 4 0.155
Mouse
single organism organelle organization GO:1902589 180 0.154
positive regulation of protein phosphorylation GO:0001934 135 0.154
response to extracellular stimulus GO:0009991 380 0.154
Fly
regulation of phosphate metabolic process GO:0019220 349 0.154
positive regulation of response to stimulus GO:0048584 285 0.153
regulation of cell differentiation GO:0045595 320 0.152
response to nutrient levels GO:0031667 370 0.147
Fly
regulation of protein metabolic process GO:0051246 289 0.147
intracellular transport GO:0046907 185 0.146
regulation of apoptotic process GO:0042981 335 0.145
cellular component biogenesis GO:0044085 368 0.145
negative regulation of cell differentiation GO:0045596 99 0.143
negative regulation of cell death GO:0060548 229 0.142
mesenchymal cell proliferation GO:0010463 4 0.141
Mouse
cellular response to insulin stimulus GO:0032869 81 0.140
regulation of transcription dna templated GO:0006355 374 0.139
epithelium development GO:0060429 96 0.137
negative regulation of phosphorus metabolic process GO:0010563 80 0.133
cation homeostasis GO:0055080 195 0.131
blood vessel morphogenesis GO:0048514 58 0.130
positive regulation of protein metabolic process GO:0051247 178 0.128
mesoderm development GO:0007498 2 0.127
regulation of protein phosphorylation GO:0001932 183 0.127
regulation of cell morphogenesis GO:0022604 77 0.127
regulation of multicellular organismal development GO:2000026 376 0.126
kidney development GO:0001822 67 0.124
positive regulation of cell proliferation GO:0008284 249 0.124
Mouse
multicellular organismal reproductive process GO:0048609 233 0.122
Fly
cell morphogenesis involved in differentiation GO:0000904 119 0.121
cellular divalent inorganic cation homeostasis GO:0072503 162 0.120
reproduction GO:0000003 245 0.119
Fly
response to organophosphorus GO:0046683 102 0.119
positive regulation of cellular protein metabolic process GO:0032270 167 0.117
regulation of lipid metabolic process GO:0019216 68 0.117
positive regulation of map kinase activity GO:0043406 46 0.117
action potential GO:0001508 54 0.117
g protein coupled receptor signaling pathway GO:0007186 242 0.117
cellular response to steroid hormone stimulus GO:0071383 93 0.116
regulation of protein kinase activity GO:0045859 105 0.115
reproductive structure development GO:0048608 128 0.114
circulatory system development GO:0072359 134 0.114
negative regulation of multicellular organismal process GO:0051241 203 0.114
cell cell signaling GO:0007267 335 0.112
muscle tissue development GO:0060537 58 0.112
positive regulation of gene expression GO:0010628 244 0.112
organelle organization GO:0006996 266 0.111
circulatory system process GO:0003013 183 0.110
muscle cell proliferation GO:0033002 84 0.107
cellular chemical homeostasis GO:0055082 247 0.107
regulation of kinase activity GO:0043549 117 0.107
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.107
regulation of molecular function GO:0065009 398 0.107
development of primary sexual characteristics GO:0045137 107 0.106
neuron projection development GO:0031175 273 0.105
cellular response to stress GO:0033554 269 0.104
tissue morphogenesis GO:0048729 22 0.104
organic substance catabolic process GO:1901575 316 0.101
Human Mouse
protein complex assembly GO:0006461 263 0.101
behavior GO:0007610 205 0.101
Fly
embryo development GO:0009790 49 0.100
negative regulation of apoptotic process GO:0043066 181 0.100
negative regulation of developmental process GO:0051093 125 0.099
positive regulation of cellular component organization GO:0051130 200 0.098
cell type specific apoptotic process GO:0097285 134 0.098
secretion GO:0046903 307 0.097
muscle cell differentiation GO:0042692 52 0.093
small gtpase mediated signal transduction GO:0007264 36 0.092
anterior posterior pattern specification GO:0009952 1 0.092
regulation of anatomical structure size GO:0090066 135 0.092
Fly
regulation of stem cell proliferation GO:0072091 14 0.090
Mouse
protein complex biogenesis GO:0070271 263 0.090
response to dexamethasone GO:0071548 49 0.089
