Rattus norvegicus

50 known processes

Mapt

microtubule-associated protein tau

(Aliases: MGC156663,RNPTAU,pTau,Mtapt)

Mapt biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell part morphogenesis GO:0032990 123 0.266
Human
neuron projection development GO:0031175 273 0.258
Human
positive regulation of developmental process GO:0051094 283 0.249
Human
cell projection morphogenesis GO:0048858 123 0.221
Human
regulation of nervous system development GO:0051960 264 0.215
Human
anatomical structure morphogenesis GO:0009653 298 0.169
Human
regulation of secretion GO:0051046 224 0.156
positive regulation of neurogenesis GO:0050769 165 0.143
Human
positive regulation of cell differentiation GO:0045597 217 0.141
Human
cellular component morphogenesis GO:0032989 155 0.141
Human
axon cargo transport GO:0008088 1 0.140
protein complex biogenesis GO:0070271 263 0.138
Human
neuron differentiation GO:0030182 368 0.137
Human
positive regulation of neuron projection development GO:0010976 99 0.133
Human
regulation of neuron projection development GO:0010975 161 0.129
Human
regulation of cell differentiation GO:0045595 320 0.127
Human
homeostatic process GO:0042592 331 0.121
regulation of multicellular organismal development GO:2000026 376 0.119
Human
macromolecular complex subunit organization GO:0043933 339 0.116
Human
response to wounding GO:0009611 254 0.116
regulation of cellular component organization GO:0051128 368 0.114
Human
learning or memory GO:0007611 90 0.108
cellular component movement GO:0006928 248 0.104
cellular component biogenesis GO:0044085 368 0.104
Human
single organism intracellular transport GO:1902582 166 0.103
cell projection organization GO:0030030 302 0.101
Human
regulation of neuron differentiation GO:0045664 208 0.096
Human
growth GO:0040007 165 0.096
Human
male mating behavior GO:0060179 3 0.094
cellular component assembly GO:0022607 360 0.094
Human
inorganic cation transmembrane transport GO:0098662 202 0.093
macromolecule localization GO:0033036 252 0.090
negative regulation of multicellular organismal process GO:0051241 203 0.087
single organism catabolic process GO:0044712 283 0.080
neuron projection morphogenesis GO:0048812 122 0.080
Human
multicellular organismal signaling GO:0035637 44 0.077
regulation of ion transport GO:0043269 245 0.076
response to oxygen levels GO:0070482 265 0.075
regulation of neurogenesis GO:0050767 247 0.073
Human
response to nutrient levels GO:0031667 370 0.071
neurological system process GO:0050877 219 0.070
positive regulation of multicellular organismal process GO:0051240 387 0.068
Human
response to inorganic substance GO:0010035 377 0.068
intracellular transport GO:0046907 185 0.068
regulation of anatomical structure morphogenesis GO:0022603 141 0.068
Human
cell cycle GO:0007049 101 0.067
protein oligomerization GO:0051259 191 0.067
regulation of cell development GO:0060284 263 0.067
Human
response to nutrient GO:0007584 248 0.065
cell morphogenesis involved in differentiation GO:0000904 119 0.064
Human
protein phosphorylation GO:0006468 345 0.063
positive regulation of neuron differentiation GO:0045666 126 0.062
Human
regulation of synapse maturation GO:0090128 2 0.061
negative regulation of neuron differentiation GO:0045665 62 0.060
positive regulation of nervous system development GO:0051962 178 0.059
Human
intracellular signal transduction GO:0035556 314 0.058
response to radiation GO:0009314 137 0.057
regulation of cell morphogenesis GO:0022604 77 0.056
Human
protein complex assembly GO:0006461 263 0.056
Human
ribonucleotide catabolic process GO:0009261 136 0.055
regulation of extent of cell growth GO:0061387 25 0.055
Human
positive regulation of cell development GO:0010720 176 0.054
Human
positive regulation of dendritic spine morphogenesis GO:0061003 3 0.054
central nervous system development GO:0007417 311 0.054
organophosphate catabolic process GO:0046434 148 0.053
protein localization GO:0008104 191 0.053
biological adhesion GO:0022610 110 0.053
divalent metal ion transport GO:0070838 132 0.051
metal ion transport GO:0030001 289 0.051
reproductive process GO:0022414 372 0.051
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.049
response to carbohydrate GO:0009743 183 0.049
regulation of cell cycle GO:0051726 73 0.049
regulation of growth GO:0040008 105 0.048
Human
synaptic growth at neuromuscular junction GO:0051124 1 0.048
cognition GO:0050890 92 0.048
cellular protein localization GO:0034613 122 0.047
