Rattus norvegicus

28 known processes

Mip

major intrinsic protein of lens fiber

(Aliases: Aqp0)

Mip biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
camera type eye development GO:0043010 48 0.484
Zebrafish Mouse
regulation of secretion GO:0051046 224 0.248
eye development GO:0001654 50 0.243
Zebrafish Mouse
sensory organ development GO:0007423 74 0.220
Zebrafish Mouse
adenohypophysis development GO:0021984 2 0.197
tissue development GO:0009888 252 0.185
regulation of molecular function GO:0065009 398 0.180
negative regulation of biosynthetic process GO:0009890 168 0.176
macromolecule localization GO:0033036 252 0.171
cellular lipid metabolic process GO:0044255 208 0.155
carboxylic acid metabolic process GO:0019752 289 0.146
organic acid metabolic process GO:0006082 292 0.139
inorganic ion transmembrane transport GO:0098660 229 0.138
dorsal ventral axon guidance GO:0033563 1 0.133
cellular response to organic cyclic compound GO:0071407 202 0.132
Rat
regulation of transcription dna templated GO:0006355 374 0.131
response to alkaloid GO:0043279 132 0.123
regulation of cellular localization GO:0060341 263 0.120
oxoacid metabolic process GO:0043436 290 0.119
rna metabolic process GO:0016070 406 0.118
transmembrane transport GO:0055085 412 0.110
neuron differentiation GO:0030182 368 0.110
forebrain development GO:0030900 98 0.108
Rat
rna biosynthetic process GO:0032774 380 0.106
aging GO:0007568 241 0.105
Rat
eye morphogenesis GO:0048592 4 0.101
inorganic cation transmembrane transport GO:0098662 202 0.100
regulation of rna metabolic process GO:0051252 391 0.097
anatomical structure morphogenesis GO:0009653 298 0.097
Yeast
neurological system process GO:0050877 219 0.096
Mouse
lens development in camera type eye GO:0002088 13 0.094
Zebrafish Mouse
nucleic acid templated transcription GO:0097659 379 0.093
purine nucleotide metabolic process GO:0006163 229 0.092
regulation of locomotion GO:0040012 148 0.092
Rat
transcription dna templated GO:0006351 377 0.089
ion transmembrane transport GO:0034220 365 0.087
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.087
chemical homeostasis GO:0048878 292 0.086
Rat
regulation of rna biosynthetic process GO:2001141 381 0.084
cellular response to endogenous stimulus GO:0071495 377 0.084
Rat
reproductive process GO:0022414 372 0.084
Yeast Rat
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.084
secretion GO:0046903 307 0.082
ribonucleotide metabolic process GO:0009259 231 0.080
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.075
protein transport GO:0015031 132 0.074
carbohydrate derivative metabolic process GO:1901135 346 0.074
protein localization GO:0008104 191 0.072
lipid metabolic process GO:0006629 283 0.068
gland development GO:0048732 155 0.067
positive regulation of transcription dna templated GO:0045893 197 0.067
regulation of secretion by cell GO:1903530 208 0.067
negative regulation of cell death GO:0060548 229 0.067
cation transmembrane transport GO:0098655 263 0.064
cellular component movement GO:0006928 248 0.063
Rat
negative regulation of rna biosynthetic process GO:1902679 118 0.062
intracellular transport GO:0046907 185 0.061
negative regulation of cellular biosynthetic process GO:0031327 161 0.060
positive regulation of gene expression GO:0010628 244 0.060
programmed cell death GO:0012501 392 0.060
Rat
cation transport GO:0006812 382 0.060
Rat
divalent metal ion transport GO:0070838 132 0.060
Rat
regulation of protein transport GO:0051223 68 0.059
regulation of ion transport GO:0043269 245 0.058
Rat
heart morphogenesis GO:0003007 3 0.058
negative regulation of nucleic acid templated transcription GO:1903507 117 0.058
negative regulation of cellular metabolic process GO:0031324 281 0.058
positive regulation of phosphorus metabolic process GO:0010562 262 0.057
central nervous system development GO:0007417 311 0.056
Rat
nicotine metabolic process GO:0018933 1 0.056
metal ion transport GO:0030001 289 0.056
Rat
transcription from rna polymerase ii promoter GO:0006366 252 0.056
apoptotic process GO:0006915 381 0.055
Rat
response to peptide hormone GO:0043434 278 0.055
Rat
nucleobase containing small molecule metabolic process GO:0055086 316 0.055
retina development in camera type eye GO:0060041 27 0.055
homeostatic process GO:0042592 331 0.054
Rat
nucleoside phosphate biosynthetic process GO:1901293 102 0.054
