Rattus norvegicus

32 known processes

Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

Mlc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 241 0.212
anion transport GO:0006820 178 0.190
response to carbohydrate GO:0009743 183 0.175
carboxylic acid metabolic process GO:0019752 289 0.169
cellular amino acid metabolic process GO:0006520 107 0.160
organic acid transport GO:0015849 116 0.152
organic anion transport GO:0015711 132 0.146
amino acid transport GO:0006865 70 0.140
regulation of cell proliferation GO:0042127 359 0.125
organic acid metabolic process GO:0006082 292 0.109
regulation of secretion by cell GO:1903530 208 0.105
nitrogen compound transport GO:0071705 229 0.104
response to wounding GO:0009611 254 0.103
cellular component movement GO:0006928 248 0.100
oxoacid metabolic process GO:0043436 290 0.085
homeostatic process GO:0042592 331 0.085
cardiovascular system development GO:0072358 134 0.085
cation transport GO:0006812 382 0.084
regulation of multicellular organismal development GO:2000026 376 0.084
regulation of cellular component organization GO:0051128 368 0.083
organic substance catabolic process GO:1901575 316 0.081
regulation of synaptic transmission GO:0050804 141 0.081
regulation of protein metabolic process GO:0051246 289 0.078
rna biosynthetic process GO:0032774 380 0.073
regulation of cellular amine metabolic process GO:0033238 8 0.073
regulation of cellular localization GO:0060341 263 0.071
synaptic transmission GO:0007268 235 0.071
transcription from rna polymerase ii promoter GO:0006366 252 0.067
defense response GO:0006952 194 0.066
cellular homeostasis GO:0019725 252 0.063
regulation of cellular protein metabolic process GO:0032268 267 0.062
regulation of anatomical structure morphogenesis GO:0022603 141 0.062
cellular component assembly GO:0022607 360 0.062
multi organism reproductive process GO:0044703 262 0.061
central nervous system development GO:0007417 311 0.060
single organism behavior GO:0044708 130 0.057
positive regulation of developmental process GO:0051094 283 0.057
regulation of apoptotic process GO:0042981 335 0.056
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.056
signal transduction by phosphorylation GO:0023014 144 0.056
protein phosphorylation GO:0006468 345 0.055
cellular amine metabolic process GO:0044106 38 0.054
regulation of rna metabolic process GO:0051252 391 0.054
amine metabolic process GO:0009308 38 0.054
cell motility GO:0048870 202 0.054
positive regulation of nervous system development GO:0051962 178 0.054
response to ethanol GO:0045471 162 0.053
neuron projection development GO:0031175 273 0.053
regulation of secretion GO:0051046 224 0.053
regulation of amine transport GO:0051952 54 0.052
response to decreased oxygen levels GO:0036293 237 0.052
secretion GO:0046903 307 0.051
head development GO:0060322 247 0.051
multicellular organism growth GO:0035264 1 0.050
secretion by cell GO:0032940 248 0.049
organonitrogen compound catabolic process GO:1901565 179 0.049
multicellular organismal reproductive process GO:0048609 233 0.049
amine transport GO:0015837 57 0.048
regulation of neuron projection development GO:0010975 161 0.048
cell migration GO:0016477 197 0.048
localization of cell GO:0051674 202 0.048
cell cell signaling GO:0007267 335 0.048
carboxylic acid transport GO:0046942 115 0.048
chemical homeostasis GO:0048878 292 0.047
cellular chemical homeostasis GO:0055082 247 0.047
cellular response to oxygen containing compound GO:1901701 386 0.047
protein complex assembly GO:0006461 263 0.046
negative regulation of metabolic process GO:0009892 331 0.046
regulation of transcription dna templated GO:0006355 374 0.046
positive regulation of secretion by cell GO:1903532 128 0.046
response to glucocorticoid GO:0051384 223 0.046
positive regulation of cell proliferation GO:0008284 249 0.046
rhythmic process GO:0048511 156 0.045
cellular ketone metabolic process GO:0042180 51 0.045
protein oligomerization GO:0051259 191 0.044
regulation of nucleic acid templated transcription GO:1903506 380 0.043
positive regulation of transport GO:0051050 245 0.043
nucleic acid templated transcription GO:0097659 379 0.043
