Rattus norvegicus

76 known processes

Kcnj2

potassium inwardly-rectifying channel, subfamily J, member 2

(Aliases: Kir2.1)

Kcnj2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.361
oxoacid metabolic process GO:0043436 290 0.272
organic acid metabolic process GO:0006082 292 0.225
monocarboxylic acid metabolic process GO:0032787 152 0.195
cellular chemical homeostasis GO:0055082 247 0.125
Rat
single organism biosynthetic process GO:0044711 342 0.119
cellular homeostasis GO:0019725 252 0.110
Rat
regulation of cell differentiation GO:0045595 320 0.102
reproductive process GO:0022414 372 0.102
homeostatic process GO:0042592 331 0.090
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.082
cellular response to oxygen containing compound GO:1901701 386 0.081
Rat
response to peptide GO:1901652 292 0.077
negative regulation of macromolecule metabolic process GO:0010605 260 0.077
regulation of molecular function GO:0065009 398 0.075
Rat
cellular amino acid metabolic process GO:0006520 107 0.074
dephosphorylation GO:0016311 98 0.070
immune system process GO:0002376 204 0.070
signal release GO:0023061 145 0.069
cellular response to endogenous stimulus GO:0071495 377 0.068
Rat
carbohydrate metabolic process GO:0005975 130 0.062
response to nutrient levels GO:0031667 370 0.055
cell cell signaling GO:0007267 335 0.053
organophosphate metabolic process GO:0019637 370 0.053
response to inorganic substance GO:0010035 377 0.052
positive regulation of immune system process GO:0002684 90 0.051
ion homeostasis GO:0050801 212 0.050
cellular response to organonitrogen compound GO:0071417 197 0.050
Rat
central nervous system development GO:0007417 311 0.050
regulation of protein metabolic process GO:0051246 289 0.049
positive regulation of cell projection organization GO:0031346 111 0.049
regulation of nervous system development GO:0051960 264 0.049
cellular ketone metabolic process GO:0042180 51 0.048
response to organophosphorus GO:0046683 102 0.047
negative regulation of metabolic process GO:0009892 331 0.047
glucose homeostasis GO:0042593 75 0.047
Rat
cellular ion homeostasis GO:0006873 184 0.047
regulation of cellular protein metabolic process GO:0032268 267 0.047
positive regulation of cell differentiation GO:0045597 217 0.044
single organism behavior GO:0044708 130 0.043
Fly
protein phosphorylation GO:0006468 345 0.043
chemical homeostasis GO:0048878 292 0.042
Rat
positive regulation of cellular protein metabolic process GO:0032270 167 0.042
oxidation reduction process GO:0055114 304 0.042
negative regulation of response to stimulus GO:0048585 155 0.042
Fly
regulation of neuron projection development GO:0010975 161 0.040
transcription from rna polymerase ii promoter GO:0006366 252 0.040
lipid metabolic process GO:0006629 283 0.040
positive regulation of neuron projection development GO:0010976 99 0.039
regulation of cellular component organization GO:0051128 368 0.038
regulation of immune system process GO:0002682 123 0.038
regulation of transcription dna templated GO:0006355 374 0.038
positive regulation of neurogenesis GO:0050769 165 0.036
regulation of cellular ketone metabolic process GO:0010565 27 0.035
aging GO:0007568 241 0.034
regulation of cell projection organization GO:0031344 175 0.033
cellular response to stress GO:0033554 269 0.033
response to fungicide GO:0060992 20 0.033
divalent metal ion transport GO:0070838 132 0.032
Mouse
carbohydrate derivative metabolic process GO:1901135 346 0.031
single organism reproductive process GO:0044702 297 0.031
response to decreased oxygen levels GO:0036293 237 0.031
positive regulation of nervous system development GO:0051962 178 0.031
fatty acid metabolic process GO:0006631 99 0.030
cellular response to peptide GO:1901653 133 0.030
biological adhesion GO:0022610 110 0.030
response to extracellular stimulus GO:0009991 380 0.030
regulation of locomotion GO:0040012 148 0.030
response to purine containing compound GO:0014074 126 0.029
mesoderm development GO:0007498 2 0.029
negative regulation of protein metabolic process GO:0051248 114 0.029
negative regulation of cell communication GO:0010648 158 0.029
Fly
positive regulation of catalytic activity GO:0043085 184 0.028