digestive system development GO:0055123 41 0.089
regulation of signal transduction GO:0009966 318 0.088
endocytosis GO:0006897 84 0.087
organonitrogen compound biosynthetic process GO:1901566 167 0.086
divalent inorganic cation homeostasis GO:0072507 165 0.086
developmental growth GO:0048589 100 0.086
Fly
cellular ketone metabolic process GO:0042180 51 0.086
Human
developmental process involved in reproduction GO:0003006 159 0.086
Fly
ion homeostasis GO:0050801 212 0.086
single organism intracellular transport GO:1902582 166 0.085
response to ketone GO:1901654 182 0.085
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.083
Mouse
positive regulation of protein modification process GO:0031401 142 0.083
cellular amine metabolic process GO:0044106 38 0.082
negative regulation of gene expression GO:0010629 199 0.082
regulation of reactive oxygen species metabolic process GO:2000377 26 0.082
skeletal system development GO:0001501 41 0.082
renal system development GO:0072001 67 0.081
activation of protein kinase activity GO:0032147 47 0.080
protein complex subunit organization GO:0071822 302 0.080
cellular response to corticosteroid stimulus GO:0071384 69 0.080
single organism carbohydrate metabolic process GO:0044723 118 0.080
Human
metal ion homeostasis GO:0055065 186 0.080
regulation of cellular ketone metabolic process GO:0010565 27 0.079
Human
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.078
smooth muscle cell proliferation GO:0048659 77 0.078
blood circulation GO:0008015 183 0.077
response to inorganic substance GO:0010035 377 0.077
regulation of smooth muscle cell proliferation GO:0048660 75 0.076
epithelial cell proliferation GO:0050673 54 0.075
phospholipid biosynthetic process GO:0008654 29 0.075
regulation of transferase activity GO:0051338 123 0.075
regulation of epithelial cell proliferation GO:0050678 49 0.075
negative regulation of cellular protein metabolic process GO:0032269 106 0.074
wound healing GO:0042060 122 0.074
hexose metabolic process GO:0019318 58 0.074
Human
carbohydrate derivative biosynthetic process GO:1901137 124 0.073
positive regulation of apoptotic process GO:0043065 154 0.073
regulation of blood pressure GO:0008217 83 0.072
cellular amino acid metabolic process GO:0006520 107 0.072
regulation of catabolic process GO:0009894 113 0.071
Human
regulation of cellular amine metabolic process GO:0033238 8 0.071
cytosolic calcium ion homeostasis GO:0051480 140 0.070
macromolecular complex assembly GO:0065003 273 0.070
growth GO:0040007 165 0.070
Fly
positive regulation of cell death GO:0010942 184 0.070
response to camp GO:0051591 91 0.069
ovulation cycle GO:0042698 67 0.068
carbohydrate derivative metabolic process GO:1901135 346 0.068
regulation of nervous system development GO:0051960 264 0.068
organophosphate metabolic process GO:0019637 370 0.067
regeneration GO:0031099 163 0.067
amine metabolic process GO:0009308 38 0.067
response to monosaccharide GO:0034284 159 0.067
response to other organism GO:0051707 220 0.066
reproductive system development GO:0061458 128 0.065
response to mechanical stimulus GO:0009612 134 0.065
ribonucleotide metabolic process GO:0009259 231 0.065
vasculature development GO:0001944 70 0.064
positive regulation of biomineral tissue development GO:0070169 4 0.063
synaptic transmission GO:0007268 235 0.063
response to hexose GO:0009746 144 0.063
blood vessel development GO:0001568 69 0.062
cellular response to organic cyclic compound GO:0071407 202 0.062
formation of primary germ layer GO:0001704 1 0.062
positive regulation of intracellular signal transduction GO:1902533 138 0.062
regulation of ion transport GO:0043269 245 0.062
heart development GO:0007507 72 0.061
regulation of muscle tissue development GO:1901861 25 0.061
cellular response to alcohol GO:0097306 87 0.061
positive regulation of cellular component movement GO:0051272 102 0.061
Mouse
gastrulation GO:0007369 2 0.060
cell projection organization GO:0030030 302 0.060
multi organism reproductive process GO:0044703 262 0.059
Fly
central nervous system development GO:0007417 311 0.059