protein complex biogenesis GO:0070271 263 0.043
regulation of cellular amino acid metabolic process GO:0006521 2 0.042
macromolecular complex assembly GO:0065003 273 0.042
regulation of neuron differentiation GO:0045664 208 0.042
regulation of cell development GO:0060284 263 0.041
response to glucose GO:0009749 136 0.041
response to transition metal nanoparticle GO:1990267 122 0.040
response to inorganic substance GO:0010035 377 0.040
positive regulation of multicellular organismal process GO:0051240 387 0.040
negative regulation of programmed cell death GO:0043069 183 0.039
response to hexose GO:0009746 144 0.039
response to monosaccharide GO:0034284 159 0.039
reproductive process GO:0022414 372 0.038
regulation of hormone secretion GO:0046883 106 0.038
amide transport GO:0042886 105 0.038
cellular response to stress GO:0033554 269 0.038
cellular component biogenesis GO:0044085 368 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.038
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.037
response to extracellular stimulus GO:0009991 380 0.036
cell morphogenesis involved in differentiation GO:0000904 119 0.036
positive regulation of cellular protein metabolic process GO:0032270 167 0.036
negative regulation of cellular metabolic process GO:0031324 281 0.036
response to corticosteroid GO:0031960 235 0.036
oligopeptide transport GO:0006857 4 0.036
organelle organization GO:0006996 266 0.035
response to mechanical stimulus GO:0009612 134 0.035
negative regulation of cell proliferation GO:0008285 119 0.034
mapk cascade GO:0000165 140 0.034
protein complex subunit organization GO:0071822 302 0.033
neurological system process GO:0050877 219 0.033
regulation of protein modification process GO:0031399 194 0.032
glutamate secretion GO:0014047 19 0.032
positive regulation of neurogenesis GO:0050769 165 0.032
regulation of phosphorylation GO:0042325 248 0.032
regulation of phosphorus metabolic process GO:0051174 349 0.032
macromolecular complex subunit organization GO:0043933 339 0.031
gliogenesis GO:0042063 93 0.031
brain development GO:0007420 247 0.031
epithelial cell proliferation GO:0050673 54 0.031
developmental growth GO:0048589 100 0.030
response to metal ion GO:0010038 253 0.030
regulation of organic acid transport GO:0032890 35 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
regulation of peptide transport GO:0090087 87 0.030
macromolecule localization GO:0033036 252 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
astrocyte development GO:0014002 4 0.030
response to acid chemical GO:0001101 222 0.030
positive regulation of cellular amine metabolic process GO:0033240 3 0.029
regulation of programmed cell death GO:0043067 341 0.029
circulatory system development GO:0072359 134 0.029
positive regulation of signaling GO:0023056 270 0.029
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.029
intracellular signal transduction GO:0035556 314 0.028
multicellular organism reproduction GO:0032504 233 0.028
regulation of molecular function GO:0065009 398 0.027
single organism catabolic process GO:0044712 283 0.027
locomotion GO:0040011 237 0.027
transcription dna templated GO:0006351 377 0.027
negative regulation of apoptotic process GO:0043066 181 0.027
anatomical structure morphogenesis GO:0009653 298 0.026
blood circulation GO:0008015 183 0.026
response to ketone GO:1901654 182 0.026
regulation of locomotion GO:0040012 148 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
response to temperature stimulus GO:0009266 94 0.026
regulation of rna biosynthetic process GO:2001141 381 0.026
negative regulation of cell death GO:0060548 229 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.026
regulation of neurogenesis GO:0050767 247 0.025
protein localization GO:0008104 191 0.025
neurotransmitter transport GO:0006836 42 0.025
multi multicellular organism process GO:0044706 138 0.025
catabolic process GO:0009056 351 0.025
regulation of signal transduction GO:0009966 318 0.025
cellular amino acid biosynthetic process GO:0008652 32 0.025
cellular component morphogenesis GO:0032989 155 0.025
regulation of cell motility GO:2000145 131 0.025
