Rattus norvegicus

0 known processes

Map4k3

mitogen-activated protein kinase kinase kinase kinase 3

Map4k3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
transcription dna templated GO:0006351 377 0.142
cell projection organization GO:0030030 302 0.134
cellular catabolic process GO:0044248 295 0.122
negative regulation of metabolic process GO:0009892 331 0.121
regulation of signal transduction GO:0009966 318 0.116
Fly
regulation of molecular function GO:0065009 398 0.115
regulation of rna metabolic process GO:0051252 391 0.112
regulation of purine nucleotide metabolic process GO:1900542 115 0.102
catabolic process GO:0009056 351 0.101
purine containing compound metabolic process GO:0072521 253 0.097
regulation of cellular component organization GO:0051128 368 0.097
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.090
regulation of rna biosynthetic process GO:2001141 381 0.089
regulation of cell development GO:0060284 263 0.086
positive regulation of molecular function GO:0044093 230 0.085
rna metabolic process GO:0016070 406 0.085
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.082
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.082
purine nucleotide metabolic process GO:0006163 229 0.080
rna biosynthetic process GO:0032774 380 0.078
positive regulation of multicellular organismal process GO:0051240 387 0.077
regulation of nucleic acid templated transcription GO:1903506 380 0.072
negative regulation of cellular metabolic process GO:0031324 281 0.070
nucleic acid templated transcription GO:0097659 379 0.069
regulation of transcription dna templated GO:0006355 374 0.068
neuron projection development GO:0031175 273 0.067
nucleotide metabolic process GO:0009117 279 0.067
ribonucleotide metabolic process GO:0009259 231 0.066
regulation of catalytic activity GO:0050790 304 0.066
positive regulation of developmental process GO:0051094 283 0.065
negative regulation of cell death GO:0060548 229 0.065
positive regulation of phosphorus metabolic process GO:0010562 262 0.064
Fly
nucleoside catabolic process GO:0009164 126 0.064
nucleobase containing small molecule metabolic process GO:0055086 316 0.063
regulation of cellular amine metabolic process GO:0033238 8 0.062
negative regulation of nucleic acid templated transcription GO:1903507 117 0.062
cellular component biogenesis GO:0044085 368 0.061
negative regulation of macromolecule metabolic process GO:0010605 260 0.061
regulation of neuron differentiation GO:0045664 208 0.060
positive regulation of catalytic activity GO:0043085 184 0.060
regulation of apoptotic process GO:0042981 335 0.059
Fly
neuron differentiation GO:0030182 368 0.059
nucleoside metabolic process GO:0009116 179 0.058
regulation of nervous system development GO:0051960 264 0.057
positive regulation of cellular component organization GO:0051130 200 0.057
neuron development GO:0048666 286 0.057
nucleoside phosphate metabolic process GO:0006753 283 0.056
purine ribonucleotide metabolic process GO:0009150 227 0.056
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.056
negative regulation of rna metabolic process GO:0051253 123 0.056
regulation of neuron projection development GO:0010975 161 0.055
positive regulation of neuron projection development GO:0010976 99 0.054
carbohydrate derivative metabolic process GO:1901135 346 0.054
organic substance catabolic process GO:1901575 316 0.054
organelle organization GO:0006996 266 0.054
Fly
cell morphogenesis GO:0000902 142 0.053
positive regulation of neurogenesis GO:0050769 165 0.052
positive regulation of cellular biosynthetic process GO:0031328 295 0.052
positive regulation of nucleotide metabolic process GO:0045981 91 0.051
negative regulation of cellular biosynthetic process GO:0031327 161 0.050
organophosphate metabolic process GO:0019637 370 0.050
cell projection morphogenesis GO:0048858 123 0.050
positive regulation of response to stimulus GO:0048584 285 0.050
Fly
positive regulation of cell differentiation GO:0045597 217 0.049
regulation of cellular ketone metabolic process GO:0010565 27 0.049
protein phosphorylation GO:0006468 345 0.049
Human Fly
cellular component assembly GO:0022607 360 0.048
nucleoside phosphate catabolic process GO:1901292 140 0.047
