Rattus norvegicus

30 known processes

Kdm6b

lysine (K)-specific demethylase 6B

(Aliases: Jmjd3)

Kdm6b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of rna biosynthetic process GO:1902679 118 0.401
regulation of rna biosynthetic process GO:2001141 381 0.375
rna biosynthetic process GO:0032774 380 0.363
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.339
negative regulation of metabolic process GO:0009892 331 0.328
transcription dna templated GO:0006351 377 0.314
regulation of nucleic acid templated transcription GO:1903506 380 0.281
rna metabolic process GO:0016070 406 0.277
negative regulation of rna metabolic process GO:0051253 123 0.273
regulation of transcription dna templated GO:0006355 374 0.271
nucleic acid templated transcription GO:0097659 379 0.264
regulation of rna metabolic process GO:0051252 391 0.229
negative regulation of macromolecule metabolic process GO:0010605 260 0.228
positive regulation of multicellular organismal process GO:0051240 387 0.199
negative regulation of transcription dna templated GO:0045892 116 0.196
cellular response to endogenous stimulus GO:0071495 377 0.195
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.191
negative regulation of biosynthetic process GO:0009890 168 0.191
negative regulation of nucleic acid templated transcription GO:1903507 117 0.186
single organism reproductive process GO:0044702 297 0.177
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.169
negative regulation of cellular biosynthetic process GO:0031327 161 0.160
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.160
positive regulation of gene expression GO:0010628 244 0.159
negative regulation of gene expression GO:0010629 199 0.145
negative regulation of cellular metabolic process GO:0031324 281 0.127
cellular response to hormone stimulus GO:0032870 247 0.121
response to peptide GO:1901652 292 0.120
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.114
cellular response to lipid GO:0071396 201 0.099
neuron differentiation GO:0030182 368 0.096
cellular response to organic cyclic compound GO:0071407 202 0.095
positive regulation of phosphorus metabolic process GO:0010562 262 0.092
reproductive process GO:0022414 372 0.089
protein phosphorylation GO:0006468 345 0.088
locomotion GO:0040011 237 0.088
regulation of nervous system development GO:0051960 264 0.088
cell morphogenesis involved in differentiation GO:0000904 119 0.085
cellular response to oxygen containing compound GO:1901701 386 0.083
positive regulation of nucleic acid templated transcription GO:1903508 197 0.080
regulation of phosphorus metabolic process GO:0051174 349 0.076
regulation of neurogenesis GO:0050767 247 0.076
cellular response to stress GO:0033554 269 0.075
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.074
regulation of multicellular organismal development GO:2000026 376 0.073
multi organism reproductive process GO:0044703 262 0.072
regulation of cell proliferation GO:0042127 359 0.072
localization of cell GO:0051674 202 0.070
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.069
positive regulation of rna metabolic process GO:0051254 203 0.067
regulation of cell development GO:0060284 263 0.067
response to oxygen levels GO:0070482 265 0.064
negative regulation of multicellular organismal process GO:0051241 203 0.060
positive regulation of nervous system development GO:0051962 178 0.060
response to extracellular stimulus GO:0009991 380 0.060
cell type specific apoptotic process GO:0097285 134 0.060
regulation of apoptotic process GO:0042981 335 0.060
anatomical structure morphogenesis GO:0009653 298 0.060
positive regulation of cellular biosynthetic process GO:0031328 295 0.059
positive regulation of biosynthetic process GO:0009891 319 0.059
organelle organization GO:0006996 266 0.058
protein autophosphorylation GO:0046777 66 0.057
regulation of cellular protein metabolic process GO:0032268 267 0.056
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.055
multicellular organism reproduction GO:0032504 233 0.054
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.054
regulation of phosphate metabolic process GO:0019220 349 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.054
positive regulation of neurogenesis GO:0050769 165 0.054
negative regulation of cell death GO:0060548 229 0.053
neuron projection morphogenesis GO:0048812 122 0.052
