Rattus norvegicus

66 known processes

Mthfr

methylenetetrahydrofolate reductase (NAD(P)H)

Mthfr biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of transcription dna templated GO:0006355 374 0.490
rna metabolic process GO:0016070 406 0.323
regulation of nucleic acid templated transcription GO:1903506 380 0.312
response to inorganic substance GO:0010035 377 0.203
head development GO:0060322 247 0.189
protein complex assembly GO:0006461 263 0.183
positive regulation of biosynthetic process GO:0009891 319 0.181
positive regulation of nucleic acid templated transcription GO:1903508 197 0.171
protein heterooligomerization GO:0051291 89 0.161
regulation of programmed cell death GO:0043067 341 0.160
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.159
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.158
nucleic acid templated transcription GO:0097659 379 0.143
carboxylic acid metabolic process GO:0019752 289 0.143
transcription dna templated GO:0006351 377 0.142
rna biosynthetic process GO:0032774 380 0.140
positive regulation of transcription dna templated GO:0045893 197 0.139
positive regulation of rna metabolic process GO:0051254 203 0.135
apoptotic process GO:0006915 381 0.133
central nervous system development GO:0007417 311 0.133
regulation of cellular amino acid metabolic process GO:0006521 2 0.125
positive regulation of gene expression GO:0010628 244 0.123
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.116
cellular amino acid metabolic process GO:0006520 107 0.110
developmental process involved in reproduction GO:0003006 159 0.110
regulation of rna biosynthetic process GO:2001141 381 0.103
macromolecular complex assembly GO:0065003 273 0.103
protein complex biogenesis GO:0070271 263 0.100
carbohydrate derivative metabolic process GO:1901135 346 0.095
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.094
immune system process GO:0002376 204 0.092
regulation of rna metabolic process GO:0051252 391 0.090
cellular component biogenesis GO:0044085 368 0.089
single organism biosynthetic process GO:0044711 342 0.089
regulation of apoptotic process GO:0042981 335 0.088
brain development GO:0007420 247 0.086
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.086
negative regulation of macromolecule metabolic process GO:0010605 260 0.086
positive regulation of rna biosynthetic process GO:1902680 197 0.085
positive regulation of neurogenesis GO:0050769 165 0.084
regulation of protein metabolic process GO:0051246 289 0.084
cellular component assembly GO:0022607 360 0.083
neuron projection development GO:0031175 273 0.082
transcription from rna polymerase ii promoter GO:0006366 252 0.079
positive regulation of cellular biosynthetic process GO:0031328 295 0.077
response to wounding GO:0009611 254 0.074
organophosphate metabolic process GO:0019637 370 0.073
macromolecular complex subunit organization GO:0043933 339 0.073
positive regulation of programmed cell death GO:0043068 157 0.073
organic acid metabolic process GO:0006082 292 0.071
digestive system development GO:0055123 41 0.070
oxoacid metabolic process GO:0043436 290 0.070
protein oligomerization GO:0051259 191 0.067
positive regulation of cell proliferation GO:0008284 249 0.067
anterior posterior pattern specification GO:0009952 1 0.063
reproductive process GO:0022414 372 0.058
nucleobase containing small molecule metabolic process GO:0055086 316 0.058
mesoderm development GO:0007498 2 0.058
amine metabolic process GO:0009308 38 0.058
cell projection morphogenesis GO:0048858 123 0.057
neuron differentiation GO:0030182 368 0.056
development of primary sexual characteristics GO:0045137 107 0.056
response to metal ion GO:0010038 253 0.054
axon development GO:0061564 96 0.054
single organism cellular localization GO:1902580 102 0.054
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.054
neuron development GO:0048666 286 0.053
negative regulation of metabolic process GO:0009892 331 0.053
peptidyl amino acid modification GO:0018193 126 0.053
organophosphate biosynthetic process GO:0090407 143 0.052
immune response GO:0006955 104 0.052
organonitrogen compound biosynthetic process GO:1901566 167 0.051
cellular response to stress GO:0033554 269 0.051
rhythmic process GO:0048511 156 0.050
regulation of neuron projection development GO:0010975 161 0.050
single organism reproductive process GO:0044702 297 0.049
programmed cell death GO:0012501 392 0.048
regulation of cellular ketone metabolic process GO:0010565 27 0.048
regulation of cell differentiation GO:0045595 320 0.048
positive regulation of cell death GO:0010942 184 0.047
secretion GO:0046903 307 0.047
cerebral cortex tangential migration GO:0021800 1 0.047