regulation of phosphorus metabolic process GO:0051174 349 0.046
Fly
regulation of nucleotide metabolic process GO:0006140 117 0.045
positive regulation of cell development GO:0010720 176 0.045
amine metabolic process GO:0009308 38 0.045
glycosyl compound catabolic process GO:1901658 126 0.045
macromolecular complex assembly GO:0065003 273 0.044
regulation of neurogenesis GO:0050767 247 0.044
positive regulation of biosynthetic process GO:0009891 319 0.043
regulation of protein metabolic process GO:0051246 289 0.043
negative regulation of rna biosynthetic process GO:1902679 118 0.042
negative regulation of gene expression GO:0010629 199 0.042
regulation of protein modification process GO:0031399 194 0.042
cellular component morphogenesis GO:0032989 155 0.042
positive regulation of rna biosynthetic process GO:1902680 197 0.042
intracellular signal transduction GO:0035556 314 0.041
Human Fly
regulation of protein phosphorylation GO:0001932 183 0.041
programmed cell death GO:0012501 392 0.041
Fly
protein complex biogenesis GO:0070271 263 0.041
cellular ketone metabolic process GO:0042180 51 0.041
regulation of cell differentiation GO:0045595 320 0.041
aromatic compound catabolic process GO:0019439 168 0.041
macromolecular complex subunit organization GO:0043933 339 0.040
locomotion GO:0040011 237 0.040
regulation of programmed cell death GO:0043067 341 0.040
Fly
regulation of hydrolase activity GO:0051336 143 0.039
purine nucleoside metabolic process GO:0042278 169 0.039
regulation of gtpase activity GO:0043087 57 0.038
regulation of cellular protein metabolic process GO:0032268 267 0.038
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.038
purine ribonucleoside metabolic process GO:0046128 168 0.037
single organism biosynthetic process GO:0044711 342 0.037
cation transport GO:0006812 382 0.037
regulation of cellular catabolic process GO:0031329 101 0.037
nucleobase containing compound catabolic process GO:0034655 152 0.036
single organism catabolic process GO:0044712 283 0.036
regulation of phosphate metabolic process GO:0019220 349 0.036
Fly
cellular amine metabolic process GO:0044106 38 0.036
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.036
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.035
central nervous system development GO:0007417 311 0.035
cellular nitrogen compound catabolic process GO:0044270 163 0.035
heterocycle catabolic process GO:0046700 167 0.035
behavior GO:0007610 205 0.034
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.034
protein heterooligomerization GO:0051291 89 0.034
axon development GO:0061564 96 0.034
purine containing compound catabolic process GO:0072523 138 0.034
regulation of nucleoside metabolic process GO:0009118 66 0.034
regulation of multicellular organismal development GO:2000026 376 0.033
organonitrogen compound catabolic process GO:1901565 179 0.033
cellular amino acid metabolic process GO:0006520 107 0.033
anion transport GO:0006820 178 0.033
vesicle mediated transport GO:0016192 181 0.033
transmembrane transport GO:0055085 412 0.032
positive regulation of nervous system development GO:0051962 178 0.032
reproduction GO:0000003 245 0.032
synaptic transmission GO:0007268 235 0.032
nucleoside triphosphate metabolic process GO:0009141 144 0.032
positive regulation of cell communication GO:0010647 271 0.031
Fly
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.031
cell cell signaling GO:0007267 335 0.031
single organism carbohydrate metabolic process GO:0044723 118 0.031
positive regulation of transcription dna templated GO:0045893 197 0.031
regulation of catabolic process GO:0009894 113 0.031
neuron death GO:0070997 127 0.031
carbohydrate metabolic process GO:0005975 130 0.030
purine nucleoside triphosphate catabolic process GO:0009146 122 0.030
regulation of cell projection organization GO:0031344 175 0.030
positive regulation of nucleic acid templated transcription GO:1903508 197 0.030
cell migration GO:0016477 197 0.029
positive regulation of phosphorylation GO:0042327 177 0.029
Fly
brain development GO:0007420 247 0.029
regulation of purine nucleotide catabolic process GO:0033121 65 0.029
carbohydrate derivative biosynthetic process GO:1901137 124 0.029
glycosyl compound metabolic process GO:1901657 182 0.029
