Rattus norvegicus

0 known processes

Mid1

midline 1

(Aliases: Midline1,Fxy)

Mid1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of intracellular signal transduction GO:1902531 218 0.249
Human
regulation of signal transduction GO:0009966 318 0.231
Human
regulation of programmed cell death GO:0043067 341 0.169
positive regulation of cell communication GO:0010647 271 0.159
Human
positive regulation of response to stimulus GO:0048584 285 0.146
Human
intracellular signal transduction GO:0035556 314 0.123
Human
regulation of apoptotic process GO:0042981 335 0.116
cellular response to lipid GO:0071396 201 0.107
regulation of phosphate metabolic process GO:0019220 349 0.107
Human
cell motility GO:0048870 202 0.107
response to growth factor GO:0070848 189 0.104
regulation of secretion by cell GO:1903530 208 0.101
regulation of phosphorus metabolic process GO:0051174 349 0.097
Human
regulation of ion transport GO:0043269 245 0.092
cellular response to endogenous stimulus GO:0071495 377 0.088
cation homeostasis GO:0055080 195 0.087
regulation of cellular component organization GO:0051128 368 0.087
Mouse
blood circulation GO:0008015 183 0.085
regulation of cellular protein metabolic process GO:0032268 267 0.084
regulation of mapk cascade GO:0043408 116 0.079
Human
cell projection organization GO:0030030 302 0.076
neuron development GO:0048666 286 0.076
neuron differentiation GO:0030182 368 0.076
cellular component biogenesis GO:0044085 368 0.074
programmed cell death GO:0012501 392 0.072
chemical homeostasis GO:0048878 292 0.072
positive regulation of transport GO:0051050 245 0.067
macromolecular complex subunit organization GO:0043933 339 0.066
Mouse
regulation of phosphorylation GO:0042325 248 0.064
Human
positive regulation of response to external stimulus GO:0032103 51 0.064
regulation of multicellular organismal development GO:2000026 376 0.063
protein complex assembly GO:0006461 263 0.063
transcription dna templated GO:0006351 377 0.062
apoptotic process GO:0006915 381 0.061
regulation of rna biosynthetic process GO:2001141 381 0.059
protein phosphorylation GO:0006468 345 0.058
cell cell signaling GO:0007267 335 0.057
protein complex subunit organization GO:0071822 302 0.055
Mouse
positive regulation of secretion by cell GO:1903532 128 0.055
eye morphogenesis GO:0048592 4 0.055
cellular chemical homeostasis GO:0055082 247 0.054
locomotion GO:0040011 237 0.053
regulation of cellular localization GO:0060341 263 0.052
reproductive process GO:0022414 372 0.052
regulation of catalytic activity GO:0050790 304 0.052
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.051
positive regulation of nervous system development GO:0051962 178 0.051
positive regulation of cell death GO:0010942 184 0.051
positive regulation of locomotion GO:0040017 102 0.050
central nervous system development GO:0007417 311 0.050
positive regulation of multicellular organismal process GO:0051240 387 0.050
cellular response to growth factor stimulus GO:0071363 162 0.050
protein complex biogenesis GO:0070271 263 0.047
regulation of cell development GO:0060284 263 0.047
localization of cell GO:0051674 202 0.046
cellular component assembly GO:0022607 360 0.045
cellular response to oxygen containing compound GO:1901701 386 0.044
rna metabolic process GO:0016070 406 0.044
cellular component movement GO:0006928 248 0.044
cell projection morphogenesis GO:0048858 123 0.044
negative regulation of apoptotic process GO:0043066 181 0.042
nucleic acid templated transcription GO:0097659 379 0.041
regulation of protein phosphorylation GO:0001932 183 0.041
regulation of cell differentiation GO:0045595 320 0.041
cell migration GO:0016477 197 0.041
inflammatory response GO:0006954 150 0.040
secretion GO:0046903 307 0.039
regulation of protein metabolic process GO:0051246 289 0.039
cellular homeostasis GO:0019725 252 0.039
response to nutrient levels GO:0031667 370 0.039
cellular response to hormone stimulus GO:0032870 247 0.039
signal transduction by phosphorylation GO:0023014 144 0.039
Human
anterior posterior pattern specification GO:0009952 1 0.038
positive regulation of phosphorus metabolic process GO:0010562 262 0.038
Human
