Rattus norvegicus

38 known processes

Mdh1

malate dehydrogenase 1, NAD (soluble)

(Aliases: Mor2,MDL1,Mdhl)

Mdh1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neurotransmitter uptake GO:0001504 3 0.932
oxidation reduction process GO:0055114 304 0.874
nucleoside monophosphate metabolic process GO:0009123 93 0.873
purine nucleoside triphosphate metabolic process GO:0009144 141 0.859
organophosphate metabolic process GO:0019637 370 0.822
positive regulation of atp biosynthetic process GO:2001171 2 0.817
nucleotide metabolic process GO:0009117 279 0.804
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.749
nucleobase containing small molecule metabolic process GO:0055086 316 0.733
nucleoside triphosphate metabolic process GO:0009141 144 0.703
porphyrin containing compound biosynthetic process GO:0006779 6 0.697
aerobic respiration GO:0009060 13 0.689
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.652
adenine nucleotide transport GO:0051503 2 0.616
ribonucleotide metabolic process GO:0009259 231 0.612
cofactor metabolic process GO:0051186 95 0.600
nucleoside phosphate metabolic process GO:0006753 283 0.600
ribonucleoside monophosphate metabolic process GO:0009161 88 0.593
organonitrogen compound biosynthetic process GO:1901566 167 0.584
porphyrin containing compound metabolic process GO:0006778 8 0.549
electron transport chain GO:0022900 5 0.537
purine nucleotide metabolic process GO:0006163 229 0.535
purine nucleoside monophosphate metabolic process GO:0009126 84 0.518
atp metabolic process GO:0046034 72 0.518
ribonucleoside metabolic process GO:0009119 174 0.501
purine nucleoside diphosphate biosynthetic process GO:0009136 9 0.499
purine nucleoside metabolic process GO:0042278 169 0.495
purine ribonucleoside metabolic process GO:0046128 168 0.482
cofactor biosynthetic process GO:0051188 28 0.482
purine nucleoside monophosphate biosynthetic process GO:0009127 20 0.464
tetrapyrrole biosynthetic process GO:0033014 7 0.463
l glutamate import GO:0051938 2 0.461
single organism biosynthetic process GO:0044711 342 0.458
purine nucleoside biosynthetic process GO:0042451 21 0.454
organophosphate biosynthetic process GO:0090407 143 0.448
regulation of atp biosynthetic process GO:2001169 2 0.435
ribose phosphate metabolic process GO:0019693 235 0.429
nucleoside metabolic process GO:0009116 179 0.407
purine ribonucleotide metabolic process GO:0009150 227 0.405
tetrapyrrole metabolic process GO:0033013 11 0.395
purine containing compound metabolic process GO:0072521 253 0.390
organic acid metabolic process GO:0006082 292 0.385
ribonucleoside triphosphate metabolic process GO:0009199 141 0.385
heme biosynthetic process GO:0006783 4 0.370
glycosyl compound metabolic process GO:1901657 182 0.357
apoptotic mitochondrial changes GO:0008637 10 0.341
purine ribonucleoside diphosphate biosynthetic process GO:0009180 9 0.322
purine nucleoside diphosphate metabolic process GO:0009135 9 0.317
oxidative phosphorylation GO:0006119 4 0.303
nucleoside transport GO:0015858 8 0.284
nucleotide biosynthetic process GO:0009165 98 0.276
acidic amino acid transport GO:0015800 10 0.266
cellular respiration GO:0045333 21 0.266
carbohydrate derivative metabolic process GO:1901135 346 0.261
purine ribonucleotide biosynthetic process GO:0009152 81 0.249
purine nucleotide biosynthetic process GO:0006164 83 0.226
action potential GO:0001508 54 0.211
atp catabolic process GO:0006200 54 0.205
adp transport GO:0015866 1 0.200
monovalent inorganic cation transport GO:0015672 172 0.191
positive regulation of cellular biosynthetic process GO:0031328 295 0.190
nucleoside monophosphate biosynthetic process GO:0009124 28 0.186
anion transport GO:0006820 178 0.183
generation of precursor metabolites and energy GO:0006091 62 0.183
dicarboxylic acid metabolic process GO:0043648 42 0.177
oxoacid metabolic process GO:0043436 290 0.161
adult locomotory behavior GO:0008344 4 0.156
regulation of nucleotide biosynthetic process GO:0030808 47 0.155
anion transmembrane transport GO:0098656 77 0.154
carboxylic acid metabolic process GO:0019752 289 0.146
organic acid transport GO:0015849 116 0.143
ribonucleoside monophosphate catabolic process GO:0009158 55 0.137
purine ribonucleoside biosynthetic process GO:0046129 21 0.135