positive regulation of cellular amine metabolic process GO:0033240 3 0.029
negative regulation of cell communication GO:0010648 158 0.029
Fly
oxoacid metabolic process GO:0043436 290 0.028
axonogenesis GO:0007409 71 0.028
regulation of response to stress GO:0080134 126 0.028
Fly
carboxylic acid metabolic process GO:0019752 289 0.028
organophosphate catabolic process GO:0046434 148 0.028
organic anion transport GO:0015711 132 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.027
purine nucleoside catabolic process GO:0006152 124 0.027
transcription from rna polymerase ii promoter GO:0006366 252 0.027
protein oligomerization GO:0051259 191 0.027
carbohydrate derivative catabolic process GO:1901136 147 0.027
positive regulation of protein metabolic process GO:0051247 178 0.026
purine nucleotide catabolic process GO:0006195 136 0.026
developmental growth GO:0048589 100 0.026
protein complex subunit organization GO:0071822 302 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.025
Fly
cytoplasmic transport GO:0016482 115 0.025
cellular component movement GO:0006928 248 0.025
positive regulation of protein phosphorylation GO:0001934 135 0.025
nucleoside triphosphate catabolic process GO:0009143 123 0.025
gtp catabolic process GO:0006184 71 0.025
enzyme linked receptor protein signaling pathway GO:0007167 116 0.024
Fly
organophosphate biosynthetic process GO:0090407 143 0.024
metal ion transport GO:0030001 289 0.024
nucleotide catabolic process GO:0009166 139 0.024
guanosine containing compound metabolic process GO:1901068 74 0.024
purine ribonucleoside catabolic process GO:0046130 124 0.024
positive regulation of hydrolase activity GO:0051345 86 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
organic cyclic compound catabolic process GO:1901361 175 0.024
positive regulation of gene expression GO:0010628 244 0.024
negative regulation of biosynthetic process GO:0009890 168 0.023
positive regulation of cell projection organization GO:0031346 111 0.023
regulation of intracellular signal transduction GO:1902531 218 0.023
Fly
anatomical structure morphogenesis GO:0009653 298 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.023
ion homeostasis GO:0050801 212 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
ribonucleoside catabolic process GO:0042454 126 0.023
cgmp biosynthetic process GO:0006182 15 0.023
head development GO:0060322 247 0.023
chemical homeostasis GO:0048878 292 0.023
Fly
response to growth factor GO:0070848 189 0.023
intracellular protein transport GO:0006886 79 0.023
regulation of developmental growth GO:0048638 45 0.023
positive regulation of rna metabolic process GO:0051254 203 0.023
cyclic purine nucleotide metabolic process GO:0052652 62 0.022
purine ribonucleotide catabolic process GO:0009154 136 0.022
establishment of protein localization GO:0045184 141 0.022
ribonucleoside triphosphate metabolic process GO:0009199 141 0.022
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.022
regulation of synaptic transmission GO:0050804 141 0.022
negative regulation of cellular component organization GO:0051129 83 0.022
positive regulation of protein modification process GO:0031401 142 0.022
cellular response to growth factor stimulus GO:0071363 162 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.022
ras protein signal transduction GO:0007265 29 0.021
single organism intracellular transport GO:1902582 166 0.021
ion transmembrane transport GO:0034220 365 0.021
organonitrogen compound biosynthetic process GO:1901566 167 0.021
regulation of neuron apoptotic process GO:0043523 83 0.021
nitrogen compound transport GO:0071705 229 0.021
cyclic nucleotide metabolic process GO:0009187 80 0.021
regulation of organelle organization GO:0033043 80 0.021
positive regulation of neuron differentiation GO:0045666 126 0.021
negative regulation of response to stimulus GO:0048585 155 0.021
Fly
regulation of axonogenesis GO:0050770 37 0.021
multi organism reproductive process GO:0044703 262 0.021
positive regulation of signal transduction GO:0009967 175 0.021
Fly
negative regulation of multicellular organismal process GO:0051241 203 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.021
regulation of nucleotide catabolic process GO:0030811 65 0.021
