Rattus norvegicus

0 known processes

Klf12

Kruppel-like factor 12

Klf12 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of molecular function GO:0065009 398 0.267
regulation of phosphorus metabolic process GO:0051174 349 0.244
negative regulation of metabolic process GO:0009892 331 0.180
negative regulation of cellular metabolic process GO:0031324 281 0.174
rna metabolic process GO:0016070 406 0.163
regulation of phosphate metabolic process GO:0019220 349 0.140
regulation of protein modification process GO:0031399 194 0.129
regulation of transcription dna templated GO:0006355 374 0.118
regulation of cellular protein metabolic process GO:0032268 267 0.118
transcription dna templated GO:0006351 377 0.117
negative regulation of phosphorus metabolic process GO:0010563 80 0.108
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.105
cell cell signaling GO:0007267 335 0.105
intracellular signal transduction GO:0035556 314 0.102
protein phosphorylation GO:0006468 345 0.101
central nervous system development GO:0007417 311 0.098
regulation of signal transduction GO:0009966 318 0.094
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.086
positive regulation of molecular function GO:0044093 230 0.086
response to hexose GO:0009746 144 0.085
regulation of phosphorylation GO:0042325 248 0.085
cation transport GO:0006812 382 0.085
neuron differentiation GO:0030182 368 0.084
nucleic acid templated transcription GO:0097659 379 0.084
negative regulation of macromolecule metabolic process GO:0010605 260 0.082
regulation of nucleic acid templated transcription GO:1903506 380 0.082
regulation of catalytic activity GO:0050790 304 0.081
regulation of rna biosynthetic process GO:2001141 381 0.080
response to monosaccharide GO:0034284 159 0.078
positive regulation of phosphate metabolic process GO:0045937 262 0.077
positive regulation of phosphorus metabolic process GO:0010562 262 0.076
regulation of protein metabolic process GO:0051246 289 0.074
negative regulation of cellular protein metabolic process GO:0032269 106 0.073
transcription from rna polymerase ii promoter GO:0006366 252 0.073
regulation of rna metabolic process GO:0051252 391 0.071
negative regulation of cell death GO:0060548 229 0.070
positive regulation of signal transduction GO:0009967 175 0.070
response to extracellular stimulus GO:0009991 380 0.069
positive regulation of cellular biosynthetic process GO:0031328 295 0.066
programmed cell death GO:0012501 392 0.064
rna biosynthetic process GO:0032774 380 0.063
reproductive process GO:0022414 372 0.060
negative regulation of phosphate metabolic process GO:0045936 80 0.058
response to carbohydrate GO:0009743 183 0.058
apoptotic process GO:0006915 381 0.057
positive regulation of biosynthetic process GO:0009891 319 0.054
regulation of protein phosphorylation GO:0001932 183 0.053
cellular response to endogenous stimulus GO:0071495 377 0.053
response to glucocorticoid GO:0051384 223 0.053
cellular amino acid metabolic process GO:0006520 107 0.053
regulation of cell development GO:0060284 263 0.052
regulation of cell differentiation GO:0045595 320 0.052
negative regulation of gene expression GO:0010629 199 0.052
response to nutrient GO:0007584 248 0.051
macromolecule localization GO:0033036 252 0.050
positive regulation of protein metabolic process GO:0051247 178 0.049
calcium ion homeostasis GO:0055074 162 0.049
response to estrogen GO:0043627 232 0.049
positive regulation of phosphorylation GO:0042327 177 0.049
regulation of calcium ion transport GO:0051924 77 0.048
macromolecular complex subunit organization GO:0043933 339 0.048
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.047
macromolecular complex assembly GO:0065003 273 0.047
response to estradiol GO:0032355 164 0.047
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.046
negative regulation of response to stimulus GO:0048585 155 0.045
cellular catabolic process GO:0044248 295 0.045
positive regulation of cell communication GO:0010647 271 0.045
organic substance catabolic process GO:1901575 316 0.044
cellular calcium ion homeostasis GO:0006874 160 0.044
negative regulation of signaling GO:0023057 157 0.043
positive regulation of transcription dna templated GO:0045893 197 0.043
response to oxygen levels GO:0070482 265 0.042
regulation of programmed cell death GO:0043067 341 0.042
metal ion transport GO:0030001 289 0.042
homeostatic process GO:0042592 331 0.042