negative regulation of metabolic process GO:0009892 331 0.038
regulation of system process GO:0044057 208 0.037
positive regulation of gene expression GO:0010628 244 0.037
macromolecular complex assembly GO:0065003 273 0.037
positive regulation of cell differentiation GO:0045597 217 0.036
response to glucocorticoid GO:0051384 223 0.036
cellular amino acid metabolic process GO:0006520 107 0.036
protein oligomerization GO:0051259 191 0.036
negative regulation of cellular metabolic process GO:0031324 281 0.035
cellular ketone metabolic process GO:0042180 51 0.035
regulation of molecular function GO:0065009 398 0.035
positive regulation of developmental process GO:0051094 283 0.035
circulatory system process GO:0003013 183 0.035
negative regulation of osteoblast differentiation GO:0045668 2 0.034
regulation of secretion GO:0051046 224 0.034
positive regulation of secretion GO:0051047 140 0.034
neuron projection development GO:0031175 273 0.034
transcription from rna polymerase ii promoter GO:0006366 252 0.033
multi organism reproductive process GO:0044703 262 0.033
homeostatic process GO:0042592 331 0.033
response to oxygen levels GO:0070482 265 0.033
positive regulation of intracellular signal transduction GO:1902533 138 0.033
Human
cellular potassium ion transport GO:0071804 72 0.033
positive regulation of signal transduction GO:0009967 175 0.032
Human
single organism biosynthetic process GO:0044711 342 0.032
response to wounding GO:0009611 254 0.032
nucleoside metabolic process GO:0009116 179 0.032
multicellular organism reproduction GO:0032504 233 0.032
urogenital system development GO:0001655 78 0.031
organophosphate metabolic process GO:0019637 370 0.031
cellular response to external stimulus GO:0071496 118 0.031
regulation of neuron projection development GO:0010975 161 0.031
reproduction GO:0000003 245 0.031
tissue morphogenesis GO:0048729 22 0.031
regulation of nucleic acid templated transcription GO:1903506 380 0.030
negative regulation of programmed cell death GO:0043069 183 0.030
potassium ion transmembrane transport GO:0071805 71 0.030
positive regulation of cell development GO:0010720 176 0.029
cellular cation homeostasis GO:0030003 180 0.029
muscle system process GO:0003012 115 0.029
regulation of cell migration GO:0030334 128 0.029
circulatory system development GO:0072359 134 0.029
rna biosynthetic process GO:0032774 380 0.029
positive regulation of mapk cascade GO:0043410 92 0.028
Human
regulation of cell projection organization GO:0031344 175 0.028
negative regulation of transport GO:0051051 136 0.027
positive regulation of transcription dna templated GO:0045893 197 0.027
cerebral cortex tangential migration GO:0021800 1 0.027
aging GO:0007568 241 0.027
single organism reproductive process GO:0044702 297 0.027
inorganic ion transmembrane transport GO:0098660 229 0.027
response to nutrient GO:0007584 248 0.027
response to acid chemical GO:0001101 222 0.027
cellular metal ion homeostasis GO:0006875 172 0.026
positive regulation of neurogenesis GO:0050769 165 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
defense response GO:0006952 194 0.026
single organismal cell cell adhesion GO:0016337 42 0.026
negative regulation of response to stimulus GO:0048585 155 0.025
regulation of transcription dna templated GO:0006355 374 0.025
response to extracellular stimulus GO:0009991 380 0.025
regulation of canonical wnt signaling pathway GO:0060828 4 0.025
regulation of anatomical structure size GO:0090066 135 0.024
cell part morphogenesis GO:0032990 123 0.024
cell adhesion GO:0007155 110 0.024
glandular epithelial cell differentiation GO:0002067 4 0.024
positive regulation of cell proliferation GO:0008284 249 0.024
regulation of membrane potential GO:0042391 110 0.024
regulation of rna metabolic process GO:0051252 391 0.024
regulation of calcium ion transport GO:0051924 77 0.024
synaptic transmission GO:0007268 235 0.024
cellular response to organic cyclic compound GO:0071407 202 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
positive regulation of cellular component movement GO:0051272 102 0.024
negative regulation of signaling GO:0023057 157 0.023
regulation of cell proliferation GO:0042127 359 0.023
