Rattus norvegicus

23 known processes

Mthfd1

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Mthfd1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid metabolic process GO:0006082 292 0.190
Yeast
alpha amino acid metabolic process GO:1901605 71 0.121
Yeast
single organism biosynthetic process GO:0044711 342 0.118
Yeast
oxoacid metabolic process GO:0043436 290 0.099
Yeast
cellular amino acid metabolic process GO:0006520 107 0.077
Yeast
carboxylic acid metabolic process GO:0019752 289 0.072
Yeast
response to nutrient GO:0007584 248 0.071
cellular amino acid biosynthetic process GO:0008652 32 0.065
response to extracellular stimulus GO:0009991 380 0.065
small molecule biosynthetic process GO:0044283 124 0.064
response to decreased oxygen levels GO:0036293 237 0.063
response to oxygen levels GO:0070482 265 0.062
organonitrogen compound biosynthetic process GO:1901566 167 0.054
Yeast
macromolecular complex subunit organization GO:0043933 339 0.053
response to inorganic substance GO:0010035 377 0.053
organelle organization GO:0006996 266 0.051
organic acid biosynthetic process GO:0016053 83 0.048
alpha amino acid biosynthetic process GO:1901607 23 0.048
carboxylic acid biosynthetic process GO:0046394 83 0.047
cellular ketone metabolic process GO:0042180 51 0.046
carbohydrate derivative metabolic process GO:1901135 346 0.044
cellular component assembly GO:0022607 360 0.044
cellular response to oxygen containing compound GO:1901701 386 0.043
cellular modified amino acid metabolic process GO:0006575 61 0.043
Yeast
positive regulation of cell communication GO:0010647 271 0.042
apoptotic process GO:0006915 381 0.042
response to bacterium GO:0009617 200 0.041
rna metabolic process GO:0016070 406 0.041
response to hypoxia GO:0001666 231 0.041
reproductive process GO:0022414 372 0.041
response to nutrient levels GO:0031667 370 0.041
amine metabolic process GO:0009308 38 0.039
cofactor metabolic process GO:0051186 95 0.038
Yeast
behavior GO:0007610 205 0.038
nucleobase containing small molecule metabolic process GO:0055086 316 0.037
regulation of cellular amino acid metabolic process GO:0006521 2 0.036
carboxylic acid catabolic process GO:0046395 49 0.035
single organism organelle organization GO:1902589 180 0.035
protein complex subunit organization GO:0071822 302 0.035
catabolic process GO:0009056 351 0.035
regulation of molecular function GO:0065009 398 0.035
response to acid chemical GO:0001101 222 0.033
response to toxic substance GO:0009636 133 0.032
homeostatic process GO:0042592 331 0.032
cellular amine metabolic process GO:0044106 38 0.031
organic substance catabolic process GO:1901575 316 0.031
purine containing compound metabolic process GO:0072521 253 0.030
Yeast
response to peptide hormone GO:0043434 278 0.029
protein phosphorylation GO:0006468 345 0.028
cellular catabolic process GO:0044248 295 0.028
positive regulation of transport GO:0051050 245 0.028
regulation of signal transduction GO:0009966 318 0.028
gland development GO:0048732 155 0.028
regulation of programmed cell death GO:0043067 341 0.027
sulfur compound metabolic process GO:0006790 70 0.027
regulation of apoptotic process GO:0042981 335 0.027
regulation of multicellular organismal development GO:2000026 376 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.026
macromolecular complex assembly GO:0065003 273 0.026
defense response GO:0006952 194 0.026
rna biosynthetic process GO:0032774 380 0.026
protein complex assembly GO:0006461 263 0.025
secretion GO:0046903 307 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.025
regulation of cellular amine metabolic process GO:0033238 8 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
response to biotic stimulus GO:0009607 226 0.024
response to growth factor GO:0070848 189 0.024
small molecule catabolic process GO:0044282 59 0.024
head development GO:0060322 247 0.024
protein oligomerization GO:0051259 191 0.023
central nervous system development GO:0007417 311 0.023
regulation of cellular component organization GO:0051128 368 0.023
single organism reproductive process GO:0044702 297 0.023
positive regulation of cell proliferation GO:0008284 249 0.023
rhythmic process GO:0048511 156 0.023
response to metal ion GO:0010038 253 0.023
positive regulation of molecular function GO:0044093 230 0.023
programmed cell death GO:0012501 392 0.023
regulation of transcription dna templated GO:0006355 374 0.023
cellular response to growth factor stimulus GO:0071363 162 0.022
response to transition metal nanoparticle GO:1990267 122 0.022
transcription dna templated GO:0006351 377 0.022
protein complex biogenesis GO:0070271 263 0.022
multicellular organismal reproductive process GO:0048609 233 0.022
response to lipopolysaccharide GO:0032496 191 0.022
response to external biotic stimulus GO:0043207 221 0.022
organic acid catabolic process GO:0016054 49 0.021
cellular homeostasis GO:0019725 252 0.021