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.024
negative regulation of cell differentiation GO:0045596 99 0.024
negative regulation of transport GO:0051051 136 0.024
positive regulation of cell development GO:0010720 176 0.024
tissue development GO:0009888 252 0.024
positive regulation of cellular component organization GO:0051130 200 0.024
negative regulation of signaling GO:0023057 157 0.024
negative regulation of cell development GO:0010721 82 0.024
organophosphate metabolic process GO:0019637 370 0.024
regulation of tube size GO:0035150 89 0.024
positive regulation of catalytic activity GO:0043085 184 0.024
response to estradiol GO:0032355 164 0.023
regulation of response to wounding GO:1903034 69 0.023
cellular response to growth factor stimulus GO:0071363 162 0.023
cellular response to endogenous stimulus GO:0071495 377 0.023
response to peptide hormone GO:0043434 278 0.023
regulation of ion transport GO:0043269 245 0.023
immune system process GO:0002376 204 0.023
carbohydrate homeostasis GO:0033500 75 0.023
regulation of protein phosphorylation GO:0001932 183 0.023
response to estrogen GO:0043627 232 0.023
organic hydroxy compound metabolic process GO:1901615 115 0.023
regulation of anatomical structure size GO:0090066 135 0.023
response to nutrient GO:0007584 248 0.022
regulation of nervous system development GO:0051960 264 0.022
regulation of cell differentiation GO:0045595 320 0.022
negative regulation of gene expression GO:0010629 199 0.022
negative regulation of neurogenesis GO:0050768 78 0.022
sexual reproduction GO:0019953 148 0.022
positive regulation of protein modification process GO:0031401 142 0.022
response to alkaloid GO:0043279 132 0.022
negative regulation of protein metabolic process GO:0051248 114 0.022
negative regulation of developmental process GO:0051093 125 0.022
sensory organ development GO:0007423 74 0.022
positive regulation of phosphorus metabolic process GO:0010562 262 0.022
behavior GO:0007610 205 0.022
negative regulation of phosphorus metabolic process GO:0010563 80 0.022
rna metabolic process GO:0016070 406 0.022
cellular ion homeostasis GO:0006873 184 0.022
cellular response to external stimulus GO:0071496 118 0.021
ion transmembrane transport GO:0034220 365 0.021
reproduction GO:0000003 245 0.021
dicarboxylic acid transport GO:0006835 34 0.021
regeneration GO:0031099 163 0.021
metal ion transport GO:0030001 289 0.021
positive regulation of response to stimulus GO:0048584 285 0.021
programmed cell death GO:0012501 392 0.021
axon development GO:0061564 96 0.021
circulatory system process GO:0003013 183 0.021
response to camp GO:0051591 91 0.021
regulation of cell migration GO:0030334 128 0.021
response to hypoxia GO:0001666 231 0.021
regulation of cell projection organization GO:0031344 175 0.021
positive regulation of cell communication GO:0010647 271 0.020
regulation of response to stress GO:0080134 126 0.020
response to nutrient levels GO:0031667 370 0.020
growth GO:0040007 165 0.020
regulation of phosphate metabolic process GO:0019220 349 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
cellular nitrogen compound catabolic process GO:0044270 163 0.020
wound healing GO:0042060 122 0.020
cell projection organization GO:0030030 302 0.020
ion homeostasis GO:0050801 212 0.019
negative regulation of molecular function GO:0044092 133 0.019
purine containing compound metabolic process GO:0072521 253 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
signal release GO:0023061 145 0.019
neuron development GO:0048666 286 0.019
cellular response to organonitrogen compound GO:0071417 197 0.018
positive regulation of secretion GO:0051047 140 0.018
neurotransmitter uptake GO:0001504 3 0.018
negative regulation of nervous system development GO:0051961 79 0.018
g protein coupled receptor signaling pathway GO:0007186 242 0.018
neuron differentiation GO:0030182 368 0.018
response to purine containing compound GO:0014074 126 0.018
regulation of anion transport GO:0044070 43 0.018
renal sodium excretion GO:0035812 20 0.018
positive regulation of apoptotic process GO:0043065 154 0.018
hepaticobiliary system development GO:0061008 90 0.018
