Rattus norvegicus

104 known processes

Kcne1

potassium voltage-gated channel, Isk-related family, member 1

(Aliases: Isk,m)

Kcne1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to extracellular stimulus GO:0009991 380 0.558
response to nutrient levels GO:0031667 370 0.448
response to nutrient GO:0007584 248 0.348
lipid biosynthetic process GO:0008610 128 0.245
response to corticosteroid GO:0031960 235 0.214
single organism biosynthetic process GO:0044711 342 0.194
inorganic cation transmembrane transport GO:0098662 202 0.193
hormone metabolic process GO:0042445 69 0.180
response to organophosphorus GO:0046683 102 0.170
rhythmic process GO:0048511 156 0.162
response to vitamin GO:0033273 131 0.154
cellular ketone metabolic process GO:0042180 51 0.147
response to purine containing compound GO:0014074 126 0.135
response to camp GO:0051591 91 0.134
response to transition metal nanoparticle GO:1990267 122 0.128
steroid biosynthetic process GO:0006694 48 0.110
homeostatic process GO:0042592 331 0.104
ion transmembrane transport GO:0034220 365 0.103
cellular amine metabolic process GO:0044106 38 0.102
cation transport GO:0006812 382 0.102
cation transmembrane transport GO:0098655 263 0.101
organic acid metabolic process GO:0006082 292 0.098
regulation of cellular amino acid metabolic process GO:0006521 2 0.097
oxoacid metabolic process GO:0043436 290 0.092
chemical homeostasis GO:0048878 292 0.089
hormone biosynthetic process GO:0042446 25 0.088
response to cytokine GO:0034097 215 0.087
glycerolipid metabolic process GO:0046486 67 0.087
cellular response to endogenous stimulus GO:0071495 377 0.086
positive regulation of cellular biosynthetic process GO:0031328 295 0.086
carboxylic acid metabolic process GO:0019752 289 0.086
cellular amino acid metabolic process GO:0006520 107 0.082
metal ion transport GO:0030001 289 0.080
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.078
regulation of ion transport GO:0043269 245 0.076
transmembrane transport GO:0055085 412 0.076
amine metabolic process GO:0009308 38 0.074
head development GO:0060322 247 0.074
positive regulation of cell proliferation GO:0008284 249 0.073
response to estrogen GO:0043627 232 0.073
regulation of cellular amine metabolic process GO:0033238 8 0.072
regulation of nervous system development GO:0051960 264 0.072
intracellular signal transduction GO:0035556 314 0.070
response to toxic substance GO:0009636 133 0.070
positive regulation of biosynthetic process GO:0009891 319 0.067
kidney development GO:0001822 67 0.063
lipid metabolic process GO:0006629 283 0.062
organic substance catabolic process GO:1901575 316 0.062
cellular response to oxygen containing compound GO:1901701 386 0.061
regulation of multicellular organismal development GO:2000026 376 0.060
regulation of cellular ketone metabolic process GO:0010565 27 0.058
reproductive structure development GO:0048608 128 0.057
cellular response to stress GO:0033554 269 0.056
single organism reproductive process GO:0044702 297 0.054
multicellular organism reproduction GO:0032504 233 0.054
organonitrogen compound biosynthetic process GO:1901566 167 0.054
inorganic ion transmembrane transport GO:0098660 229 0.053
regulation of lipid metabolic process GO:0019216 68 0.053
regulation of phosphorus metabolic process GO:0051174 349 0.052
response to fungicide GO:0060992 20 0.052
cellular response to organic cyclic compound GO:0071407 202 0.051
response to amino acid GO:0043200 75 0.051
response to inorganic substance GO:0010035 377 0.051
regulation of cell proliferation GO:0042127 359 0.051
circadian rhythm GO:0007623 88 0.050
response to acid chemical GO:0001101 222 0.047
reproductive process GO:0022414 372 0.045
regulation of cellular component organization GO:0051128 368 0.045
response to carbohydrate GO:0009743 183 0.045
peptidyl tyrosine phosphorylation GO:0018108 72 0.045
regulation of hydrolase activity GO:0051336 143 0.043
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.043
multi multicellular organism process GO:0044706 138 0.042
positive regulation of growth GO:0045927 55 0.042
response to mineralocorticoid GO:0051385 49 0.042
response to peptide hormone GO:0043434 278 0.041
cellular response to growth factor stimulus GO:0071363 162 0.041
regulation of catalytic activity GO:0050790 304 0.041
cellular response to external stimulus GO:0071496 118 0.041
peptidyl tyrosine modification GO:0018212 72 0.041
response to biotic stimulus GO:0009607 226 0.040
ethanolamine containing compound metabolic process GO:0042439 14 0.040
response to decreased oxygen levels GO:0036293 237 0.040