ribonucleotide catabolic process GO:0009261 136 0.021
synapse organization GO:0050808 46 0.020
negative regulation of apoptotic process GO:0043066 181 0.020
cell morphogenesis involved in differentiation GO:0000904 119 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.020
protein complex assembly GO:0006461 263 0.020
cellular protein localization GO:0034613 122 0.020
guanosine containing compound catabolic process GO:1901069 71 0.020
cellular response to stress GO:0033554 269 0.019
Fly
regulation of transferase activity GO:0051338 123 0.019
neurological system process GO:0050877 219 0.019
response to carbohydrate GO:0009743 183 0.019
mitotic spindle organization GO:0007052 2 0.019
purine nucleoside triphosphate metabolic process GO:0009144 141 0.019
cellular response to endogenous stimulus GO:0071495 377 0.019
Fly
homeostatic process GO:0042592 331 0.019
Fly
chromosome segregation GO:0007059 2 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
organic acid transport GO:0015849 116 0.019
synaptic growth at neuromuscular junction GO:0051124 1 0.019
gtp metabolic process GO:0046039 72 0.019
regulation of anatomical structure size GO:0090066 135 0.019
Fly
response to extracellular stimulus GO:0009991 380 0.018
negative regulation of transcription dna templated GO:0045892 116 0.018
multicellular organism reproduction GO:0032504 233 0.018
neuron apoptotic process GO:0051402 88 0.018
regulation of ion transport GO:0043269 245 0.018
peptidyl amino acid modification GO:0018193 126 0.018
regulation of phosphorylation GO:0042325 248 0.018
Fly
negative regulation of programmed cell death GO:0043069 183 0.018
mitotic sister chromatid segregation GO:0000070 1 0.018
organic acid metabolic process GO:0006082 292 0.017
ribonucleoside triphosphate catabolic process GO:0009203 122 0.017
regulation of growth GO:0040008 105 0.017
Fly
regulation of cell migration GO:0030334 128 0.017
intracellular transport GO:0046907 185 0.017
negative regulation of transport GO:0051051 136 0.017
carboxylic acid transport GO:0046942 115 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
growth GO:0040007 165 0.017
Fly
positive regulation of cellular catabolic process GO:0031331 71 0.017
single organism reproductive process GO:0044702 297 0.016
negative regulation of signaling GO:0023057 157 0.016
Fly
regulation of cell morphogenesis GO:0022604 77 0.016
regulation of secretion by cell GO:1903530 208 0.016
macromolecule localization GO:0033036 252 0.016
purine ribonucleotide biosynthetic process GO:0009152 81 0.016
chromatin modification GO:0016568 33 0.016
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.016
cell part morphogenesis GO:0032990 123 0.016
cyclic nucleotide biosynthetic process GO:0009190 63 0.016
lipid metabolic process GO:0006629 283 0.016
positive regulation of signaling GO:0023056 270 0.016
Fly
protein localization to organelle GO:0033365 57 0.016
regulation of canonical wnt signaling pathway GO:0060828 4 0.016
apoptotic process GO:0006915 381 0.016
Fly
regulation of cellular component size GO:0032535 51 0.015
Fly
negative regulation of developmental process GO:0051093 125 0.015
single organism behavior GO:0044708 130 0.015
Fly
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.015
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.015
regulation of cell growth GO:0001558 85 0.015
learning or memory GO:0007611 90 0.015
regulation of secretion GO:0051046 224 0.015
regulation of axon extension GO:0030516 24 0.015
protein localization GO:0008104 191 0.015
regulation of response to external stimulus GO:0032101 106 0.015
regulation of protein kinase activity GO:0045859 105 0.015
positive regulation of transport GO:0051050 245 0.015
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.015
positive regulation of gtp catabolic process GO:0033126 48 0.014
response to hexose GO:0009746 144 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
protein homooligomerization GO:0051260 91 0.014
cellular homeostasis GO:0019725 252 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
response to peptide hormone GO:0043434 278 0.014
Fly
negative regulation of cell cycle phase transition GO:1901988 4 0.014
cell cycle GO:0007049 101 0.014
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.014