neuron development GO:0048666 286 0.047
Human
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.046
Human
positive regulation of synapse maturation GO:0090129 2 0.046
response to estradiol GO:0032355 164 0.045
Rat
purine containing compound metabolic process GO:0072521 253 0.045
positive regulation of cellular component organization GO:0051130 200 0.045
Human
heterocycle catabolic process GO:0046700 167 0.044
cellular macromolecule localization GO:0070727 122 0.043
nucleotide metabolic process GO:0009117 279 0.043
potassium ion transport GO:0006813 97 0.043
macromolecular complex assembly GO:0065003 273 0.043
Human
positive regulation of biosynthetic process GO:0009891 319 0.043
nucleoside triphosphate metabolic process GO:0009141 144 0.041
cation transport GO:0006812 382 0.041
cellular homeostasis GO:0019725 252 0.041
single organism organelle organization GO:1902589 180 0.041
Human
calcium ion transport GO:0006816 131 0.041
catabolic process GO:0009056 351 0.041
Human
divalent inorganic cation transport GO:0072511 134 0.041
intracellular protein transport GO:0006886 79 0.041
positive regulation of cell communication GO:0010647 271 0.041
ion homeostasis GO:0050801 212 0.040
gliogenesis GO:0042063 93 0.039
aromatic compound catabolic process GO:0019439 168 0.039
organonitrogen compound catabolic process GO:1901565 179 0.039
regulation of developmental growth GO:0048638 45 0.038
Human
developmental growth involved in morphogenesis GO:0060560 33 0.037
Human
protein complex subunit organization GO:0071822 302 0.037
Human
secretion by cell GO:0032940 248 0.037
regulation of rna biosynthetic process GO:2001141 381 0.037
second messenger mediated signaling GO:0019932 51 0.037
regulation of cell projection organization GO:0031344 175 0.037
Human
organic acid metabolic process GO:0006082 292 0.037
cell migration GO:0016477 197 0.037
synaptic transmission GO:0007268 235 0.037
reproduction GO:0000003 245 0.036
response to estrogen GO:0043627 232 0.036
Rat
nucleoside phosphate metabolic process GO:0006753 283 0.036
chemical homeostasis GO:0048878 292 0.036
locomotion GO:0040011 237 0.036
regulation of membrane potential GO:0042391 110 0.035
cell adhesion GO:0007155 110 0.035
memory GO:0007613 54 0.035
axon ensheathment GO:0008366 40 0.035
regulation of nucleic acid templated transcription GO:1903506 380 0.034
response to decreased oxygen levels GO:0036293 237 0.034
heart morphogenesis GO:0003007 3 0.033
cellular ketone metabolic process GO:0042180 51 0.033
regulation of vesicle mediated transport GO:0060627 81 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.033
regulation of intracellular signal transduction GO:1902531 218 0.033
transmission of nerve impulse GO:0019226 42 0.032
cellular response to oxygen containing compound GO:1901701 386 0.032
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.032
Human
response to metal ion GO:0010038 253 0.032
vesicle mediated transport GO:0016192 181 0.032
single organism reproductive process GO:0044702 297 0.032
single organism biosynthetic process GO:0044711 342 0.032
cellular amino acid metabolic process GO:0006520 107 0.031
circulatory system development GO:0072359 134 0.031
cell cell signaling GO:0007267 335 0.031
cellular nitrogen compound catabolic process GO:0044270 163 0.031
nucleoside triphosphate catabolic process GO:0009143 123 0.031
programmed cell death GO:0012501 392 0.030
regulation of signal transduction GO:0009966 318 0.030
regulation of dendrite development GO:0050773 59 0.030
response to extracellular stimulus GO:0009991 380 0.030
regulation of hormone secretion GO:0046883 106 0.030
negative regulation of nervous system development GO:0051961 79 0.030
regulation of secretion by cell GO:1903530 208 0.029
insulin secretion GO:0030073 69 0.029
multicellular organism reproduction GO:0032504 233 0.029
neuron projection extension GO:1990138 26 0.029
Human
synapse organization GO:0050808 46 0.029
nucleoside phosphate catabolic process GO:1901292 140 0.029
nucleotide catabolic process GO:0009166 139 0.028
positive regulation of signal transduction GO:0009967 175 0.028
response to temperature stimulus GO:0009266 94 0.028
cation homeostasis GO:0055080 195 0.027
negative regulation of developmental process GO:0051093 125 0.027
secretion GO:0046903 307 0.027
organophosphate metabolic process GO:0019637 370 0.027
ensheathment of neurons GO:0007272 40 0.027
ribose phosphate metabolic process GO:0019693 235 0.027
cellular catabolic process GO:0044248 295 0.027