programmed necrotic cell death GO:0097300 2 0.135
regulation of programmed cell death GO:0043067 341 0.134
glycosyl compound catabolic process GO:1901658 126 0.132
inorganic ion transmembrane transport GO:0098660 229 0.130
dicarboxylic acid transport GO:0006835 34 0.127
energy derivation by oxidation of organic compounds GO:0015980 46 0.123
ribonucleoside triphosphate catabolic process GO:0009203 122 0.118
purine nucleotide transport GO:0015865 3 0.111
ribonucleoside biosynthetic process GO:0042455 25 0.104
regulation of necroptotic process GO:0060544 2 0.104
organic anion transport GO:0015711 132 0.095
cofactor transport GO:0051181 5 0.094
ribonucleotide catabolic process GO:0009261 136 0.094
vesicle mediated transport GO:0016192 181 0.093
apoptotic process GO:0006915 381 0.093
cellular chemical homeostasis GO:0055082 247 0.092
purine containing compound catabolic process GO:0072523 138 0.091
transmembrane transport GO:0055085 412 0.091
purine nucleoside triphosphate catabolic process GO:0009146 122 0.090
nadh metabolic process GO:0006734 10 0.089
organophosphate catabolic process GO:0046434 148 0.089
response to nutrient GO:0007584 248 0.088
synaptic vesicle localization GO:0097479 24 0.088
purine ribonucleoside monophosphate biosynthetic process GO:0009168 20 0.085
regulation of purine nucleotide metabolic process GO:1900542 115 0.085
ribonucleoside diphosphate biosynthetic process GO:0009188 10 0.083
adp biosynthetic process GO:0006172 8 0.083
purine ribonucleotide catabolic process GO:0009154 136 0.083
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.083
pigment biosynthetic process GO:0046148 4 0.079
carbohydrate derivative biosynthetic process GO:1901137 124 0.079
response to interleukin 1 GO:0070555 55 0.079
behavior GO:0007610 205 0.079
mitochondrial calcium ion homeostasis GO:0051560 3 0.077
single organism catabolic process GO:0044712 283 0.076
ion homeostasis GO:0050801 212 0.076
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.076
regulation of apoptotic process GO:0042981 335 0.075
cation homeostasis GO:0055080 195 0.073
purine containing compound biosynthetic process GO:0072522 85 0.071
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.070
tricarboxylic acid metabolic process GO:0072350 10 0.070
protein heterooligomerization GO:0051291 89 0.069
cellular ion homeostasis GO:0006873 184 0.068
monocarboxylic acid metabolic process GO:0032787 152 0.068
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.067
adp metabolic process GO:0046031 8 0.066
ribonucleotide biosynthetic process GO:0009260 85 0.066
ribose phosphate biosynthetic process GO:0046390 87 0.066
necroptotic process GO:0070266 2 0.066
nad metabolic process GO:0019674 15 0.065
lipid biosynthetic process GO:0008610 128 0.065
regulation of ion transport GO:0043269 245 0.064
syncytium formation by plasma membrane fusion GO:0000768 3 0.063
regulation of transporter activity GO:0032409 50 0.062
locomotion GO:0040011 237 0.062
regulation of phosphate metabolic process GO:0019220 349 0.060
heterocycle catabolic process GO:0046700 167 0.060
organic cyclic compound catabolic process GO:1901361 175 0.059
positive regulation of phosphate metabolic process GO:0045937 262 0.057
positive regulation of molecular function GO:0044093 230 0.056
single organism behavior GO:0044708 130 0.056
nucleoside phosphate catabolic process GO:1901292 140 0.056
amino acid transport GO:0006865 70 0.055
alditol metabolic process GO:0019400 4 0.055
response to oxidative stress GO:0006979 186 0.055
nucleotide catabolic process GO:0009166 139 0.054
l amino acid transport GO:0015807 21 0.054
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.054
organelle localization GO:0051640 55 0.053
chemical homeostasis GO:0048878 292 0.053
cellular nitrogen compound catabolic process GO:0044270 163 0.053
regulation of nucleotide metabolic process GO:0006140 117 0.052
calcium ion homeostasis GO:0055074 162 0.052
positive regulation of apoptotic process GO:0043065 154 0.051
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.051
regulation of membrane potential GO:0042391 110 0.051
purine nucleoside triphosphate biosynthetic process GO:0009145 6 0.051
purine nucleoside catabolic process GO:0006152 124 0.050
ribonucleoside triphosphate biosynthetic process GO:0009201 7 0.049
