Rattus norvegicus

13 known processes

Myl2

myosin, light polypeptide 2, regulatory, cardiac, slow

(Aliases: Mlc2)

Myl2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cardiac muscle tissue morphogenesis GO:0055008 1 0.927
muscle organ morphogenesis GO:0048644 1 0.771
cardiac myofibril assembly GO:0055003 1 0.698
muscle tissue morphogenesis GO:0060415 1 0.558
twitch skeletal muscle contraction GO:0014721 3 0.477
heart morphogenesis GO:0003007 3 0.460
cardiac muscle contraction GO:0060048 27 0.379
sarcoplasmic reticulum calcium ion transport GO:0070296 8 0.379
striated muscle contraction GO:0006941 44 0.335
actin mediated cell contraction GO:0070252 12 0.334
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.329
actin myosin filament sliding GO:0033275 2 0.299
cellular response to endogenous stimulus GO:0071495 377 0.281
regulation of system process GO:0044057 208 0.281
regulation of muscle system process GO:0090257 79 0.259
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.244
myosin filament assembly GO:0031034 1 0.226
actin filament based movement GO:0030048 16 0.224
heart development GO:0007507 72 0.220
cardiac ventricle development GO:0003231 1 0.215
anatomical structure formation involved in morphogenesis GO:0048646 83 0.215
negative regulation of molecular function GO:0044092 133 0.211
cardiac chamber development GO:0003205 1 0.206
cardiac muscle cell development GO:0055013 16 0.196
regulation of molecular function GO:0065009 398 0.187
response to wounding GO:0009611 254 0.179
anatomical structure morphogenesis GO:0009653 298 0.171
striated muscle tissue development GO:0014706 58 0.159
musculoskeletal movement GO:0050881 17 0.157
muscle structure development GO:0061061 87 0.155
actin filament based process GO:0030029 86 0.152
response to inorganic substance GO:0010035 377 0.146
regulation of muscle contraction GO:0006937 53 0.145
multicellular organismal movement GO:0050879 17 0.142
regulation of nucleic acid templated transcription GO:1903506 380 0.141
muscle cell development GO:0055001 26 0.140
circulatory system process GO:0003013 183 0.139
nucleic acid templated transcription GO:0097659 379 0.136
cardiovascular system development GO:0072358 134 0.134
negative regulation of metabolic process GO:0009892 331 0.129
tissue development GO:0009888 252 0.126
response to heat GO:0009408 60 0.126
positive regulation of transport GO:0051050 245 0.121
sarcomere organization GO:0045214 6 0.120
regeneration GO:0031099 163 0.115
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.109
regulation of striated muscle contraction GO:0006942 21 0.108
positive regulation of developmental process GO:0051094 283 0.106
cellular response to oxygen containing compound GO:1901701 386 0.099
circulatory system development GO:0072359 134 0.099
homeostatic process GO:0042592 331 0.098
cellular response to organic cyclic compound GO:0071407 202 0.094
muscle contraction GO:0006936 88 0.091
cytoskeleton organization GO:0007010 111 0.088
muscle organ development GO:0007517 50 0.087
developmental induction GO:0031128 2 0.086
negative regulation of cell death GO:0060548 229 0.086
calcium ion import GO:0070509 22 0.085
actin cytoskeleton organization GO:0030036 73 0.085
muscle system process GO:0003012 115 0.084
organelle organization GO:0006996 266 0.084
heart contraction GO:0060047 57 0.083
negative regulation of apoptotic process GO:0043066 181 0.082
protein complex biogenesis GO:0070271 263 0.082
chemical homeostasis GO:0048878 292 0.081
cardiac muscle tissue development GO:0048738 26 0.080
cation transport GO:0006812 382 0.078
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.075
metal ion transport GO:0030001 289 0.074
muscle tissue development GO:0060537 58 0.073
myosin filament organization GO:0031033 2 0.073
voluntary skeletal muscle contraction GO:0003010 3 0.072