negative regulation of cellular biosynthetic process GO:0031327 161 0.046
reproduction GO:0000003 245 0.045
multicellular organism reproduction GO:0032504 233 0.045
negative regulation of biosynthetic process GO:0009890 168 0.045
homeostatic process GO:0042592 331 0.045
nucleotide metabolic process GO:0009117 279 0.045
cell projection organization GO:0030030 302 0.043
myelination GO:0042552 39 0.043
vesicle mediated transport GO:0016192 181 0.043
response to other organism GO:0051707 220 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.042
negative regulation of growth GO:0045926 37 0.042
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.042
carbohydrate derivative biosynthetic process GO:1901137 124 0.042
cell adhesion GO:0007155 110 0.041
female gonad development GO:0008585 53 0.041
positive regulation of developmental process GO:0051094 283 0.041
cellular response to oxygen containing compound GO:1901701 386 0.041
immune system development GO:0002520 41 0.041
cellular amine metabolic process GO:0044106 38 0.040
negative regulation of transcription dna templated GO:0045892 116 0.040
enzyme linked receptor protein signaling pathway GO:0007167 116 0.040
neuron projection morphogenesis GO:0048812 122 0.040
organelle organization GO:0006996 266 0.039
negative regulation of cellular metabolic process GO:0031324 281 0.039
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.039
multicellular organismal reproductive process GO:0048609 233 0.039
cytokine mediated signaling pathway GO:0019221 43 0.038
chemical homeostasis GO:0048878 292 0.038
coenzyme metabolic process GO:0006732 86 0.038
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.037
negative regulation of nucleic acid templated transcription GO:1903507 117 0.037
regulation of nervous system development GO:0051960 264 0.037
dendrite development GO:0016358 72 0.036
negative regulation of multicellular organismal process GO:0051241 203 0.036
female pregnancy GO:0007565 122 0.036
response to cytokine GO:0034097 215 0.036
protein phosphorylation GO:0006468 345 0.036
regulation of neuron differentiation GO:0045664 208 0.035
metal ion homeostasis GO:0055065 186 0.035
protein complex subunit organization GO:0071822 302 0.034
cellular ketone metabolic process GO:0042180 51 0.034
positive regulation of cell development GO:0010720 176 0.034
cellular macromolecule localization GO:0070727 122 0.034
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.034
peptidyl tyrosine phosphorylation GO:0018108 72 0.033
aging GO:0007568 241 0.032
positive regulation of neuron differentiation GO:0045666 126 0.032
cation transport GO:0006812 382 0.031
response to biotic stimulus GO:0009607 226 0.031
negative regulation of programmed cell death GO:0043069 183 0.031
organ morphogenesis GO:0009887 75 0.031
salivary gland development GO:0007431 3 0.031
regulation of phosphorus metabolic process GO:0051174 349 0.031
cellular response to nitrogen compound GO:1901699 210 0.031
negative regulation of gene expression GO:0010629 199 0.030
negative regulation of rna metabolic process GO:0051253 123 0.030
protein targeting GO:0006605 61 0.030
cell part morphogenesis GO:0032990 123 0.029
forebrain development GO:0030900 98 0.029
limbic system development GO:0021761 38 0.029
reproductive structure development GO:0048608 128 0.029
regulation of cellular response to stress GO:0080135 49 0.029
regulation of cellular localization GO:0060341 263 0.028
regulation of molecular function GO:0065009 398 0.028
g protein coupled receptor signaling pathway GO:0007186 242 0.028
sex differentiation GO:0007548 113 0.028
regulation of neuron death GO:1901214 115 0.028
purine nucleotide metabolic process GO:0006163 229 0.028
regulation of cellular protein metabolic process GO:0032268 267 0.027
cellular response to organic cyclic compound GO:0071407 202 0.027
regulation of cell development GO:0060284 263 0.027
biological adhesion GO:0022610 110 0.027
neural crest cell migration GO:0001755 1 0.027
regulation of phosphorylation GO:0042325 248 0.027
endocytosis GO:0006897 84 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
ribonucleotide metabolic process GO:0009259 231 0.026
regulation of protein modification process GO:0031399 194 0.026
protein autophosphorylation GO:0046777 66 0.026
cellular protein localization GO:0034613 122 0.026
circulatory system development GO:0072359 134 0.025
negative regulation of developmental process GO:0051093 125 0.025
negative regulation of cell communication GO:0010648 158 0.025
negative regulation of neuron differentiation GO:0045665 62 0.025
positive regulation of cellular amine metabolic process GO:0033240 3 0.025