apoptotic process GO:0006915 381 0.052
tissue development GO:0009888 252 0.052
cell motility GO:0048870 202 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.050
transcription from rna polymerase ii promoter GO:0006366 252 0.050
cell migration GO:0016477 197 0.049
regulation of cell differentiation GO:0045595 320 0.048
intracellular signal transduction GO:0035556 314 0.047
regulation of programmed cell death GO:0043067 341 0.046
cellular response to nitrogen compound GO:1901699 210 0.046
dendrite morphogenesis GO:0048813 43 0.046
cell projection morphogenesis GO:0048858 123 0.044
regulation of neuron projection development GO:0010975 161 0.044
regulation of molecular function GO:0065009 398 0.044
neuron projection development GO:0031175 273 0.044
multicellular organismal reproductive process GO:0048609 233 0.044
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.043
response to nutrient levels GO:0031667 370 0.043
negative regulation of programmed cell death GO:0043069 183 0.042
programmed cell death GO:0012501 392 0.042
negative regulation of apoptotic process GO:0043066 181 0.042
axis specification GO:0009798 4 0.041
regulation of axonogenesis GO:0050770 37 0.040
response to camp GO:0051591 91 0.040
regulation of canonical wnt signaling pathway GO:0060828 4 0.040
regulation of protein kinase activity GO:0045859 105 0.040
positive regulation of response to stimulus GO:0048584 285 0.040
positive regulation of signaling GO:0023056 270 0.039
macromolecular complex subunit organization GO:0043933 339 0.039
rhythmic process GO:0048511 156 0.039
positive regulation of rna biosynthetic process GO:1902680 197 0.038
circadian regulation of gene expression GO:0032922 3 0.038
regulation of protein metabolic process GO:0051246 289 0.038
regulation of neuron differentiation GO:0045664 208 0.038
cellular response to organonitrogen compound GO:0071417 197 0.038
axonogenesis GO:0007409 71 0.037
reproduction GO:0000003 245 0.036
response to growth factor GO:0070848 189 0.036
small gtpase mediated signal transduction GO:0007264 36 0.036
cell part morphogenesis GO:0032990 123 0.034
positive regulation of transcription dna templated GO:0045893 197 0.034
cell morphogenesis GO:0000902 142 0.033
regulation of protein phosphorylation GO:0001932 183 0.033
aging GO:0007568 241 0.033
negative regulation of cellular protein metabolic process GO:0032269 106 0.033
response to decreased oxygen levels GO:0036293 237 0.033
growth GO:0040007 165 0.033
positive regulation of cell differentiation GO:0045597 217 0.033
reproductive structure development GO:0048608 128 0.032
regulation of cell projection organization GO:0031344 175 0.032
neuron development GO:0048666 286 0.032
response to molecule of bacterial origin GO:0002237 194 0.032
negative regulation of cell proliferation GO:0008285 119 0.032
positive regulation of cell development GO:0010720 176 0.031
cellular divalent inorganic cation homeostasis GO:0072503 162 0.031
protein complex biogenesis GO:0070271 263 0.031
cell projection organization GO:0030030 302 0.031
positive regulation of developmental process GO:0051094 283 0.030
gamete generation GO:0007276 124 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.030
regulation of cell morphogenesis GO:0022604 77 0.030
brain development GO:0007420 247 0.030
behavior GO:0007610 205 0.030
eye morphogenesis GO:0048592 4 0.030
regulation of cellular component organization GO:0051128 368 0.029
positive regulation of neuron projection development GO:0010976 99 0.029
carbohydrate metabolic process GO:0005975 130 0.029
macromolecular complex assembly GO:0065003 273 0.029
axon development GO:0061564 96 0.029
regulation of signal transduction GO:0009966 318 0.028
neuron death GO:0070997 127 0.028
positive regulation of cell migration GO:0030335 96 0.028
bmp signaling pathway GO:0030509 4 0.028
nucleotide metabolic process GO:0009117 279 0.028
developmental process involved in reproduction GO:0003006 159 0.028
single organism biosynthetic process GO:0044711 342 0.028
cell cell signaling GO:0007267 335 0.028
regulation of proteasomal protein catabolic process GO:0061136 4 0.027
regulation of catalytic activity GO:0050790 304 0.027
response to other organism GO:0051707 220 0.026
response to lipopolysaccharide GO:0032496 191 0.026
cellular component movement GO:0006928 248 0.026