carbohydrate derivative biosynthetic process GO:1901137 124 0.021
lipid metabolic process GO:0006629 283 0.021
cellular response to organic cyclic compound GO:0071407 202 0.021
transmembrane transport GO:0055085 412 0.021
response to vitamin GO:0033273 131 0.021
reproduction GO:0000003 245 0.020
folic acid containing compound metabolic process GO:0006760 10 0.020
Yeast
regulation of cell differentiation GO:0045595 320 0.020
cellular component biogenesis GO:0044085 368 0.020
positive regulation of signaling GO:0023056 270 0.020
cellular response to stress GO:0033554 269 0.020
regulation of protein metabolic process GO:0051246 289 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
nitrogen compound transport GO:0071705 229 0.019
cellular modified amino acid biosynthetic process GO:0042398 18 0.019
neurological system process GO:0050877 219 0.019
brain development GO:0007420 247 0.019
single organism intracellular transport GO:1902582 166 0.018
alpha amino acid catabolic process GO:1901606 20 0.018
positive regulation of response to stimulus GO:0048584 285 0.018
cellular response to endogenous stimulus GO:0071495 377 0.018
positive regulation of biosynthetic process GO:0009891 319 0.018
coenzyme metabolic process GO:0006732 86 0.018
Yeast
anatomical structure morphogenesis GO:0009653 298 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
intracellular signal transduction GO:0035556 314 0.018
macromolecule localization GO:0033036 252 0.018
pteridine containing compound metabolic process GO:0042558 14 0.017
Yeast
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
organophosphate metabolic process GO:0019637 370 0.017
positive regulation of cellular biosynthetic process GO:0031328 295 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
response to corticosteroid GO:0031960 235 0.017
protein localization GO:0008104 191 0.017
neuron differentiation GO:0030182 368 0.017
intracellular transport GO:0046907 185 0.017
multicellular organism reproduction GO:0032504 233 0.017
cellular amino acid catabolic process GO:0009063 21 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
response to molecule of bacterial origin GO:0002237 194 0.016
purine containing compound biosynthetic process GO:0072522 85 0.016
Yeast
regulation of rna metabolic process GO:0051252 391 0.016
nucleotide metabolic process GO:0009117 279 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
ion transmembrane transport GO:0034220 365 0.016
sex differentiation GO:0007548 113 0.016
pigment biosynthetic process GO:0046148 4 0.016
Yeast
positive regulation of catalytic activity GO:0043085 184 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
ribose phosphate metabolic process GO:0019693 235 0.015
positive regulation of developmental process GO:0051094 283 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
peptidyl amino acid modification GO:0018193 126 0.015
response to estrogen GO:0043627 232 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
chemical homeostasis GO:0048878 292 0.015
growth GO:0040007 165 0.015
regulation of cell proliferation GO:0042127 359 0.015
regulation of growth GO:0040008 105 0.015
response to peptide GO:1901652 292 0.015
sensory organ development GO:0007423 74 0.015
regulation of phosphorylation GO:0042325 248 0.015
cellular lipid metabolic process GO:0044255 208 0.015
regulation of cell development GO:0060284 263 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
negative regulation of response to stimulus GO:0048585 155 0.014
single organism catabolic process GO:0044712 283 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
cellular response to lipid GO:0071396 201 0.014
response to ketone GO:1901654 182 0.014
multi organism reproductive process GO:0044703 262 0.014
gonad development GO:0008406 104 0.014
muscle structure development GO:0061061 87 0.014
positive regulation of cell death GO:0010942 184 0.014
proteolysis GO:0006508 175 0.014
neuron projection development GO:0031175 273 0.014
regeneration GO:0031099 163 0.014
nucleoside metabolic process GO:0009116 179 0.014
ribonucleoside metabolic process GO:0009119 174 0.014
cell projection organization GO:0030030 302 0.014
nucleoside phosphate metabolic process GO:0006753 283 0.014
positive regulation of phosphate metabolic process GO:0045937 262 0.014
response to carbohydrate GO:0009743 183 0.014
regulation of protein phosphorylation GO:0001932 183 0.014
cell growth GO:0016049 104 0.014
axis specification GO:0009798 4 0.014
cation transport GO:0006812 382 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
regulation of secretion GO:0051046 224 0.014
response to radiation GO:0009314 137 0.014
cellular chemical homeostasis GO:0055082 247 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
lipid biosynthetic process GO:0008610 128 0.013
organic anion transport GO:0015711 132 0.013
negative regulation of cell communication GO:0010648 158 0.013
