Rattus norvegicus

0 known processes

Lats2

large tumor suppressor 2

Lats2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of molecular function GO:0065009 398 0.164
cellular response to endogenous stimulus GO:0071495 377 0.129
regulation of rna metabolic process GO:0051252 391 0.127
regulation of transcription dna templated GO:0006355 374 0.116
positive regulation of cell communication GO:0010647 271 0.111
protein phosphorylation GO:0006468 345 0.108
regulation of apoptotic process GO:0042981 335 0.106
positive regulation of programmed cell death GO:0043068 157 0.100
regulation of phosphorylation GO:0042325 248 0.097
regulation of nucleic acid templated transcription GO:1903506 380 0.096
regulation of cell development GO:0060284 263 0.095
nucleic acid templated transcription GO:0097659 379 0.091
transcription dna templated GO:0006351 377 0.088
regulation of signal transduction GO:0009966 318 0.087
regulation of neuron differentiation GO:0045664 208 0.084
protein localization GO:0008104 191 0.083
regulation of phosphate metabolic process GO:0019220 349 0.083
intracellular signal transduction GO:0035556 314 0.082
regulation of nervous system development GO:0051960 264 0.080
regulation of cell differentiation GO:0045595 320 0.080
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.077
positive regulation of developmental process GO:0051094 283 0.077
regulation of rna biosynthetic process GO:2001141 381 0.076
positive regulation of cell differentiation GO:0045597 217 0.075
regulation of neurogenesis GO:0050767 247 0.074
positive regulation of nervous system development GO:0051962 178 0.070
organophosphate metabolic process GO:0019637 370 0.069
positive regulation of cell projection organization GO:0031346 111 0.066
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.064
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.063
rna biosynthetic process GO:0032774 380 0.062
regulation of multicellular organismal development GO:2000026 376 0.062
cardiovascular system development GO:0072358 134 0.061
programmed cell death GO:0012501 392 0.060
positive regulation of neuron projection development GO:0010976 99 0.060
regulation of cell projection organization GO:0031344 175 0.059
neuron projection development GO:0031175 273 0.058
negative regulation of macromolecule metabolic process GO:0010605 260 0.057
regulation of protein phosphorylation GO:0001932 183 0.056
regulation of protein modification process GO:0031399 194 0.055
positive regulation of phosphorus metabolic process GO:0010562 262 0.054
response to growth factor GO:0070848 189 0.054
positive regulation of cellular biosynthetic process GO:0031328 295 0.053
regulation of programmed cell death GO:0043067 341 0.052
anatomical structure morphogenesis GO:0009653 298 0.051
enzyme linked receptor protein signaling pathway GO:0007167 116 0.050
neuron development GO:0048666 286 0.049
endocytosis GO:0006897 84 0.049
amine metabolic process GO:0009308 38 0.049
positive regulation of neuron differentiation GO:0045666 126 0.048
positive regulation of cell development GO:0010720 176 0.048
rna metabolic process GO:0016070 406 0.047
cell projection organization GO:0030030 302 0.047
regulation of intracellular signal transduction GO:1902531 218 0.046
negative regulation of metabolic process GO:0009892 331 0.046
regulation of protein metabolic process GO:0051246 289 0.045
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.045
positive regulation of neurogenesis GO:0050769 165 0.044
positive regulation of phosphate metabolic process GO:0045937 262 0.042
positive regulation of catalytic activity GO:0043085 184 0.041
positive regulation of multicellular organismal process GO:0051240 387 0.041
g protein coupled receptor signaling pathway GO:0007186 242 0.041
negative regulation of cellular metabolic process GO:0031324 281 0.040
organic acid metabolic process GO:0006082 292 0.040
regulation of kinase activity GO:0043549 117 0.039
cellular component biogenesis GO:0044085 368 0.039
regulation of mapk cascade GO:0043408 116 0.039
negative regulation of rna metabolic process GO:0051253 123 0.039
positive regulation of cellular component organization GO:0051130 200 0.039
positive regulation of protein modification process GO:0031401 142 0.039
regulation of neuron projection development GO:0010975 161 0.039
negative regulation of multicellular organismal process GO:0051241 203 0.037
regulation of protein kinase activity GO:0045859 105 0.037
regulation of system process GO:0044057 208 0.036
regulation of catalytic activity GO:0050790 304 0.036
positive regulation of transcription dna templated GO:0045893 197 0.036
actin filament based process GO:0030029 86 0.035
positive regulation of signaling GO:0023056 270 0.035
negative regulation of developmental process GO:0051093 125 0.035
positive regulation of phosphorylation GO:0042327 177 0.033
action potential GO:0001508 54 0.033
vesicle mediated transport GO:0016192 181 0.033
muscle system process GO:0003012 115 0.033
positive regulation of signal transduction GO:0009967 175 0.033
inorganic cation transmembrane transport GO:0098662 202 0.033
