Rattus norvegicus

2 known processes

Man2b1

mannosidase, alpha, class 2B, member 1

(Aliases: MGC72561,Manb)

Man2b1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism catabolic process GO:0044712 283 0.205
catabolic process GO:0009056 351 0.199
cellular response to endogenous stimulus GO:0071495 377 0.189
organonitrogen compound catabolic process GO:1901565 179 0.175
organic substance catabolic process GO:1901575 316 0.171
tissue development GO:0009888 252 0.118
organic acid metabolic process GO:0006082 292 0.117
cell morphogenesis involved in differentiation GO:0000904 119 0.116
sulfur compound metabolic process GO:0006790 70 0.110
carbohydrate derivative catabolic process GO:1901136 147 0.107
oxoacid metabolic process GO:0043436 290 0.095
regulation of molecular function GO:0065009 398 0.087
response to inorganic substance GO:0010035 377 0.084
inflammatory response GO:0006954 150 0.081
carbohydrate derivative metabolic process GO:1901135 346 0.073
regulation of secretion by cell GO:1903530 208 0.068
organelle organization GO:0006996 266 0.068
immune system development GO:0002520 41 0.064
keratan sulfate metabolic process GO:0042339 1 0.062
cellular response to organonitrogen compound GO:0071417 197 0.060
cellular response to peptide GO:1901653 133 0.057
oxidation reduction process GO:0055114 304 0.057
ion homeostasis GO:0050801 212 0.056
cellular response to hormone stimulus GO:0032870 247 0.055
response to carbohydrate GO:0009743 183 0.053
multicellular organism reproduction GO:0032504 233 0.051
t cell tolerance induction GO:0002517 3 0.049
cellular chemical homeostasis GO:0055082 247 0.047
cellular response to nitrogen compound GO:1901699 210 0.047
dephosphorylation GO:0016311 98 0.046
cellular amine metabolic process GO:0044106 38 0.045
regulation of cellular component organization GO:0051128 368 0.045
cell cell signaling GO:0007267 335 0.044
cellular catabolic process GO:0044248 295 0.044
carboxylic acid metabolic process GO:0019752 289 0.043
respiratory system development GO:0060541 45 0.043
anatomical structure morphogenesis GO:0009653 298 0.042
positive regulation of multicellular organismal process GO:0051240 387 0.042
heart morphogenesis GO:0003007 3 0.041
regulation of body fluid levels GO:0050878 90 0.041
response to fatty acid GO:0070542 65 0.040
cellular amino acid metabolic process GO:0006520 107 0.040
regulation of system process GO:0044057 208 0.039
lipid metabolic process GO:0006629 283 0.039
head development GO:0060322 247 0.039
wound healing GO:0042060 122 0.038
cellular response to abiotic stimulus GO:0071214 85 0.038
intracellular signal transduction GO:0035556 314 0.036
regulation of hormone levels GO:0010817 187 0.036
sulfur compound catabolic process GO:0044273 3 0.036
monocarboxylic acid metabolic process GO:0032787 152 0.036
cellular response to organic cyclic compound GO:0071407 202 0.036
positive regulation of response to stimulus GO:0048584 285 0.036
nucleoside phosphate metabolic process GO:0006753 283 0.035
amine metabolic process GO:0009308 38 0.035
reproductive process GO:0022414 372 0.035
nucleobase containing small molecule metabolic process GO:0055086 316 0.035
single organism carbohydrate metabolic process GO:0044723 118 0.035
cation homeostasis GO:0055080 195 0.035
gland development GO:0048732 155 0.035
chemical homeostasis GO:0048878 292 0.034
response to metal ion GO:0010038 253 0.034
response to monosaccharide GO:0034284 159 0.034
regulation of organelle organization GO:0033043 80 0.034
positive regulation of cell differentiation GO:0045597 217 0.034
protein phosphorylation GO:0006468 345 0.034
nucleic acid templated transcription GO:0097659 379 0.033
positive regulation of signaling GO:0023056 270 0.033
hemopoiesis GO:0030097 34 0.033
regulation of multicellular organismal development GO:2000026 376 0.032
neuron differentiation GO:0030182 368 0.032
secretion GO:0046903 307 0.032
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.032
hematopoietic or lymphoid organ development GO:0048534 36 0.031
regulation of cellular protein metabolic process GO:0032268 267 0.031
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.031
response to decreased oxygen levels GO:0036293 237 0.031
single organism reproductive process GO:0044702 297 0.031
hematopoietic progenitor cell differentiation GO:0002244 2 0.031
sensory perception GO:0007600 101 0.031
