Rattus norvegicus

25 known processes

Msh2

mutS homolog 2 (E. coli)

Msh2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oxoacid metabolic process GO:0043436 290 0.130
cellular amino acid metabolic process GO:0006520 107 0.105
negative regulation of biosynthetic process GO:0009890 168 0.102
negative regulation of macromolecule metabolic process GO:0010605 260 0.101
single organism biosynthetic process GO:0044711 342 0.087
response to nutrient GO:0007584 248 0.085
regulation of cellular ketone metabolic process GO:0010565 27 0.078
carboxylic acid metabolic process GO:0019752 289 0.076
response to metal ion GO:0010038 253 0.076
organelle organization GO:0006996 266 0.074
organic acid metabolic process GO:0006082 292 0.072
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.071
response to amino acid GO:0043200 75 0.068
intracellular signal transduction GO:0035556 314 0.061
protein phosphorylation GO:0006468 345 0.060
response to extracellular stimulus GO:0009991 380 0.059
single organism reproductive process GO:0044702 297 0.059
response to toxic substance GO:0009636 133 0.058
regulation of programmed cell death GO:0043067 341 0.052
folic acid containing compound metabolic process GO:0006760 10 0.052
regulation of multicellular organismal development GO:2000026 376 0.051
dna metabolic process GO:0006259 96 0.050
transcription dna templated GO:0006351 377 0.048
response to nutrient levels GO:0031667 370 0.048
positive regulation of transport GO:0051050 245 0.048
nucleic acid templated transcription GO:0097659 379 0.047
rna metabolic process GO:0016070 406 0.045
macromolecular complex subunit organization GO:0043933 339 0.045
response to estrogen GO:0043627 232 0.044
response to oxygen levels GO:0070482 265 0.044
positive regulation of rna biosynthetic process GO:1902680 197 0.044
cellular ketone metabolic process GO:0042180 51 0.043
regulation of apoptotic process GO:0042981 335 0.042
alpha amino acid metabolic process GO:1901605 71 0.041
negative regulation of rna metabolic process GO:0051253 123 0.040
transcription from rna polymerase ii promoter GO:0006366 252 0.040
regulation of cellular component organization GO:0051128 368 0.040
response to vitamin GO:0033273 131 0.040
apoptotic process GO:0006915 381 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.039
positive regulation of developmental process GO:0051094 283 0.038
response to molecule of bacterial origin GO:0002237 194 0.037
regulation of molecular function GO:0065009 398 0.037
regulation of cell proliferation GO:0042127 359 0.036
positive regulation of biosynthetic process GO:0009891 319 0.036
organonitrogen compound biosynthetic process GO:1901566 167 0.036
response to hypoxia GO:0001666 231 0.036
negative regulation of metabolic process GO:0009892 331 0.036
regulation of protein metabolic process GO:0051246 289 0.036
positive regulation of multicellular organismal process GO:0051240 387 0.036
negative regulation of nucleic acid templated transcription GO:1903507 117 0.035
positive regulation of cellular protein metabolic process GO:0032270 167 0.035
protein complex assembly GO:0006461 263 0.035
cellular lipid metabolic process GO:0044255 208 0.035
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.034
positive regulation of cell proliferation GO:0008284 249 0.034
nucleoside phosphate biosynthetic process GO:1901293 102 0.034
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
response to growth factor GO:0070848 189 0.034
response to purine containing compound GO:0014074 126 0.034
response to decreased oxygen levels GO:0036293 237 0.034
protein complex subunit organization GO:0071822 302 0.033
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.033
response to ethanol GO:0045471 162 0.032
catabolic process GO:0009056 351 0.032
negative regulation of cell death GO:0060548 229 0.032
positive regulation of apoptotic process GO:0043065 154 0.032
response to acid chemical GO:0001101 222 0.032
amine metabolic process GO:0009308 38 0.032
organophosphate metabolic process GO:0019637 370 0.031
negative regulation of rna biosynthetic process GO:1902679 118 0.031
cofactor metabolic process GO:0051186 95 0.031
regulation of nucleic acid templated transcription GO:1903506 380 0.031
cellular response to oxygen containing compound GO:1901701 386 0.031
cellular response to stress GO:0033554 269 0.031
cell migration GO:0016477 197 0.030
cellular component movement GO:0006928 248 0.030
lipid biosynthetic process GO:0008610 128 0.030
chromatin assembly or disassembly GO:0006333 1 0.030
cellular amine metabolic process GO:0044106 38 0.030
regulation of rna biosynthetic process GO:2001141 381 0.030
positive regulation of transcription dna templated GO:0045893 197 0.030
response to lipopolysaccharide GO:0032496 191 0.029