positive regulation of apoptotic process GO:0043065 154 0.032
negative regulation of signal transduction GO:0009968 83 0.032
positive regulation of cell death GO:0010942 184 0.032
growth GO:0040007 165 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
positive regulation of gene expression GO:0010628 244 0.032
cell projection morphogenesis GO:0048858 123 0.031
positive regulation of rna biosynthetic process GO:1902680 197 0.031
negative regulation of cell proliferation GO:0008285 119 0.031
guanosine containing compound catabolic process GO:1901069 71 0.031
positive regulation of rna metabolic process GO:0051254 203 0.031
anterior posterior pattern specification GO:0009952 1 0.030
circulatory system development GO:0072359 134 0.030
cellular response to stress GO:0033554 269 0.030
regulation of transferase activity GO:0051338 123 0.029
negative regulation of organ growth GO:0046621 3 0.028
regulation of cellular localization GO:0060341 263 0.028
aromatic compound catabolic process GO:0019439 168 0.028
regulation of cell morphogenesis GO:0022604 77 0.028
regulation of phosphorus metabolic process GO:0051174 349 0.028
response to nutrient levels GO:0031667 370 0.028
regulation of canonical wnt signaling pathway GO:0060828 4 0.028
transmembrane transport GO:0055085 412 0.027
potassium ion transport GO:0006813 97 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.027
regulation of dendrite morphogenesis GO:0048814 33 0.027
dendrite morphogenesis GO:0048813 43 0.027
negative regulation of cellular biosynthetic process GO:0031327 161 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
cellular response to growth factor stimulus GO:0071363 162 0.027
regulation of membrane potential GO:0042391 110 0.027
single organism biosynthetic process GO:0044711 342 0.027
heart development GO:0007507 72 0.027
positive regulation of molecular function GO:0044093 230 0.027
glycosyl compound catabolic process GO:1901658 126 0.026
single organism catabolic process GO:0044712 283 0.026
positive regulation of cellular amine metabolic process GO:0033240 3 0.026
negative regulation of biosynthetic process GO:0009890 168 0.026
cellular response to oxygen containing compound GO:1901701 386 0.026
negative regulation of transport GO:0051051 136 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
cellular amino acid metabolic process GO:0006520 107 0.026
neuron differentiation GO:0030182 368 0.026
inorganic ion transmembrane transport GO:0098660 229 0.026
transcription from rna polymerase ii promoter GO:0006366 252 0.026
positive regulation of mapk cascade GO:0043410 92 0.026
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.025
ras protein signal transduction GO:0007265 29 0.025
mapk cascade GO:0000165 140 0.025
cellular response to hormone stimulus GO:0032870 247 0.025
cell migration GO:0016477 197 0.025
macromolecular complex assembly GO:0065003 273 0.025
cell type specific apoptotic process GO:0097285 134 0.025
synaptic transmission GO:0007268 235 0.025
developmental growth GO:0048589 100 0.025
purine ribonucleoside catabolic process GO:0046130 124 0.025
positive regulation of response to stimulus GO:0048584 285 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
catabolic process GO:0009056 351 0.024
lipid metabolic process GO:0006629 283 0.024
cation transport GO:0006812 382 0.024
regulation of cellular protein metabolic process GO:0032268 267 0.024
cell morphogenesis GO:0000902 142 0.024
guanosine containing compound metabolic process GO:1901068 74 0.024
negative regulation of signaling GO:0023057 157 0.023
cellular component morphogenesis GO:0032989 155 0.023
organic cyclic compound catabolic process GO:1901361 175 0.023
cell cell signaling GO:0007267 335 0.023
organophosphate catabolic process GO:0046434 148 0.023
ion transmembrane transport GO:0034220 365 0.023
cardiac muscle contraction GO:0060048 27 0.023
establishment of protein localization GO:0045184 141 0.023
anatomical structure formation involved in morphogenesis GO:0048646 83 0.023
immune system process GO:0002376 204 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
regulation of muscle system process GO:0090257 79 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.022
cellular response to organonitrogen compound GO:0071417 197 0.022
cellular protein localization GO:0034613 122 0.022
heart morphogenesis GO:0003007 3 0.022
circulatory system process GO:0003013 183 0.022
cardiac ventricle development GO:0003231 1 0.021
purine containing compound catabolic process GO:0072523 138 0.021
cellular amine metabolic process GO:0044106 38 0.021
chemical homeostasis GO:0048878 292 0.021
cellular component movement GO:0006928 248 0.021
secretion GO:0046903 307 0.021
rhythmic process GO:0048511 156 0.021
carbohydrate derivative catabolic process GO:1901136 147 0.021
single organism intracellular transport GO:1902582 166 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
mesoderm development GO:0007498 2 0.021
carboxylic acid metabolic process GO:0019752 289 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
