Rattus norvegicus

56 known processes

Lta4h

leukotriene A4 hydrolase

Lta4h biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.206
carbohydrate metabolic process GO:0005975 130 0.146
single organism catabolic process GO:0044712 283 0.146
response to radiation GO:0009314 137 0.124
oxoacid metabolic process GO:0043436 290 0.115
single organism biosynthetic process GO:0044711 342 0.101
Human
positive regulation of multicellular organismal process GO:0051240 387 0.094
anatomical structure morphogenesis GO:0009653 298 0.089
regulation of catalytic activity GO:0050790 304 0.081
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.075
oxidation reduction process GO:0055114 304 0.073
single organism carbohydrate metabolic process GO:0044723 118 0.072
tube development GO:0035295 89 0.069
carbohydrate derivative metabolic process GO:1901135 346 0.068
catabolic process GO:0009056 351 0.063
Human Yeast
cellular amino acid metabolic process GO:0006520 107 0.062
reproductive process GO:0022414 372 0.059
g protein coupled receptor signaling pathway GO:0007186 242 0.057
secretion GO:0046903 307 0.054
response to extracellular stimulus GO:0009991 380 0.053
regulation of cellular ketone metabolic process GO:0010565 27 0.052
programmed cell death GO:0012501 392 0.051
carboxylic acid metabolic process GO:0019752 289 0.051
rna metabolic process GO:0016070 406 0.050
behavior GO:0007610 205 0.050
neuron development GO:0048666 286 0.048
lipid metabolic process GO:0006629 283 0.047
multi organism reproductive process GO:0044703 262 0.047
cellular response to nitrogen compound GO:1901699 210 0.046
cellular ketone metabolic process GO:0042180 51 0.045
positive regulation of developmental process GO:0051094 283 0.041
cellular component movement GO:0006928 248 0.041
positive regulation of protein metabolic process GO:0051247 178 0.041
nitrogen compound transport GO:0071705 229 0.041
rna biosynthetic process GO:0032774 380 0.040
regulation of cellular localization GO:0060341 263 0.039
developmental process involved in reproduction GO:0003006 159 0.039
response to monosaccharide GO:0034284 159 0.039
tissue development GO:0009888 252 0.038
response to metal ion GO:0010038 253 0.038
regulation of protein metabolic process GO:0051246 289 0.038
response to hexose GO:0009746 144 0.038
single organism reproductive process GO:0044702 297 0.038
circulatory system process GO:0003013 183 0.037
Rat
nucleic acid templated transcription GO:0097659 379 0.037
cell growth GO:0016049 104 0.037
reproduction GO:0000003 245 0.036
neuron projection development GO:0031175 273 0.036
multicellular organismal reproductive process GO:0048609 233 0.036
regulation of cellular amino acid metabolic process GO:0006521 2 0.035
cellular amine metabolic process GO:0044106 38 0.035
gamete generation GO:0007276 124 0.035
vesicle mediated transport GO:0016192 181 0.035
cellular response to endogenous stimulus GO:0071495 377 0.035
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.034
transcription dna templated GO:0006351 377 0.034
positive regulation of transport GO:0051050 245 0.034
rhythmic process GO:0048511 156 0.034
regulation of rna metabolic process GO:0051252 391 0.034
positive regulation of cell proliferation GO:0008284 249 0.034
homeostatic process GO:0042592 331 0.033
amine metabolic process GO:0009308 38 0.033
cell cell signaling GO:0007267 335 0.033
ribonucleotide catabolic process GO:0009261 136 0.033
ion homeostasis GO:0050801 212 0.033
regulation of cellular component organization GO:0051128 368 0.033
response to bacterium GO:0009617 200 0.033
cellular response to stress GO:0033554 269 0.032
positive regulation of cell death GO:0010942 184 0.032
cellular lipid metabolic process GO:0044255 208 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
positive regulation of gene expression GO:0010628 244 0.032
reproductive structure development GO:0048608 128 0.032
intracellular signal transduction GO:0035556 314 0.032
regulation of multicellular organismal development GO:2000026 376 0.031
response to inorganic substance GO:0010035 377 0.031
transcription from rna polymerase ii promoter GO:0006366 252 0.031
growth GO:0040007 165 0.031
response to peptide GO:1901652 292 0.031
apoptotic process GO:0006915 381 0.031
regulation of rna biosynthetic process GO:2001141 381 0.030
regulation of growth GO:0040008 105 0.030
protein phosphorylation GO:0006468 345 0.030
synaptic transmission GO:0007268 235 0.030
