Rattus norvegicus

28 known processes

Loxl1

lysyl oxidase-like 1

(Aliases: MGC105563)

Loxl1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to fluoride GO:1902617 3 0.843
response to transforming growth factor beta GO:0071559 46 0.452
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.382
embryonic skeletal system development GO:0048706 3 0.370
wound healing GO:0042060 122 0.356
Rat
extracellular fibril organization GO:0043206 1 0.352
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.317
respiratory system development GO:0060541 45 0.305
response to vitamin e GO:0033197 24 0.299
collagen fibril organization GO:0030199 1 0.288
Rat
tube development GO:0035295 89 0.282
macromolecular complex subunit organization GO:0043933 339 0.263
Rat
response to alkaloid GO:0043279 132 0.241
response to estradiol GO:0032355 164 0.240
reproductive process GO:0022414 372 0.230
cellular response to vitamin e GO:0071306 3 0.226
response to estrogen GO:0043627 232 0.222
cell motility GO:0048870 202 0.211
response to extracellular stimulus GO:0009991 380 0.207
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.205
cellular response to hormone stimulus GO:0032870 247 0.205
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.178
positive regulation of gene expression GO:0010628 244 0.159
tissue remodeling GO:0048771 40 0.153
tissue development GO:0009888 252 0.150
epithelium development GO:0060429 96 0.147
response to camp GO:0051591 91 0.146
endochondral bone morphogenesis GO:0060350 7 0.139
response to mechanical stimulus GO:0009612 134 0.137
cellular response to oxygen containing compound GO:1901701 386 0.133
cartilage development involved in endochondral bone morphogenesis GO:0060351 3 0.128
response to wounding GO:0009611 254 0.127
Rat
response to retinoic acid GO:0032526 63 0.123
cellular response to lipid GO:0071396 201 0.122
regulation of rna biosynthetic process GO:2001141 381 0.121
cellular response to peptide GO:1901653 133 0.119
cell activation GO:0001775 97 0.119
cellular response to external stimulus GO:0071496 118 0.116
organ morphogenesis GO:0009887 75 0.116
anatomical structure morphogenesis GO:0009653 298 0.109
multicellular organismal macromolecule metabolic process GO:0044259 21 0.107
response to nicotine GO:0035094 51 0.106
positive regulation of rna metabolic process GO:0051254 203 0.105
gastrulation GO:0007369 2 0.104
response to organophosphorus GO:0046683 102 0.102
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 5 0.102
aorta development GO:0035904 2 0.101
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.095
response to inorganic substance GO:0010035 377 0.095
cartilage development GO:0051216 22 0.093
developmental process involved in reproduction GO:0003006 159 0.093
cellular response to growth factor stimulus GO:0071363 162 0.092
cellular component movement GO:0006928 248 0.091
regulation of phosphate metabolic process GO:0019220 349 0.090
response to corticosteroid GO:0031960 235 0.085
response to peptide GO:1901652 292 0.083
cellular response to endogenous stimulus GO:0071495 377 0.083
multicellular organism reproduction GO:0032504 233 0.082
embryonic cranial skeleton morphogenesis GO:0048701 2 0.081
skeletal system morphogenesis GO:0048705 12 0.079
tooth eruption GO:0044691 1 0.078
response to increased oxygen levels GO:0036296 45 0.077
response to hyperoxia GO:0055093 45 0.076
ossification GO:0001503 70 0.074
intracellular signal transduction GO:0035556 314 0.074
transcription from rna polymerase ii promoter GO:0006366 252 0.073
macromolecular complex assembly GO:0065003 273 0.071
muscle tissue morphogenesis GO:0060415 1 0.071
protein oligomerization GO:0051259 191 0.071
negative regulation of cell proliferation GO:0008285 119 0.069
positive regulation of rna biosynthetic process GO:1902680 197 0.069
rna metabolic process GO:0016070 406 0.066
positive regulation of phosphate metabolic process GO:0045937 262 0.065
positive regulation of transcription dna templated GO:0045893 197 0.065
growth plate cartilage development GO:0003417 2 0.064
response to vitamin GO:0033273 131 0.064
response to nutrient levels GO:0031667 370 0.064
digestive system development GO:0055123 41 0.062
single organism catabolic process GO:0044712 283 0.062
regulation of nucleic acid templated transcription GO:1903506 380 0.062