female pregnancy GO:0007565 122 0.018
regulation of hydrolase activity GO:0051336 143 0.018
organic acid biosynthetic process GO:0016053 83 0.018
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
amino acid transmembrane transport GO:0003333 33 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
sensory perception of pain GO:0019233 73 0.017
regulation of response to external stimulus GO:0032101 106 0.017
regulation of catalytic activity GO:0050790 304 0.017
response to axon injury GO:0048678 59 0.017
positive regulation of cell migration GO:0030335 96 0.017
ovulation cycle process GO:0022602 50 0.017
multicellular organismal homeostasis GO:0048871 49 0.017
gland development GO:0048732 155 0.017
peptide secretion GO:0002790 86 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
regulation of inflammatory response GO:0050727 48 0.017
negative regulation of catalytic activity GO:0043086 103 0.017
neural crest cell differentiation GO:0014033 2 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
glucose homeostasis GO:0042593 75 0.017
alpha amino acid metabolic process GO:1901605 71 0.017
regulation of neurotransmitter uptake GO:0051580 1 0.016
proteolysis GO:0006508 175 0.016
hormone secretion GO:0046879 115 0.016
anion transmembrane transport GO:0098656 77 0.016
lipid metabolic process GO:0006629 283 0.016
vesicle mediated transport GO:0016192 181 0.016
learning or memory GO:0007611 90 0.016
positive regulation of molecular function GO:0044093 230 0.016
regulation of neurological system process GO:0031644 43 0.016
developmental process involved in reproduction GO:0003006 159 0.016
positive regulation of phosphorylation GO:0042327 177 0.016
response to heat GO:0009408 60 0.015
protein homooligomerization GO:0051260 91 0.015
regulation of peptide secretion GO:0002791 82 0.015
regulation of amino acid transport GO:0051955 25 0.015
response to growth factor GO:0070848 189 0.015
negative regulation of macromolecule metabolic process GO:0010605 260 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
glial cell differentiation GO:0010001 65 0.015
protein maturation GO:0051604 68 0.015
secretion by tissue GO:0032941 37 0.015
small molecule biosynthetic process GO:0044283 124 0.015
positive regulation of biosynthetic process GO:0009891 319 0.015
negative regulation of neuron differentiation GO:0045665 62 0.015
negative regulation of signal transduction GO:0009968 83 0.015
monovalent inorganic cation transport GO:0015672 172 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
inflammatory response GO:0006954 150 0.014
heterocycle catabolic process GO:0046700 167 0.014
negative regulation of cell communication GO:0010648 158 0.014
carboxylic acid biosynthetic process GO:0046394 83 0.014
response to cocaine GO:0042220 39 0.014
regulation of epithelial cell proliferation GO:0050678 49 0.014
vascular process in circulatory system GO:0003018 96 0.014
response to peptide GO:1901652 292 0.014
gamete generation GO:0007276 124 0.014
cellular response to acid chemical GO:0071229 75 0.014
mesoderm development GO:0007498 2 0.014
catecholamine transport GO:0051937 37 0.014
regulation of cell growth GO:0001558 85 0.014
peptidyl amino acid modification GO:0018193 126 0.013
organic cyclic compound catabolic process GO:1901361 175 0.013
neural crest cell migration GO:0001755 1 0.013
cation homeostasis GO:0055080 195 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
response to cytokine GO:0034097 215 0.013
cellular amino acid catabolic process GO:0009063 21 0.013
peptide transport GO:0015833 97 0.013
regulation of vasculature development GO:1901342 44 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
positive regulation of protein metabolic process GO:0051247 178 0.013
regulation of neuronal synaptic plasticity GO:0048168 31 0.013
heart morphogenesis GO:0003007 3 0.013
positive regulation of cell differentiation GO:0045597 217 0.013
reactive oxygen species biosynthetic process GO:1903409 8 0.013
positive regulation of cell death GO:0010942 184 0.013
reproductive structure development GO:0048608 128 0.013
regulation of cell morphogenesis GO:0022604 77 0.013