Human
transcription dna templated GO:0006351 377 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.027
cell cell junction organization GO:0045216 20 0.026
wound healing GO:0042060 122 0.026
multi organism reproductive process GO:0044703 262 0.026
ribonucleoside catabolic process GO:0042454 126 0.026
glycosyl compound metabolic process GO:1901657 182 0.026
positive regulation of cell projection organization GO:0031346 111 0.026
Human
response to cytokine GO:0034097 215 0.026
organic cyclic compound catabolic process GO:1901361 175 0.026
glycosyl compound catabolic process GO:1901658 126 0.025
aging GO:0007568 241 0.025
negative regulation of cellular component organization GO:0051129 83 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
response to hypoxia GO:0001666 231 0.025
negative regulation of response to stimulus GO:0048585 155 0.025
divalent inorganic cation homeostasis GO:0072507 165 0.025
response to monosaccharide GO:0034284 159 0.025
regulation of synaptic transmission GO:0050804 141 0.025
ribonucleoside metabolic process GO:0009119 174 0.025
multicellular organismal reproductive process GO:0048609 233 0.025
carbohydrate metabolic process GO:0005975 130 0.025
positive regulation of transport GO:0051050 245 0.025
carbohydrate derivative metabolic process GO:1901135 346 0.024
multicellular organismal homeostasis GO:0048871 49 0.024
purine ribonucleoside catabolic process GO:0046130 124 0.024
positive regulation of signaling GO:0023056 270 0.024
purine nucleoside triphosphate metabolic process GO:0009144 141 0.024
cellular chemical homeostasis GO:0055082 247 0.024
regulation of cell motility GO:2000145 131 0.024
negative regulation of neurogenesis GO:0050768 78 0.024
regulation of transcription dna templated GO:0006355 374 0.024
vesicle docking involved in exocytosis GO:0006904 4 0.024
negative regulation of cell development GO:0010721 82 0.023
response to axon injury GO:0048678 59 0.023
regulation of body fluid levels GO:0050878 90 0.023
ribonucleoside triphosphate catabolic process GO:0009203 122 0.023
protein homooligomerization GO:0051260 91 0.023
establishment of protein localization GO:0045184 141 0.023
cellular response to endogenous stimulus GO:0071495 377 0.023
negative regulation of cell communication GO:0010648 158 0.023
renal system development GO:0072001 67 0.023
behavior GO:0007610 205 0.023
organelle organization GO:0006996 266 0.023
Human
regulation of homeostatic process GO:0032844 101 0.023
response to vitamin GO:0033273 131 0.022
purine ribonucleotide catabolic process GO:0009154 136 0.022
purine nucleotide catabolic process GO:0006195 136 0.022
oxoacid metabolic process GO:0043436 290 0.022
carboxylic acid metabolic process GO:0019752 289 0.021
neuronal action potential GO:0019228 35 0.021
purine ribonucleotide metabolic process GO:0009150 227 0.021
nucleobase containing small molecule metabolic process GO:0055086 316 0.021
rna biosynthetic process GO:0032774 380 0.021
cellular calcium ion homeostasis GO:0006874 160 0.021
cellular divalent inorganic cation homeostasis GO:0072503 162 0.021
nuclear transport GO:0051169 49 0.021
negative regulation of signaling GO:0023057 157 0.021
amine metabolic process GO:0009308 38 0.020
response to glucose GO:0009749 136 0.020
maintenance of location GO:0051235 17 0.020
vesicle localization GO:0051648 33 0.020
monovalent inorganic cation transport GO:0015672 172 0.020
positive regulation of lipid catabolic process GO:0050996 4 0.020
response to light stimulus GO:0009416 52 0.020
cell morphogenesis GO:0000902 142 0.020
Human
synaptic vesicle endocytosis GO:0048488 4 0.020
regulation of synaptic plasticity GO:0048167 70 0.020
cellular response to stress GO:0033554 269 0.020
axonogenesis GO:0007409 71 0.020
Human
carbohydrate derivative catabolic process GO:1901136 147 0.019
spindle organization GO:0007051 2 0.019
regulation of metal ion transport GO:0010959 118 0.019
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
signal release GO:0023061 145 0.019
regulation of cellular component biogenesis GO:0044087 86 0.019
Human
adult locomotory behavior GO:0008344 4 0.019
regulation of cellular amino acid metabolic process GO:0006521 2 0.019
negative regulation of cell differentiation GO:0045596 99 0.019
regeneration GO:0031099 163 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
positive regulation of response to stimulus GO:0048584 285 0.019
developmental growth GO:0048589 100 0.019
Human