positive regulation of stem cell differentiation GO:2000738 2 0.061
bmp signaling pathway GO:0030509 4 0.059
lung development GO:0030324 43 0.059
cellular response to peptide hormone stimulus GO:0071375 120 0.059
kidney development GO:0001822 67 0.058
response to radiation GO:0009314 137 0.058
response to fibroblast growth factor GO:0071774 29 0.057
eye morphogenesis GO:0048592 4 0.057
reproductive system development GO:0061458 128 0.055
response to growth factor GO:0070848 189 0.054
muscle organ development GO:0007517 50 0.054
cellular component assembly GO:0022607 360 0.053
Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.053
connective tissue development GO:0061448 33 0.053
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.053
positive regulation of signal transduction GO:0009967 175 0.052
cellular response to organic cyclic compound GO:0071407 202 0.051
collagen metabolic process GO:0032963 21 0.051
cellular response to thyroid hormone stimulus GO:0097067 5 0.051
blood vessel development GO:0001568 69 0.051
regulation of proteasomal protein catabolic process GO:0061136 4 0.051
bone development GO:0060348 25 0.051
regulation of multicellular organismal development GO:2000026 376 0.050
positive regulation of biosynthetic process GO:0009891 319 0.050
small gtpase mediated signal transduction GO:0007264 36 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.050
regulation of anatomical structure morphogenesis GO:0022603 141 0.050
digestive tract development GO:0048565 39 0.049
epithelial cell differentiation GO:0030855 71 0.049
cell adhesion GO:0007155 110 0.049
positive regulation of cellular biosynthetic process GO:0031328 295 0.048
response to glucocorticoid GO:0051384 223 0.048
response to other organism GO:0051707 220 0.047
cellular macromolecule localization GO:0070727 122 0.047
regulation of phosphorus metabolic process GO:0051174 349 0.047
rna biosynthetic process GO:0032774 380 0.046
reproductive structure development GO:0048608 128 0.045
female pregnancy GO:0007565 122 0.045
cellular response to nicotine GO:0071316 7 0.045
cellular response to nutrient levels GO:0031669 60 0.045
nucleic acid templated transcription GO:0097659 379 0.044
vasculature development GO:0001944 70 0.043
response to nutrient GO:0007584 248 0.043
response to oxygen levels GO:0070482 265 0.043
cellular protein localization GO:0034613 122 0.043
cardiovascular system development GO:0072358 134 0.043
odontogenesis GO:0042476 32 0.042
multi organism reproductive process GO:0044703 262 0.042
artery development GO:0060840 3 0.042
response to purine containing compound GO:0014074 126 0.041
developmental growth involved in morphogenesis GO:0060560 33 0.041
non canonical wnt signaling pathway GO:0035567 3 0.041
regulation of stem cell differentiation GO:2000736 2 0.041
protein heterotrimerization GO:0070208 2 0.040
prostate gland morphogenesis GO:0060512 2 0.040
morphogenesis of embryonic epithelium GO:0016331 3 0.040
organic substance catabolic process GO:1901575 316 0.040
digestive tract morphogenesis GO:0048546 8 0.040
regulation of transcription dna templated GO:0006355 374 0.040
locomotion GO:0040011 237 0.039
cellular catabolic process GO:0044248 295 0.038
skeletal system development GO:0001501 41 0.038
appendage morphogenesis GO:0035107 4 0.038
regulation of embryonic development GO:0045995 2 0.038
cellular response to nitrogen compound GO:1901699 210 0.038
cellular response to vitamin GO:0071295 21 0.037
protein complex biogenesis GO:0070271 263 0.037
cellular response to retinoic acid GO:0071300 27 0.037
ras protein signal transduction GO:0007265 29 0.036
protein complex subunit organization GO:0071822 302 0.036
Rat
biological adhesion GO:0022610 110 0.036
cellular response to acid chemical GO:0071229 75 0.036
regulation of establishment of planar polarity GO:0090175 2 0.036
circulatory system development GO:0072359 134 0.036
tissue morphogenesis GO:0048729 22 0.036
positive regulation of nucleic acid templated transcription GO:1903508 197 0.035
response to peptide hormone GO:0043434 278 0.035
positive regulation of multicellular organismal process GO:0051240 387 0.034
positive regulation of response to stimulus GO:0048584 285 0.034
protein complex assembly GO:0006461 263 0.034
embryonic skeletal system morphogenesis GO:0048704 3 0.034
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.034