intracellular transport GO:0046907 185 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
neuron projection morphogenesis GO:0048812 122 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
nucleoside metabolic process GO:0009116 179 0.020
cellular response to nitrogen compound GO:1901699 210 0.020
gtp metabolic process GO:0046039 72 0.020
positive regulation of protein metabolic process GO:0051247 178 0.020
cellular component assembly GO:0022607 360 0.020
neuronal action potential GO:0019228 35 0.020
central nervous system development GO:0007417 311 0.020
nucleoside catabolic process GO:0009164 126 0.020
locomotion GO:0040011 237 0.020
histone h3 acetylation GO:0043966 2 0.020
ribonucleotide metabolic process GO:0009259 231 0.020
regulation of g protein coupled receptor protein signaling pathway GO:0008277 28 0.019
protein complex biogenesis GO:0070271 263 0.019
single organism organelle organization GO:1902589 180 0.019
regulation of catabolic process GO:0009894 113 0.019
positive regulation of protein kinase activity GO:0045860 73 0.019
nucleotide catabolic process GO:0009166 139 0.019
ventricular cardiac muscle cell action potential GO:0086005 2 0.019
response to decreased oxygen levels GO:0036293 237 0.019
eye morphogenesis GO:0048592 4 0.019
negative regulation of cell communication GO:0010648 158 0.018
nitrogen compound transport GO:0071705 229 0.018
tissue development GO:0009888 252 0.018
peptidyl tyrosine modification GO:0018212 72 0.018
small gtpase mediated signal transduction GO:0007264 36 0.018
positive regulation of cellular component movement GO:0051272 102 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
negative regulation of phosphate metabolic process GO:0045936 80 0.018
homeostatic process GO:0042592 331 0.018
organic substance catabolic process GO:1901575 316 0.018
cation homeostasis GO:0055080 195 0.018
ribose phosphate metabolic process GO:0019693 235 0.017
gap junction assembly GO:0016264 2 0.017
response to peptide hormone GO:0043434 278 0.017
regulation of cell proliferation GO:0042127 359 0.017
cell part morphogenesis GO:0032990 123 0.017
cell adhesion GO:0007155 110 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
multicellular organismal signaling GO:0035637 44 0.017
regulation of growth GO:0040008 105 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
metal ion homeostasis GO:0055065 186 0.017
transmission of nerve impulse GO:0019226 42 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
regulation of small gtpase mediated signal transduction GO:0051056 48 0.016
cation transmembrane transport GO:0098655 263 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
regulation of locomotion GO:0040012 148 0.016
response to estrogen GO:0043627 232 0.016
positive regulation of hydrolase activity GO:0051345 86 0.016
protein complex subunit organization GO:0071822 302 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
localization of cell GO:0051674 202 0.016
negative regulation of rna biosynthetic process GO:1902679 118 0.016
purine nucleoside catabolic process GO:0006152 124 0.016
positive regulation of nucleic acid templated transcription GO:1903508 197 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
alcohol metabolic process GO:0006066 77 0.016
response to extracellular stimulus GO:0009991 380 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.015
neurological system process GO:0050877 219 0.015
positive regulation of kinase activity GO:0033674 77 0.015
response to oxygen levels GO:0070482 265 0.015
cellular response to peptide GO:1901653 133 0.015
nucleotide metabolic process GO:0009117 279 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
positive regulation of rap gtpase activity GO:0032854 4 0.015
cytoskeleton organization GO:0007010 111 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
organonitrogen compound catabolic process GO:1901565 179 0.015
single organism reproductive process GO:0044702 297 0.015
regulation of cell migration GO:0030334 128 0.015
negative regulation of neurogenesis GO:0050768 78 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
regulation of synaptic transmission GO:0050804 141 0.015
response to reactive oxygen species GO:0000302 120 0.015
negative regulation of ion transport GO:0043271 51 0.015
apoptotic process GO:0006915 381 0.014
positive regulation of transferase activity GO:0051347 81 0.014
regulation of gtpase activity GO:0043087 57 0.014
macromolecule localization GO:0033036 252 0.014
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.014
metal ion transport GO:0030001 289 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
response to wounding GO:0009611 254 0.014
maintenance of location GO:0051235 17 0.014
negative regulation of neuron differentiation GO:0045665 62 0.014
regulation of g0 to g1 transition GO:0070316 3 0.014
regulation of fat cell differentiation GO:0045598 3 0.014
chromosome segregation GO:0007059 2 0.014
cell motility GO:0048870 202 0.014
regulation of secretion by cell GO:1903530 208 0.014
response to hypoxia GO:0001666 231 0.014