regulation of dendritic spine morphogenesis GO:0061001 6 0.019
regulation of cellular localization GO:0060341 263 0.019
regulation of peptide hormone secretion GO:0090276 80 0.019
regulation of locomotion GO:0040012 148 0.019
nucleoside metabolic process GO:0009116 179 0.019
negative regulation of transport GO:0051051 136 0.018
regulation of apoptotic process GO:0042981 335 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
positive regulation of phosphate metabolic process GO:0045937 262 0.018
cardiovascular system development GO:0072358 134 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
purine nucleoside triphosphate catabolic process GO:0009146 122 0.018
cell cycle process GO:0022402 57 0.018
sensory perception GO:0007600 101 0.018
regulation of cell proliferation GO:0042127 359 0.017
response to purine containing compound GO:0014074 126 0.017
response to acid chemical GO:0001101 222 0.017
axis specification GO:0009798 4 0.017
nitrogen compound transport GO:0071705 229 0.017
sequestering of metal ion GO:0051238 9 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.017
response to organophosphorus GO:0046683 102 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
regulation of system process GO:0044057 208 0.016
eye morphogenesis GO:0048592 4 0.016
cellular cation homeostasis GO:0030003 180 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
developmental maturation GO:0021700 25 0.016
regulation of axonogenesis GO:0050770 37 0.016
Human
regulation of calcium ion transport GO:0051924 77 0.016
nucleic acid templated transcription GO:0097659 379 0.016
head development GO:0060322 247 0.016
transcription from rna polymerase ii promoter GO:0006366 252 0.016
olfactory learning GO:0008355 1 0.016
inorganic ion transmembrane transport GO:0098660 229 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
regulation of phosphorylation GO:0042325 248 0.015
locomotory exploration behavior GO:0035641 1 0.015
regulation of rna metabolic process GO:0051252 391 0.015
negative regulation of cell projection organization GO:0031345 50 0.015
reproductive system development GO:0061458 128 0.015
regulation of insulin secretion GO:0050796 65 0.015
morphogenesis of a polarized epithelium GO:0001738 1 0.015
regulation of cell migration GO:0030334 128 0.015
response to hexose GO:0009746 144 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
response to other organism GO:0051707 220 0.015
guanosine containing compound metabolic process GO:1901068 74 0.015
monocarboxylic acid metabolic process GO:0032787 152 0.015
negative regulation of signal transduction GO:0009968 83 0.015
cellular amine metabolic process GO:0044106 38 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
cellular macromolecular complex assembly GO:0034622 58 0.015
Human
cellular ion homeostasis GO:0006873 184 0.014
rna metabolic process GO:0016070 406 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
purine containing compound catabolic process GO:0072523 138 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
neuronal ion channel clustering GO:0045161 3 0.014
axon extension GO:0048675 26 0.014
Human
response to oxidative stress GO:0006979 186 0.014
peptide secretion GO:0002790 86 0.014
multi multicellular organism process GO:0044706 138 0.014
regulation of protein complex assembly GO:0043254 33 0.014
Human
cell cycle checkpoint GO:0000075 2 0.014
regulation of cell growth GO:0001558 85 0.014
Human
negative regulation of neuron projection development GO:0010977 46 0.014
circulatory system process GO:0003013 183 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
peptidyl amino acid modification GO:0018193 126 0.014
kidney development GO:0001822 67 0.014
cellular response to lipid GO:0071396 201 0.014
peptidyl tyrosine phosphorylation GO:0018108 72 0.013
single organism behavior GO:0044708 130 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
response to ketone GO:1901654 182 0.013
Rat
response to growth factor GO:0070848 189 0.013
sexual reproduction GO:0019953 148 0.013
immune system process GO:0002376 204 0.013
reproductive structure development GO:0048608 128 0.013
cellular protein complex assembly GO:0043623 44 0.013
Human
mapk cascade GO:0000165 140 0.013
positive regulation of gene expression GO:0010628 244 0.013
positive regulation of programmed cell death GO:0043068 157 0.013
cellular lipid metabolic process GO:0044255 208 0.013
axon development GO:0061564 96 0.013
Human
negative regulation of cellular metabolic process GO:0031324 281 0.013