cellular response to hormone stimulus GO:0032870 247 0.039
positive regulation of developmental process GO:0051094 283 0.039
cellular biogenic amine metabolic process GO:0006576 30 0.039
regulation of hormone levels GO:0010817 187 0.038
small molecule biosynthetic process GO:0044283 124 0.038
cellular response to nitrogen compound GO:1901699 210 0.038
nucleic acid templated transcription GO:0097659 379 0.037
regulation of neurogenesis GO:0050767 247 0.037
alcohol metabolic process GO:0006066 77 0.037
macromolecule localization GO:0033036 252 0.037
nucleobase containing small molecule metabolic process GO:0055086 316 0.037
catabolic process GO:0009056 351 0.036
regulation of protein maturation GO:1903317 50 0.036
response to estradiol GO:0032355 164 0.036
single organism catabolic process GO:0044712 283 0.036
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.036
negative regulation of metabolic process GO:0009892 331 0.036
regulation of cellular catabolic process GO:0031329 101 0.036
carbohydrate derivative metabolic process GO:1901135 346 0.035
cardiac ventricle development GO:0003231 1 0.035
positive regulation of lipid metabolic process GO:0045834 33 0.035
tissue development GO:0009888 252 0.035
response to growth factor GO:0070848 189 0.034
response to hexose GO:0009746 144 0.034
organelle organization GO:0006996 266 0.034
positive regulation of cellular amine metabolic process GO:0033240 3 0.034
negative regulation of gene expression GO:0010629 199 0.033
transmission of nerve impulse GO:0019226 42 0.033
neuron differentiation GO:0030182 368 0.033
negative regulation of ion transport GO:0043271 51 0.033
response to tumor necrosis factor GO:0034612 56 0.033
positive regulation of phosphate metabolic process GO:0045937 262 0.032
protein complex biogenesis GO:0070271 263 0.032
regulation of rna biosynthetic process GO:2001141 381 0.032
steroid metabolic process GO:0008202 73 0.032
response to external biotic stimulus GO:0043207 221 0.032
response to oxygen levels GO:0070482 265 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.032
female pregnancy GO:0007565 122 0.031
cellular response to extracellular stimulus GO:0031668 73 0.031
response to glucocorticoid GO:0051384 223 0.031
cation homeostasis GO:0055080 195 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.031
alcohol biosynthetic process GO:0046165 38 0.031
negative regulation of cellular biosynthetic process GO:0031327 161 0.030
cell motility GO:0048870 202 0.030
response to food GO:0032094 27 0.030
response to metal ion GO:0010038 253 0.029
response to oxidative stress GO:0006979 186 0.029
cellular hormone metabolic process GO:0034754 49 0.029
response to corticosterone GO:0051412 40 0.029
immune system process GO:0002376 204 0.028
monovalent inorganic cation transport GO:0015672 172 0.028
cellular component assembly GO:0022607 360 0.028
multicellular organismal homeostasis GO:0048871 49 0.028
apoptotic process GO:0006915 381 0.028
positive regulation of phosphorylation GO:0042327 177 0.027
c21 steroid hormone biosynthetic process GO:0006700 10 0.027
response to starvation GO:0042594 59 0.027
calcium ion transport into cytosol GO:0060402 38 0.027
protein phosphorylation GO:0006468 345 0.027
multicellular organismal reproductive process GO:0048609 233 0.027
positive regulation of dna metabolic process GO:0051054 39 0.027
peptide biosynthetic process GO:0043043 3 0.027
regulation of membrane potential GO:0042391 110 0.027
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
cardiovascular system development GO:0072358 134 0.026
salivary gland development GO:0007431 3 0.026
phospholipid metabolic process GO:0006644 61 0.026
ras protein signal transduction GO:0007265 29 0.026
small gtpase mediated signal transduction GO:0007264 36 0.026
cardiac muscle tissue morphogenesis GO:0055008 1 0.026
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.026
negative regulation of rna biosynthetic process GO:1902679 118 0.026
signal transduction by phosphorylation GO:0023014 144 0.026
regulation of cell projection organization GO:0031344 175 0.026
response to dexamethasone GO:0071548 49 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
response to bacterium GO:0009617 200 0.025
regulation of nucleic acid templated transcription GO:1903506 380 0.025
c21 steroid hormone metabolic process GO:0008207 14 0.025
female sex differentiation GO:0046660 59 0.025
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.025
negative regulation of response to stimulus GO:0048585 155 0.024
divalent metal ion transport GO:0070838 132 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