negative regulation of cell differentiation GO:0045596 99 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
regulation of anatomical structure morphogenesis GO:0022603 141 0.013
purine containing compound metabolic process GO:0072521 253 0.013
response to acid chemical GO:0001101 222 0.013
reproductive process GO:0022414 372 0.013
cellular macromolecule localization GO:0070727 122 0.013
signal transduction by phosphorylation GO:0023014 144 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
membrane organization GO:0061024 94 0.013
positive regulation of cellular component biogenesis GO:0044089 55 0.013
regulation of cell motility GO:2000145 131 0.013
heterocycle catabolic process GO:0046700 167 0.013
gastrulation GO:0007369 2 0.013
regulation of nucleoside metabolic process GO:0009118 66 0.013
cellular chemical homeostasis GO:0055082 247 0.013
cellular ketone metabolic process GO:0042180 51 0.013
response to corticosteroid GO:0031960 235 0.013
positive regulation of fat cell differentiation GO:0045600 2 0.013
amide transport GO:0042886 105 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
negative regulation of cell death GO:0060548 229 0.013
sex differentiation GO:0007548 113 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
regulation of tube size GO:0035150 89 0.012
negative regulation of transporter activity GO:0032410 13 0.012
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
cardiac muscle cell contraction GO:0086003 10 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
vascular process in circulatory system GO:0003018 96 0.012
negative regulation of programmed cell death GO:0043069 183 0.012
regulation of blood circulation GO:1903522 110 0.012
regulation of response to stress GO:0080134 126 0.012
purine nucleoside triphosphate metabolic process GO:0009144 141 0.012
regulation of ras gtpase activity GO:0032318 32 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
gtp catabolic process GO:0006184 71 0.012
cell morphogenesis involved in differentiation GO:0000904 119 0.012
oxoacid metabolic process GO:0043436 290 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
positive regulation of locomotion GO:0040017 102 0.012
adult locomotory behavior GO:0008344 4 0.012
tube formation GO:0035148 3 0.012
response to calcium ion GO:0051592 59 0.012
intracellular protein transport GO:0006886 79 0.012
regulation of cellular component organization GO:0051128 368 0.012
cellular ion homeostasis GO:0006873 184 0.012
blood vessel morphogenesis GO:0048514 58 0.012
regulation of dendrite development GO:0050773 59 0.011
blood circulation GO:0008015 183 0.011
hematopoietic progenitor cell differentiation GO:0002244 2 0.011
regulation of gtp catabolic process GO:0033124 58 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.011
cellular cation homeostasis GO:0030003 180 0.011
response to peptide GO:1901652 292 0.011
regulation of anatomical structure size GO:0090066 135 0.011
erk1 and erk2 cascade GO:0070371 48 0.011
positive regulation of gtpase activity GO:0043547 47 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
cellular response to external stimulus GO:0071496 118 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.011
vasculature development GO:0001944 70 0.011
cellular homeostasis GO:0019725 252 0.011
cellular response to oxidative stress GO:0034599 76 0.011
intracellular receptor signaling pathway GO:0030522 35 0.011
response to nutrient GO:0007584 248 0.011
regulation of nucleotide catabolic process GO:0030811 65 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
formation of primary germ layer GO:0001704 1 0.011
cardiac chamber development GO:0003205 1 0.011
muscle tissue development GO:0060537 58 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
single organism cellular localization GO:1902580 102 0.011
gland development GO:0048732 155 0.011
organ growth GO:0035265 24 0.011
positive regulation of gtp catabolic process GO:0033126 48 0.011
positive regulation of cell motility GO:2000147 97 0.011
protein transport GO:0015031 132 0.011
behavior GO:0007610 205 0.011
actin cytoskeleton organization GO:0030036 73 0.011
muscle organ development GO:0007517 50 0.010
rho protein signal transduction GO:0007266 11 0.010
calcium ion homeostasis GO:0055074 162 0.010
reproduction GO:0000003 245 0.010
positive regulation of cell migration GO:0030335 96 0.010
positive regulation of catabolic process GO:0009896 78 0.010
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.010
negative regulation of cell development GO:0010721 82 0.010
protein complex assembly GO:0006461 263 0.010
cellular divalent inorganic cation homeostasis GO:0072503 162 0.010
multicellular organism reproduction GO:0032504 233 0.010
purine ribonucleotide metabolic process GO:0009150 227 0.010
regulation of muscle contraction GO:0006937 53 0.010
response to glucocorticoid GO:0051384 223 0.010
cellular potassium ion transport GO:0071804 72 0.010

Lats2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
nervous system disease DOID:863 0 0.043
central nervous system disease DOID:331 0 0.033
brain disease DOID:936 0 0.033
epilepsy syndrome DOID:1826 0 0.024