l glutamate transport GO:0015813 7 0.049
cellular cation homeostasis GO:0030003 180 0.049
organonitrogen compound catabolic process GO:1901565 179 0.049
pigment metabolic process GO:0042440 7 0.048
response to decreased oxygen levels GO:0036293 237 0.048
cellular metal ion homeostasis GO:0006875 172 0.048
programmed cell death GO:0012501 392 0.047
cation transmembrane transport GO:0098655 263 0.047
circulatory system development GO:0072359 134 0.047
metal ion homeostasis GO:0055065 186 0.047
organelle organization GO:0006996 266 0.047
single organism reproductive process GO:0044702 297 0.046
response to transition metal nanoparticle GO:1990267 122 0.046
cellular amino acid biosynthetic process GO:0008652 32 0.046
synapse organization GO:0050808 46 0.045
catabolic process GO:0009056 351 0.045
citrate metabolic process GO:0006101 3 0.045
anatomical structure formation involved in morphogenesis GO:0048646 83 0.043
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.043
vesicle localization GO:0051648 33 0.043
negative regulation of hydrogen peroxide metabolic process GO:0010727 2 0.041
divalent inorganic cation homeostasis GO:0072507 165 0.041
regulation of cell proliferation GO:0042127 359 0.040
nucleoside monophosphate catabolic process GO:0009125 56 0.040
nucleoside biosynthetic process GO:0009163 25 0.040
ribonucleoside diphosphate metabolic process GO:0009185 10 0.039
growth GO:0040007 165 0.039
gamete generation GO:0007276 124 0.039
positive regulation of transmembrane transport GO:0034764 25 0.039
glycosyl compound biosynthetic process GO:1901659 25 0.039
pyridine containing compound metabolic process GO:0072524 32 0.039
cellular component assembly GO:0022607 360 0.038
nucleoside phosphate biosynthetic process GO:1901293 102 0.037
organic substance catabolic process GO:1901575 316 0.037
establishment of organelle localization GO:0051656 37 0.037
cellular component biogenesis GO:0044085 368 0.037
organic hydroxy compound metabolic process GO:1901615 115 0.037
ribonucleoside catabolic process GO:0042454 126 0.036
nucleoside triphosphate catabolic process GO:0009143 123 0.036
neuron apoptotic process GO:0051402 88 0.036
positive regulation of nucleotide metabolic process GO:0045981 91 0.035
purine nucleotide catabolic process GO:0006195 136 0.035
positive regulation of biosynthetic process GO:0009891 319 0.035
lipid localization GO:0010876 62 0.035
positive regulation of transport GO:0051050 245 0.034
atp synthesis coupled electron transport GO:0042773 2 0.034
response to organophosphorus GO:0046683 102 0.034
regulation of molecular function GO:0065009 398 0.034
cellular calcium ion homeostasis GO:0006874 160 0.034
establishment of vesicle localization GO:0051650 31 0.033
aromatic compound catabolic process GO:0019439 168 0.033
neurotransmitter transport GO:0006836 42 0.033
reproductive process GO:0022414 372 0.033
single organism intracellular transport GO:1902582 166 0.032
response to ethanol GO:0045471 162 0.032
nicotinamide nucleotide metabolic process GO:0046496 28 0.032
purine ribonucleoside catabolic process GO:0046130 124 0.032
sulfur compound metabolic process GO:0006790 70 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.032
macromolecular complex subunit organization GO:0043933 339 0.032
cellular homeostasis GO:0019725 252 0.032
cellular divalent inorganic cation homeostasis GO:0072503 162 0.031
nucleoside catabolic process GO:0009164 126 0.031
synapse assembly GO:0007416 29 0.031
developmental growth GO:0048589 100 0.031
multicellular organism reproduction GO:0032504 233 0.031
aspartate family amino acid biosynthetic process GO:0009067 4 0.031
regulation of transmembrane transporter activity GO:0022898 49 0.030
developmental process involved in reproduction GO:0003006 159 0.030
negative regulation of cell death GO:0060548 229 0.030
response to nutrient levels GO:0031667 370 0.029
rna metabolic process GO:0016070 406 0.028
regulation of transmembrane transport GO:0034762 122 0.028
regulation of hormone levels GO:0010817 187 0.028
cellular lipid metabolic process GO:0044255 208 0.028
cellular response to oxygen containing compound GO:1901701 386 0.027
response to extracellular stimulus GO:0009991 380 0.027
regulation of phosphorus metabolic process GO:0051174 349 0.027