positive regulation of rna biosynthetic process GO:1902680 197 0.041
regulation of nervous system development GO:0051960 264 0.041
cellular response to oxygen containing compound GO:1901701 386 0.041
response to growth factor GO:0070848 189 0.041
negative regulation of protein metabolic process GO:0051248 114 0.041
regulation of apoptotic process GO:0042981 335 0.040
cellular component biogenesis GO:0044085 368 0.039
positive regulation of catalytic activity GO:0043085 184 0.039
cellular response to hormone stimulus GO:0032870 247 0.039
positive regulation of response to stimulus GO:0048584 285 0.039
regulation of hormone levels GO:0010817 187 0.038
developmental process involved in reproduction GO:0003006 159 0.038
reproductive system development GO:0061458 128 0.038
regulation of cell proliferation GO:0042127 359 0.038
cell motility GO:0048870 202 0.037
regulation of hydrolase activity GO:0051336 143 0.037
regulation of cellular localization GO:0060341 263 0.037
negative regulation of molecular function GO:0044092 133 0.037
positive regulation of gene expression GO:0010628 244 0.037
neuron projection development GO:0031175 273 0.037
defense response GO:0006952 194 0.037
intracellular transport GO:0046907 185 0.037
positive regulation of cell proliferation GO:0008284 249 0.036
positive regulation of nucleic acid templated transcription GO:1903508 197 0.036
response to hypoxia GO:0001666 231 0.036
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
carboxylic acid metabolic process GO:0019752 289 0.035
positive regulation of nervous system development GO:0051962 178 0.035
vesicle mediated transport GO:0016192 181 0.034
neuron death GO:0070997 127 0.034
negative regulation of biosynthetic process GO:0009890 168 0.033
regulation of secretion GO:0051046 224 0.033
positive regulation of cellular protein metabolic process GO:0032270 167 0.033
positive regulation of protein modification process GO:0031401 142 0.033
positive regulation of signaling GO:0023056 270 0.033
regulation of protein kinase activity GO:0045859 105 0.033
cellular homeostasis GO:0019725 252 0.033
nitrogen compound transport GO:0071705 229 0.033
cellular ion homeostasis GO:0006873 184 0.032
regulation of transferase activity GO:0051338 123 0.032
cellular metal ion homeostasis GO:0006875 172 0.032
response to glucose GO:0009749 136 0.032
negative regulation of cell communication GO:0010648 158 0.031
regulation of multicellular organismal development GO:2000026 376 0.031
regulation of cellular amine metabolic process GO:0033238 8 0.031
cellular component assembly GO:0022607 360 0.030
response to oxidative stress GO:0006979 186 0.030
negative regulation of transport GO:0051051 136 0.030
protein complex assembly GO:0006461 263 0.030
secretion by cell GO:0032940 248 0.030
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.030
organophosphate metabolic process GO:0019637 370 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
regulation of neuron death GO:1901214 115 0.029
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.029
cellular cation homeostasis GO:0030003 180 0.029
cellular response to growth factor stimulus GO:0071363 162 0.029
amine metabolic process GO:0009308 38 0.029
cellular response to stress GO:0033554 269 0.029
response to decreased oxygen levels GO:0036293 237 0.029
response to nutrient levels GO:0031667 370 0.029
signal transduction by phosphorylation GO:0023014 144 0.028
localization of cell GO:0051674 202 0.028
cellular amine metabolic process GO:0044106 38 0.028
positive regulation of cellular component organization GO:0051130 200 0.028
regulation of cellular component organization GO:0051128 368 0.027
brain development GO:0007420 247 0.027
single organism behavior GO:0044708 130 0.027
organelle localization GO:0051640 55 0.027
organic acid metabolic process GO:0006082 292 0.027
protein complex subunit organization GO:0071822 302 0.027
regulation of intracellular signal transduction GO:1902531 218 0.027
negative regulation of cellular biosynthetic process GO:0031327 161 0.027
negative regulation of cell proliferation GO:0008285 119 0.027
metal ion homeostasis GO:0055065 186 0.026
oxoacid metabolic process GO:0043436 290 0.026
response to radiation GO:0009314 137 0.026
response to external biotic stimulus GO:0043207 221 0.026
multicellular organismal reproductive process GO:0048609 233 0.026
behavior GO:0007610 205 0.026