cellular catabolic process GO:0044248 295 0.029
response to estradiol GO:0032355 164 0.029
regulation of cell differentiation GO:0045595 320 0.029
organophosphate biosynthetic process GO:0090407 143 0.029
response to cytokine GO:0034097 215 0.029
cellular response to endogenous stimulus GO:0071495 377 0.029
rhythmic process GO:0048511 156 0.028
reproductive process GO:0022414 372 0.028
homeostatic process GO:0042592 331 0.028
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.028
response to inorganic substance GO:0010035 377 0.028
regulation of signal transduction GO:0009966 318 0.028
aging GO:0007568 241 0.028
macromolecule localization GO:0033036 252 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.027
response to ketone GO:1901654 182 0.027
positive regulation of protein modification process GO:0031401 142 0.027
regulation of cellular amine metabolic process GO:0033238 8 0.027
multi organism reproductive process GO:0044703 262 0.027
protein localization GO:0008104 191 0.027
regulation of protein modification process GO:0031399 194 0.027
response to bacterium GO:0009617 200 0.026
reproduction GO:0000003 245 0.026
purine containing compound metabolic process GO:0072521 253 0.026
neuron differentiation GO:0030182 368 0.026
protein complex biogenesis GO:0070271 263 0.026
cell cycle GO:0007049 101 0.026
response to alkaloid GO:0043279 132 0.025
regeneration GO:0031099 163 0.025
cellular response to organic cyclic compound GO:0071407 202 0.025
single organism catabolic process GO:0044712 283 0.025
response to external biotic stimulus GO:0043207 221 0.025
cellular component assembly GO:0022607 360 0.025
cellular nitrogen compound catabolic process GO:0044270 163 0.024
growth GO:0040007 165 0.024
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
lipid metabolic process GO:0006629 283 0.024
regulation of catalytic activity GO:0050790 304 0.024
negative regulation of gene expression GO:0010629 199 0.024
positive regulation of cell development GO:0010720 176 0.024
negative regulation of transcription dna templated GO:0045892 116 0.024
positive regulation of protein metabolic process GO:0051247 178 0.024
negative regulation of cellular biosynthetic process GO:0031327 161 0.023
response to biotic stimulus GO:0009607 226 0.023
cellular response to growth factor stimulus GO:0071363 162 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
regulation of lipid metabolic process GO:0019216 68 0.023
anion transport GO:0006820 178 0.022
positive regulation of response to stimulus GO:0048584 285 0.022
urogenital system development GO:0001655 78 0.022
regulation of cell development GO:0060284 263 0.022
nucleobase containing small molecule metabolic process GO:0055086 316 0.022
nucleotide metabolic process GO:0009117 279 0.022
positive regulation of cell differentiation GO:0045597 217 0.022
secretion GO:0046903 307 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
carbohydrate metabolic process GO:0005975 130 0.022
response to glucocorticoid GO:0051384 223 0.022
circadian rhythm GO:0007623 88 0.022
positive regulation of gene expression GO:0010628 244 0.022
macromolecular complex assembly GO:0065003 273 0.021
programmed cell death GO:0012501 392 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
response to corticosteroid GO:0031960 235 0.021
response to other organism GO:0051707 220 0.021
cellular response to organonitrogen compound GO:0071417 197 0.021
protein transport GO:0015031 132 0.021
head development GO:0060322 247 0.021
positive regulation of rna metabolic process GO:0051254 203 0.021
positive regulation of molecular function GO:0044093 230 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
neuron apoptotic process GO:0051402 88 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
peptidyl amino acid modification GO:0018193 126 0.020
regulation of phosphate metabolic process GO:0019220 349 0.020
protein oligomerization GO:0051259 191 0.020
chromosome segregation GO:0007059 2 0.020
carbohydrate derivative catabolic process GO:1901136 147 0.020
cellular response to nitrogen compound GO:1901699 210 0.020
ribose phosphate metabolic process GO:0019693 235 0.019
multicellular organism growth GO:0035264 1 0.019
cellular modified amino acid metabolic process GO:0006575 61 0.019
response to temperature stimulus GO:0009266 94 0.019
transmembrane transport GO:0055085 412 0.019
positive regulation of signaling GO:0023056 270 0.019
single organism organelle organization GO:1902589 180 0.019
rna biosynthetic process GO:0032774 380 0.019
chemical homeostasis GO:0048878 292 0.019
deoxyribonucleoside monophosphate metabolic process GO:0009162 6 0.019
regulation of catabolic process GO:0009894 113 0.019
kidney development GO:0001822 67 0.018
response to oxidative stress GO:0006979 186 0.018
response to peptide hormone GO:0043434 278 0.018