regulation of molecular function GO:0065009 398 0.034
organic acid metabolic process GO:0006082 292 0.033
camera type eye morphogenesis GO:0048593 2 0.033
single organismal cell cell adhesion GO:0016337 42 0.033
apoptotic process GO:0006915 381 0.032
cellular response to extracellular stimulus GO:0031668 73 0.032
regulation of bmp signaling pathway GO:0030510 2 0.032
skin morphogenesis GO:0043589 2 0.032
cellular response to iron iii ion GO:0071283 3 0.031
cellular response to nutrient GO:0031670 30 0.031
carboxylic acid metabolic process GO:0019752 289 0.031
purine ribonucleotide metabolic process GO:0009150 227 0.030
cellular response to mechanical stimulus GO:0071260 48 0.030
response to activity GO:0014823 73 0.030
regulation of hydrolase activity GO:0051336 143 0.030
formation of primary germ layer GO:0001704 1 0.030
response to oxidative stress GO:0006979 186 0.030
single organism cell adhesion GO:0098602 46 0.030
renal system development GO:0072001 67 0.029
positive regulation of signaling GO:0023056 270 0.029
cell morphogenesis GO:0000902 142 0.029
tube morphogenesis GO:0035239 23 0.029
metanephric s shaped body morphogenesis GO:0072284 2 0.029
enzyme linked receptor protein signaling pathway GO:0007167 116 0.028
embryo development GO:0009790 49 0.028
endochondral ossification GO:0001958 2 0.028
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.028
regulation of intracellular signal transduction GO:1902531 218 0.028
response to amino acid GO:0043200 75 0.028
organophosphate metabolic process GO:0019637 370 0.027
response to monosaccharide GO:0034284 159 0.027
regulation of nervous system development GO:0051960 264 0.027
lipid biosynthetic process GO:0008610 128 0.027
carbohydrate derivative metabolic process GO:1901135 346 0.027
cellular response to abiotic stimulus GO:0071214 85 0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.027
muscle organ morphogenesis GO:0048644 1 0.026
organelle organization GO:0006996 266 0.026
regulation of epithelial to mesenchymal transition GO:0010717 2 0.026
response to catecholamine GO:0071869 16 0.026
gland development GO:0048732 155 0.026
tube formation GO:0035148 3 0.026
gland morphogenesis GO:0022612 12 0.026
transcription dna templated GO:0006351 377 0.025
cellular response to organonitrogen compound GO:0071417 197 0.025
response to reactive oxygen species GO:0000302 120 0.025
proteolysis GO:0006508 175 0.025
camera type eye development GO:0043010 48 0.025
nucleoside phosphate metabolic process GO:0006753 283 0.025
embryonic morphogenesis GO:0048598 14 0.025
reproduction GO:0000003 245 0.025
response to acid chemical GO:0001101 222 0.025
gamete generation GO:0007276 124 0.025
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.024
sexual reproduction GO:0019953 148 0.024
cation homeostasis GO:0055080 195 0.024
response to hexose GO:0009746 144 0.024
rho protein signal transduction GO:0007266 11 0.024
replacement ossification GO:0036075 2 0.024
skeletal muscle organ development GO:0060538 33 0.023
regulation of canonical wnt signaling pathway GO:0060828 4 0.023
response to norepinephrine GO:0071873 5 0.023
lung alveolus development GO:0048286 6 0.023
cellular response to alkaloid GO:0071312 25 0.023
regulation of rna metabolic process GO:0051252 391 0.023
single organism reproductive process GO:0044702 297 0.023
positive regulation of molecular function GO:0044093 230 0.022
response to hydrogen peroxide GO:0042542 89 0.022
response to vitamin d GO:0033280 34 0.022
regulation of hormone levels GO:0010817 187 0.022
protein targeting GO:0006605 61 0.021
multicellular organismal catabolic process GO:0044243 2 0.021
organonitrogen compound catabolic process GO:1901565 179 0.021
growth GO:0040007 165 0.021
aromatic compound catabolic process GO:0019439 168 0.021
positive regulation of developmental process GO:0051094 283 0.021
cellular response to fluoride GO:1902618 1 0.021
positive regulation of cellular component movement GO:0051272 102 0.021
synaptic growth at neuromuscular junction GO:0051124 1 0.020
cell communication by chemical coupling GO:0010643 2 0.020
chemical homeostasis GO:0048878 292 0.020
catabolic process GO:0009056 351 0.020
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.020
localization of cell GO:0051674 202 0.020
negative regulation of atp catabolic process GO:1903290 2 0.020
cellular ion homeostasis GO:0006873 184 0.020