negative regulation of signaling GO:0023057 157 0.030
cellular response to hormone stimulus GO:0032870 247 0.029
organonitrogen compound biosynthetic process GO:1901566 167 0.029
neuron differentiation GO:0030182 368 0.029
cytokine production GO:0001816 61 0.029
negative regulation of response to stimulus GO:0048585 155 0.029
blood circulation GO:0008015 183 0.029
Rat
regulation of molecular function GO:0065009 398 0.029
cellular carbohydrate metabolic process GO:0044262 72 0.029
establishment of protein localization GO:0045184 141 0.028
regulation of programmed cell death GO:0043067 341 0.028
cellular response to peptide hormone stimulus GO:0071375 120 0.028
response to oxidative stress GO:0006979 186 0.028
response to ethanol GO:0045471 162 0.028
response to peptide hormone GO:0043434 278 0.027
regulation of secretion by cell GO:1903530 208 0.027
organophosphate metabolic process GO:0019637 370 0.027
neuron death GO:0070997 127 0.027
reproductive system development GO:0061458 128 0.027
chemical homeostasis GO:0048878 292 0.026
response to estrogen GO:0043627 232 0.026
regulation of nucleic acid templated transcription GO:1903506 380 0.026
neuron projection morphogenesis GO:0048812 122 0.026
secretion by cell GO:0032940 248 0.026
positive regulation of transcription dna templated GO:0045893 197 0.025
cell motility GO:0048870 202 0.025
multicellular organism reproduction GO:0032504 233 0.025
developmental growth GO:0048589 100 0.025
monocarboxylic acid metabolic process GO:0032787 152 0.025
response to oxygen levels GO:0070482 265 0.025
organonitrogen compound catabolic process GO:1901565 179 0.025
Human
negative regulation of cell communication GO:0010648 158 0.025
cell type specific apoptotic process GO:0097285 134 0.025
negative regulation of cell death GO:0060548 229 0.024
regulation of secretion GO:0051046 224 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
circadian rhythm GO:0007623 88 0.024
regulation of cellular protein metabolic process GO:0032268 267 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
protein localization GO:0008104 191 0.024
chromosome segregation GO:0007059 2 0.024
cardiovascular system development GO:0072358 134 0.023
regulation of catabolic process GO:0009894 113 0.023
axon development GO:0061564 96 0.023
regulation of signal transduction GO:0009966 318 0.023
cellular response to organonitrogen compound GO:0071417 197 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
cell morphogenesis involved in differentiation GO:0000904 119 0.023
negative regulation of programmed cell death GO:0043069 183 0.023
cellular response to peptide GO:1901653 133 0.022
hexose metabolic process GO:0019318 58 0.022
response to insulin GO:0032868 133 0.022
positive regulation of locomotion GO:0040017 102 0.022
negative regulation of gene expression GO:0010629 199 0.022
cell projection organization GO:0030030 302 0.022
sexual reproduction GO:0019953 148 0.021
response to hypoxia GO:0001666 231 0.021
response to nutrient GO:0007584 248 0.021
wound healing GO:0042060 122 0.021
regulation of transferase activity GO:0051338 123 0.021
response to nutrient levels GO:0031667 370 0.021
renal system development GO:0072001 67 0.021
cation homeostasis GO:0055080 195 0.021
positive regulation of signal transduction GO:0009967 175 0.021
negative regulation of metabolic process GO:0009892 331 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
cellular response to abiotic stimulus GO:0071214 85 0.021
head development GO:0060322 247 0.021
response to carbohydrate GO:0009743 183 0.020
regulation of kinase activity GO:0043549 117 0.020
regulation of cell cycle GO:0051726 73 0.020
response to wounding GO:0009611 254 0.020
regulation of neuron death GO:1901214 115 0.020
cell cycle phase transition GO:0044770 21 0.020
digestive system development GO:0055123 41 0.019
regulation of cell growth GO:0001558 85 0.019
cellular catabolic process GO:0044248 295 0.019
Human
metal ion homeostasis GO:0055065 186 0.019
response to reactive oxygen species GO:0000302 120 0.019
regulation of transcription dna templated GO:0006355 374 0.019
aging GO:0007568 241 0.019
Rat
positive regulation of apoptotic process GO:0043065 154 0.019
response to glucose GO:0009749 136 0.019
response to decreased oxygen levels GO:0036293 237 0.019
cellular response to oxygen containing compound GO:1901701 386 0.019
regulation of neuron apoptotic process GO:0043523 83 0.019