regulation of secretion GO:0051046 224 0.031
renal system development GO:0072001 67 0.030
synaptic transmission GO:0007268 235 0.030
cellular response to peptide hormone stimulus GO:0071375 120 0.030
negative regulation of innate immune response GO:0045824 4 0.030
multi organism reproductive process GO:0044703 262 0.030
regulation of tolerance induction to nonself antigen GO:0002655 1 0.030
homeostatic process GO:0042592 331 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.030
response to wounding GO:0009611 254 0.029
positive regulation of tolerance induction GO:0002645 1 0.029
regulation of cell development GO:0060284 263 0.029
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.029
organ morphogenesis GO:0009887 75 0.029
ribonucleotide metabolic process GO:0009259 231 0.029
regulation of signal transduction GO:0009966 318 0.028
metal ion transport GO:0030001 289 0.028
liver development GO:0001889 90 0.028
regulation of kinase activity GO:0043549 117 0.028
macromolecule catabolic process GO:0009057 58 0.028
b cell differentiation GO:0030183 2 0.028
positive regulation of transport GO:0051050 245 0.028
response to peptide GO:1901652 292 0.027
axis specification GO:0009798 4 0.027
cellular component movement GO:0006928 248 0.027
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.027
lymphocyte activation GO:0046649 43 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of cell differentiation GO:0045595 320 0.026
immune system process GO:0002376 204 0.026
regulation of rna biosynthetic process GO:2001141 381 0.026
ion transmembrane transport GO:0034220 365 0.026
tube development GO:0035295 89 0.026
organophosphate metabolic process GO:0019637 370 0.026
secretion by cell GO:0032940 248 0.025
response to extracellular stimulus GO:0009991 380 0.025
sequestering of metal ion GO:0051238 9 0.025
cellular response to external stimulus GO:0071496 118 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
gamete generation GO:0007276 124 0.025
ossification GO:0001503 70 0.024
regulation of metal ion transport GO:0010959 118 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
behavior GO:0007610 205 0.024
ribose phosphate metabolic process GO:0019693 235 0.024
response to peptide hormone GO:0043434 278 0.024
activation of cysteine type endopeptidase activity GO:0097202 4 0.023
positive regulation of programmed cell death GO:0043068 157 0.023
cell motility GO:0048870 202 0.023
myeloid cell differentiation GO:0030099 22 0.023
glycosyl compound metabolic process GO:1901657 182 0.023
positive regulation of gene expression GO:0010628 244 0.023
response to hexose GO:0009746 144 0.022
single organism carbohydrate catabolic process GO:0044724 40 0.022
leukocyte differentiation GO:0002521 30 0.022
cellular ketone metabolic process GO:0042180 51 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
signal transduction by phosphorylation GO:0023014 144 0.022
lymphocyte proliferation GO:0046651 29 0.022
memory GO:0007613 54 0.022
cellular response to lipid GO:0071396 201 0.022
response to aluminum ion GO:0010044 10 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
embryonic pattern specification GO:0009880 1 0.022
reproduction GO:0000003 245 0.022
regulation of anatomical structure size GO:0090066 135 0.022
apoptotic process GO:0006915 381 0.022
response to acid chemical GO:0001101 222 0.021
reproductive system development GO:0061458 128 0.021
transcription from rna polymerase ii promoter GO:0006366 252 0.021
sequestering of calcium ion GO:0051208 8 0.021
positive regulation of neuron projection development GO:0010976 99 0.021
regulation of intracellular transport GO:0032386 65 0.021
purine containing compound metabolic process GO:0072521 253 0.021
regulation of cell projection organization GO:0031344 175 0.021
enzyme linked receptor protein signaling pathway GO:0007167 116 0.021
regulation of ion homeostasis GO:2000021 63 0.020
response to radiation GO:0009314 137 0.020
response to glucose GO:0009749 136 0.020
programmed cell death GO:0012501 392 0.020
leukocyte mediated immunity GO:0002443 28 0.020
cellular response to growth factor stimulus GO:0071363 162 0.020
chromosome organization GO:0051276 36 0.020
response to oxygen levels GO:0070482 265 0.020
divalent inorganic cation homeostasis GO:0072507 165 0.020
single organism behavior GO:0044708 130 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