hemopoiesis GO:0030097 34 0.025
neuronal action potential GO:0019228 35 0.025
purine nucleoside metabolic process GO:0042278 169 0.025
single organism carbohydrate metabolic process GO:0044723 118 0.025
positive regulation of nervous system development GO:0051962 178 0.025
regulation of fat cell differentiation GO:0045598 3 0.024
cellular response to cytokine stimulus GO:0071345 127 0.024
intracellular signal transduction GO:0035556 314 0.024
positive regulation of apoptotic process GO:0043065 154 0.024
fatty acid biosynthetic process GO:0006633 33 0.024
hematopoietic or lymphoid organ development GO:0048534 36 0.024
cell cycle GO:0007049 101 0.024
axon ensheathment GO:0008366 40 0.024
purine nucleotide biosynthetic process GO:0006164 83 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
regulation of secretion GO:0051046 224 0.023
protein localization to organelle GO:0033365 57 0.023
multi organism reproductive process GO:0044703 262 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.023
cellular metal ion homeostasis GO:0006875 172 0.023
regulation of response to stress GO:0080134 126 0.023
regulation of neurogenesis GO:0050767 247 0.023
positive regulation of multicellular organismal process GO:0051240 387 0.022
regulation of immune system process GO:0002682 123 0.022
regulation of cellular amine metabolic process GO:0033238 8 0.022
development of primary female sexual characteristics GO:0046545 56 0.022
ribonucleotide biosynthetic process GO:0009260 85 0.022
small molecule biosynthetic process GO:0044283 124 0.022
neuron death GO:0070997 127 0.022
negative regulation of cell differentiation GO:0045596 99 0.022
multicellular organism growth GO:0035264 1 0.021
cellular ion homeostasis GO:0006873 184 0.021
regulation of signal transduction GO:0009966 318 0.021
regulation of protein phosphorylation GO:0001932 183 0.021
negative regulation of muscle cell apoptotic process GO:0010656 21 0.021
peptidyl tyrosine modification GO:0018212 72 0.021
positive regulation of phosphate metabolic process GO:0045937 262 0.021
transmission of nerve impulse GO:0019226 42 0.021
phototransduction visible light GO:0007603 2 0.020
behavioral response to nicotine GO:0035095 2 0.020
parasympathetic nervous system development GO:0048486 1 0.020
leukocyte activation GO:0045321 76 0.020
hematopoietic progenitor cell differentiation GO:0002244 2 0.020
tissue development GO:0009888 252 0.020
defense response GO:0006952 194 0.020
embryonic pattern specification GO:0009880 1 0.020
positive regulation of immune system process GO:0002684 90 0.020
negative regulation of rna biosynthetic process GO:1902679 118 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
response to estradiol GO:0032355 164 0.020
positive regulation of protein metabolic process GO:0051247 178 0.019
dendrite morphogenesis GO:0048813 43 0.019
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.019
female sex differentiation GO:0046660 59 0.019
response to molecule of bacterial origin GO:0002237 194 0.019
response to ketone GO:1901654 182 0.019
nuclear transport GO:0051169 49 0.019
regulation of catalytic activity GO:0050790 304 0.019
response to hydrogen peroxide GO:0042542 89 0.019
regulation of phosphate metabolic process GO:0019220 349 0.019
response to oxidative stress GO:0006979 186 0.019
transmembrane transport GO:0055085 412 0.019
cell morphogenesis GO:0000902 142 0.018
response to decreased oxygen levels GO:0036293 237 0.018
glial cell differentiation GO:0010001 65 0.018
positive regulation of protein phosphorylation GO:0001934 135 0.018
gland development GO:0048732 155 0.018
cofactor metabolic process GO:0051186 95 0.018
regulation of multicellular organismal development GO:2000026 376 0.018
gastrulation GO:0007369 2 0.018
reactive oxygen species metabolic process GO:0072593 37 0.018
neural crest cell development GO:0014032 2 0.017
regulation of sequence specific dna binding transcription factor activity GO:0051090 35 0.017
sensory organ development GO:0007423 74 0.017
gonad development GO:0008406 104 0.017
negative regulation of cell proliferation GO:0008285 119 0.017
cyclic purine nucleotide metabolic process GO:0052652 62 0.017
mesoderm morphogenesis GO:0048332 1 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
action potential GO:0001508 54 0.017
negative regulation of organ growth GO:0046621 3 0.017
reproductive system development GO:0061458 128 0.017
purine containing compound metabolic process GO:0072521 253 0.017
gliogenesis GO:0042063 93 0.017
cytoplasmic transport GO:0016482 115 0.017
ovulation cycle GO:0042698 67 0.017
detection of visible light GO:0009584 3 0.017