regulation of neurogenesis GO:0050767 247 0.023
vesicle mediated transport GO:0016192 181 0.023
carbohydrate derivative catabolic process GO:1901136 147 0.023
columnar cuboidal epithelial cell differentiation GO:0002065 8 0.023
action potential GO:0001508 54 0.023
protein localization GO:0008104 191 0.023
Human
regulation of immune system process GO:0002682 123 0.023
divalent inorganic cation homeostasis GO:0072507 165 0.023
negative regulation of cell development GO:0010721 82 0.023
positive regulation of protein phosphorylation GO:0001934 135 0.023
secretion by cell GO:0032940 248 0.023
cellular ion homeostasis GO:0006873 184 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
positive regulation of neuron differentiation GO:0045666 126 0.022
cellular amine metabolic process GO:0044106 38 0.022
neurological system process GO:0050877 219 0.022
osteoblast differentiation GO:0001649 26 0.022
gastrulation GO:0007369 2 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
Human
regulation of osteoblast differentiation GO:0045667 14 0.022
regulation of cellular component movement GO:0051270 150 0.022
divalent inorganic cation transport GO:0072511 134 0.022
negative regulation of vascular permeability GO:0043116 3 0.022
mapk cascade GO:0000165 140 0.022
Human
regulation of nervous system development GO:0051960 264 0.022
gland development GO:0048732 155 0.022
positive regulation of cellular component organization GO:0051130 200 0.021
g protein coupled receptor signaling pathway GO:0007186 242 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
chemotaxis GO:0006935 66 0.021
negative regulation of rna biosynthetic process GO:1902679 118 0.021
regulation of response to stress GO:0080134 126 0.020
Human
regulation of protein modification process GO:0031399 194 0.020
muscle contraction GO:0006936 88 0.020
organ morphogenesis GO:0009887 75 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
immune system process GO:0002376 204 0.020
epithelial cell proliferation GO:0050673 54 0.020
negative regulation of biosynthetic process GO:0009890 168 0.020
regulation of cellular amino acid metabolic process GO:0006521 2 0.020
vascular process in circulatory system GO:0003018 96 0.019
positive regulation of rna metabolic process GO:0051254 203 0.019
regulation of neuron differentiation GO:0045664 208 0.019
nucleotide metabolic process GO:0009117 279 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
cell morphogenesis involved in differentiation GO:0000904 119 0.019
organonitrogen compound catabolic process GO:1901565 179 0.019
tube development GO:0035295 89 0.019
mammary gland epithelium development GO:0061180 1 0.019
positive regulation of apoptotic process GO:0043065 154 0.019
biological adhesion GO:0022610 110 0.019
head development GO:0060322 247 0.019
negative regulation of developmental process GO:0051093 125 0.019
neuron projection morphogenesis GO:0048812 122 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
Human
calcium ion transport GO:0006816 131 0.019
purine containing compound metabolic process GO:0072521 253 0.019
gonad development GO:0008406 104 0.019
positive regulation of biosynthetic process GO:0009891 319 0.018
cation transport GO:0006812 382 0.018
ovulation cycle process GO:0022602 50 0.018
single organism catabolic process GO:0044712 283 0.018
regulation of protein kinase activity GO:0045859 105 0.018
divalent metal ion transport GO:0070838 132 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
amine metabolic process GO:0009308 38 0.018
rhythmic process GO:0048511 156 0.018
macromolecule localization GO:0033036 252 0.018
Human
cardiovascular system development GO:0072358 134 0.018
monovalent inorganic cation transport GO:0015672 172 0.018
positive regulation of cell motility GO:2000147 97 0.018
lipid metabolic process GO:0006629 283 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.018
calcium ion homeostasis GO:0055074 162 0.018
cellular protein localization GO:0034613 122 0.017
Human
nucleobase containing small molecule metabolic process GO:0055086 316 0.017
blood vessel development GO:0001568 69 0.017
pancreatic a cell differentiation GO:0003310 1 0.017
brain development GO:0007420 247 0.017