purine nucleotide biosynthetic process GO:0006164 83 0.054
regulation of nucleic acid templated transcription GO:1903506 380 0.053
ribose phosphate metabolic process GO:0019693 235 0.052
negative regulation of metabolic process GO:0009892 331 0.052
purine ribonucleotide metabolic process GO:0009150 227 0.051
peptide secretion GO:0002790 86 0.051
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.051
positive regulation of nucleic acid templated transcription GO:1903508 197 0.050
negative regulation of macromolecule metabolic process GO:0010605 260 0.049
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.049
regulation of hydrolase activity GO:0051336 143 0.048
positive regulation of phosphate metabolic process GO:0045937 262 0.048
secretion by cell GO:0032940 248 0.048
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.045
negative regulation of apoptotic process GO:0043066 181 0.045
startle response GO:0001964 2 0.044
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.044
macromolecular complex assembly GO:0065003 273 0.044
Rat
divalent inorganic cation transport GO:0072511 134 0.044
Rat
regulation of programmed cell death GO:0043067 341 0.043
regulation of cellular amino acid metabolic process GO:0006521 2 0.043
positive regulation of rna metabolic process GO:0051254 203 0.042
regulation of protein localization GO:0032880 81 0.042
cellular catabolic process GO:0044248 295 0.041
neuron development GO:0048666 286 0.041
response to nutrient GO:0007584 248 0.041
odontogenesis GO:0042476 32 0.040
negative regulation of signal transduction GO:0009968 83 0.040
cellular amine metabolic process GO:0044106 38 0.040
brain development GO:0007420 247 0.040
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.039
regulation of apoptotic process GO:0042981 335 0.039
hormone transport GO:0009914 121 0.039
cellular response to lipid GO:0071396 201 0.039
Rat
organic hydroxy compound metabolic process GO:1901615 115 0.039
response to glucocorticoid GO:0051384 223 0.037
Rat
nucleotide metabolic process GO:0009117 279 0.037
positive regulation of molecular function GO:0044093 230 0.036
cellular response to oxygen containing compound GO:1901701 386 0.036
Rat
organophosphate metabolic process GO:0019637 370 0.036
development of primary sexual characteristics GO:0045137 107 0.036
response to inorganic substance GO:0010035 377 0.035
Rat
multi organism reproductive process GO:0044703 262 0.035
Yeast Rat
organic substance catabolic process GO:1901575 316 0.035
response to extracellular stimulus GO:0009991 380 0.035
Rat
response to corticosteroid GO:0031960 235 0.035
Rat
urogenital system development GO:0001655 78 0.034
protein complex biogenesis GO:0070271 263 0.034
Rat
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.034
regulation of hormone secretion GO:0046883 106 0.034
response to nutrient levels GO:0031667 370 0.034
Rat
monocarboxylic acid metabolic process GO:0032787 152 0.033
epithelium development GO:0060429 96 0.033
cell motility GO:0048870 202 0.033
Rat
negative regulation of programmed cell death GO:0043069 183 0.032
regulation of establishment of protein localization GO:0070201 69 0.032
chemotaxis GO:0006935 66 0.032
response to oxygen levels GO:0070482 265 0.032
regulation of purine nucleotide metabolic process GO:1900542 115 0.031
protein phosphorylation GO:0006468 345 0.031
anion transport GO:0006820 178 0.031
monocarboxylic acid biosynthetic process GO:0072330 48 0.030
reproduction GO:0000003 245 0.030
Yeast
positive regulation of amine transport GO:0051954 26 0.030
calcium ion transport GO:0006816 131 0.030
Rat
regulation of phosphate metabolic process GO:0019220 349 0.029
peptide hormone secretion GO:0030072 84 0.028
locomotion GO:0040011 237 0.028
Rat
regulation of cellular ketone metabolic process GO:0010565 27 0.028
regulation of neuron differentiation GO:0045664 208 0.028
regulation of hormone levels GO:0010817 187 0.028
regulation of peptide transport GO:0090087 87 0.027
catabolic process GO:0009056 351 0.027
negative regulation of rna metabolic process GO:0051253 123 0.027
regulation of cell proliferation GO:0042127 359 0.027
divalent inorganic cation homeostasis GO:0072507 165 0.027
cell cell signaling GO:0007267 335 0.027
ribonucleotide biosynthetic process GO:0009260 85 0.027
sensory perception GO:0007600 101 0.027
Mouse
cell morphogenesis GO:0000902 142 0.026