negative regulation of signaling GO:0023057 157 0.020
cell type specific apoptotic process GO:0097285 134 0.020
immune response GO:0006955 104 0.020
organ growth GO:0035265 24 0.020
placenta development GO:0001890 22 0.019
multicellular organismal metabolic process GO:0044236 22 0.019
regulation of ossification GO:0030278 32 0.019
embryonic neurocranium morphogenesis GO:0048702 2 0.019
cellular response to cytokine stimulus GO:0071345 127 0.019
heart morphogenesis GO:0003007 3 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
developmental growth GO:0048589 100 0.019
regulation of protein modification process GO:0031399 194 0.018
nucleotide metabolic process GO:0009117 279 0.018
regulation of cellular response to growth factor stimulus GO:0090287 15 0.018
cellular amide metabolic process GO:0043603 44 0.018
oxoacid metabolic process GO:0043436 290 0.018
regulation of cell differentiation GO:0045595 320 0.018
blood circulation GO:0008015 183 0.018
regulation of nucleotide metabolic process GO:0006140 117 0.018
endocrine system development GO:0035270 30 0.018
response to carbohydrate GO:0009743 183 0.018
immune system process GO:0002376 204 0.018
ion homeostasis GO:0050801 212 0.017
mapk cascade GO:0000165 140 0.017
heterocycle catabolic process GO:0046700 167 0.017
response to epidermal growth factor GO:0070849 18 0.017
neuron apoptotic process GO:0051402 88 0.017
cellular component biogenesis GO:0044085 368 0.017
Rat
negative regulation of apoptotic process GO:0043066 181 0.017
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.017
platelet activation GO:0030168 8 0.017
neural crest cell differentiation GO:0014033 2 0.017
limb morphogenesis GO:0035108 4 0.017
positive regulation of cellular component organization GO:0051130 200 0.017
regulation of cell development GO:0060284 263 0.017
sensory organ development GO:0007423 74 0.017
protein heterooligomerization GO:0051291 89 0.016
nephric duct development GO:0072176 1 0.016
nucleobase containing small molecule metabolic process GO:0055086 316 0.016
epithelial tube formation GO:0072175 3 0.016
epiboly GO:0090504 2 0.016
positive regulation of nervous system development GO:0051962 178 0.016
protein localization GO:0008104 191 0.016
negative regulation of response to stimulus GO:0048585 155 0.016
osteoblast differentiation GO:0001649 26 0.016
morphogenesis of a polarized epithelium GO:0001738 1 0.016
positive regulation of cell communication GO:0010647 271 0.016
s shaped body morphogenesis GO:0072050 2 0.016
cardiac chamber development GO:0003205 1 0.016
cellular response to tumor necrosis factor GO:0071356 46 0.016
aging GO:0007568 241 0.016
positive regulation of intracellular signal transduction GO:1902533 138 0.016
establishment of tissue polarity GO:0007164 2 0.016
regulation of system process GO:0044057 208 0.015
response to ethanol GO:0045471 162 0.015
cellular hormone metabolic process GO:0034754 49 0.015
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.015
regulation of purine nucleotide catabolic process GO:0033121 65 0.015
regulation of signal transduction GO:0009966 318 0.015
regulation of cell motility GO:2000145 131 0.015
peptide cross linking GO:0018149 1 0.015
response to ketone GO:1901654 182 0.015
kidney vasculature development GO:0061440 6 0.015
regulation of catalytic activity GO:0050790 304 0.015
urogenital system development GO:0001655 78 0.015
response to cytokine GO:0034097 215 0.014
regulation of protein metabolic process GO:0051246 289 0.014
single organism nuclear import GO:1902593 35 0.014
hormone metabolic process GO:0042445 69 0.014
male sex differentiation GO:0046661 64 0.014
stem cell differentiation GO:0048863 16 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 2 0.014
respiratory tube development GO:0030323 43 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
regulation of neurogenesis GO:0050767 247 0.014
cell migration GO:0016477 197 0.014
response to tumor necrosis factor GO:0034612 56 0.014
neural tube formation GO:0001841 1 0.014
wound healing spreading of cells GO:0044319 2 0.014
response to transition metal nanoparticle GO:1990267 122 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
cardiac ventricle development GO:0003231 1 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.013
regulation of apoptotic process GO:0042981 335 0.013
