Rattus norvegicus

8 known processes

Mx1

myxovirus (influenza virus) resistance 1

(Aliases: IFI78)

Mx1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of viral genome replication GO:0045071 1 0.725
Human
response to cytokine GO:0034097 215 0.573
immune response GO:0006955 104 0.491
response to external biotic stimulus GO:0043207 221 0.485
response to biotic stimulus GO:0009607 226 0.404
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.343
response to other organism GO:0051707 220 0.342
cellular response to cytokine stimulus GO:0071345 127 0.340
nucleotide metabolic process GO:0009117 279 0.294
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.242
jak stat cascade GO:0007259 26 0.235
negative regulation of jak stat cascade GO:0046426 3 0.204
nucleoside phosphate metabolic process GO:0006753 283 0.199
cellular response to peptide hormone stimulus GO:0071375 120 0.193
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.165
cellular amino acid metabolic process GO:0006520 107 0.159
positive regulation of multicellular organismal process GO:0051240 387 0.158
organonitrogen compound biosynthetic process GO:1901566 167 0.151
immune system process GO:0002376 204 0.139
mammary gland involution GO:0060056 5 0.138
cellular response to oxygen containing compound GO:1901701 386 0.134
cellular response to hormone stimulus GO:0032870 247 0.134
cellular ketone metabolic process GO:0042180 51 0.134
rhythmic process GO:0048511 156 0.132
regulation of cellular amino acid metabolic process GO:0006521 2 0.122
organophosphate metabolic process GO:0019637 370 0.116
carboxylic acid metabolic process GO:0019752 289 0.115
regulation of jak stat cascade GO:0046425 21 0.105
cellular response to endogenous stimulus GO:0071495 377 0.103
reproductive process GO:0022414 372 0.095
amine metabolic process GO:0009308 38 0.095
nucleoside phosphate biosynthetic process GO:1901293 102 0.086
positive regulation of t cell migration GO:2000406 1 0.084
response to virus GO:0009615 17 0.084
regulation of tolerance induction to nonself antigen GO:0002655 1 0.084
regulation of cell proliferation GO:0042127 359 0.081
purine containing compound metabolic process GO:0072521 253 0.081
intracellular signal transduction GO:0035556 314 0.081
regulation of satellite cell proliferation GO:0014842 1 0.081
regulation of purine nucleotide metabolic process GO:1900542 115 0.080
nucleotide biosynthetic process GO:0009165 98 0.080
purine containing compound biosynthetic process GO:0072522 85 0.080
metal ion transport GO:0030001 289 0.079
negative regulation of protein metabolic process GO:0051248 114 0.078
cellular response to nitrogen compound GO:1901699 210 0.077
response to nutrient GO:0007584 248 0.076
cellular response to peptide GO:1901653 133 0.076
nucleobase containing small molecule metabolic process GO:0055086 316 0.072
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.071
antigen processing and presentation of endogenous antigen GO:0019883 1 0.071
response to extracellular stimulus GO:0009991 380 0.068
positive regulation of cellular biosynthetic process GO:0031328 295 0.067
t cell tolerance induction GO:0002517 3 0.067
purine nucleotide biosynthetic process GO:0006164 83 0.066
regulation of rna metabolic process GO:0051252 391 0.065
regulation of phosphorus metabolic process GO:0051174 349 0.064
transcription dna templated GO:0006351 377 0.063
ovulation cycle GO:0042698 67 0.062
negative regulation of viral process GO:0048525 4 0.062
Human
negative regulation of kidney development GO:0090185 2 0.060
negative regulation of response to stimulus GO:0048585 155 0.059
tolerance induction to nonself antigen GO:0002462 2 0.059
purine nucleotide metabolic process GO:0006163 229 0.057
neuron differentiation GO:0030182 368 0.056
neuron development GO:0048666 286 0.056
defense response GO:0006952 194 0.055
regulation of t cell migration GO:2000404 1 0.055
regulation of cellular amine metabolic process GO:0033238 8 0.054
regulation of phosphate metabolic process GO:0019220 349 0.054
metal ion homeostasis GO:0055065 186 0.053
rna metabolic process GO:0016070 406 0.053
response to peptide GO:1901652 292 0.053
regulation of protein phosphorylation GO:0001932 183 0.051
response to mechanical stimulus GO:0009612 134 0.051
multi organism reproductive process GO:0044703 262 0.051
protein phosphorylation GO:0006468 345 0.050
macromolecular complex assembly GO:0065003 273 0.049
gonad development GO:0008406 104 0.049
positive regulation of tolerance induction GO:0002645 1 0.049
development of primary sexual characteristics GO:0045137 107 0.049
ribose phosphate metabolic process GO:0019693 235 0.048
neuron projection development GO:0031175 273 0.048
regulation of cell development GO:0060284 263 0.048
g protein coupled receptor signaling pathway GO:0007186 242 0.047