glutamate secretion GO:0014047 19 0.026
multicellular organism growth GO:0035264 1 0.026
regulation of metal ion transport GO:0010959 118 0.026
Rat
calcium ion transmembrane transport GO:0070588 70 0.026
nucleoside phosphate metabolic process GO:0006753 283 0.026
sexual reproduction GO:0019953 148 0.026
Yeast
negative regulation of secretion GO:0051048 82 0.025
cellular ketone metabolic process GO:0042180 51 0.025
positive regulation of secretion GO:0051047 140 0.025
negative regulation of transport GO:0051051 136 0.025
single organism catabolic process GO:0044712 283 0.025
regulation of peptide hormone secretion GO:0090276 80 0.025
regulation of anatomical structure size GO:0090066 135 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
hepaticobiliary system development GO:0061008 90 0.025
peptidyl tyrosine modification GO:0018212 72 0.025
organ formation GO:0048645 3 0.025
single organism biosynthetic process GO:0044711 342 0.025
positive regulation of fat cell differentiation GO:0045600 2 0.024
purine containing compound metabolic process GO:0072521 253 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.024
hormone secretion GO:0046879 115 0.024
response to wounding GO:0009611 254 0.024
learning or memory GO:0007611 90 0.023
negative regulation of transcription dna templated GO:0045892 116 0.023
synaptic transmission GO:0007268 235 0.023
pituitary gland development GO:0021983 10 0.023
regulation of transferase activity GO:0051338 123 0.023
regulation of neuron death GO:1901214 115 0.023
negative regulation of gene expression GO:0010629 199 0.023
negative regulation of peptide hormone secretion GO:0090278 30 0.023
positive regulation of ion transport GO:0043270 94 0.023
Rat
tissue morphogenesis GO:0048729 22 0.023
cellular response to insulin stimulus GO:0032869 81 0.023
positive regulation of cell communication GO:0010647 271 0.023
skeletal system development GO:0001501 41 0.023
regulation of protein metabolic process GO:0051246 289 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.022
regulation of neuron apoptotic process GO:0043523 83 0.022
regulation of catalytic activity GO:0050790 304 0.022
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.022
regulation of phosphorus metabolic process GO:0051174 349 0.022
response to growth factor GO:0070848 189 0.022
positive regulation of cellular component movement GO:0051272 102 0.022
Rat
positive regulation of hormone secretion GO:0046887 65 0.022
single organism intracellular transport GO:1902582 166 0.022
negative regulation of hormone secretion GO:0046888 46 0.022
organonitrogen compound catabolic process GO:1901565 179 0.021
amine metabolic process GO:0009308 38 0.021
positive regulation of nucleotide metabolic process GO:0045981 91 0.021
gamete generation GO:0007276 124 0.021
cellular divalent inorganic cation homeostasis GO:0072503 162 0.021
positive regulation of secretion by cell GO:1903532 128 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.021
amide transport GO:0042886 105 0.021
negative regulation of secretion by cell GO:1903531 72 0.021
cellular amino acid metabolic process GO:0006520 107 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.020
head development GO:0060322 247 0.020
Rat
cell type specific apoptotic process GO:0097285 134 0.020
digestive tract development GO:0048565 39 0.020
positive regulation of locomotion GO:0040017 102 0.020
Rat
intracellular signal transduction GO:0035556 314 0.020
gastrulation GO:0007369 2 0.020
sodium ion transmembrane transport GO:0035725 67 0.019
lipid biosynthetic process GO:0008610 128 0.019
telencephalon regionalization GO:0021978 1 0.019
organ morphogenesis GO:0009887 75 0.019
positive regulation of cellular protein metabolic process GO:0032270 167 0.019
response to hexose GO:0009746 144 0.019
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
ribose phosphate biosynthetic process GO:0046390 87 0.019
motor neuron axon guidance GO:0008045 1 0.019
response to metal ion GO:0010038 253 0.018
Rat
liver development GO:0001889 90 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
cyclic purine nucleotide metabolic process GO:0052652 62 0.018
single organism reproductive process GO:0044702 297 0.018
Yeast
purine ribonucleotide biosynthetic process GO:0009152 81 0.018
morphogenesis of embryonic epithelium GO:0016331 3 0.018