sexual reproduction GO:0019953 148 0.020
regulation of cellular component movement GO:0051270 150 0.019
nitrogen compound transport GO:0071705 229 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
cell projection organization GO:0030030 302 0.019
negative regulation of immune system process GO:0002683 39 0.019
regulation of neurogenesis GO:0050767 247 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
regulation of protein transport GO:0051223 68 0.019
rna metabolic process GO:0016070 406 0.019
cell adhesion GO:0007155 110 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
regulation of phosphorus metabolic process GO:0051174 349 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
developmental process involved in reproduction GO:0003006 159 0.019
hormone secretion GO:0046879 115 0.019
limb morphogenesis GO:0035108 4 0.019
regulation of blood pressure GO:0008217 83 0.019
single organism biosynthetic process GO:0044711 342 0.019
negative regulation of transport GO:0051051 136 0.018
regulation of response to external stimulus GO:0032101 106 0.018
regulation of protein metabolic process GO:0051246 289 0.018
nucleotide metabolic process GO:0009117 279 0.018
regulation of cellular localization GO:0060341 263 0.018
metal ion homeostasis GO:0055065 186 0.018
regulation of smooth muscle cell proliferation GO:0048660 75 0.018
immunoglobulin mediated immune response GO:0016064 4 0.018
response to nutrient levels GO:0031667 370 0.018
regulation of catalytic activity GO:0050790 304 0.018
calcium ion homeostasis GO:0055074 162 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
cellular response to oxygen containing compound GO:1901701 386 0.018
cell migration GO:0016477 197 0.018
positive regulation of cell communication GO:0010647 271 0.018
nucleoside phosphate biosynthetic process GO:1901293 102 0.018
rna biosynthetic process GO:0032774 380 0.017
protein localization GO:0008104 191 0.017
receptor mediated endocytosis GO:0006898 42 0.017
aromatic compound catabolic process GO:0019439 168 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.017
epithelial cell differentiation GO:0030855 71 0.017
regulation of homeostatic process GO:0032844 101 0.017
mapk cascade GO:0000165 140 0.017
neuron projection development GO:0031175 273 0.017
positive regulation of cytokine production GO:0001819 42 0.017
developmental growth GO:0048589 100 0.017
platelet aggregation GO:0070527 4 0.017
response to organophosphorus GO:0046683 102 0.017
lung development GO:0030324 43 0.017
proteolysis GO:0006508 175 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.017
regulation of cellular amine metabolic process GO:0033238 8 0.017
cellular response to iron ion starvation GO:0010106 1 0.017
nucleotide biosynthetic process GO:0009165 98 0.017
response to hypoxia GO:0001666 231 0.017
carbohydrate metabolic process GO:0005975 130 0.017
transmembrane transport GO:0055085 412 0.016
macromolecule localization GO:0033036 252 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
response to ketone GO:1901654 182 0.016
calcium ion transport GO:0006816 131 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.016
positive regulation of cell development GO:0010720 176 0.016
positive regulation of protein kinase activity GO:0045860 73 0.016
cell part morphogenesis GO:0032990 123 0.016
cellular ion homeostasis GO:0006873 184 0.016
response to oxidative stress GO:0006979 186 0.016
calcium ion transport into cytosol GO:0060402 38 0.016
localization of cell GO:0051674 202 0.016
neuron development GO:0048666 286 0.016
regulation of apoptotic process GO:0042981 335 0.016
response to insulin GO:0032868 133 0.016
nucleotide catabolic process GO:0009166 139 0.016
positive regulation of kinase activity GO:0033674 77 0.016
regulation of neuron projection development GO:0010975 161 0.016
sensory perception of pain GO:0019233 73 0.015
cellular response to ketone GO:1901655 51 0.015
tissue morphogenesis GO:0048729 22 0.015
regulation of nucleotide metabolic process GO:0006140 117 0.015
transcription dna templated GO:0006351 377 0.015
cation transport GO:0006812 382 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.015
salivary gland development GO:0007431 3 0.015
b cell mediated immunity GO:0019724 4 0.015
positive regulation of molecular function GO:0044093 230 0.015