cellular response to lipid GO:0071396 201 0.028
gland development GO:0048732 155 0.028
response to monosaccharide GO:0034284 159 0.027
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.027
organophosphate biosynthetic process GO:0090407 143 0.027
cellular component morphogenesis GO:0032989 155 0.026
Fly
regulation of metal ion transport GO:0010959 118 0.026
negative regulation of transport GO:0051051 136 0.026
positive regulation of multicellular organismal process GO:0051240 387 0.026
inorganic ion transmembrane transport GO:0098660 229 0.026
regulation of peptide transport GO:0090087 87 0.026
cognition GO:0050890 92 0.026
metal ion transport GO:0030001 289 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
defense response GO:0006952 194 0.025
single organism intracellular transport GO:1902582 166 0.025
hepaticobiliary system development GO:0061008 90 0.025
intracellular signal transduction GO:0035556 314 0.025
multi organism reproductive process GO:0044703 262 0.025
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.025
cellular metal ion homeostasis GO:0006875 172 0.025
regulation of protein modification process GO:0031399 194 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
Rat
response to carbohydrate GO:0009743 183 0.025
Rat
response to vitamin GO:0033273 131 0.024
response to cytokine GO:0034097 215 0.024
Rat
protein localization GO:0008104 191 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.024
regulation of system process GO:0044057 208 0.024
positive regulation of cell development GO:0010720 176 0.024
cellular response to reactive oxygen species GO:0034614 55 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
regulation of multicellular organismal development GO:2000026 376 0.023
brain development GO:0007420 247 0.023
synaptic transmission GO:0007268 235 0.023
positive regulation of protein phosphorylation GO:0001934 135 0.023
response to oxygen levels GO:0070482 265 0.022
response to growth factor GO:0070848 189 0.022
steroid metabolic process GO:0008202 73 0.022
lipid oxidation GO:0034440 30 0.022
divalent inorganic cation transport GO:0072511 134 0.021
Mouse
amine metabolic process GO:0009308 38 0.021
immune response GO:0006955 104 0.021
organic hydroxy compound metabolic process GO:1901615 115 0.021
liver development GO:0001889 90 0.021
positive regulation of developmental process GO:0051094 283 0.021
negative regulation of gene expression GO:0010629 199 0.021
rna biosynthetic process GO:0032774 380 0.021
positive regulation of neuron differentiation GO:0045666 126 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
reproduction GO:0000003 245 0.021
regulation of catalytic activity GO:0050790 304 0.021
regulation of neuron differentiation GO:0045664 208 0.021
response to peptide hormone GO:0043434 278 0.020
positive regulation of programmed cell death GO:0043068 157 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
sequestering of metal ion GO:0051238 9 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
regulation of phosphorus metabolic process GO:0051174 349 0.020
regulation of calcium ion transport GO:0051924 77 0.020
response to glucose GO:0009749 136 0.020
Rat
adenylate cyclase inhibiting serotonin receptor signaling pathway GO:0007198 1 0.020
cellular response to lipopolysaccharide GO:0071222 55 0.020
positive regulation of phosphorus metabolic process GO:0010562 262 0.020
negative regulation of cell differentiation GO:0045596 99 0.019
regulation of blood pressure GO:0008217 83 0.019
response to reactive oxygen species GO:0000302 120 0.019
response to nutrient GO:0007584 248 0.019
chemosensory behavior GO:0007635 2 0.019
behavior GO:0007610 205 0.019
Fly
regulation of insulin secretion GO:0050796 65 0.019
regulation of cell development GO:0060284 263 0.019
regulation of homeostatic process GO:0032844 101 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
small molecule biosynthetic process GO:0044283 124 0.019
response to wounding GO:0009611 254 0.018
intracellular transport GO:0046907 185 0.018
hemopoiesis GO:0030097 34 0.018
cellular divalent inorganic cation homeostasis GO:0072503 162 0.018
mesoderm morphogenesis GO:0048332 1 0.018
negative regulation of nucleic acid templated transcription GO:1903507 117 0.018