negative regulation of macromolecule metabolic process GO:0010605 260 0.024
regulation of phosphate metabolic process GO:0019220 349 0.024
response to glucose GO:0009749 136 0.024
divalent inorganic cation transport GO:0072511 134 0.024
negative regulation of cell differentiation GO:0045596 99 0.024
negative regulation of cell communication GO:0010648 158 0.023
gland development GO:0048732 155 0.023
peptidyl amino acid modification GO:0018193 126 0.023
coronary vasculature morphogenesis GO:0060977 3 0.023
epithelial cell differentiation involved in kidney development GO:0035850 3 0.023
enzyme linked receptor protein signaling pathway GO:0007167 116 0.023
regulation of immune system process GO:0002682 123 0.023
ion homeostasis GO:0050801 212 0.023
sodium ion transmembrane transport GO:0035725 67 0.023
phospholipid biosynthetic process GO:0008654 29 0.023
regulation of growth GO:0040008 105 0.023
small molecule catabolic process GO:0044282 59 0.023
lymphoid progenitor cell differentiation GO:0002320 2 0.022
reproduction GO:0000003 245 0.022
monocarboxylic acid metabolic process GO:0032787 152 0.022
organophosphate metabolic process GO:0019637 370 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
negative regulation of apoptotic process GO:0043066 181 0.021
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.021
central nervous system development GO:0007417 311 0.021
negative regulation of rna metabolic process GO:0051253 123 0.021
regulation of protein metabolic process GO:0051246 289 0.021
negative regulation of transport GO:0051051 136 0.021
negative regulation of molecular function GO:0044092 133 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
regulation of apoptotic process GO:0042981 335 0.021
renal system development GO:0072001 67 0.021
positive regulation of cell differentiation GO:0045597 217 0.021
response to monosaccharide GO:0034284 159 0.021
positive regulation of molecular function GO:0044093 230 0.021
calcium ion transmembrane transport GO:0070588 70 0.020
androgen metabolic process GO:0008209 14 0.020
positive regulation of muscle contraction GO:0045933 22 0.020
cellular response to lipid GO:0071396 201 0.020
blood circulation GO:0008015 183 0.020
regulation of protein complex assembly GO:0043254 33 0.020
regulation of lipid biosynthetic process GO:0046890 38 0.020
cellular response to camp GO:0071320 26 0.020
positive regulation of lipid kinase activity GO:0090218 2 0.020
mesonephros development GO:0001823 14 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
transcription dna templated GO:0006351 377 0.020
response to ethanol GO:0045471 162 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
cellular response to insulin stimulus GO:0032869 81 0.019
response to peptide GO:1901652 292 0.019
circulatory system process GO:0003013 183 0.019
growth GO:0040007 165 0.019
regulation of molecular function GO:0065009 398 0.019
negative regulation of transcription dna templated GO:0045892 116 0.019
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.019
cellular response to reactive oxygen species GO:0034614 55 0.019
organ formation GO:0048645 3 0.019
female gonad development GO:0008585 53 0.019
cellular response to nutrient levels GO:0031669 60 0.019
regulation of cell development GO:0060284 263 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
reproductive system development GO:0061458 128 0.018
cellular response to starvation GO:0009267 27 0.018
organ induction GO:0001759 1 0.018
cytosolic calcium ion transport GO:0060401 39 0.018
regulation of cell differentiation GO:0045595 320 0.018
response to vitamin e GO:0033197 24 0.018
calcium ion import GO:0070509 22 0.018
negative regulation of signaling GO:0023057 157 0.018
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.018
negative regulation of cell death GO:0060548 229 0.017
rna metabolic process GO:0016070 406 0.017
regulation of neuron projection development GO:0010975 161 0.017
heart morphogenesis GO:0003007 3 0.017
secretion GO:0046903 307 0.017
regulation of fat cell proliferation GO:0070344 1 0.017
cell projection organization GO:0030030 302 0.017
regulation of rna metabolic process GO:0051252 391 0.017
neuron projection development GO:0031175 273 0.017
ovulation cycle process GO:0022602 50 0.017
organic acid transport GO:0015849 116 0.017
response to hydrogen peroxide GO:0042542 89 0.017
programmed cell death GO:0012501 392 0.017
heart development GO:0007507 72 0.017
regulation of phosphorylation GO:0042325 248 0.017
regulation of organelle organization GO:0033043 80 0.017