regulation of cell development GO:0060284 263 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
response to alkaloid GO:0043279 132 0.018
response to estradiol GO:0032355 164 0.018
small molecule catabolic process GO:0044282 59 0.018
sex differentiation GO:0007548 113 0.018
regulation of phosphorylation GO:0042325 248 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
response to external biotic stimulus GO:0043207 221 0.018
ossification GO:0001503 70 0.018
kidney development GO:0001822 67 0.017
locomotion GO:0040011 237 0.017
purine containing compound metabolic process GO:0072521 253 0.017
blood vessel development GO:0001568 69 0.017
circulatory system development GO:0072359 134 0.017
response to other organism GO:0051707 220 0.017
regeneration GO:0031099 163 0.017
positive regulation of rna metabolic process GO:0051254 203 0.017
leukocyte activation GO:0045321 76 0.017
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
response to growth factor GO:0070848 189 0.017
neuron apoptotic process GO:0051402 88 0.017
response to biotic stimulus GO:0009607 226 0.017
positive regulation of protein modification process GO:0031401 142 0.017
negative regulation of transport GO:0051051 136 0.016
polysaccharide metabolic process GO:0005976 25 0.016
negative regulation of phosphate metabolic process GO:0045936 80 0.016
gonad development GO:0008406 104 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
regulation of anatomical structure morphogenesis GO:0022603 141 0.016
peptidyl amino acid modification GO:0018193 126 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
apoptotic signaling pathway GO:0097190 27 0.016
macromolecule localization GO:0033036 252 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.016
positive regulation of cell growth GO:0030307 44 0.016
response to nicotine GO:0035094 51 0.016
single organism intracellular transport GO:1902582 166 0.016
intracellular transport GO:0046907 185 0.016
protein transport GO:0015031 132 0.015
axonogenesis GO:0007409 71 0.015
response to acid chemical GO:0001101 222 0.015
regulation of system process GO:0044057 208 0.015
response to vitamin GO:0033273 131 0.015
cell migration GO:0016477 197 0.015
cellular homeostasis GO:0019725 252 0.015
spermatogenesis GO:0007283 99 0.015
positive regulation of cell communication GO:0010647 271 0.015
regulation of phosphate metabolic process GO:0019220 349 0.015
peptidyl tyrosine phosphorylation GO:0018108 72 0.015
single organism behavior GO:0044708 130 0.015
cellular response to external stimulus GO:0071496 118 0.015
vasculature development GO:0001944 70 0.015
central nervous system development GO:0007417 311 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
monosaccharide metabolic process GO:0005996 61 0.015
negative regulation of secretion GO:0051048 82 0.015
organic substance catabolic process GO:1901575 316 0.015
Human Yeast
divalent inorganic cation homeostasis GO:0072507 165 0.014
motor neuron axon guidance GO:0008045 1 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
digestive tract development GO:0048565 39 0.014
positive regulation of cell differentiation GO:0045597 217 0.014
dna recombination GO:0006310 3 0.014
regulation of hormone levels GO:0010817 187 0.014
protein maturation GO:0051604 68 0.014
multicellular organism growth GO:0035264 1 0.014
regulation of hydrolase activity GO:0051336 143 0.014
localization of cell GO:0051674 202 0.014
regulation of hormone secretion GO:0046883 106 0.014
cellular protein localization GO:0034613 122 0.014
heterocycle catabolic process GO:0046700 167 0.014
protein complex biogenesis GO:0070271 263 0.014
regulation of membrane potential GO:0042391 110 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
protein oligomerization GO:0051259 191 0.014
positive regulation of protein kinase activity GO:0045860 73 0.014
development of primary sexual characteristics GO:0045137 107 0.014
regulation of protein modification process GO:0031399 194 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.013
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
carboxylic acid catabolic process GO:0046395 49 0.013
cytoskeleton dependent cytokinesis GO:0061640 2 0.013
organophosphate catabolic process GO:0046434 148 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.013
negative regulation of signal transduction GO:0009968 83 0.013
cell part morphogenesis GO:0032990 123 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