tissue development GO:0009888 252 0.013
relaxation of muscle GO:0090075 4 0.013
glial cell differentiation GO:0010001 65 0.013
cytoplasmic transport GO:0016482 115 0.013
regulation of axon extension GO:0030516 24 0.013
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
metal ion homeostasis GO:0055065 186 0.013
mitotic spindle organization GO:0007052 2 0.012
gamete generation GO:0007276 124 0.012
macrophage chemotaxis GO:0048246 2 0.012
regulation of cellular protein metabolic process GO:0032268 267 0.012
phototransduction visible light GO:0007603 2 0.012
protein transport GO:0015031 132 0.012
mitotic cell cycle process GO:1903047 35 0.012
immune effector process GO:0002252 53 0.012
rna localization GO:0006403 4 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
synapse assembly GO:0007416 29 0.012
cell cell signaling involved in cell fate commitment GO:0045168 2 0.012
transmembrane transport GO:0055085 412 0.012
defense response GO:0006952 194 0.012
carbohydrate homeostasis GO:0033500 75 0.012
centrosome organization GO:0051297 1 0.012
regulation of blood vessel size GO:0050880 89 0.012
cell motility GO:0048870 202 0.012
cell growth GO:0016049 104 0.012
Human
cell junction organization GO:0034330 21 0.012
negative regulation of secretion GO:0051048 82 0.012
ribonucleoside triphosphate metabolic process GO:0009199 141 0.012
gastrulation GO:0007369 2 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
response to activity GO:0014823 73 0.011
action potential GO:0001508 54 0.011
small molecule biosynthetic process GO:0044283 124 0.011
regulation of nucleotide catabolic process GO:0030811 65 0.011
regulation of ion homeostasis GO:2000021 63 0.011
regulation of protein modification process GO:0031399 194 0.011
cellular component maintenance GO:0043954 4 0.011
embryonic pattern specification GO:0009880 1 0.011
regulation of dendrite morphogenesis GO:0048814 33 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
leukocyte cell cell adhesion GO:0007159 4 0.011
urogenital system development GO:0001655 78 0.011
anion transport GO:0006820 178 0.011
cellular response to hormone stimulus GO:0032870 247 0.011
positive regulation of potassium ion transmembrane transport GO:1901381 4 0.011
membrane organization GO:0061024 94 0.011
ion transmembrane transport GO:0034220 365 0.011
protein localization to chromosome centromeric region GO:0071459 1 0.011
olfactory behavior GO:0042048 2 0.011
positive regulation of dendrite morphogenesis GO:0050775 21 0.011
calcium ion homeostasis GO:0055074 162 0.011
ras protein signal transduction GO:0007265 29 0.011
regulation of ovulation GO:0060278 2 0.011
response to molecule of bacterial origin GO:0002237 194 0.011
sensory perception of bitter taste GO:0050913 4 0.011
male gamete generation GO:0048232 99 0.011
cardiac conduction GO:0061337 2 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
Human
cellular response to glucose stimulus GO:0071333 65 0.010
positive regulation of protein modification process GO:0031401 142 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
circadian rhythm GO:0007623 88 0.010
regulation of gtpase activity GO:0043087 57 0.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.010
cellular response to organonitrogen compound GO:0071417 197 0.010
positive regulation of ion transport GO:0043270 94 0.010
anterior posterior pattern specification GO:0009952 1 0.010
hormone secretion GO:0046879 115 0.010
regulation of anatomical structure size GO:0090066 135 0.010
Human
positive regulation of protein metabolic process GO:0051247 178 0.010
regulation of cell maturation GO:1903429 3 0.010
centrosome cycle GO:0007098 1 0.010
cell cycle g1 s phase transition GO:0044843 13 0.010
response to corticosteroid GO:0031960 235 0.010
positive regulation of rna biosynthetic process GO:1902680 197 0.010
positive regulation of rna metabolic process GO:0051254 203 0.010

Mapt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.067
Human
nervous system disease DOID:863 0 0.067
Human
central nervous system disease DOID:331 0 0.036
Human
brain disease DOID:936 0 0.036
Human
disease of metabolism DOID:0014667 0 0.021
inherited metabolic disorder DOID:655 0 0.021
carbohydrate metabolic disorder DOID:2978 0 0.020
long qt syndrome DOID:2843 0 0.017
epilepsy syndrome DOID:1826 0 0.016
electroclinical syndrome DOID:0050701 0 0.011
neonatal period electroclinical syndrome DOID:0050702 0 0.011
ohtahara syndrome DOID:0050709 0 0.011