tube development GO:0035295 89 0.025
growth GO:0040007 165 0.025
response to molecule of bacterial origin GO:0002237 194 0.025
reproduction GO:0000003 245 0.025
regulation of neuron projection development GO:0010975 161 0.025
circulatory system development GO:0072359 134 0.025
cellular nitrogen compound catabolic process GO:0044270 163 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.024
non canonical wnt signaling pathway GO:0035567 3 0.024
sex differentiation GO:0007548 113 0.024
single organism cellular localization GO:1902580 102 0.024
positive regulation of neurogenesis GO:0050769 165 0.024
positive regulation of protein phosphorylation GO:0001934 135 0.024
catabolic process GO:0009056 351 0.024
locomotion GO:0040011 237 0.023
cellular response to organonitrogen compound GO:0071417 197 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.023
cellular component movement GO:0006928 248 0.023
response to ethanol GO:0045471 162 0.023
neuron development GO:0048666 286 0.023
purine containing compound metabolic process GO:0072521 253 0.023
cell type specific apoptotic process GO:0097285 134 0.023
biological adhesion GO:0022610 110 0.023
cellular protein localization GO:0034613 122 0.023
regulation of neurogenesis GO:0050767 247 0.023
synaptic transmission GO:0007268 235 0.022
negative regulation of multicellular organismal process GO:0051241 203 0.022
carbohydrate derivative metabolic process GO:1901135 346 0.022
cellular divalent inorganic cation homeostasis GO:0072503 162 0.022
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
cellular ketone metabolic process GO:0042180 51 0.021
response to inorganic substance GO:0010035 377 0.021
positive regulation of developmental process GO:0051094 283 0.021
peptidyl amino acid modification GO:0018193 126 0.021
regulation of peptide transport GO:0090087 87 0.021
blood vessel development GO:0001568 69 0.021
head development GO:0060322 247 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
calcium ion transport GO:0006816 131 0.021
chemical homeostasis GO:0048878 292 0.021
ras protein signal transduction GO:0007265 29 0.020
regulation of neuron differentiation GO:0045664 208 0.020
cell projection morphogenesis GO:0048858 123 0.020
regulation of growth GO:0040008 105 0.020
protein localization GO:0008104 191 0.020
anatomical structure morphogenesis GO:0009653 298 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
multicellular organismal signaling GO:0035637 44 0.020
protein complex biogenesis GO:0070271 263 0.020
single organism reproductive process GO:0044702 297 0.020
cation homeostasis GO:0055080 195 0.020
regulation of kinase activity GO:0043549 117 0.020
regulation of system process GO:0044057 208 0.019
regulation of vesicle mediated transport GO:0060627 81 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
nucleoside triphosphate catabolic process GO:0009143 123 0.019
positive regulation of transferase activity GO:0051347 81 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
intracellular protein transport GO:0006886 79 0.019
amide transport GO:0042886 105 0.019
aging GO:0007568 241 0.019
negative regulation of neuron death GO:1901215 69 0.019
smooth muscle cell migration GO:0014909 36 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
positive regulation of cell development GO:0010720 176 0.019
positive regulation of multicellular organismal process GO:0051240 387 0.019
negative regulation of apoptotic process GO:0043066 181 0.018
muscle tissue development GO:0060537 58 0.018
negative regulation of catalytic activity GO:0043086 103 0.018
tissue development GO:0009888 252 0.018
regeneration GO:0031099 163 0.018
development of primary sexual characteristics GO:0045137 107 0.018
anterior posterior pattern specification GO:0009952 1 0.018
response to peptide hormone GO:0043434 278 0.018
peptide transport GO:0015833 97 0.018
regulation of cellular catabolic process GO:0031329 101 0.018
cellular response to nitrogen compound GO:1901699 210 0.018
hormone transport GO:0009914 121 0.018
response to wounding GO:0009611 254 0.018
cellular response to abiotic stimulus GO:0071214 85 0.018
organelle organization GO:0006996 266 0.017
negative regulation of phosphorylation GO:0042326 57 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
mapk cascade GO:0000165 140 0.017
response to acid chemical GO:0001101 222 0.017
regulation of cell projection organization GO:0031344 175 0.017