tolerance induction dependent upon immune response GO:0002461 2 0.015
cation transmembrane transport GO:0098655 263 0.015
dna metabolic process GO:0006259 96 0.015
regulation of protein modification process GO:0031399 194 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
positive regulation of developmental process GO:0051094 283 0.015
response to mechanical stimulus GO:0009612 134 0.015
organophosphate catabolic process GO:0046434 148 0.015
tissue regeneration GO:0042246 36 0.015
synapse organization GO:0050808 46 0.015
positive regulation of transferase activity GO:0051347 81 0.015
anion transport GO:0006820 178 0.015
regulation of hormone secretion GO:0046883 106 0.015
positive regulation of rna biosynthetic process GO:1902680 197 0.015
cellular homeostasis GO:0019725 252 0.015
ovulation cycle GO:0042698 67 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.014
regulation of neuron differentiation GO:0045664 208 0.014
regulation of immune system process GO:0002682 123 0.014
defense response GO:0006952 194 0.014
regulation of cellular ketone metabolic process GO:0010565 27 0.014
tolerance induction to nonself antigen GO:0002462 2 0.014
g protein coupled receptor signaling pathway GO:0007186 242 0.014
cell activation GO:0001775 97 0.014
regulation of protein kinase activity GO:0045859 105 0.014
embryonic skeletal system development GO:0048706 3 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
salivary gland morphogenesis GO:0007435 1 0.014
peptidyl amino acid modification GO:0018193 126 0.014
positive regulation of locomotion GO:0040017 102 0.014
regulation of nervous system development GO:0051960 264 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
positive regulation of cell migration GO:0030335 96 0.014
detection of stimulus GO:0051606 24 0.014
response to purine containing compound GO:0014074 126 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
positive regulation of nervous system development GO:0051962 178 0.014
cytoplasmic transport GO:0016482 115 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
cellular lipid metabolic process GO:0044255 208 0.014
negative regulation of cell death GO:0060548 229 0.014
negative regulation of signaling GO:0023057 157 0.014
epithelium development GO:0060429 96 0.014
macromolecular complex subunit organization GO:0043933 339 0.014
respiratory tube development GO:0030323 43 0.014
vasculogenesis GO:0001570 3 0.014
cellular cation homeostasis GO:0030003 180 0.013
hexose metabolic process GO:0019318 58 0.013
cell cycle checkpoint GO:0000075 2 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
regulation of cell motility GO:2000145 131 0.013
response to hydrogen peroxide GO:0042542 89 0.013
appendage morphogenesis GO:0035107 4 0.013
protein transport GO:0015031 132 0.013
brain development GO:0007420 247 0.013
smooth muscle cell migration GO:0014909 36 0.013
neurological system process GO:0050877 219 0.013
regulation of phosphate metabolic process GO:0019220 349 0.013
cytosolic calcium ion transport GO:0060401 39 0.013
spermatogenesis GO:0007283 99 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
erbb signaling pathway GO:0038127 23 0.013
regulation of b cell mediated immunity GO:0002712 2 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
cell morphogenesis GO:0000902 142 0.013
reproductive structure development GO:0048608 128 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
embryonic skeletal system morphogenesis GO:0048704 3 0.013
regulation of tube size GO:0035150 89 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.012
regulation of ion transport GO:0043269 245 0.012
positive regulation of hydrolase activity GO:0051345 86 0.012
positive regulation of dendrite development GO:1900006 35 0.012
central nervous system development GO:0007417 311 0.012
cerebral cortex cell migration GO:0021795 4 0.012
positive regulation of protein modification process GO:0031401 142 0.012
blood circulation GO:0008015 183 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
regulation of hydrolase activity GO:0051336 143 0.012
negative regulation of secretion by cell GO:1903531 72 0.012
regulation of phosphorylation GO:0042325 248 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
response to sterol GO:0036314 13 0.012
artery development GO:0060840 3 0.012
regulation of cell cycle GO:0051726 73 0.012
learning or memory GO:0007611 90 0.012