purine nucleotide metabolic process GO:0006163 229 0.058
oxoacid metabolic process GO:0043436 290 0.058
Human
cellular protein localization GO:0034613 122 0.058
Mouse
response to vitamin GO:0033273 131 0.057
response to ethanol GO:0045471 162 0.057
negative regulation of biosynthetic process GO:0009890 168 0.057
positive regulation of catalytic activity GO:0043085 184 0.057
striated muscle tissue development GO:0014706 58 0.057
neuron development GO:0048666 286 0.056
negative regulation of signal transduction GO:0009968 83 0.056
heart morphogenesis GO:0003007 3 0.056
regulation of response to stress GO:0080134 126 0.056
positive regulation of programmed cell death GO:0043068 157 0.056
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.055
morphogenesis of an epithelium GO:0002009 20 0.055
organ formation GO:0048645 3 0.055
negative regulation of programmed cell death GO:0043069 183 0.055
vesicle mediated transport GO:0016192 181 0.054
negative regulation of protein metabolic process GO:0051248 114 0.054
appendage morphogenesis GO:0035107 4 0.054
cellular cation homeostasis GO:0030003 180 0.053
response to decreased oxygen levels GO:0036293 237 0.053
Fly
positive regulation of protein kinase activity GO:0045860 73 0.053
regulation of organ formation GO:0003156 2 0.053
biological adhesion GO:0022610 110 0.052
cellular response to glucocorticoid stimulus GO:0071385 68 0.052
regulation of map kinase activity GO:0043405 53 0.052
receptor mediated endocytosis GO:0006898 42 0.052
bmp signaling pathway GO:0030509 4 0.051
phospholipid metabolic process GO:0006644 61 0.050
organic hydroxy compound metabolic process GO:1901615 115 0.050
forebrain development GO:0030900 98 0.050
neural crest cell differentiation GO:0014033 2 0.050
b cell differentiation GO:0030183 2 0.050
erk1 and erk2 cascade GO:0070371 48 0.050
cellular component morphogenesis GO:0032989 155 0.050
Fly
regulation of organelle organization GO:0033043 80 0.049
connective tissue development GO:0061448 33 0.049
multicellular organismal signaling GO:0035637 44 0.049
small molecule biosynthetic process GO:0044283 124 0.049
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.049
lipid modification GO:0030258 52 0.049
skeletal muscle tissue development GO:0007519 31 0.048
cell cycle GO:0007049 101 0.048
regulation of cell development GO:0060284 263 0.048
response to oxidative stress GO:0006979 186 0.048
regulation of cellular amino acid metabolic process GO:0006521 2 0.048
cellular catabolic process GO:0044248 295 0.047
Human
response to metal ion GO:0010038 253 0.047
tissue regeneration GO:0042246 36 0.047
angiogenesis GO:0001525 53 0.047
positive regulation of epithelial cell proliferation GO:0050679 32 0.046
cellular component assembly GO:0022607 360 0.046
cation transport GO:0006812 382 0.046
carbohydrate metabolic process GO:0005975 130 0.046
Human
gland development GO:0048732 155 0.045
Mouse
positive regulation of neurogenesis GO:0050769 165 0.045
chemotaxis GO:0006935 66 0.045
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.045
carboxylic acid metabolic process GO:0019752 289 0.044
Human
regulation of response to external stimulus GO:0032101 106 0.044
positive regulation of molecular function GO:0044093 230 0.043
transmission of nerve impulse GO:0019226 42 0.043
protein transport GO:0015031 132 0.043
actin filament based process GO:0030029 86 0.043
cytokine production GO:0001816 61 0.043
gonad development GO:0008406 104 0.042
sex differentiation GO:0007548 113 0.042
protein localization to nucleus GO:0034504 39 0.042
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 117 0.042
peptidyl amino acid modification GO:0018193 126 0.042
cellular glucan metabolic process GO:0006073 23 0.042
Human
positive regulation of bone mineralization GO:0030501 4 0.042
neuron death GO:0070997 127 0.041
tube development GO:0035295 89 0.041
positive regulation of cell development GO:0010720 176 0.041
neuron differentiation GO:0030182 368 0.040
reactive oxygen species biosynthetic process GO:1903409 8 0.040