enzyme linked receptor protein signaling pathway GO:0007167 116 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
regulation of intracellular signal transduction GO:1902531 218 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.026
positive regulation of molecular function GO:0044093 230 0.026
cellular amine metabolic process GO:0044106 38 0.025
negative regulation of developmental process GO:0051093 125 0.025
sexual reproduction GO:0019953 148 0.025
reproductive system development GO:0061458 128 0.025
negative regulation of molecular function GO:0044092 133 0.025
organic substance catabolic process GO:1901575 316 0.025
sex differentiation GO:0007548 113 0.025
positive regulation of neuron differentiation GO:0045666 126 0.025
cellular component assembly GO:0022607 360 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
response to inorganic substance GO:0010035 377 0.024
response to hypoxia GO:0001666 231 0.024
gastrulation GO:0007369 2 0.024
organic acid metabolic process GO:0006082 292 0.024
single organism carbohydrate metabolic process GO:0044723 118 0.024
cellular response to peptide GO:1901653 133 0.024
metal ion transport GO:0030001 289 0.024
response to acid chemical GO:0001101 222 0.024
developmental growth GO:0048589 100 0.024
regulation of protein modification process GO:0031399 194 0.024
response to peptide hormone GO:0043434 278 0.024
response to biotic stimulus GO:0009607 226 0.023
homeostatic process GO:0042592 331 0.023
positive regulation of cell projection organization GO:0031346 111 0.023
proteolysis GO:0006508 175 0.023
positive regulation of cell communication GO:0010647 271 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
response to external biotic stimulus GO:0043207 221 0.023
development of primary sexual characteristics GO:0045137 107 0.023
formation of primary germ layer GO:0001704 1 0.022
regulation of anatomical structure morphogenesis GO:0022603 141 0.022
cellular component morphogenesis GO:0032989 155 0.022
catabolic process GO:0009056 351 0.022
cellular component biogenesis GO:0044085 368 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
amine metabolic process GO:0009308 38 0.022
posttranscriptional regulation of gene expression GO:0010608 37 0.021
purine containing compound metabolic process GO:0072521 253 0.021
cellular response to lipopolysaccharide GO:0071222 55 0.021
secretion GO:0046903 307 0.021
response to oxidative stress GO:0006979 186 0.021
cellular carbohydrate metabolic process GO:0044262 72 0.021
regulation of phosphorylation GO:0042325 248 0.021
regulation of transferase activity GO:0051338 123 0.021
regulation of cell motility GO:2000145 131 0.020
nucleobase containing compound catabolic process GO:0034655 152 0.020
positive regulation of programmed cell death GO:0043068 157 0.020
embryonic pattern specification GO:0009880 1 0.020
response to organophosphorus GO:0046683 102 0.020
regulation of growth GO:0040008 105 0.020
positive regulation of apoptotic process GO:0043065 154 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.020
negative regulation of protein metabolic process GO:0051248 114 0.020
regulation of developmental growth GO:0048638 45 0.020
regulation of neuron death GO:1901214 115 0.019
central nervous system development GO:0007417 311 0.019
cellular response to acid chemical GO:0071229 75 0.019
synaptic growth at neuromuscular junction GO:0051124 1 0.019
response to cytokine GO:0034097 215 0.019
gonad development GO:0008406 104 0.019
motor neuron axon guidance GO:0008045 1 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
organic cyclic compound catabolic process GO:1901361 175 0.019
positive regulation of cellular component organization GO:0051130 200 0.019
protein complex assembly GO:0006461 263 0.019
regulation of catabolic process GO:0009894 113 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.018
response to purine containing compound GO:0014074 126 0.018
negative regulation of signaling GO:0023057 157 0.018
carboxylic acid metabolic process GO:0019752 289 0.018
response to metal ion GO:0010038 253 0.018
retina morphogenesis in camera type eye GO:0060042 1 0.018
cell adhesion GO:0007155 110 0.018
neurological system process GO:0050877 219 0.018
spermatogenesis GO:0007283 99 0.018
regulation of metal ion transport GO:0010959 118 0.018
anion transport GO:0006820 178 0.018
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