negative regulation of tyrosine phosphorylation of stat5 protein GO:0042524 1 0.017
mechanoreceptor differentiation GO:0042490 2 0.017
multicellular organismal signaling GO:0035637 44 0.017
establishment of protein localization GO:0045184 141 0.017
carbohydrate metabolic process GO:0005975 130 0.017
negative regulation of collagen biosynthetic process GO:0032966 4 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
response to bacterium GO:0009617 200 0.017
positive regulation of secretion GO:0051047 140 0.017
nitrogen compound transport GO:0071705 229 0.016
cellular component morphogenesis GO:0032989 155 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
regulation of dendrite development GO:0050773 59 0.016
macromolecule localization GO:0033036 252 0.016
response to external biotic stimulus GO:0043207 221 0.016
lipid metabolic process GO:0006629 283 0.016
peptide transport GO:0015833 97 0.016
response to ethanol GO:0045471 162 0.016
organelle localization GO:0051640 55 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
single organism intracellular transport GO:1902582 166 0.016
ras protein signal transduction GO:0007265 29 0.016
regulation of cell proliferation GO:0042127 359 0.016
digestive tract development GO:0048565 39 0.016
negative regulation of cell death GO:0060548 229 0.016
leukocyte differentiation GO:0002521 30 0.015
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.015
ion transmembrane transport GO:0034220 365 0.015
behavior GO:0007610 205 0.015
cellular response to organonitrogen compound GO:0071417 197 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
pancreatic stellate cell proliferation GO:0072343 2 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
bmp signaling pathway GO:0030509 4 0.015
jak stat cascade GO:0007259 26 0.015
axonogenesis GO:0007409 71 0.015
positive regulation of signal transduction GO:0009967 175 0.015
regulation of stress activated protein kinase signaling cascade GO:0070302 23 0.015
response to estrogen GO:0043627 232 0.015
regulation of purine nucleotide metabolic process GO:1900542 115 0.015
response to peptide hormone GO:0043434 278 0.015
potassium ion transport GO:0006813 97 0.015
oxidation reduction process GO:0055114 304 0.015
response to growth factor GO:0070848 189 0.015
cellular cation homeostasis GO:0030003 180 0.015
lipid biosynthetic process GO:0008610 128 0.014
maintenance of location GO:0051235 17 0.014
morphogenesis of embryonic epithelium GO:0016331 3 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
mesoderm formation GO:0001707 1 0.014
regulation of intracellular signal transduction GO:1902531 218 0.014
cellular homeostasis GO:0019725 252 0.014
cellular response to vitamin e GO:0071306 3 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.014
regulation of system process GO:0044057 208 0.014
cell activation GO:0001775 97 0.014
synaptic transmission GO:0007268 235 0.014
lymphoid progenitor cell differentiation GO:0002320 2 0.014
positive regulation of response to stimulus GO:0048584 285 0.014
cellular chemical homeostasis GO:0055082 247 0.014
neural crest cell differentiation GO:0014033 2 0.014
positive regulation of signaling GO:0023056 270 0.014
cell morphogenesis involved in differentiation GO:0000904 119 0.014
reactive nitrogen species metabolic process GO:2001057 1 0.014
regulation of reactive oxygen species metabolic process GO:2000377 26 0.014
response to glucose GO:0009749 136 0.014
purine ribonucleotide biosynthetic process GO:0009152 81 0.013
positive regulation of camp biosynthetic process GO:0030819 28 0.013
cyclic nucleotide biosynthetic process GO:0009190 63 0.013
response to hexose GO:0009746 144 0.013
sympathetic nervous system development GO:0048485 1 0.013
neurological system process GO:0050877 219 0.013
amide transport GO:0042886 105 0.013
protein localization to nucleus GO:0034504 39 0.013
nucleotide biosynthetic process GO:0009165 98 0.013
tube formation GO:0035148 3 0.013
potassium ion transmembrane transport GO:0071805 71 0.013
monocarboxylic acid metabolic process GO:0032787 152 0.013
multi multicellular organism process GO:0044706 138 0.013
regulation of stress activated mapk cascade GO:0032872 23 0.013
negative regulation of molecular function GO:0044092 133 0.013
negative regulation of neurogenesis GO:0050768 78 0.013
response to retinoic acid GO:0032526 63 0.013
cell fate determination GO:0001709 2 0.013
dna metabolic process GO:0006259 96 0.013
hexose metabolic process GO:0019318 58 0.013
anion transport GO:0006820 178 0.013
establishment of protein localization to organelle GO:0072594 44 0.012
tube development GO:0035295 89 0.012