ribonucleotide metabolic process GO:0009259 231 0.017
development of primary sexual characteristics GO:0045137 107 0.017
metal ion transport GO:0030001 289 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
positive regulation of molecular function GO:0044093 230 0.017
ion homeostasis GO:0050801 212 0.017
response to corticosteroid GO:0031960 235 0.017
inorganic cation transmembrane transport GO:0098662 202 0.017
reactive oxygen species metabolic process GO:0072593 37 0.017
negative regulation of cell proliferation GO:0008285 119 0.017
response to metal ion GO:0010038 253 0.017
heterocycle catabolic process GO:0046700 167 0.017
ovulation cycle GO:0042698 67 0.017
oxoacid metabolic process GO:0043436 290 0.016
nitrogen compound transport GO:0071705 229 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
negative regulation of cell death GO:0060548 229 0.016
nucleocytoplasmic transport GO:0006913 48 0.016
wound healing GO:0042060 122 0.016
glycosyl compound metabolic process GO:1901657 182 0.015
positive regulation of signaling GO:0023056 270 0.015
Human
regulation of metal ion transport GO:0010959 118 0.015
calcium mediated signaling GO:0019722 23 0.015
spermatogenesis GO:0007283 99 0.015
neural crest cell development GO:0014032 2 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
renal system development GO:0072001 67 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
cellular divalent inorganic cation homeostasis GO:0072503 162 0.015
calcium ion transmembrane transport GO:0070588 70 0.015
response to ketone GO:1901654 182 0.015
regulation of hormone secretion GO:0046883 106 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 19 0.015
cell type specific apoptotic process GO:0097285 134 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
hormone transport GO:0009914 121 0.015
cellular macromolecule localization GO:0070727 122 0.015
Human
negative regulation of cellular biosynthetic process GO:0031327 161 0.015
response to estrogen GO:0043627 232 0.014
cellular nitrogen compound catabolic process GO:0044270 163 0.014
forebrain development GO:0030900 98 0.014
kidney development GO:0001822 67 0.014
erk1 and erk2 cascade GO:0070371 48 0.014
metal ion homeostasis GO:0055065 186 0.014
regulation of organ formation GO:0003156 2 0.014
negative regulation of innate immune response GO:0045824 4 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.014
alpha amino acid metabolic process GO:1901605 71 0.014
negative regulation of molecular function GO:0044092 133 0.014
sexual reproduction GO:0019953 148 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
cellular calcium ion homeostasis GO:0006874 160 0.014
response to activity GO:0014823 73 0.014
regulation of tube size GO:0035150 89 0.014
multi multicellular organism process GO:0044706 138 0.014
platelet aggregation GO:0070527 4 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.014
protein heterooligomerization GO:0051291 89 0.013
protein homooligomerization GO:0051260 91 0.013
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.013
purine nucleotide catabolic process GO:0006195 136 0.013
catabolic process GO:0009056 351 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
male sex differentiation GO:0046661 64 0.013
positive regulation of neuron migration GO:2001224 2 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
negative regulation of gene expression GO:0010629 199 0.013
organophosphate biosynthetic process GO:0090407 143 0.013
signal release GO:0023061 145 0.013
carboxylic acid metabolic process GO:0019752 289 0.013
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 3 0.013
response to radiation GO:0009314 137 0.013
cytoplasmic transport GO:0016482 115 0.013
cellular catabolic process GO:0044248 295 0.013
regulation of muscle system process GO:0090257 79 0.013
positive regulation of immune system process GO:0002684 90 0.013
glucagon secretion GO:0070091 5 0.013
glycerolipid metabolic process GO:0046486 67 0.013
purine nucleoside metabolic process GO:0042278 169 0.013
purine ribonucleoside metabolic process GO:0046128 168 0.013
cellular response to glucocorticoid stimulus GO:0071385 68 0.013
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 2 0.013