cytosolic calcium ion homeostasis GO:0051480 140 0.026
response to cytokine GO:0034097 215 0.026
positive regulation of ion transport GO:0043270 94 0.026
l amino acid import GO:0043092 5 0.026
multi organism reproductive process GO:0044703 262 0.026
response to hypoxia GO:0001666 231 0.026
oxaloacetate metabolic process GO:0006107 6 0.026
positive regulation of cell communication GO:0010647 271 0.025
lipid metabolic process GO:0006629 283 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
central nervous system development GO:0007417 311 0.024
intracellular signal transduction GO:0035556 314 0.024
locomotory behavior GO:0007626 15 0.024
amino acid import GO:0043090 7 0.024
sulfur compound biosynthetic process GO:0044272 19 0.024
hippocampus development GO:0021766 30 0.024
nucleoside triphosphate biosynthetic process GO:0009142 8 0.024
inorganic cation transmembrane transport GO:0098662 202 0.023
small molecule biosynthetic process GO:0044283 124 0.023
urogenital system development GO:0001655 78 0.023
cellular component movement GO:0006928 248 0.022
cellular response to organic cyclic compound GO:0071407 202 0.022
regulation of reactive oxygen species metabolic process GO:2000377 26 0.022
hormone transport GO:0009914 121 0.021
cellular response to ketone GO:1901655 51 0.021
muscle cell cellular homeostasis GO:0046716 1 0.021
establishment of synaptic vesicle localization GO:0097480 23 0.021
protein complex subunit organization GO:0071822 302 0.020
lipid storage GO:0019915 1 0.020
cellular response to organonitrogen compound GO:0071417 197 0.020
synaptic growth at neuromuscular junction GO:0051124 1 0.019
cellular hormone metabolic process GO:0034754 49 0.019
synaptic vesicle transport GO:0048489 23 0.019
multi multicellular organism process GO:0044706 138 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
myoblast fusion GO:0007520 2 0.019
response to toxic substance GO:0009636 133 0.019
regulation of signal transduction GO:0009966 318 0.019
hormone metabolic process GO:0042445 69 0.019
regulation of nucleoside metabolic process GO:0009118 66 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
negative regulation of apoptotic process GO:0043066 181 0.019
response to hexose GO:0009746 144 0.019
regulation of cellular localization GO:0060341 263 0.018
adult behavior GO:0030534 16 0.018
alcohol biosynthetic process GO:0046165 38 0.018
negative regulation of developmental process GO:0051093 125 0.018
reproduction GO:0000003 245 0.018
activation of cysteine type endopeptidase activity GO:0097202 4 0.018
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
organic acid biosynthetic process GO:0016053 83 0.018
cell cell signaling involved in cell fate commitment GO:0045168 2 0.017
Fly
secretion by cell GO:0032940 248 0.017
renal system development GO:0072001 67 0.017
response to purine containing compound GO:0014074 126 0.017
cellular response to endogenous stimulus GO:0071495 377 0.017
multicellular organismal signaling GO:0035637 44 0.017
regulation of catalytic activity GO:0050790 304 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
positive regulation of response to stimulus GO:0048584 285 0.017
regulation of secretion GO:0051046 224 0.016
response to other organism GO:0051707 220 0.016
alpha amino acid biosynthetic process GO:1901607 23 0.016
regulation of neurotransmitter levels GO:0001505 42 0.016
lactate metabolic process GO:0006089 3 0.016
cellular response to nitrogen compound GO:1901699 210 0.016
cell type specific apoptotic process GO:0097285 134 0.016
anatomical structure homeostasis GO:0060249 29 0.016
macromolecular complex assembly GO:0065003 273 0.016
cation transport GO:0006812 382 0.016
alpha amino acid catabolic process GO:1901606 20 0.016
nucleoside diphosphate metabolic process GO:0009132 14 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
fatty acid metabolic process GO:0006631 99 0.016
carboxylic acid biosynthetic process GO:0046394 83 0.016
positive regulation of cellular protein metabolic process GO:0032270 167 0.016
sexual reproduction GO:0019953 148 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
synaptic transmission GO:0007268 235 0.016
aging GO:0007568 241 0.015
ion transmembrane transport GO:0034220 365 0.015
purine ribonucleoside diphosphate metabolic process GO:0009179 9 0.015