regulation of peptide hormone secretion GO:0090276 80 0.013
intracellular transport GO:0046907 185 0.012
neuron death GO:0070997 127 0.012
vitamin transport GO:0051180 14 0.012
cell cycle GO:0007049 101 0.012
vasculature development GO:0001944 70 0.012
regulation of protein kinase activity GO:0045859 105 0.012
regulation of neuron death GO:1901214 115 0.012
action potential GO:0001508 54 0.012
regulation of neurotransmitter levels GO:0001505 42 0.012
calcium ion homeostasis GO:0055074 162 0.012
cellular response to lipid GO:0071396 201 0.012
regulation of system process GO:0044057 208 0.012
response to bacterium GO:0009617 200 0.012
nucleobase containing compound catabolic process GO:0034655 152 0.012
regulation of transferase activity GO:0051338 123 0.012
response to insulin GO:0032868 133 0.012
axis specification GO:0009798 4 0.012
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
cellular catabolic process GO:0044248 295 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
cellular cation homeostasis GO:0030003 180 0.012
monocarboxylic acid metabolic process GO:0032787 152 0.012
negative regulation of amine transport GO:0051953 24 0.012
regulation of catabolic process GO:0009894 113 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
hormone metabolic process GO:0042445 69 0.012
eye development GO:0001654 50 0.012
gonad development GO:0008406 104 0.012
metal ion homeostasis GO:0055065 186 0.012
positive regulation of gene expression GO:0010628 244 0.012
regulation of kinase activity GO:0043549 117 0.012
single organism intracellular transport GO:1902582 166 0.011
circadian rhythm GO:0007623 88 0.011
multicellular organismal signaling GO:0035637 44 0.011
blood vessel morphogenesis GO:0048514 58 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
single organism reproductive process GO:0044702 297 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
carbohydrate derivative metabolic process GO:1901135 346 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.011
angiotensin mediated drinking behavior GO:0003051 2 0.011
carbohydrate metabolic process GO:0005975 130 0.011
sex differentiation GO:0007548 113 0.011
ras protein signal transduction GO:0007265 29 0.011
response to oxidative stress GO:0006979 186 0.011
cell fate determination GO:0001709 2 0.011
nucleoside metabolic process GO:0009116 179 0.011
regulation of angiogenesis GO:0045765 39 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
single organism organelle organization GO:1902589 180 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.011
sensory perception GO:0007600 101 0.011
muscle system process GO:0003012 115 0.011
positive regulation of saliva secretion GO:0046878 3 0.011
muscle cell proliferation GO:0033002 84 0.011
isoprenoid metabolic process GO:0006720 45 0.011
liver development GO:0001889 90 0.011
protein processing GO:0016485 68 0.011
response to other organism GO:0051707 220 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.010
cellular lipid metabolic process GO:0044255 208 0.010
chemosensory behavior GO:0007635 2 0.010
axonogenesis GO:0007409 71 0.010
phosphatidylinositol dephosphorylation GO:0046856 4 0.010
negative regulation of response to stimulus GO:0048585 155 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
regulation of body fluid levels GO:0050878 90 0.010
glutamate receptor signaling pathway GO:0007215 43 0.010
regulation of synaptic plasticity GO:0048167 70 0.010
regulation of vasoconstriction GO:0019229 44 0.010
cellular response to nutrient levels GO:0031669 60 0.010
positive regulation of blood circulation GO:1903524 65 0.010
forebrain development GO:0030900 98 0.010
cation transmembrane transport GO:0098655 263 0.010
spinal cord development GO:0021510 27 0.010
salivary gland development GO:0007431 3 0.010
positive regulation of synaptic transmission GO:0050806 62 0.010

Mlc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
sensory system disease DOID:0050155 0 0.014
cerebral degeneration DOID:1443 0 0.013
central nervous system disease DOID:331 0 0.013
brain disease DOID:936 0 0.013
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.011