receptor mediated endocytosis GO:0006898 42 0.014
regulation of neuron death GO:1901214 115 0.014
secretion by cell GO:0032940 248 0.014
positive regulation of secretion GO:0051047 140 0.014
divalent metal ion transport GO:0070838 132 0.014
cell type specific apoptotic process GO:0097285 134 0.014
motor neuron axon guidance GO:0008045 1 0.013
response to monosaccharide GO:0034284 159 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
anterior posterior pattern specification GO:0009952 1 0.013
muscle system process GO:0003012 115 0.013
response to nutrient levels GO:0031667 370 0.013
reproductive process GO:0022414 372 0.013
localization of cell GO:0051674 202 0.013
positive regulation of catabolic process GO:0009896 78 0.013
memory GO:0007613 54 0.013
positive regulation of ion transport GO:0043270 94 0.013
regulation of gtp catabolic process GO:0033124 58 0.013
mapk cascade GO:0000165 140 0.013
Fly
inorganic ion transmembrane transport GO:0098660 229 0.012
neuron projection morphogenesis GO:0048812 122 0.012
dna metabolic process GO:0006259 96 0.012
negative regulation of cellular protein metabolic process GO:0032269 106 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
positive regulation of developmental growth GO:0048639 29 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
positive regulation of cellular component biogenesis GO:0044089 55 0.012
regulation of system process GO:0044057 208 0.012
regulation of cell cycle GO:0051726 73 0.012
cell cycle checkpoint GO:0000075 2 0.012
development of primary sexual characteristics GO:0045137 107 0.012
dendrite development GO:0016358 72 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
regulation of membrane potential GO:0042391 110 0.012
regulation of nucleotide biosynthetic process GO:0030808 47 0.012
sex differentiation GO:0007548 113 0.012
regeneration GO:0031099 163 0.012
positive regulation of growth GO:0045927 55 0.012
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.012
regulation of cellular localization GO:0060341 263 0.012
macromolecule catabolic process GO:0009057 58 0.011
single organism organelle organization GO:1902589 180 0.011
cell adhesion GO:0007155 110 0.011
amide transport GO:0042886 105 0.011
response to ketone GO:1901654 182 0.011
regulation of extent of cell growth GO:0061387 25 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
metal ion homeostasis GO:0055065 186 0.011
positive regulation of cell death GO:0010942 184 0.011
Fly
negative regulation of signal transduction GO:0009968 83 0.011
Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.011
Fly
divalent inorganic cation homeostasis GO:0072507 165 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
cell growth GO:0016049 104 0.011
multicellular organism growth GO:0035264 1 0.011
axon extension GO:0048675 26 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
sexual reproduction GO:0019953 148 0.011
response to acid chemical GO:0001101 222 0.011
purine nucleotide biosynthetic process GO:0006164 83 0.011
gonad development GO:0008406 104 0.011
protein import GO:0017038 37 0.011
response to decreased oxygen levels GO:0036293 237 0.010
positive regulation of kinase activity GO:0033674 77 0.010
positive regulation of gtpase activity GO:0043547 47 0.010
rho protein signal transduction GO:0007266 11 0.010
positive regulation of nucleotide catabolic process GO:0030813 53 0.010
defense response GO:0006952 194 0.010
response to cytokine GO:0034097 215 0.010
Human
calcium ion transport GO:0006816 131 0.010
response to peptide GO:1901652 292 0.010
Fly
response to organophosphorus GO:0046683 102 0.010
regulation of cell size GO:0008361 37 0.010
Fly
spindle organization GO:0007051 2 0.010
store operated calcium entry GO:0002115 2 0.010
multi multicellular organism process GO:0044706 138 0.010
protein transport GO:0015031 132 0.010
cellular response to oxygen containing compound GO:1901701 386 0.010
Fly
regulation of metal ion transport GO:0010959 118 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010
muscle structure development GO:0061061 87 0.010

Map4k3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
nervous system disease DOID:863 0 0.042
central nervous system disease DOID:331 0 0.024