circadian rhythm GO:0007623 88 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
regulation of locomotion GO:0040012 148 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
response to nutrient GO:0007584 248 0.017
negative regulation of metanephros development GO:0072217 2 0.017
cellular homeostasis GO:0019725 252 0.017
multicellular organism growth GO:0035264 1 0.017
negative regulation of neurogenesis GO:0050768 78 0.017
ion transmembrane transport GO:0034220 365 0.017
head development GO:0060322 247 0.017
positive regulation of cell death GO:0010942 184 0.017
negative regulation of cellular component organization GO:0051129 83 0.017
male gamete generation GO:0048232 99 0.017
negative regulation of protein phosphorylation GO:0001933 44 0.017
cellular ketone metabolic process GO:0042180 51 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.017
immune system process GO:0002376 204 0.017
dendrite development GO:0016358 72 0.017
cellular response to external stimulus GO:0071496 118 0.017
response to mechanical stimulus GO:0009612 134 0.017
single organism organelle organization GO:1902589 180 0.016
regulation of gene expression epigenetic GO:0040029 10 0.016
regulation of ion transport GO:0043269 245 0.016
regulation of dendrite development GO:0050773 59 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
mapk cascade GO:0000165 140 0.016
tube development GO:0035295 89 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.016
entrainment of circadian clock GO:0009649 3 0.016
response to reactive oxygen species GO:0000302 120 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
nucleoside metabolic process GO:0009116 179 0.016
transmembrane transport GO:0055085 412 0.016
dna metabolic process GO:0006259 96 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.015
liver development GO:0001889 90 0.015
ion homeostasis GO:0050801 212 0.015
cellular ion homeostasis GO:0006873 184 0.015
ribose phosphate metabolic process GO:0019693 235 0.015
dephosphorylation GO:0016311 98 0.015
cation homeostasis GO:0055080 195 0.015
regulation of stem cell differentiation GO:2000736 2 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
protein complex subunit organization GO:0071822 302 0.015
regulation of kinase activity GO:0043549 117 0.015
heterocycle catabolic process GO:0046700 167 0.015
calcium ion transport GO:0006816 131 0.015
regulation of cell migration GO:0030334 128 0.015
positive regulation of immunoglobulin production GO:0002639 4 0.015
negative regulation of nervous system development GO:0051961 79 0.015
ras protein signal transduction GO:0007265 29 0.015
hepaticobiliary system development GO:0061008 90 0.015
anterior posterior pattern specification GO:0009952 1 0.015
mechanoreceptor differentiation GO:0042490 2 0.015
response to hydrogen peroxide GO:0042542 89 0.014
negative regulation of cell communication GO:0010648 158 0.014
negative regulation of cell development GO:0010721 82 0.014
carbohydrate derivative biosynthetic process GO:1901137 124 0.014
eye development GO:0001654 50 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
positive regulation of catabolic process GO:0009896 78 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.014
response to wounding GO:0009611 254 0.014
response to ethanol GO:0045471 162 0.014
negative regulation of protein modification process GO:0031400 52 0.014
regulation of organ formation GO:0003156 2 0.014
metal ion homeostasis GO:0055065 186 0.014
cellular response to biotic stimulus GO:0071216 59 0.014
purine ribonucleoside metabolic process GO:0046128 168 0.014
response to retinoic acid GO:0032526 63 0.014
vesicle mediated transport GO:0016192 181 0.014
nucleoside triphosphate metabolic process GO:0009141 144 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.014
cellular response to molecule of bacterial origin GO:0071219 56 0.014
biological adhesion GO:0022610 110 0.013
oxidation reduction process GO:0055114 304 0.013
carboxylic acid transport GO:0046942 115 0.013
embryo development GO:0009790 49 0.013
synaptic transmission GO:0007268 235 0.013
regulation of anatomical structure size GO:0090066 135 0.013
regulation of p38mapk cascade GO:1900744 1 0.013
response to ammonium ion GO:0060359 71 0.013
negative regulation of neuron death GO:1901215 69 0.013
calcium ion homeostasis GO:0055074 162 0.013