development of primary sexual characteristics GO:0045137 107 0.012
hormone mediated signaling pathway GO:0009755 23 0.012
regulation of muscle system process GO:0090257 79 0.012
negative regulation of cell proliferation GO:0008285 119 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
positive regulation of epidermis development GO:0045684 1 0.012
cell projection morphogenesis GO:0048858 123 0.012
response to starvation GO:0042594 59 0.012
response to molecule of bacterial origin GO:0002237 194 0.011
vesicle mediated transport GO:0016192 181 0.011
organic anion transport GO:0015711 132 0.011
positive regulation of neurogenesis GO:0050769 165 0.011
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.011
regulation of metanephros development GO:0072215 4 0.011
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.011
cellular component morphogenesis GO:0032989 155 0.011
regulation of mapk cascade GO:0043408 116 0.011
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
hemostasis GO:0007599 26 0.011
multicellular organism growth GO:0035264 1 0.011
regulation of immune response GO:0050776 55 0.011
phospholipid metabolic process GO:0006644 61 0.011
positive regulation of cell death GO:0010942 184 0.011
endocytosis GO:0006897 84 0.011
ribonucleoside monophosphate metabolic process GO:0009161 88 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
gtp metabolic process GO:0046039 72 0.011
cellular response to insulin stimulus GO:0032869 81 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
myeloid leukocyte differentiation GO:0002573 20 0.011
cellular response to corticosteroid stimulus GO:0071384 69 0.011
positive regulation of protein transport GO:0051222 41 0.011
anterior posterior pattern specification GO:0009952 1 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
sex differentiation GO:0007548 113 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
feeding behavior GO:0007631 53 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
prostate gland morphogenesis GO:0060512 2 0.011
positive regulation of protein phosphorylation GO:0001934 135 0.011
cyclic purine nucleotide metabolic process GO:0052652 62 0.011
neuron fate commitment GO:0048663 4 0.011
positive regulation of secretion GO:0051047 140 0.011
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.011
divalent inorganic cation transport GO:0072511 134 0.011
embryonic cranial skeleton morphogenesis GO:0048701 2 0.011
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 2 0.010
smooth muscle cell proliferation GO:0048659 77 0.010
inner ear receptor cell differentiation GO:0060113 2 0.010
lymphocyte mediated immunity GO:0002449 14 0.010
cellular lipid catabolic process GO:0044242 37 0.010
hormone metabolic process GO:0042445 69 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.010
positive regulation of tolerance induction to nonself antigen GO:0002657 1 0.010
embryonic limb morphogenesis GO:0030326 4 0.010
circulatory system process GO:0003013 183 0.010
regulation of immune effector process GO:0002697 32 0.010
hepaticobiliary system development GO:0061008 90 0.010
negative regulation of ion transport GO:0043271 51 0.010
dna integrity checkpoint GO:0031570 2 0.010
positive regulation of cellular component movement GO:0051272 102 0.010
hormone transport GO:0009914 121 0.010
mesoderm development GO:0007498 2 0.010
sensory perception of bitter taste GO:0050913 4 0.010
endoplasmic reticulum organization GO:0007029 1 0.010
synaptic vesicle endocytosis GO:0048488 4 0.010
regulation of blood vessel size GO:0050880 89 0.010
positive regulation of cell growth GO:0030307 44 0.010
positive regulation of endothelial cell migration GO:0010595 4 0.010
negative regulation of secretion GO:0051048 82 0.010

Man2b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.039
brain disease DOID:936 0 0.039
cerebral degeneration DOID:1443 0 0.039
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.039
inherited metabolic disorder DOID:655 0 0.032
Human
disease of metabolism DOID:0014667 0 0.032
Human
eye disease DOID:5614 0 0.013
eye and adnexa disease DOID:1492 0 0.013
sensory system disease DOID:0050155 0 0.013
connective tissue disease DOID:65 0 0.011
musculoskeletal system disease DOID:17 0 0.011
bone disease DOID:0080001 0 0.011
cardiovascular system disease DOID:1287 0 0.011
vascular disease DOID:178 0 0.011