nuclear transport GO:0051169 49 0.040
protein oligomerization GO:0051259 191 0.040
regulation of neuron differentiation GO:0045664 208 0.040
limb morphogenesis GO:0035108 4 0.040
response to carbohydrate GO:0009743 183 0.039
mesonephric tubule development GO:0072164 14 0.039
positive regulation of nervous system development GO:0051962 178 0.039
catabolic process GO:0009056 351 0.039
Human Mouse
multi multicellular organism process GO:0044706 138 0.039
positive regulation of secretion GO:0051047 140 0.039
development of primary female sexual characteristics GO:0046545 56 0.038
negative regulation of cardiac muscle tissue development GO:0055026 3 0.038
response to reactive oxygen species GO:0000302 120 0.037
response to bacterium GO:0009617 200 0.037
regulation of cellular component biogenesis GO:0044087 86 0.037
cartilage development GO:0051216 22 0.037
defense response GO:0006952 194 0.036
regulation of cell cell adhesion GO:0022407 14 0.036
ameboidal type cell migration GO:0001667 26 0.036
regulation of catalytic activity GO:0050790 304 0.036
proteolysis GO:0006508 175 0.036
rhythmic process GO:0048511 156 0.036
digestive tract development GO:0048565 39 0.035
regulation of protein serine threonine kinase activity GO:0071900 64 0.035
ossification GO:0001503 70 0.035
cell growth GO:0016049 104 0.035
Fly
germline stem cell asymmetric division GO:0098728 1 0.035
Fly
regulation of membrane potential GO:0042391 110 0.035
positive regulation of catabolic process GO:0009896 78 0.035
Human
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.035
reactive nitrogen species metabolic process GO:2001057 1 0.035
female gonad development GO:0008585 53 0.034
negative regulation of cellular biosynthetic process GO:0031327 161 0.034
regulation of skeletal muscle tissue regeneration GO:0043416 2 0.034
actin cytoskeleton organization GO:0030036 73 0.034
neuron projection morphogenesis GO:0048812 122 0.034
leukocyte activation GO:0045321 76 0.034
regulation of cellular localization GO:0060341 263 0.034
positive regulation of neuron differentiation GO:0045666 126 0.034
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.033
response to increased oxygen levels GO:0036296 45 0.033
brain development GO:0007420 247 0.033
cytoplasmic transport GO:0016482 115 0.033
nucleotide metabolic process GO:0009117 279 0.033
glycogen biosynthetic process GO:0005978 15 0.033
Human
embryonic skeletal system development GO:0048706 3 0.032
embryonic pattern specification GO:0009880 1 0.032
purine nucleotide biosynthetic process GO:0006164 83 0.032
axon development GO:0061564 96 0.032
response to acid chemical GO:0001101 222 0.032
oxidation reduction process GO:0055114 304 0.032
Human
striated muscle cell development GO:0055002 26 0.032
neurological system process GO:0050877 219 0.032
Fly
kidney epithelium development GO:0072073 19 0.032
regulation of cellular catabolic process GO:0031329 101 0.032
Human
signal release GO:0023061 145 0.032
ras protein signal transduction GO:0007265 29 0.031
mesoderm morphogenesis GO:0048332 1 0.031
protein import GO:0017038 37 0.031
regulation of stem cell differentiation GO:2000736 2 0.031
polysaccharide metabolic process GO:0005976 25 0.031
Human
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.031
neuronal action potential GO:0019228 35 0.031
single organism cell adhesion GO:0098602 46 0.031
response to alkaloid GO:0043279 132 0.031
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.031
embryonic appendage morphogenesis GO:0035113 4 0.030
regulation of metanephros development GO:0072215 4 0.030
intracellular protein transport GO:0006886 79 0.030
positive regulation of response to wounding GO:1903036 34 0.030
inorganic cation transmembrane transport GO:0098662 202 0.030
multicellular organism growth GO:0035264 1 0.030
Fly
single organism nuclear import GO:1902593 35 0.030
vasculogenesis GO:0001570 3 0.030
regulation of myeloid cell differentiation GO:0045637 12 0.030
response to wounding GO:0009611 254 0.030
response to hypoxia GO:0001666 231 0.029
kidney morphogenesis GO:0060993 13 0.029