response to light stimulus GO:0009416 52 0.013
gastrulation GO:0007369 2 0.013
positive regulation of signaling GO:0023056 270 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
cell projection morphogenesis GO:0048858 123 0.013
regulation of peptide transport GO:0090087 87 0.013
mapk cascade GO:0000165 140 0.013
positive regulation of molecular function GO:0044093 230 0.013
negative regulation of cellular metabolic process GO:0031324 281 0.013
angiogenesis GO:0001525 53 0.013
carbohydrate catabolic process GO:0016052 40 0.013
hormone transport GO:0009914 121 0.013
hormone secretion GO:0046879 115 0.013
sulfur compound metabolic process GO:0006790 70 0.012
regulation of homeostatic process GO:0032844 101 0.012
regulation of mrna splicing via spliceosome GO:0048024 3 0.012
positive regulation of catabolic process GO:0009896 78 0.012
regulation of protein kinase activity GO:0045859 105 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
carbohydrate derivative catabolic process GO:1901136 147 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
positive regulation of growth GO:0045927 55 0.012
cellular polysaccharide metabolic process GO:0044264 23 0.012
positive regulation of lipid catabolic process GO:0050996 4 0.012
mrna metabolic process GO:0016071 20 0.012
ribose phosphate metabolic process GO:0019693 235 0.012
positive regulation of cell migration GO:0030335 96 0.012
negative regulation of molecular function GO:0044092 133 0.012
negative regulation of neuron death GO:1901215 69 0.012
proteolysis GO:0006508 175 0.012
Human Yeast Rat
male gamete generation GO:0048232 99 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
dna metabolic process GO:0006259 96 0.012
nucleotide metabolic process GO:0009117 279 0.012
rna localization GO:0006403 4 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
regulation of circadian rhythm GO:0042752 27 0.012
cell cycle GO:0007049 101 0.011
learning or memory GO:0007611 90 0.011
macromolecular complex subunit organization GO:0043933 339 0.011
alpha amino acid biosynthetic process GO:1901607 23 0.011
regulation of cell differentiation GO:0045595 320 0.011
positive regulation of response to stimulus GO:0048584 285 0.011
brain development GO:0007420 247 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
neurological system process GO:0050877 219 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.011
regulation of response to stress GO:0080134 126 0.011
protein complex assembly GO:0006461 263 0.011
rho protein signal transduction GO:0007266 11 0.011
urogenital system development GO:0001655 78 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
cellular modified amino acid metabolic process GO:0006575 61 0.011
organic cyclic compound catabolic process GO:1901361 175 0.011
muscle structure development GO:0061061 87 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
protein processing GO:0016485 68 0.011
cellular response to growth factor stimulus GO:0071363 162 0.011
cellular chemical homeostasis GO:0055082 247 0.011
amide transport GO:0042886 105 0.011
carbohydrate biosynthetic process GO:0016051 42 0.011
regulation of nervous system development GO:0051960 264 0.011
chemotaxis GO:0006935 66 0.011
regulation of cell projection organization GO:0031344 175 0.011
dephosphorylation GO:0016311 98 0.011
spindle organization GO:0007051 2 0.011
regulation of anatomical structure size GO:0090066 135 0.011
positive regulation of cell motility GO:2000147 97 0.011
regulation of phosphorus metabolic process GO:0051174 349 0.011
regulation of proteolysis GO:0030162 66 0.011
signal release GO:0023061 145 0.011
erythrocyte differentiation GO:0030218 1 0.011
purine nucleotide metabolic process GO:0006163 229 0.011
mitotic cell cycle phase transition GO:0044772 20 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
response to mechanical stimulus GO:0009612 134 0.010
regulation of neurogenesis GO:0050767 247 0.010
axis specification GO:0009798 4 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.010
epithelium development GO:0060429 96 0.010
negative regulation of biosynthetic process GO:0009890 168 0.010
erythrocyte homeostasis GO:0034101 2 0.010

Lta4h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
musculoskeletal system disease DOID:17 0 0.028
connective tissue disease DOID:65 0 0.017
bone disease DOID:0080001 0 0.011
disease of cellular proliferation DOID:14566 0 0.010
nervous system disease DOID:863 0 0.010