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003339 2 0.013
cation transport GO:0006812 382 0.013
response to bacterium GO:0009617 200 0.013
single organism catabolic process GO:0044712 283 0.013
single organism intracellular transport GO:1902582 166 0.013
insulin like growth factor receptor signaling pathway GO:0048009 3 0.012
negative regulation of kidney development GO:0090185 2 0.012
intracellular transport GO:0046907 185 0.012
negative regulation of phosphorus metabolic process GO:0010563 80 0.012
chromatin organization GO:0006325 34 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
generation of precursor metabolites and energy GO:0006091 62 0.012
cellular cation homeostasis GO:0030003 180 0.012
mitotic spindle organization GO:0007052 2 0.012
oxoacid metabolic process GO:0043436 290 0.012
negative regulation of cell differentiation GO:0045596 99 0.012
axon guidance GO:0007411 24 0.012
positive regulation of cellular catabolic process GO:0031331 71 0.012
macromolecule localization GO:0033036 252 0.012
chromatin modification GO:0016568 33 0.012
positive regulation of protein metabolic process GO:0051247 178 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
negative regulation of osteoblast differentiation GO:0045668 2 0.012
organophosphate metabolic process GO:0019637 370 0.012
regulation of cellular component movement GO:0051270 150 0.012
respiratory system development GO:0060541 45 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
rho protein signal transduction GO:0007266 11 0.012
translation GO:0006412 35 0.012
cellular response to mechanical stimulus GO:0071260 48 0.012
regulation of secretion GO:0051046 224 0.011
regulation of immune system process GO:0002682 123 0.011
regulation of carbohydrate metabolic process GO:0006109 41 0.011
response to estrogen GO:0043627 232 0.011
regulation of translation GO:0006417 27 0.011
spindle organization GO:0007051 2 0.011
cellular response to alcohol GO:0097306 87 0.011
regulation of hormone levels GO:0010817 187 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
immune effector process GO:0002252 53 0.011
cellular response to peptide hormone stimulus GO:0071375 120 0.011
forebrain development GO:0030900 98 0.011
olfactory behavior GO:0042048 2 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
chemosensory behavior GO:0007635 2 0.011
regeneration GO:0031099 163 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
aromatic compound catabolic process GO:0019439 168 0.011
cellular chemical homeostasis GO:0055082 247 0.011
cellular catabolic process GO:0044248 295 0.011
response to transforming growth factor beta GO:0071559 46 0.011
gland development GO:0048732 155 0.011
glycogen metabolic process GO:0005977 23 0.011
hormone metabolic process GO:0042445 69 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
lipid biosynthetic process GO:0008610 128 0.011
positive regulation of proteasomal protein catabolic process GO:1901800 3 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
regulation of cytoskeleton organization GO:0051493 49 0.011
positive regulation of phosphorylation GO:0042327 177 0.010
regulation of synaptic transmission GO:0050804 141 0.010
positive regulation of cell motility GO:2000147 97 0.010
muscle system process GO:0003012 115 0.010
lung development GO:0030324 43 0.010
chromosome segregation GO:0007059 2 0.010
positive regulation of protein modification process GO:0031401 142 0.010
regulation of cell growth GO:0001558 85 0.010
salivary gland development GO:0007431 3 0.010
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.010
inner ear receptor cell differentiation GO:0060113 2 0.010
divalent metal ion transport GO:0070838 132 0.010
signal transduction by phosphorylation GO:0023014 144 0.010
wnt signaling pathway involved in dorsal ventral axis specification GO:0044332 1 0.010
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 3 0.010
camera type eye morphogenesis GO:0048593 2 0.010
chemotaxis GO:0006935 66 0.010
intracellular receptor signaling pathway GO:0030522 35 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
erythrocyte differentiation GO:0030218 1 0.010
divalent inorganic cation transport GO:0072511 134 0.010

Kdm6b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.013
nervous system disease DOID:863 0 0.011
disease of anatomical entity DOID:7 0 0.011