organ morphogenesis GO:0009887 75 0.029
regulation of ion homeostasis GO:2000021 63 0.029
response to biotic stimulus GO:0009607 226 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.029
renal system process GO:0003014 40 0.029
osteoblast differentiation GO:0001649 26 0.029
ovulation cycle process GO:0022602 50 0.029
glycogen metabolic process GO:0005977 23 0.029
Human
response to hyperoxia GO:0055093 45 0.028
steroid biosynthetic process GO:0006694 48 0.028
glucan biosynthetic process GO:0009250 15 0.028
Human
macromolecule catabolic process GO:0009057 58 0.028
positive regulation of transferase activity GO:0051347 81 0.028
negative regulation of muscle cell apoptotic process GO:0010656 21 0.028
single organism catabolic process GO:0044712 283 0.028
Human Mouse
negative regulation of molecular function GO:0044092 133 0.028
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.028
neural crest cell development GO:0014032 2 0.028
negative regulation of osteoblast differentiation GO:0045668 2 0.027
glycerolipid metabolic process GO:0046486 67 0.027
neural crest cell migration GO:0001755 1 0.027
ion transmembrane transport GO:0034220 365 0.027
regulation of blood circulation GO:1903522 110 0.027
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.027
regulation of neurogenesis GO:0050767 247 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.026
sequestering of calcium ion GO:0051208 8 0.026
protein localization to organelle GO:0033365 57 0.026
Mouse
single organism cellular localization GO:1902580 102 0.026
specification of organ identity GO:0010092 2 0.026
mesoderm formation GO:0001707 1 0.026
glycerophospholipid metabolic process GO:0006650 47 0.026
protein localization GO:0008104 191 0.026
Mouse
response to fatty acid GO:0070542 65 0.026
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.026
metal ion transport GO:0030001 289 0.026
organ regeneration GO:0031100 101 0.026
regulation of ossification GO:0030278 32 0.025
purine ribonucleotide biosynthetic process GO:0009152 81 0.025
syncytium formation by plasma membrane fusion GO:0000768 3 0.025
negative regulation of signaling GO:0023057 157 0.025
regulation of cell adhesion GO:0030155 52 0.025
positive regulation of cellular catabolic process GO:0031331 71 0.025
Human
peptidyl tyrosine modification GO:0018212 72 0.025
regulation of homeostatic process GO:0032844 101 0.025
skeletal muscle organ development GO:0060538 33 0.025
gliogenesis GO:0042063 93 0.025
myelination GO:0042552 39 0.025
regulation of body fluid levels GO:0050878 90 0.024
embryonic morphogenesis GO:0048598 14 0.024
dna metabolic process GO:0006259 96 0.024
regulation of intracellular transport GO:0032386 65 0.024
digestive tract morphogenesis GO:0048546 8 0.024
protein catabolic process GO:0030163 30 0.024
muscle organ development GO:0007517 50 0.024
female sex differentiation GO:0046660 59 0.024
protein import into nucleus GO:0006606 35 0.024
regulation of vasculature development GO:1901342 44 0.024
adult locomotory behavior GO:0008344 4 0.024
metanephric comma shaped body morphogenesis GO:0072278 2 0.023
mesenchymal to epithelial transition GO:0060231 3 0.023
regulation of system process GO:0044057 208 0.023
epithelial cell differentiation GO:0030855 71 0.023
cellular response to ketone GO:1901655 51 0.023
negative regulation of rna metabolic process GO:0051253 123 0.023
lipid catabolic process GO:0016042 46 0.023
Human Mouse
positive regulation of transforming growth factor beta3 production GO:0032916 2 0.023
regulation of smooth muscle cell migration GO:0014910 36 0.023
regulation of cell size GO:0008361 37 0.023

Irs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.036
Human
inherited metabolic disorder DOID:655 0 0.036
disease of anatomical entity DOID:7 0 0.033
musculoskeletal system disease DOID:17 0 0.033
connective tissue disease DOID:65 0 0.033
cancer DOID:162 0 0.028
disease of cellular proliferation DOID:14566 0 0.028
nervous system disease DOID:863 0 0.025
vascular disease DOID:178 0 0.023
cardiovascular system disease DOID:1287 0 0.023