cytosolic calcium ion homeostasis GO:0051480 140 0.013
positive regulation of catalytic activity GO:0043085 184 0.013
regulation of cell motility GO:2000145 131 0.013
spinal cord development GO:0021510 27 0.013
single organism organelle organization GO:1902589 180 0.012
Mouse
regulation of vesicle mediated transport GO:0060627 81 0.012
organ formation GO:0048645 3 0.012
vasculature development GO:0001944 70 0.012
sensory perception of pain GO:0019233 73 0.012
single organism cellular localization GO:1902580 102 0.012
cell fate determination GO:0001709 2 0.012
response to vitamin GO:0033273 131 0.012
developmental induction GO:0031128 2 0.012
female gonad development GO:0008585 53 0.012
regulation of protein transport GO:0051223 68 0.012
response to decreased oxygen levels GO:0036293 237 0.012
organic acid metabolic process GO:0006082 292 0.012
signal transduction involved in regulation of gene expression GO:0023019 4 0.012
retina development in camera type eye GO:0060041 27 0.012
hexose metabolic process GO:0019318 58 0.012
reproductive structure development GO:0048608 128 0.012
camera type eye development GO:0043010 48 0.012
regulation of locomotion GO:0040012 148 0.012
epithelium development GO:0060429 96 0.012
regulation of kinase activity GO:0043549 117 0.012
nucleoside triphosphate catabolic process GO:0009143 123 0.012
cellular response to alcohol GO:0097306 87 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
cellular component morphogenesis GO:0032989 155 0.012
response to mechanical stimulus GO:0009612 134 0.012
ribose phosphate metabolic process GO:0019693 235 0.012
heart morphogenesis GO:0003007 3 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
cellular response to stress GO:0033554 269 0.012
Human
cell growth GO:0016049 104 0.012
negative regulation of long term synaptic potentiation GO:1900272 1 0.012
protein transport GO:0015031 132 0.011
axis specification GO:0009798 4 0.011
proteolysis GO:0006508 175 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
regulation of transferase activity GO:0051338 123 0.011
neural crest cell migration GO:0001755 1 0.011
establishment of protein localization GO:0045184 141 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
response to cytokine GO:0034097 215 0.011
cell cycle GO:0007049 101 0.011
male gamete generation GO:0048232 99 0.011
mesoderm development GO:0007498 2 0.011
carbohydrate derivative metabolic process GO:1901135 346 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
regulation of leukocyte migration GO:0002685 24 0.011
purine containing compound catabolic process GO:0072523 138 0.011
response to purine containing compound GO:0014074 126 0.011
phototransduction visible light GO:0007603 2 0.011
ossification GO:0001503 70 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
regulation of blood pressure GO:0008217 83 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
leukocyte migration GO:0050900 38 0.011
nucleotide catabolic process GO:0009166 139 0.011
retina morphogenesis in camera type eye GO:0060042 1 0.011
smooth muscle cell proliferation GO:0048659 77 0.011
regulation of response to wounding GO:1903034 69 0.011
negative regulation of nervous system development GO:0051961 79 0.011
ameboidal type cell migration GO:0001667 26 0.010
cellular response to corticosteroid stimulus GO:0071384 69 0.010
t cell tolerance induction GO:0002517 3 0.010
organic substance catabolic process GO:1901575 316 0.010
gliogenesis GO:0042063 93 0.010
response to biotic stimulus GO:0009607 226 0.010
regulation of establishment of protein localization GO:0070201 69 0.010
cell activation GO:0001775 97 0.010
carbohydrate metabolic process GO:0005975 130 0.010
lymphocyte chemotaxis GO:0048247 3 0.010
aromatic compound catabolic process GO:0019439 168 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
response to inorganic substance GO:0010035 377 0.010
neural crest cell differentiation GO:0014033 2 0.010
regulation of cell growth GO:0001558 85 0.010
regulation of protein maturation GO:1903317 50 0.010

Mid1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.024
nervous system disease DOID:863 0 0.022
disease of anatomical entity DOID:7 0 0.022