cell projection organization GO:0030030 302 0.017
muscle structure development GO:0061061 87 0.017
cell growth GO:0016049 104 0.017
response to corticosteroid GO:0031960 235 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
negative regulation of secretion GO:0051048 82 0.017
divalent inorganic cation transport GO:0072511 134 0.017
proteolysis GO:0006508 175 0.017
regulation of epithelial cell proliferation GO:0050678 49 0.017
cell adhesion GO:0007155 110 0.017
cell part morphogenesis GO:0032990 123 0.017
regulation of cellular component movement GO:0051270 150 0.017
protein heterooligomerization GO:0051291 89 0.017
single organism organelle organization GO:1902589 180 0.017
regulation of locomotion GO:0040012 148 0.017
gamete generation GO:0007276 124 0.017
multicellular organism growth GO:0035264 1 0.016
positive regulation of neuron differentiation GO:0045666 126 0.016
regulation of dendrite development GO:0050773 59 0.016
single organism catabolic process GO:0044712 283 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.016
regulation of catabolic process GO:0009894 113 0.016
sequestering of calcium ion GO:0051208 8 0.016
regulation of behavior GO:0050795 61 0.016
lipid metabolic process GO:0006629 283 0.016
multi multicellular organism process GO:0044706 138 0.016
regulation of nucleotide metabolic process GO:0006140 117 0.015
cytoplasmic transport GO:0016482 115 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 35 0.015
cytosolic calcium ion homeostasis GO:0051480 140 0.015
regulation of metal ion transport GO:0010959 118 0.015
single organism intracellular transport GO:1902582 166 0.015
gonad development GO:0008406 104 0.015
regulation of secretion by cell GO:1903530 208 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
circulatory system process GO:0003013 183 0.015
muscle system process GO:0003012 115 0.015
response to ketone GO:1901654 182 0.015
positive regulation of cell death GO:0010942 184 0.015
negative regulation of cellular component organization GO:0051129 83 0.015
small gtpase mediated signal transduction GO:0007264 36 0.015
response to biotic stimulus GO:0009607 226 0.015
neuron projection morphogenesis GO:0048812 122 0.015
positive regulation of intracellular signal transduction GO:1902533 138 0.015
female pregnancy GO:0007565 122 0.015
vasculature development GO:0001944 70 0.015
reproductive structure development GO:0048608 128 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.014
taxis GO:0042330 67 0.014
cytoskeleton organization GO:0007010 111 0.014
divalent inorganic cation homeostasis GO:0072507 165 0.014
embryonic pattern specification GO:0009880 1 0.014
organic cyclic compound catabolic process GO:1901361 175 0.014
axis specification GO:0009798 4 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
organ regeneration GO:0031100 101 0.014
nucleotide metabolic process GO:0009117 279 0.014
multi organism reproductive process GO:0044703 262 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
positive regulation of apoptotic process GO:0043065 154 0.014
negative regulation of protein phosphorylation GO:0001933 44 0.014
exocytosis GO:0006887 60 0.014
cellular component morphogenesis GO:0032989 155 0.013
response to lipopolysaccharide GO:0032496 191 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 3 0.013
hormone secretion GO:0046879 115 0.013
cardiac conduction GO:0061337 2 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
cellular chemical homeostasis GO:0055082 247 0.013
response to cytokine GO:0034097 215 0.013
dephosphorylation GO:0016311 98 0.013
macromolecule catabolic process GO:0009057 58 0.013
negative regulation of signal transduction GO:0009968 83 0.013
cell morphogenesis GO:0000902 142 0.013
response to peptide GO:1901652 292 0.013
cellular response to mechanical stimulus GO:0071260 48 0.013
action potential GO:0001508 54 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
negative regulation of neuron differentiation GO:0045665 62 0.013
stress activated protein kinase signaling cascade GO:0031098 37 0.013
muscle cell differentiation GO:0042692 52 0.013
synaptic vesicle endocytosis GO:0048488 4 0.013
establishment of protein localization GO:0045184 141 0.013
ribonucleotide metabolic process GO:0009259 231 0.013
divalent metal ion transport GO:0070838 132 0.012
salivary gland development GO:0007431 3 0.012