regeneration GO:0031099 163 0.016
action potential GO:0001508 54 0.016
regulation of dna metabolic process GO:0051052 60 0.016
response to hypoxia GO:0001666 231 0.016
regulation of neuron differentiation GO:0045664 208 0.016
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.016
regulation of transferase activity GO:0051338 123 0.016
regulation of blood pressure GO:0008217 83 0.016
gonad development GO:0008406 104 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
negative regulation of neuron death GO:1901215 69 0.016
regulation of cell adhesion GO:0030155 52 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
metal ion homeostasis GO:0055065 186 0.016
protein complex assembly GO:0006461 263 0.016
development of primary sexual characteristics GO:0045137 107 0.016
cardiac muscle contraction GO:0060048 27 0.016
muscle tissue morphogenesis GO:0060415 1 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
negative regulation of cell proliferation GO:0008285 119 0.015
cellular response to oxidative stress GO:0034599 76 0.015
amide biosynthetic process GO:0043604 10 0.015
regulation of programmed cell death GO:0043067 341 0.015
urogenital system development GO:0001655 78 0.015
cellular homeostasis GO:0019725 252 0.015
cellular cation homeostasis GO:0030003 180 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
transcription from rna polymerase ii promoter GO:0006366 252 0.015
rna biosynthetic process GO:0032774 380 0.015
cell morphogenesis involved in differentiation GO:0000904 119 0.015
positive regulation of multicellular organismal process GO:0051240 387 0.014
response to axon injury GO:0048678 59 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
neuron development GO:0048666 286 0.014
biological adhesion GO:0022610 110 0.014
sequestering of metal ion GO:0051238 9 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
fat cell proliferation GO:0070341 2 0.014
regulation of mapk cascade GO:0043408 116 0.014
carbohydrate metabolic process GO:0005975 130 0.014
response to herbicide GO:0009635 16 0.014
development of primary female sexual characteristics GO:0046545 56 0.014
intracellular transport GO:0046907 185 0.014
positive regulation of the force of heart contraction by epinephrine norepinephrine GO:0001997 2 0.014
glycerophospholipid metabolic process GO:0006650 47 0.014
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.014
calcium ion transport GO:0006816 131 0.014
positive regulation of protein kinase activity GO:0045860 73 0.014
positive regulation of cell development GO:0010720 176 0.014
developmental induction GO:0031128 2 0.013
organic hydroxy compound metabolic process GO:1901615 115 0.013
cellular macromolecular complex assembly GO:0034622 58 0.013
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.013
macromolecular complex assembly GO:0065003 273 0.013
specification of organ identity GO:0010092 2 0.013
regulation of establishment of protein localization GO:0070201 69 0.013
response to ketone GO:1901654 182 0.013
tissue morphogenesis GO:0048729 22 0.013
indole containing compound metabolic process GO:0042430 11 0.013
maternal process involved in female pregnancy GO:0060135 38 0.013
cellular protein complex assembly GO:0043623 44 0.013
developmental growth GO:0048589 100 0.013
generation of precursor metabolites and energy GO:0006091 62 0.013
molting cycle process GO:0022404 2 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
multicellular organismal signaling GO:0035637 44 0.013
striated muscle contraction GO:0006941 44 0.013
negative regulation of peptidase activity GO:0010466 38 0.013
regulation of homotypic cell cell adhesion GO:0034110 4 0.013
positive regulation of brown fat cell proliferation GO:0070349 1 0.013
cellular modified amino acid metabolic process GO:0006575 61 0.013
molting cycle GO:0042303 3 0.013
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.013
positive regulation of cardiac muscle contraction GO:0060452 4 0.013
regulation of catabolic process GO:0009894 113 0.013
multi organism reproductive process GO:0044703 262 0.013
estrogen biosynthetic process GO:0006703 6 0.013
tolerance induction dependent upon immune response GO:0002461 2 0.013
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.012
activation of protein kinase activity GO:0032147 47 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.012
response to vitamin d GO:0033280 34 0.012
regulation of organ formation GO:0003156 2 0.012
cellular metal ion homeostasis GO:0006875 172 0.012
regulation of transcription dna templated GO:0006355 374 0.012
aging GO:0007568 241 0.012