chondrocyte differentiation GO:0002062 10 0.013
negative regulation of cell communication GO:0010648 158 0.013
response to monoamine GO:0071867 17 0.013
cellular response to alcohol GO:0097306 87 0.013
maternal process involved in female pregnancy GO:0060135 38 0.013
intramembranous ossification GO:0001957 1 0.013
positive regulation of cell motility GO:2000147 97 0.013
protein localization to nucleus GO:0034504 39 0.013
development of primary sexual characteristics GO:0045137 107 0.013
sex differentiation GO:0007548 113 0.012
regulation of phosphorylation GO:0042325 248 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
male gamete generation GO:0048232 99 0.012
retinoic acid metabolic process GO:0042573 13 0.012
regulation of protein kinase activity GO:0045859 105 0.012
cell projection organization GO:0030030 302 0.012
anterior posterior pattern specification GO:0009952 1 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
purine containing compound metabolic process GO:0072521 253 0.012
positive regulation of cell development GO:0010720 176 0.012
bone morphogenesis GO:0060349 11 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
embryonic limb morphogenesis GO:0030326 4 0.012
autophagic cell death GO:0048102 4 0.012
regulation of cell migration GO:0030334 128 0.012
positive regulation of cell migration GO:0030335 96 0.012
positive regulation of hepatocyte differentiation GO:0070368 2 0.012
protein phosphorylation GO:0006468 345 0.012
regulation of catabolic process GO:0009894 113 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
negative regulation of metabolic process GO:0009892 331 0.012
negative regulation of immune system process GO:0002683 39 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
response to starvation GO:0042594 59 0.011
positive regulation of synaptic plasticity GO:0031915 3 0.011
triglyceride homeostasis GO:0070328 2 0.011
cellular response to metal ion GO:0071248 55 0.011
negative regulation of neuron death GO:1901215 69 0.011
cellular response to steroid hormone stimulus GO:0071383 93 0.011
regulation of response to stress GO:0080134 126 0.011
inner ear morphogenesis GO:0042472 1 0.011
positive regulation of apoptotic process GO:0043065 154 0.011
cranial suture morphogenesis GO:0060363 4 0.011
programmed cell death GO:0012501 392 0.011
protein localization to organelle GO:0033365 57 0.011
response to decreased oxygen levels GO:0036293 237 0.011
neuron projection development GO:0031175 273 0.011
negative regulation of cellular metabolic process GO:0031324 281 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
cellular lipid metabolic process GO:0044255 208 0.011
negative regulation of nervous system development GO:0051961 79 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
cellular response to stress GO:0033554 269 0.011
cell cell signaling GO:0007267 335 0.011
cellular amino acid metabolic process GO:0006520 107 0.011
regulation of synapse assembly GO:0051963 15 0.010
regulation of programmed cell death GO:0043067 341 0.010
negative regulation of catalytic activity GO:0043086 103 0.010
protein import into nucleus GO:0006606 35 0.010
cellular response to inorganic substance GO:0071241 65 0.010
response to hypoxia GO:0001666 231 0.010
palate development GO:0060021 2 0.010
ribonucleoside metabolic process GO:0009119 174 0.010
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.010
spermatogenesis GO:0007283 99 0.010
response to glucose GO:0009749 136 0.010
response to molecule of bacterial origin GO:0002237 194 0.010
response to metal ion GO:0010038 253 0.010
prostate gland epithelium morphogenesis GO:0060740 2 0.010
neuron differentiation GO:0030182 368 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.010
cellular amine metabolic process GO:0044106 38 0.010
cellular response to glucocorticoid stimulus GO:0071385 68 0.010
cellular response to fibroblast growth factor stimulus GO:0044344 24 0.010

Loxl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.124
Human
musculoskeletal system disease DOID:17 0 0.124
collagen disease DOID:854 0 0.085
ehlers danlos syndrome DOID:13359 0 0.085
connective tissue disease DOID:65 0 0.085
osteochondrodysplasia DOID:2256 0 0.082
osteogenesis imperfecta DOID:12347 0 0.082
bone development disease DOID:0080006 0 0.082
bone disease DOID:0080001 0 0.082
muscular disease DOID:0080000 0 0.015