negative regulation of cellular metabolic process GO:0031324 281 0.018
multicellular organismal reproductive process GO:0048609 233 0.017
developmental process involved in reproduction GO:0003006 159 0.017
embryonic pattern specification GO:0009880 1 0.017
cellular calcium ion homeostasis GO:0006874 160 0.017
leukocyte differentiation GO:0002521 30 0.017
eye morphogenesis GO:0048592 4 0.017
female pregnancy GO:0007565 122 0.017
head development GO:0060322 247 0.017
regulation of cell growth GO:0001558 85 0.017
development of primary sexual characteristics GO:0045137 107 0.017
organic substance catabolic process GO:1901575 316 0.016
cellular lipid metabolic process GO:0044255 208 0.016
rna metabolic process GO:0016070 406 0.016
regulation of rna metabolic process GO:0051252 391 0.016
fatty acid oxidation GO:0019395 29 0.016
programmed cell death GO:0012501 392 0.016
insulin secretion GO:0030073 69 0.016
positive regulation of apoptotic process GO:0043065 154 0.016
response to toxic substance GO:0009636 133 0.016
calcium ion homeostasis GO:0055074 162 0.016
positive regulation of mapk cascade GO:0043410 92 0.016
cellular amine metabolic process GO:0044106 38 0.016
nucleoside metabolic process GO:0009116 179 0.016
negative regulation of cell death GO:0060548 229 0.016
response to oxidative stress GO:0006979 186 0.016
tissue development GO:0009888 252 0.016
sequestering of calcium ion GO:0051208 8 0.016
regulation of response to stress GO:0080134 126 0.016
neuron differentiation GO:0030182 368 0.016
Fly
insulin like growth factor receptor signaling pathway GO:0048009 3 0.016
negative regulation of rna biosynthetic process GO:1902679 118 0.015
positive regulation of cellular biosynthetic process GO:0031328 295 0.015
metal ion homeostasis GO:0055065 186 0.015
cellular response to cytokine stimulus GO:0071345 127 0.015
Rat
locomotion GO:0040011 237 0.015
sex differentiation GO:0007548 113 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
response to corticosteroid GO:0031960 235 0.015
multicellular organismal homeostasis GO:0048871 49 0.015
neuron development GO:0048666 286 0.015
Fly
peptidyl amino acid modification GO:0018193 126 0.015
activation of cysteine type endopeptidase activity GO:0097202 4 0.015
dicarboxylic acid metabolic process GO:0043648 42 0.014
response to hexose GO:0009746 144 0.014
Rat
adult locomotory behavior GO:0008344 4 0.014
sexual reproduction GO:0019953 148 0.014
cellular component movement GO:0006928 248 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
regulation of cellular amino acid metabolic process GO:0006521 2 0.014
lipid biosynthetic process GO:0008610 128 0.014
regulation of hydrolase activity GO:0051336 143 0.014
cellular response to tumor necrosis factor GO:0071356 46 0.014
Rat
positive regulation of phosphorylation GO:0042327 177 0.014
erythrocyte differentiation GO:0030218 1 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
regulation of transferase activity GO:0051338 123 0.014
cellular cation homeostasis GO:0030003 180 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
response to activity GO:0014823 73 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
purine containing compound metabolic process GO:0072521 253 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
positive regulation of cellular component organization GO:0051130 200 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
cellular response to oxidative stress GO:0034599 76 0.013
salivary gland development GO:0007431 3 0.013
regulation of potassium ion transport GO:0043266 29 0.013
response to external biotic stimulus GO:0043207 221 0.013
regulation of apoptotic process GO:0042981 335 0.013
regulation of neurogenesis GO:0050767 247 0.013
response to follicle stimulating hormone GO:0032354 18 0.013
gamete generation GO:0007276 124 0.013
immunoglobulin secretion GO:0048305 1 0.013
apoptotic process GO:0006915 381 0.013
regulation of transmembrane transport GO:0034762 122 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
lipid modification GO:0030258 52 0.013
muscle tissue development GO:0060537 58 0.013
peptide transport GO:0015833 97 0.013