inorganic cation transmembrane transport GO:0098662 202 0.012
regulation of proteolysis GO:0030162 66 0.012
response to vitamin GO:0033273 131 0.012
response to hyperoxia GO:0055093 45 0.012
response to camp GO:0051591 91 0.012
purine containing compound catabolic process GO:0072523 138 0.012
regulation of establishment of planar polarity GO:0090175 2 0.012
respiratory system development GO:0060541 45 0.012
gland development GO:0048732 155 0.012
response to bacterium GO:0009617 200 0.012
sexual reproduction GO:0019953 148 0.012
insulin secretion GO:0030073 69 0.012
aromatic compound catabolic process GO:0019439 168 0.012
dendrite development GO:0016358 72 0.012
dna metabolic process GO:0006259 96 0.012
regulation of ion transport GO:0043269 245 0.012
cellular response to external stimulus GO:0071496 118 0.012
negative regulation of protein modification process GO:0031400 52 0.012
positive regulation of kinase activity GO:0033674 77 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
cell morphogenesis involved in differentiation GO:0000904 119 0.012
regulation of peptide hormone secretion GO:0090276 80 0.012
negative regulation of secretion by cell GO:1903531 72 0.012
sulfur compound metabolic process GO:0006790 70 0.012
sequestering of metal ion GO:0051238 9 0.011
neuron apoptotic process GO:0051402 88 0.011
developmental growth GO:0048589 100 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
cellular macromolecule localization GO:0070727 122 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
neural crest cell differentiation GO:0014033 2 0.011
development of primary female sexual characteristics GO:0046545 56 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
single organism biosynthetic process GO:0044711 342 0.011
cell cycle GO:0007049 101 0.011
regulation of organelle organization GO:0033043 80 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
organonitrogen compound catabolic process GO:1901565 179 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
cation transmembrane transport GO:0098655 263 0.011
rna localization GO:0006403 4 0.011
response to metal ion GO:0010038 253 0.011
transmembrane transport GO:0055085 412 0.011
response to hydrogen peroxide GO:0042542 89 0.011
negative regulation of proteolysis GO:0045861 41 0.011
negative regulation of organ growth GO:0046621 3 0.011
embryonic appendage morphogenesis GO:0035113 4 0.011
signal release GO:0023061 145 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
regulation of cellular response to stress GO:0080135 49 0.011
circadian rhythm GO:0007623 88 0.011
ion homeostasis GO:0050801 212 0.011
regulation of embryonic development GO:0045995 2 0.011
regulation of transmembrane transport GO:0034762 122 0.011
reactive oxygen species metabolic process GO:0072593 37 0.011
negative regulation of intracellular signal transduction GO:1902532 38 0.011
cardiovascular system development GO:0072358 134 0.011
microtubule based process GO:0007017 36 0.011
positive regulation of cell migration GO:0030335 96 0.011
stress activated mapk cascade GO:0051403 35 0.011
maintenance of location GO:0051235 17 0.011
positive regulation of stress activated protein kinase signaling cascade GO:0070304 17 0.011
cellular response to peptide GO:1901653 133 0.010
nucleoside phosphate catabolic process GO:1901292 140 0.010
multicellular organism reproduction GO:0032504 233 0.010
regulation of peptidase activity GO:0052547 55 0.010
embryonic axis specification GO:0000578 1 0.010
lung development GO:0030324 43 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
multicellular organismal homeostasis GO:0048871 49 0.010
peptide hormone secretion GO:0030072 84 0.010
cell cycle checkpoint GO:0000075 2 0.010
response to starvation GO:0042594 59 0.010
negative regulation of cell cycle phase transition GO:1901988 4 0.010
response to light stimulus GO:0009416 52 0.010
neuronal action potential GO:0019228 35 0.010
positive regulation of cellular catabolic process GO:0031331 71 0.010
ossification GO:0001503 70 0.010
negative regulation of cell differentiation GO:0045596 99 0.010
negative regulation of response to wounding GO:1903035 23 0.010
calcium ion import GO:0070509 22 0.010
transmission of nerve impulse GO:0019226 42 0.010
gastrulation GO:0007369 2 0.010

Klf12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.028
sensory system disease DOID:0050155 0 0.012
gastrointestinal system disease DOID:77 0 0.011