response to epidermal growth factor GO:0070849 18 0.018
regulation of vascular smooth muscle contraction GO:0003056 3 0.017
cellular response to acid chemical GO:0071229 75 0.017
Rat
response to insulin GO:0032868 133 0.017
cellular component biogenesis GO:0044085 368 0.017
Rat
multicellular organism reproduction GO:0032504 233 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
Rat
cellular response to stress GO:0033554 269 0.017
Rat
multi multicellular organism process GO:0044706 138 0.017
Rat
nitrogen compound transport GO:0071705 229 0.017
Rat
blood circulation GO:0008015 183 0.016
ribonucleoside monophosphate metabolic process GO:0009161 88 0.016
regulation of system process GO:0044057 208 0.016
lens fiber cell differentiation GO:0070306 3 0.016
anion transmembrane transport GO:0098656 77 0.016
regulation of cell development GO:0060284 263 0.016
maintenance of location GO:0051235 17 0.016
cellular response to abiotic stimulus GO:0071214 85 0.016
Rat
positive regulation of signaling GO:0023056 270 0.016
positive regulation of transport GO:0051050 245 0.016
Rat
response to peptide GO:1901652 292 0.016
Rat
negative regulation of cell proliferation GO:0008285 119 0.016
cell morphogenesis involved in differentiation GO:0000904 119 0.016
response to oxidative stress GO:0006979 186 0.016
signal release GO:0023061 145 0.016
positive regulation of phosphorylation GO:0042327 177 0.016
regulation of transmembrane transport GO:0034762 122 0.016
protein complex assembly GO:0006461 263 0.016
Rat
organonitrogen compound biosynthetic process GO:1901566 167 0.016
spermatogenesis GO:0007283 99 0.015
positive regulation of phosphatidylinositol 3 kinase activity GO:0043552 2 0.015
response to ionizing radiation GO:0010212 59 0.015
carbohydrate metabolic process GO:0005975 130 0.015
mesoderm development GO:0007498 2 0.015
positive regulation of peptide hormone secretion GO:0090277 50 0.015
fatty acid biosynthetic process GO:0006633 33 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
cellular response to magnesium ion GO:0071286 4 0.015
regulation of insulin secretion GO:0050796 65 0.015
cellular response to external stimulus GO:0071496 118 0.015
Rat
regulation of tube size GO:0035150 89 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
cellular response to nitrogen compound GO:1901699 210 0.015
regulation of membrane potential GO:0042391 110 0.014
response to carbohydrate GO:0009743 183 0.014
Rat
digestive system development GO:0055123 41 0.014
neuron projection development GO:0031175 273 0.014
regulation of phosphorylation GO:0042325 248 0.014
amino acid transport GO:0006865 70 0.014
salivary gland development GO:0007431 3 0.014
response to monosaccharide GO:0034284 159 0.014
Rat
axis specification GO:0009798 4 0.014
female sex differentiation GO:0046660 59 0.014
proteolysis GO:0006508 175 0.014
positive regulation of cell proliferation GO:0008284 249 0.014
camera type eye morphogenesis GO:0048593 2 0.014
regulation of ion transmembrane transport GO:0034765 121 0.014
regulation of neurogenesis GO:0050767 247 0.014
multicellular organismal reproductive process GO:0048609 233 0.014
response to amine GO:0014075 46 0.014
tube development GO:0035295 89 0.013
organic acid transport GO:0015849 116 0.013
g protein coupled acetylcholine receptor signaling pathway GO:0007213 5 0.013
glycosyl compound metabolic process GO:1901657 182 0.013
central nervous system neuron differentiation GO:0021953 17 0.013
regulation of protein phosphorylation GO:0001932 183 0.013
peptidyl amino acid modification GO:0018193 126 0.013
regulation of protein kinase activity GO:0045859 105 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
regulation of blood vessel size GO:0050880 89 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
cellular response to oxidative stress GO:0034599 76 0.013
insulin secretion GO:0030073 69 0.013
palate development GO:0060021 2 0.013
response to glucose GO:0009749 136 0.013
Rat
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.013
lipid localization GO:0010876 62 0.013
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.013
cellular response to carbohydrate stimulus GO:0071322 72 0.013
Rat
developmental process involved in reproduction GO:0003006 159 0.013
Yeast
anatomical structure formation involved in morphogenesis GO:0048646 83 0.013
Yeast
sex differentiation GO:0007548 113 0.013