response to wounding GO:0009611 254 0.047
response to exogenous dsrna GO:0043330 3 0.047
Zebrafish
organophosphate biosynthetic process GO:0090407 143 0.047
central nervous system development GO:0007417 311 0.047
regulation of programmed cell death GO:0043067 341 0.046
cellular response to organonitrogen compound GO:0071417 197 0.043
response to interleukin 1 GO:0070555 55 0.043
negative regulation of phosphorus metabolic process GO:0010563 80 0.041
regulation of sequestering of calcium ion GO:0051282 26 0.040
response to vitamin GO:0033273 131 0.040
single organism biosynthetic process GO:0044711 342 0.040
innate immune response GO:0045087 35 0.039
multicellular organism reproduction GO:0032504 233 0.039
cellular response to external stimulus GO:0071496 118 0.039
regulation of camp metabolic process GO:0030814 43 0.039
negative regulation of cellular metabolic process GO:0031324 281 0.039
regulation of cellular protein metabolic process GO:0032268 267 0.037
cellular response to stress GO:0033554 269 0.037
positive regulation of response to stimulus GO:0048584 285 0.037
positive regulation of tolerance induction to nonself antigen GO:0002657 1 0.037
amide biosynthetic process GO:0043604 10 0.037
positive regulation of lymphocyte migration GO:2000403 1 0.036
brain development GO:0007420 247 0.036
oxoacid metabolic process GO:0043436 290 0.036
response to growth factor GO:0070848 189 0.036
response to oxygen levels GO:0070482 265 0.036
positive regulation of biosynthetic process GO:0009891 319 0.035
ion homeostasis GO:0050801 212 0.034
negative regulation of innate immune response GO:0045824 4 0.034
regulation of immune system process GO:0002682 123 0.034
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.034
aging GO:0007568 241 0.034
protein complex subunit organization GO:0071822 302 0.034
positive regulation of phosphate metabolic process GO:0045937 262 0.034
response to peptide hormone GO:0043434 278 0.033
regulation of phosphorylation GO:0042325 248 0.033
regulation of lymphocyte migration GO:2000401 1 0.033
regulation of immune response GO:0050776 55 0.033
blood vessel morphogenesis GO:0048514 58 0.032
cellular response to organic cyclic compound GO:0071407 202 0.032
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003340 2 0.032
acute phase response GO:0006953 20 0.032
response to dsrna GO:0043331 9 0.031
Zebrafish
positive regulation of cell proliferation GO:0008284 249 0.031
regulation of protein metabolic process GO:0051246 289 0.031
tolerance induction dependent upon immune response GO:0002461 2 0.031
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.030
negative regulation of protein phosphorylation GO:0001933 44 0.030
defense response to other organism GO:0098542 17 0.029
reproduction GO:0000003 245 0.029
cellular amine metabolic process GO:0044106 38 0.029
macromolecule localization GO:0033036 252 0.029
carbohydrate metabolic process GO:0005975 130 0.029
leukocyte mediated immunity GO:0002443 28 0.028
negative regulation of signaling GO:0023057 157 0.028
cellular component biogenesis GO:0044085 368 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.027
protein oligomerization GO:0051259 191 0.027
positive regulation of rna biosynthetic process GO:1902680 197 0.027
regulation of signal transduction GO:0009966 318 0.027
response to nutrient levels GO:0031667 370 0.027
female pregnancy GO:0007565 122 0.026
positive regulation of cellular amine metabolic process GO:0033240 3 0.026
positive regulation of nucleotide metabolic process GO:0045981 91 0.026
positive regulation of phosphorus metabolic process GO:0010562 262 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.026
regulation of protein modification process GO:0031399 194 0.026
circulatory system process GO:0003013 183 0.025
regulation of rna biosynthetic process GO:2001141 381 0.025
cellular response to nutrient levels GO:0031669 60 0.025
leukocyte migration GO:0050900 38 0.025
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.025
gland development GO:0048732 155 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.024
cation homeostasis GO:0055080 195 0.024
cytokine production GO:0001816 61 0.024
divalent inorganic cation transport GO:0072511 134 0.024
response to ethanol GO:0045471 162 0.024
positive regulation of camp mediated signaling GO:0043950 2 0.024
negative regulation of cell death GO:0060548 229 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
monosaccharide metabolic process GO:0005996 61 0.023
response to retinoic acid GO:0032526 63 0.023
regulation of viral genome replication GO:0045069 2 0.023
Human
camp metabolic process GO:0046058 63 0.023
cyclic nucleotide metabolic process GO:0009187 80 0.023
metanephric nephron tubule epithelial cell differentiation GO:0072257 1 0.023