cellular component biogenesis GO:0044085 368 0.018
central nervous system development GO:0007417 311 0.018
tissue development GO:0009888 252 0.018
regulation of neurogenesis GO:0050767 247 0.018
response to monosaccharide GO:0034284 159 0.018
regulation of rna metabolic process GO:0051252 391 0.018
localization of cell GO:0051674 202 0.018
nucleoside metabolic process GO:0009116 179 0.018
regulation of nervous system development GO:0051960 264 0.018
nucleoside phosphate metabolic process GO:0006753 283 0.018
regulation of cell projection organization GO:0031344 175 0.018
response to carbohydrate GO:0009743 183 0.018
carbohydrate derivative biosynthetic process GO:1901137 124 0.018
dna replication GO:0006260 37 0.018
ribonucleoside monophosphate metabolic process GO:0009161 88 0.018
purine nucleotide metabolic process GO:0006163 229 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
cellular protein localization GO:0034613 122 0.018
cellular response to lipid GO:0071396 201 0.018
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.017
locomotion GO:0040011 237 0.017
response to hydrogen peroxide GO:0042542 89 0.017
coenzyme metabolic process GO:0006732 86 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
synaptic transmission GO:0007268 235 0.017
spindle organization GO:0007051 2 0.017
embryonic pattern specification GO:0009880 1 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
regulation of phosphorus metabolic process GO:0051174 349 0.017
eye morphogenesis GO:0048592 4 0.017
regulation of cellular localization GO:0060341 263 0.017
response to transition metal nanoparticle GO:1990267 122 0.017
double strand break repair GO:0006302 1 0.017
negative regulation of protein metabolic process GO:0051248 114 0.017
organic anion transport GO:0015711 132 0.017
regulation of protein phosphorylation GO:0001932 183 0.016
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.016
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
cellular response to cytokine stimulus GO:0071345 127 0.016
response to heat GO:0009408 60 0.016
protein autophosphorylation GO:0046777 66 0.016
ion transmembrane transport GO:0034220 365 0.016
response to ionizing radiation GO:0010212 59 0.016
positive regulation of neurogenesis GO:0050769 165 0.016
regulation of neuron projection development GO:0010975 161 0.016
organ regeneration GO:0031100 101 0.016
positive regulation of cell death GO:0010942 184 0.016
positive regulation of nervous system development GO:0051962 178 0.016
axis specification GO:0009798 4 0.016
regulation of organelle organization GO:0033043 80 0.016
response to peptide GO:1901652 292 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
brain development GO:0007420 247 0.016
purine nucleoside metabolic process GO:0042278 169 0.015
negative regulation of cell cycle phase transition GO:1901988 4 0.015
cellular response to abiotic stimulus GO:0071214 85 0.015
metal ion transport GO:0030001 289 0.015
deoxyribonucleotide biosynthetic process GO:0009263 6 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.015
negative regulation of response to stimulus GO:0048585 155 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
negative regulation of signaling GO:0023057 157 0.015
positive regulation of phosphate metabolic process GO:0045937 262 0.015
response to hexose GO:0009746 144 0.015
sexual reproduction GO:0019953 148 0.015
tetrahydrofolate metabolic process GO:0046653 9 0.015
small molecule biosynthetic process GO:0044283 124 0.015
response to wounding GO:0009611 254 0.015
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.015
circulatory system process GO:0003013 183 0.015
neuron death GO:0070997 127 0.015
cell cycle checkpoint GO:0000075 2 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
negative regulation of molecular function GO:0044092 133 0.014
organic substance catabolic process GO:1901575 316 0.014
response to radiation GO:0009314 137 0.014
pyrimidine nucleobase metabolic process GO:0006206 8 0.014
negative regulation of cell communication GO:0010648 158 0.014
reproductive system development GO:0061458 128 0.014
heterocycle catabolic process GO:0046700 167 0.014
cell cell signaling GO:0007267 335 0.014
multicellular organism reproduction GO:0032504 233 0.014
neurological system process GO:0050877 219 0.014
neuronal action potential GO:0019228 35 0.014
reproductive structure development GO:0048608 128 0.014
regulation of transferase activity GO:0051338 123 0.014
sex differentiation GO:0007548 113 0.014
response to reactive oxygen species GO:0000302 120 0.014
oxidation reduction process GO:0055114 304 0.014
regulation of cellular protein metabolic process GO:0032268 267 0.014
renal system development GO:0072001 67 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