cytoplasmic transport GO:0016482 115 0.012
cellular lipid metabolic process GO:0044255 208 0.012
positive regulation of gene expression GO:0010628 244 0.012
anion transport GO:0006820 178 0.012
negative regulation of cell development GO:0010721 82 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.012
regulation of stem cell differentiation GO:2000736 2 0.012
regulation of secretion by cell GO:1903530 208 0.012
salivary gland morphogenesis GO:0007435 1 0.012
vasoconstriction GO:0042310 54 0.012
negative regulation of transporter activity GO:0032410 13 0.012
positive regulation of fat cell proliferation GO:0070346 1 0.012
lipid storage GO:0019915 1 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
macromolecule catabolic process GO:0009057 58 0.012
epithelium development GO:0060429 96 0.012
regulation of reactive oxygen species metabolic process GO:2000377 26 0.012
response to reactive oxygen species GO:0000302 120 0.012
regulation of protein modification process GO:0031399 194 0.012
renin secretion into blood stream GO:0002001 1 0.011
response to cgmp GO:0070305 3 0.011
translation GO:0006412 35 0.011
regulation of the force of heart contraction by chemical signal GO:0003057 2 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
anatomical structure morphogenesis GO:0009653 298 0.011
regulation of metanephros development GO:0072215 4 0.011
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.011
regulation of protein kinase activity GO:0045859 105 0.011
glucose homeostasis GO:0042593 75 0.011
positive regulation of catabolic process GO:0009896 78 0.011
positive regulation of nervous system development GO:0051962 178 0.011
maintenance of location GO:0051235 17 0.011
brown fat cell proliferation GO:0070342 2 0.011
urinary bladder smooth muscle contraction GO:0014832 4 0.011
adrenal gland development GO:0030325 11 0.011
cellular response to acid chemical GO:0071229 75 0.011
anatomical structure homeostasis GO:0060249 29 0.011
regulation of protein transport GO:0051223 68 0.011
regulation of metal ion transport GO:0010959 118 0.011
axon development GO:0061564 96 0.011
endoplasmic reticulum to cytosol transport GO:1903513 4 0.011
tissue regeneration GO:0042246 36 0.011
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.011
axis specification GO:0009798 4 0.011
energy derivation by oxidation of organic compounds GO:0015980 46 0.011
behavior GO:0007610 205 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
immune system development GO:0002520 41 0.011
purine containing compound metabolic process GO:0072521 253 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
single organism organelle organization GO:1902589 180 0.011
regulation of protein polymerization GO:0032271 19 0.011
positive regulation of protein secretion GO:0050714 19 0.011
ossification GO:0001503 70 0.011
muscle structure development GO:0061061 87 0.011
b cell differentiation GO:0030183 2 0.011
tissue homeostasis GO:0001894 28 0.011
multicellular organism growth GO:0035264 1 0.011
muscle contraction GO:0006936 88 0.011
single organism cell adhesion GO:0098602 46 0.011
glucose metabolic process GO:0006006 52 0.011
negative regulation of endopeptidase activity GO:0010951 36 0.010
hair follicle development GO:0001942 2 0.010
regulation of cell growth GO:0001558 85 0.010
regulation of brown fat cell proliferation GO:0070347 1 0.010
protein complex subunit organization GO:0071822 302 0.010
leydig cell differentiation GO:0033327 8 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010
cardiac chamber development GO:0003205 1 0.010
negative regulation of intracellular signal transduction GO:1902532 38 0.010
cellular component biogenesis GO:0044085 368 0.010
regulation of translation GO:0006417 27 0.010
negative regulation of programmed cell death GO:0043069 183 0.010
urinary tract smooth muscle contraction GO:0014848 4 0.010
neural precursor cell proliferation GO:0061351 23 0.010
embryonic pattern specification GO:0009880 1 0.010
respiratory system development GO:0060541 45 0.010
negative regulation of nervous system development GO:0051961 79 0.010
hair cycle GO:0042633 3 0.010
androgen biosynthetic process GO:0006702 10 0.010
odontogenesis GO:0042476 32 0.010
regulation of calcium ion transport GO:0051924 77 0.010
mapk cascade GO:0000165 140 0.010

Kcne1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
urinary system disease DOID:18 0 0.060
kidney disease DOID:557 0 0.060
disease of anatomical entity DOID:7 0 0.060
musculoskeletal system disease DOID:17 0 0.028
renal tubular transport disease DOID:447 0 0.012
nervous system disease DOID:863 0 0.010