cellular response to iron ion starvation GO:0010106 1 0.023
positive regulation of rna metabolic process GO:0051254 203 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
positive regulation of programmed cell death GO:0043068 157 0.022
response to organophosphorus GO:0046683 102 0.022
sodium ion transport GO:0006814 82 0.022
negative regulation of cell communication GO:0010648 158 0.022
cell cell signaling GO:0007267 335 0.022
cellular response to lipid GO:0071396 201 0.022
positive regulation of camp metabolic process GO:0030816 31 0.021
regulation of homeostatic process GO:0032844 101 0.021
monovalent inorganic cation transport GO:0015672 172 0.021
cell killing GO:0001906 13 0.021
rna biosynthetic process GO:0032774 380 0.021
multi multicellular organism process GO:0044706 138 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
immune effector process GO:0002252 53 0.021
calcium ion transport GO:0006816 131 0.020
regeneration GO:0031099 163 0.020
positive regulation of protein modification process GO:0031401 142 0.020
acute inflammatory response GO:0002526 58 0.020
chemical homeostasis GO:0048878 292 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
glucose metabolic process GO:0006006 52 0.020
single organism carbohydrate metabolic process GO:0044723 118 0.019
negative regulation of hydrogen peroxide metabolic process GO:0010727 2 0.019
peptidyl amino acid modification GO:0018193 126 0.019
defense response to gram positive bacterium GO:0050830 2 0.019
regulation of nucleotide metabolic process GO:0006140 117 0.019
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.019
regulation of nervous system development GO:0051960 264 0.019
cellular component assembly GO:0022607 360 0.018
cellular response to molecule of bacterial origin GO:0071219 56 0.018
response to acid chemical GO:0001101 222 0.018
response to estradiol GO:0032355 164 0.018
negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308 1 0.018
ribonucleotide metabolic process GO:0009259 231 0.018
regulation of cellular component movement GO:0051270 150 0.018
positive regulation of immune response GO:0050778 42 0.018
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
hexose metabolic process GO:0019318 58 0.017
intracellular transport GO:0046907 185 0.017
positive regulation of immune system process GO:0002684 90 0.017
regulation of nucleic acid templated transcription GO:1903506 380 0.017
positive regulation of gene expression GO:0010628 244 0.017
defense response to virus GO:0051607 9 0.017
response to bacterium GO:0009617 200 0.017
organic acid metabolic process GO:0006082 292 0.017
macromolecular complex subunit organization GO:0043933 339 0.017
cell projection organization GO:0030030 302 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.017
regulation of hormone levels GO:0010817 187 0.016
response to camp GO:0051591 91 0.016
negative regulation of signal transduction GO:0009968 83 0.016
negative regulation of programmed cell death GO:0043069 183 0.016
purine ribonucleotide metabolic process GO:0009150 227 0.016
hindlimb morphogenesis GO:0035137 2 0.016
sex differentiation GO:0007548 113 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
positive regulation of leukocyte mediated immunity GO:0002705 13 0.016
response to corticosteroid GO:0031960 235 0.016
response to estrogen GO:0043627 232 0.016
positive regulation of cell communication GO:0010647 271 0.016
ossification GO:0001503 70 0.016
regulation of transcription dna templated GO:0006355 374 0.016
positive regulation of cytokine production GO:0001819 42 0.016
response to ketone GO:1901654 182 0.016
regulation of kinase activity GO:0043549 117 0.016
positive regulation of transcription dna templated GO:0045893 197 0.015
positive regulation of smooth muscle cell proliferation GO:0048661 51 0.015
sequestering of calcium ion GO:0051208 8 0.015
positive regulation of i kappab kinase nf kappab signaling GO:0043123 8 0.015
regulation of molecular function GO:0065009 398 0.015
liver development GO:0001889 90 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
cation transport GO:0006812 382 0.015
regulation of adaptive immune response GO:0002819 8 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.015
anatomical structure morphogenesis GO:0009653 298 0.015
t cell chemotaxis GO:0010818 2 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
homeostatic process GO:0042592 331 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.015
protein complex biogenesis GO:0070271 263 0.014
maintenance of location GO:0051235 17 0.014
regulation of ion homeostasis GO:2000021 63 0.014
response to starvation GO:0042594 59 0.014
positive regulation of molecular function GO:0044093 230 0.014
response to temperature stimulus GO:0009266 94 0.014