gland development GO:0048732 155 0.013
gamete generation GO:0007276 124 0.013
regulation of cell morphogenesis GO:0022604 77 0.013
neuron development GO:0048666 286 0.013
regulation of transcription dna templated GO:0006355 374 0.013
proteolysis GO:0006508 175 0.013
organophosphate catabolic process GO:0046434 148 0.013
wound healing GO:0042060 122 0.013
positive regulation of cellular component organization GO:0051130 200 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
tube development GO:0035295 89 0.013
limb morphogenesis GO:0035108 4 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.013
cell motility GO:0048870 202 0.013
anterior posterior pattern specification GO:0009952 1 0.013
establishment of protein localization GO:0045184 141 0.013
protein maturation GO:0051604 68 0.013
cytoskeleton organization GO:0007010 111 0.012
cellular homeostasis GO:0019725 252 0.012
cation transport GO:0006812 382 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
negative regulation of neuron death GO:1901215 69 0.012
heart morphogenesis GO:0003007 3 0.012
nucleoside monophosphate metabolic process GO:0009123 93 0.012
organic cyclic compound catabolic process GO:1901361 175 0.012
ovulation cycle process GO:0022602 50 0.012
behavior GO:0007610 205 0.012
glycosyl compound metabolic process GO:1901657 182 0.012
carboxylic acid transport GO:0046942 115 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
organ morphogenesis GO:0009887 75 0.012
cellular response to insulin stimulus GO:0032869 81 0.012
regulation of actin filament based process GO:0032970 42 0.012
regulation of proteolysis GO:0030162 66 0.012
response to glucose GO:0009749 136 0.012
regulation of protein transport GO:0051223 68 0.012
regulation of response to stress GO:0080134 126 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
hematopoietic progenitor cell differentiation GO:0002244 2 0.012
positive regulation of neuron projection development GO:0010976 99 0.012
regulation of phosphorylation GO:0042325 248 0.012
cell morphogenesis GO:0000902 142 0.012
cellular macromolecule localization GO:0070727 122 0.012
pteridine containing compound metabolic process GO:0042558 14 0.012
organic acid transport GO:0015849 116 0.012
regulation of neuron death GO:1901214 115 0.012
mesoderm development GO:0007498 2 0.011
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
positive regulation of cell communication GO:0010647 271 0.011
ovulation cycle GO:0042698 67 0.011
sensory organ development GO:0007423 74 0.011
regulation of system process GO:0044057 208 0.011
aromatic compound catabolic process GO:0019439 168 0.011
positive regulation of neuron differentiation GO:0045666 126 0.011
regulation of hormone levels GO:0010817 187 0.011
single organism intracellular transport GO:1902582 166 0.011
mitotic spindle organization GO:0007052 2 0.011
molting cycle GO:0042303 3 0.011
positive regulation of signal transduction GO:0009967 175 0.011
neuron projection development GO:0031175 273 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
regulation of cell migration GO:0030334 128 0.011
purine nucleoside monophosphate metabolic process GO:0009126 84 0.011
jak stat cascade GO:0007259 26 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
positive regulation of protein transport GO:0051222 41 0.011
spermatogenesis GO:0007283 99 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
purine nucleoside monophosphate catabolic process GO:0009128 55 0.011
cytoplasmic transport GO:0016482 115 0.011
glycerolipid metabolic process GO:0046486 67 0.011
cell projection organization GO:0030030 302 0.011
regulation of cellular component movement GO:0051270 150 0.011
response to testosterone GO:0033574 55 0.010
regulation of protein localization GO:0032880 81 0.010
hair follicle development GO:0001942 2 0.010
nucleoside monophosphate biosynthetic process GO:0009124 28 0.010
organic acid biosynthetic process GO:0016053 83 0.010
dephosphorylation GO:0016311 98 0.010
cardiovascular system development GO:0072358 134 0.010
cellular response to external stimulus GO:0071496 118 0.010
regulation of growth GO:0040008 105 0.010
cellular modified amino acid biosynthetic process GO:0042398 18 0.010
developmental process involved in reproduction GO:0003006 159 0.010
nucleoside triphosphate catabolic process GO:0009143 123 0.010
regulation of protein kinase activity GO:0045859 105 0.010
gonad development GO:0008406 104 0.010
cellular response to nutrient levels GO:0031669 60 0.010
regulation of epithelial cell proliferation GO:0050678 49 0.010
inflammatory response GO:0006954 150 0.010

Msh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.013
disease of anatomical entity DOID:7 0 0.013
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.012
disease of metabolism DOID:0014667 0 0.012