potassium ion transport GO:0006813 97 0.013
response to amphetamine GO:0001975 25 0.013
calcium ion homeostasis GO:0055074 162 0.012
negative regulation of cell communication GO:0010648 158 0.012
negative regulation of protein transport GO:0051224 17 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
Rat
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.012
cellular response to peptide GO:1901653 133 0.012
positive regulation of lipid kinase activity GO:0090218 2 0.012
negative regulation of signaling GO:0023057 157 0.012
regulation of protein secretion GO:0050708 28 0.012
camp biosynthetic process GO:0006171 47 0.012
diencephalon development GO:0021536 21 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
lipid storage GO:0019915 1 0.012
regulation of nucleotide biosynthetic process GO:0030808 47 0.012
peptide biosynthetic process GO:0043043 3 0.012
cell part morphogenesis GO:0032990 123 0.012
regulation of protein modification process GO:0031399 194 0.012
cellular component morphogenesis GO:0032989 155 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.012
insulin like growth factor receptor signaling pathway GO:0048009 3 0.012
immune system process GO:0002376 204 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
protein secretion GO:0009306 34 0.011
regulation of cell differentiation GO:0045595 320 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
positive regulation of cytokine production involved in immune response GO:0002720 2 0.011
cellular response to ketone GO:1901655 51 0.011
response to purine containing compound GO:0014074 126 0.011
positive regulation of peptide secretion GO:0002793 52 0.011
neuron apoptotic process GO:0051402 88 0.011
neuron death GO:0070997 127 0.011
prepulse inhibition GO:0060134 1 0.011
embryonic epithelial tube formation GO:0001838 3 0.011
reactive nitrogen species metabolic process GO:2001057 1 0.011
s shaped body morphogenesis GO:0072050 2 0.011
spinal cord development GO:0021510 27 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
calcium ion transport into cytosol GO:0060402 38 0.011
cytoplasmic transport GO:0016482 115 0.011
cyclic nucleotide metabolic process GO:0009187 80 0.011
apoptotic signaling pathway GO:0097190 27 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
peptide transport GO:0015833 97 0.011
gonad development GO:0008406 104 0.011
positive regulation of hydrolase activity GO:0051345 86 0.011
fatty acid metabolic process GO:0006631 99 0.011
response to nicotine GO:0035094 51 0.011
negative regulation of nervous system development GO:0051961 79 0.011
intracellular protein transport GO:0006886 79 0.011
male mating behavior GO:0060179 3 0.011
ion homeostasis GO:0050801 212 0.011
ventral spinal cord development GO:0021517 3 0.011
response to decreased oxygen levels GO:0036293 237 0.011
regulation of intracellular transport GO:0032386 65 0.010
retina morphogenesis in camera type eye GO:0060042 1 0.010
cellular response to peptide hormone stimulus GO:0071375 120 0.010
regulation of nervous system development GO:0051960 264 0.010
vasoconstriction GO:0042310 54 0.010
cellular response to glucocorticoid stimulus GO:0071385 68 0.010
circulatory system process GO:0003013 183 0.010
muscle system process GO:0003012 115 0.010
small gtpase mediated signal transduction GO:0007264 36 0.010
comma shaped body morphogenesis GO:0072049 2 0.010
leukocyte activation GO:0045321 76 0.010
response to vitamin GO:0033273 131 0.010
cell activation GO:0001775 97 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
Rat
muscle cell proliferation GO:0033002 84 0.010
response to starvation GO:0042594 59 0.010
Rat

Mip disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.084
retinal degeneration DOID:8466 0 0.084
sensory system disease DOID:0050155 0 0.084
disease of anatomical entity DOID:7 0 0.084
retinitis pigmentosa DOID:10584 0 0.084
eye and adnexa disease DOID:1492 0 0.084
nervous system disease DOID:863 0 0.084
eye disease DOID:5614 0 0.084
urinary system disease DOID:18 0 0.068
bone disease DOID:0080001 0 0.036
musculoskeletal system disease DOID:17 0 0.036
connective tissue disease DOID:65 0 0.036
obesity DOID:9970 0 0.012
disease of metabolism DOID:0014667 0 0.012
nutrition disease DOID:374 0 0.012
overnutrition DOID:654 0 0.012
acquired metabolic disease DOID:0060158 0 0.012
central nervous system disease DOID:331 0 0.012