regulation of growth GO:0040008 105 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
membrane organization GO:0061024 94 0.012
regulation of embryonic development GO:0045995 2 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.012
response to carbohydrate GO:0009743 183 0.012
mrna transcription GO:0009299 2 0.012
regulation of blood pressure GO:0008217 83 0.012
immune effector process GO:0002252 53 0.012
nucleocytoplasmic transport GO:0006913 48 0.012
cell growth GO:0016049 104 0.012
autonomic nervous system development GO:0048483 3 0.012
chordate embryonic development GO:0043009 18 0.012
endocrine system development GO:0035270 30 0.012
intracellular receptor signaling pathway GO:0030522 35 0.012
single organism catabolic process GO:0044712 283 0.012
embryo development GO:0009790 49 0.012
ovulation cycle process GO:0022602 50 0.012
embryonic skeletal system development GO:0048706 3 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
ensheathment of neurons GO:0007272 40 0.012
camp metabolic process GO:0046058 63 0.012
vitamin d receptor signaling pathway GO:0070561 1 0.012
generation of precursor metabolites and energy GO:0006091 62 0.012
formation of primary germ layer GO:0001704 1 0.012
positive regulation of receptor activity GO:2000273 4 0.012
chemosensory behavior GO:0007635 2 0.012
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
response to transition metal nanoparticle GO:1990267 122 0.011
regulation of intracellular transport GO:0032386 65 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
ribose phosphate biosynthetic process GO:0046390 87 0.011
vasculogenesis GO:0001570 3 0.011
response to hypoxia GO:0001666 231 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
regulation of skeletal muscle tissue regeneration GO:0043416 2 0.011
response to lipopolysaccharide GO:0032496 191 0.011
regulation of secretion by cell GO:1903530 208 0.011
positive regulation of cell communication GO:0010647 271 0.011
forebrain neuron development GO:0021884 3 0.011
development of primary male sexual characteristics GO:0046546 59 0.011
response to toxic substance GO:0009636 133 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
positive regulation of camp metabolic process GO:0030816 31 0.011
response to camp GO:0051591 91 0.011
regulation of protein localization GO:0032880 81 0.011
hair cell differentiation GO:0035315 2 0.011
cellular potassium ion transport GO:0071804 72 0.011
chromosome segregation GO:0007059 2 0.011
protein import into nucleus GO:0006606 35 0.011
b cell differentiation GO:0030183 2 0.011
negative regulation of transport GO:0051051 136 0.011
energy derivation by oxidation of organic compounds GO:0015980 46 0.011
temperature homeostasis GO:0001659 17 0.011
cyclic nucleotide metabolic process GO:0009187 80 0.011
single organism organelle organization GO:1902589 180 0.011
epithelium development GO:0060429 96 0.011
lipid storage GO:0019915 1 0.011
regulation of catabolic process GO:0009894 113 0.010
preganglionic parasympathetic nervous system development GO:0021783 1 0.010
myeloid cell differentiation GO:0030099 22 0.010
negative regulation of cellular amine metabolic process GO:0033239 3 0.010
nucleoside phosphate metabolic process GO:0006753 283 0.010
negative regulation of phosphorus metabolic process GO:0010563 80 0.010
thyroid gland development GO:0030878 1 0.010
negative regulation of protein metabolic process GO:0051248 114 0.010
digestive tract morphogenesis GO:0048546 8 0.010
positive regulation of catalytic activity GO:0043085 184 0.010
positive regulation of protein modification process GO:0031401 142 0.010
response to reactive oxygen species GO:0000302 120 0.010
glycosyl compound catabolic process GO:1901658 126 0.010
protein homooligomerization GO:0051260 91 0.010
embryonic neurocranium morphogenesis GO:0048702 2 0.010
negative regulation of cardiac muscle tissue development GO:0055026 3 0.010

Mthfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.052
disease of anatomical entity DOID:7 0 0.052
disease of metabolism DOID:0014667 0 0.036
disease of cellular proliferation DOID:14566 0 0.033
sensory system disease DOID:0050155 0 0.029
cancer DOID:162 0 0.019
organ system cancer DOID:0050686 0 0.019
eye and adnexa disease DOID:1492 0 0.018
eye disease DOID:5614 0 0.018
inherited metabolic disorder DOID:655 0 0.016
type 2 diabetes mellitus DOID:9352 0 0.013
acquired metabolic disease DOID:0060158 0 0.013
diabetes mellitus DOID:9351 0 0.013
carbohydrate metabolism disease DOID:0050013 0 0.013
glucose metabolism disease DOID:4194 0 0.013
central nervous system disease DOID:331 0 0.012
retinal degeneration DOID:8466 0 0.010
retinal disease DOID:5679 0 0.010