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.013
cellular response to interleukin 1 GO:0071347 37 0.013
cellular response to metal ion GO:0071248 55 0.013
carbohydrate biosynthetic process GO:0016051 42 0.013
cytokine mediated signaling pathway GO:0019221 43 0.013
regulation of peptide hormone secretion GO:0090276 80 0.013
cellular response to inorganic substance GO:0071241 65 0.013
cation homeostasis GO:0055080 195 0.013
negative regulation of secretion by cell GO:1903531 72 0.012
regulation of nucleic acid templated transcription GO:1903506 380 0.012
male gonad development GO:0008584 59 0.012
positive regulation of gene expression GO:0010628 244 0.012
response to radiation GO:0009314 137 0.012
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 3 0.012
negative regulation of secretion GO:0051048 82 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
cell migration GO:0016477 197 0.012
glucose metabolic process GO:0006006 52 0.012
nucleobase containing small molecule metabolic process GO:0055086 316 0.012
neurological system process GO:0050877 219 0.012
regulation of signal transduction GO:0009966 318 0.012
Fly
calcium ion transport GO:0006816 131 0.012
retina morphogenesis in camera type eye GO:0060042 1 0.012
positive regulation of transferase activity GO:0051347 81 0.012
t cell homeostasis GO:0043029 2 0.012
response to amine GO:0014075 46 0.012
platelet aggregation GO:0070527 4 0.012
regulation of response to wounding GO:1903034 69 0.012
sensory organ development GO:0007423 74 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
localization of cell GO:0051674 202 0.011
positive regulation of cell death GO:0010942 184 0.011
myeloid cell differentiation GO:0030099 22 0.011
immune system development GO:0002520 41 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.011
regulation of kinase activity GO:0043549 117 0.011
carboxylic acid catabolic process GO:0046395 49 0.011
regulation of intracellular signal transduction GO:1902531 218 0.011
neuron death GO:0070997 127 0.011
negative regulation of molecular function GO:0044092 133 0.011
secretion by cell GO:0032940 248 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.011
response to increased oxygen levels GO:0036296 45 0.011
positive regulation of immune response GO:0050778 42 0.011
macromolecule localization GO:0033036 252 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
olfactory behavior GO:0042048 2 0.011
cellular response to hexose stimulus GO:0071331 65 0.011
Rat
nucleic acid templated transcription GO:0097659 379 0.011
striated muscle tissue development GO:0014706 58 0.011
tissue remodeling GO:0048771 40 0.011
organic acid catabolic process GO:0016054 49 0.011
gonad development GO:0008406 104 0.010
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.010
cellular response to growth factor stimulus GO:0071363 162 0.010
cell adhesion GO:0007155 110 0.010
regulation of ion transport GO:0043269 245 0.010
regulation of immune response GO:0050776 55 0.010
catabolic process GO:0009056 351 0.010
gastrulation GO:0007369 2 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
purine nucleotide metabolic process GO:0006163 229 0.010
lymphocyte activation involved in immune response GO:0002285 3 0.010
carbohydrate homeostasis GO:0033500 75 0.010
Rat
negative regulation of signal transduction GO:0009968 83 0.010
Fly
organ morphogenesis GO:0009887 75 0.010
regulation of hormone secretion GO:0046883 106 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
regeneration GO:0031099 163 0.010
positive regulation of molecular function GO:0044093 230 0.010
Rat
cellular component assembly GO:0022607 360 0.010
Human
sensory perception GO:0007600 101 0.010
positive regulation of protein modification process GO:0031401 142 0.010
sodium ion transmembrane transport GO:0035725 67 0.010
b cell differentiation GO:0030183 2 0.010

Kcnj2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
Human
nervous system disease DOID:863 0 0.029
disease of metabolism DOID:0014667 0 0.017
central nervous system disease DOID:331 0 0.017
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011
inherited metabolic disorder DOID:655 0 0.011
kidney disease DOID:557 0 0.010
urinary system disease DOID:18 0 0.010