nucleoside monophosphate biosynthetic process GO:0009124 28 0.013
response to other organism GO:0051707 220 0.013
negative regulation of cell death GO:0060548 229 0.013
cytoplasmic transport GO:0016482 115 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
cell cell signaling GO:0007267 335 0.013
development of primary female sexual characteristics GO:0046545 56 0.013
synaptic transmission GO:0007268 235 0.013
protein maturation GO:0051604 68 0.013
regulation of intracellular signal transduction GO:1902531 218 0.013
positive regulation of cellular protein metabolic process GO:0032270 167 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
ion homeostasis GO:0050801 212 0.013
nucleic acid templated transcription GO:0097659 379 0.013
cellular response to cytokine stimulus GO:0071345 127 0.012
circulatory system process GO:0003013 183 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
regulation of cellular localization GO:0060341 263 0.012
cellular cation homeostasis GO:0030003 180 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
tissue development GO:0009888 252 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
regulation of nucleic acid templated transcription GO:1903506 380 0.012
regulation of response to stress GO:0080134 126 0.012
positive regulation of gene expression GO:0010628 244 0.012
anterior posterior pattern specification GO:0009952 1 0.012
secretion by cell GO:0032940 248 0.012
regulation of catalytic activity GO:0050790 304 0.012
cellular response to abiotic stimulus GO:0071214 85 0.012
single organism behavior GO:0044708 130 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
protein processing GO:0016485 68 0.012
eye morphogenesis GO:0048592 4 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
cellular response to hormone stimulus GO:0032870 247 0.012
purine ribonucleotide metabolic process GO:0009150 227 0.012
response to ethanol GO:0045471 162 0.012
neuron development GO:0048666 286 0.012
regulation of organelle organization GO:0033043 80 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
female gonad development GO:0008585 53 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
cellular ion homeostasis GO:0006873 184 0.012
immune system process GO:0002376 204 0.012
heart morphogenesis GO:0003007 3 0.012
enzyme linked receptor protein signaling pathway GO:0007167 116 0.012
response to glucocorticoid GO:0051384 223 0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
regulation of cell growth GO:0001558 85 0.011
purine ribonucleoside metabolic process GO:0046128 168 0.011
negative regulation of signaling GO:0023057 157 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
blood circulation GO:0008015 183 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
hepaticobiliary system development GO:0061008 90 0.011
development of primary sexual characteristics GO:0045137 107 0.011
regulation of ion transport GO:0043269 245 0.011
cytoskeleton organization GO:0007010 111 0.011
metal ion homeostasis GO:0055065 186 0.011
liver development GO:0001889 90 0.011
anion transport GO:0006820 178 0.011
embryonic pattern specification GO:0009880 1 0.011
cell cycle checkpoint GO:0000075 2 0.011
regulation of secretion by cell GO:1903530 208 0.011
female sex differentiation GO:0046660 59 0.011
cell morphogenesis involved in differentiation GO:0000904 119 0.011
neuron projection morphogenesis GO:0048812 122 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
cation transmembrane transport GO:0098655 263 0.011
positive regulation of protein metabolic process GO:0051247 178 0.011
protein transport GO:0015031 132 0.011
aging GO:0007568 241 0.011
metal ion transport GO:0030001 289 0.011
cation homeostasis GO:0055080 195 0.011
cell part morphogenesis GO:0032990 123 0.011
cognition GO:0050890 92 0.010
immune response GO:0006955 104 0.010
positive regulation of nucleic acid templated transcription GO:1903508 197 0.010
regulation of neurogenesis GO:0050767 247 0.010
regulation of nervous system development GO:0051960 264 0.010
response to wounding GO:0009611 254 0.010
ribonucleotide biosynthetic process GO:0009260 85 0.010
cellular component movement GO:0006928 248 0.010
cellular response to steroid hormone stimulus GO:0071383 93 0.010
positive regulation of protein phosphorylation GO:0001934 135 0.010
inflammatory response GO:0006954 150 0.010
developmental process involved in reproduction GO:0003006 159 0.010
cellular protein localization GO:0034613 122 0.010
purine nucleotide biosynthetic process GO:0006164 83 0.010
response to oxidative stress GO:0006979 186 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010

Mthfd1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.020
nervous system disease DOID:863 0 0.013
disease of anatomical entity DOID:7 0 0.013
inherited metabolic disorder DOID:655 0 0.012
sensory system disease DOID:0050155 0 0.011