homeostatic process GO:0042592 331 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
muscle structure development GO:0061061 87 0.015
regulation of smooth muscle cell proliferation GO:0048660 75 0.015
norepinephrine metabolic process GO:0042415 3 0.015
carboxylic acid transport GO:0046942 115 0.015
nucleotide transport GO:0006862 4 0.015
development of primary female sexual characteristics GO:0046545 56 0.014
response to ammonium ion GO:0060359 71 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
reactive oxygen species biosynthetic process GO:1903409 8 0.014
cellular catabolic process GO:0044248 295 0.014
membrane organization GO:0061024 94 0.014
organic acid catabolic process GO:0016054 49 0.014
metal ion transport GO:0030001 289 0.014
nitrogen compound transport GO:0071705 229 0.014
regulation of atp metabolic process GO:1903578 9 0.014
response to peptide hormone GO:0043434 278 0.013
cell cell signaling GO:0007267 335 0.013
Fly
positive regulation of signaling GO:0023056 270 0.013
connective tissue development GO:0061448 33 0.013
muscle cell differentiation GO:0042692 52 0.013
cell adhesion GO:0007155 110 0.013
substrate dependent cell migration GO:0006929 1 0.013
intracellular transport GO:0046907 185 0.013
response to peptide GO:1901652 292 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
alditol biosynthetic process GO:0019401 4 0.013
organic hydroxy compound biosynthetic process GO:1901617 51 0.013
male gamete generation GO:0048232 99 0.013
negative regulation of cell communication GO:0010648 158 0.013
cellular amine metabolic process GO:0044106 38 0.013
carbohydrate metabolic process GO:0005975 130 0.013
tricarboxylic acid cycle GO:0006099 11 0.012
negative regulation of transport GO:0051051 136 0.012
cardiovascular system development GO:0072358 134 0.012
regulation of hydrolase activity GO:0051336 143 0.012
purine ribonucleotide transport GO:0015868 3 0.012
alcohol metabolic process GO:0006066 77 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
acrosome assembly GO:0001675 3 0.012
ribonucleoside monophosphate biosynthetic process GO:0009156 24 0.012
response to starvation GO:0042594 59 0.012
regulation of intracellular signal transduction GO:1902531 218 0.012
positive regulation of intracellular signal transduction GO:1902533 138 0.012
protein oligomerization GO:0051259 191 0.012
response to hydrogen peroxide GO:0042542 89 0.012
glutamine family amino acid biosynthetic process GO:0009084 2 0.012
response to fungicide GO:0060992 20 0.011
positive regulation of signal transduction GO:0009967 175 0.011
osteoblast differentiation GO:0001649 26 0.011
mesoderm development GO:0007498 2 0.011
response to oxygen levels GO:0070482 265 0.011
cold acclimation GO:0009631 1 0.011
coenzyme metabolic process GO:0006732 86 0.011
positive regulation of cellular amine metabolic process GO:0033240 3 0.011
positive regulation of gene expression GO:0010628 244 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
regulation of mitochondrial membrane permeability GO:0046902 5 0.011
negative regulation of mitochondrion organization GO:0010823 2 0.011
inorganic anion transmembrane transport GO:0098661 35 0.011
regulation of neurogenesis GO:0050767 247 0.011
mitotic sister chromatid separation GO:0051306 1 0.011
spermatogenesis GO:0007283 99 0.011
regulation of apoptotic signaling pathway GO:2001233 13 0.011
response to glucose GO:0009749 136 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
protein complex assembly GO:0006461 263 0.010
cellular response to lipid GO:0071396 201 0.010
excretion GO:0007588 24 0.010
response to acid chemical GO:0001101 222 0.010
ossification GO:0001503 70 0.010
regulation of organelle organization GO:0033043 80 0.010
lipid transport GO:0006869 61 0.010
regulation of peptide secretion GO:0002791 82 0.010

Mdh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.032
amino acid metabolic disorder DOID:9252 0 0.032
inherited metabolic disorder DOID:655 0 0.032
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
cancer DOID:162 0 0.023
disease of cellular proliferation DOID:14566 0 0.023
central nervous system disease DOID:331 0 0.022
organ system cancer DOID:0050686 0 0.018
gastrointestinal system cancer DOID:3119 0 0.012
benign neoplasm DOID:0060072 0 0.012