lysosome localization GO:0032418 10 0.014
response to interferon alpha GO:0035455 1 0.014
secretion GO:0046903 307 0.014
regulation of sodium ion transport GO:0002028 21 0.014
sequestering of metal ion GO:0051238 9 0.014
organ morphogenesis GO:0009887 75 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
epithelium development GO:0060429 96 0.014
positive regulation of phosphorylation GO:0042327 177 0.014
regulation of cell differentiation GO:0045595 320 0.014
metanephric tubule development GO:0072170 4 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
cellular response to starvation GO:0009267 27 0.013
response to lipopolysaccharide GO:0032496 191 0.013
regulation of response to stress GO:0080134 126 0.013
cellular response to interleukin 1 GO:0071347 37 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
protein complex assembly GO:0006461 263 0.013
cellular response to tumor necrosis factor GO:0071356 46 0.013
lymphocyte chemotaxis GO:0048247 3 0.013
regulation of apoptotic process GO:0042981 335 0.013
response to ammonium ion GO:0060359 71 0.013
response to toxic substance GO:0009636 133 0.013
metanephric renal vesicle morphogenesis GO:0072283 3 0.013
response to hypoxia GO:0001666 231 0.013
mesenchymal cell differentiation involved in renal system development GO:2001012 1 0.013
ribonucleotide biosynthetic process GO:0009260 85 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
regulation of hydrolase activity GO:0051336 143 0.013
female sex differentiation GO:0046660 59 0.013
negative regulation of metabolic process GO:0009892 331 0.013
head development GO:0060322 247 0.013
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.013
striated muscle tissue development GO:0014706 58 0.013
regulation of smooth muscle cell migration GO:0014910 36 0.013
synaptic transmission GO:0007268 235 0.013
viral genome replication GO:0019079 2 0.013
Human
cytoplasmic transport GO:0016482 115 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
regulation of neurogenesis GO:0050767 247 0.013
positive regulation of cellular component movement GO:0051272 102 0.012
response to decreased oxygen levels GO:0036293 237 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
cellular ion homeostasis GO:0006873 184 0.012
ovulation cycle process GO:0022602 50 0.012
prostate gland epithelium morphogenesis GO:0060740 2 0.012
single organism reproductive process GO:0044702 297 0.012
wound healing GO:0042060 122 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.012
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.012
negative regulation of tyrosine phosphorylation of stat1 protein GO:0042512 1 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
calcium ion transport into cytosol GO:0060402 38 0.012
developmental process involved in reproduction GO:0003006 159 0.012
regulation of membrane potential GO:0042391 110 0.012
positive regulation of cell death GO:0010942 184 0.012
negative regulation of multicellular organismal process GO:0051241 203 0.012
negative regulation of chemotaxis GO:0050922 5 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.011
regulation of metanephros development GO:0072215 4 0.011
blood circulation GO:0008015 183 0.011
regulation of multicellular organismal development GO:2000026 376 0.011
positive regulation of signal transduction GO:0009967 175 0.011
negative regulation of catalytic activity GO:0043086 103 0.011
cellular response to extracellular stimulus GO:0031668 73 0.011
single organism intracellular transport GO:1902582 166 0.011
deoxyribonucleoside diphosphate metabolic process GO:0009186 4 0.011
learning or memory GO:0007611 90 0.011
negative regulation of protein modification process GO:0031400 52 0.011
positive regulation of cell development GO:0010720 176 0.011
programmed cell death GO:0012501 392 0.011
response to electrical stimulus GO:0051602 56 0.011
peptidyl tyrosine modification GO:0018212 72 0.011
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.010
cellular response to reactive oxygen species GO:0034614 55 0.010
sexual reproduction GO:0019953 148 0.010
ion transmembrane transport GO:0034220 365 0.010
renal system development GO:0072001 67 0.010
negative regulation of phosphorylation GO:0042326 57 0.010
embryonic limb morphogenesis GO:0030326 4 0.010
regulation of tolerance induction GO:0002643 2 0.010
cellular response to acid chemical GO:0071229 75 0.010
triglyceride homeostasis GO:0070328 2 0.010

Mx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
urinary system disease DOID:18 0 0.040
carbohydrate metabolism disease DOID:0050013 0 0.029
glucose metabolism disease DOID:4194 0 0.029
disease of metabolism DOID:0014667 0 0.029
type 1 diabetes mellitus DOID:9744 0 0.029
acquired metabolic disease DOID:0060158 0 0.029
diabetes mellitus DOID:9351 0 0.029