response to growth factor GO:0070848 189 0.071
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.071
regulation of programmed cell death GO:0043067 341 0.070
striated muscle cell development GO:0055002 26 0.068
regulation of actin filament based movement GO:1903115 12 0.065
carbohydrate derivative metabolic process GO:1901135 346 0.063
single organism organelle organization GO:1902589 180 0.061
muscle cell differentiation GO:0042692 52 0.061
endoplasmic reticulum to cytosol transport GO:1903513 4 0.061
regulation of rna biosynthetic process GO:2001141 381 0.058
anterior posterior pattern specification GO:0009952 1 0.058
cell growth GO:0016049 104 0.057
cellular response to nitrogen compound GO:1901699 210 0.057
atp catabolic process GO:0006200 54 0.056
regulation of cell proliferation GO:0042127 359 0.054
rna biosynthetic process GO:0032774 380 0.053
purine nucleoside monophosphate catabolic process GO:0009128 55 0.052
cellular component movement GO:0006928 248 0.051
regulation of phosphorus metabolic process GO:0051174 349 0.051
regulation of phosphate metabolic process GO:0019220 349 0.050
response to mechanical stimulus GO:0009612 134 0.050
nucleoside monophosphate metabolic process GO:0009123 93 0.050
tissue morphogenesis GO:0048729 22 0.049
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.047
cellular response to organonitrogen compound GO:0071417 197 0.047
skeletal muscle tissue development GO:0007519 31 0.047
myofibril assembly GO:0030239 6 0.047
organic substance catabolic process GO:1901575 316 0.046
catabolic process GO:0009056 351 0.046
response to nutrient levels GO:0031667 370 0.045
response to oxidative stress GO:0006979 186 0.045
positive regulation of transcription dna templated GO:0045893 197 0.044
nucleobase containing small molecule metabolic process GO:0055086 316 0.044
regulation of smooth muscle cell proliferation GO:0048660 75 0.043
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.043
bmp signaling pathway GO:0030509 4 0.043
ventricular cardiac muscle cell differentiation GO:0055012 2 0.043
coronary vasculature morphogenesis GO:0060977 3 0.042
cellular component assembly GO:0022607 360 0.042
response to purine containing compound GO:0014074 126 0.042
positive regulation of rna biosynthetic process GO:1902680 197 0.041
response to monosaccharide GO:0034284 159 0.041
regulation of multicellular organismal development GO:2000026 376 0.041
cellular component morphogenesis GO:0032989 155 0.041
cardiac cell development GO:0055006 16 0.041
ribonucleotide metabolic process GO:0009259 231 0.041
response to decreased oxygen levels GO:0036293 237 0.041
heart process GO:0003015 57 0.041
calcium ion transmembrane transport GO:0070588 70 0.040
growth GO:0040007 165 0.040
rna metabolic process GO:0016070 406 0.040
cellular calcium ion homeostasis GO:0006874 160 0.040
cellular protein complex assembly GO:0043623 44 0.040
positive regulation of gene expression GO:0010628 244 0.040
positive regulation of rna metabolic process GO:0051254 203 0.039
regulation of transcription dna templated GO:0006355 374 0.039
positive regulation of molecular function GO:0044093 230 0.038
purine nucleotide metabolic process GO:0006163 229 0.038
cardiocyte differentiation GO:0035051 22 0.037
positive regulation of cell differentiation GO:0045597 217 0.037
regulation of fat cell proliferation GO:0070344 1 0.036
regulation of ion homeostasis GO:2000021 63 0.036
regulation of membrane potential GO:0042391 110 0.036
macromolecular complex subunit organization GO:0043933 339 0.036
regulation of blood circulation GO:1903522 110 0.036
regulation of rna metabolic process GO:0051252 391 0.035
cellular ion homeostasis GO:0006873 184 0.035
potassium ion transmembrane transport GO:0071805 71 0.035
response to reactive oxygen species GO:0000302 120 0.035
positive regulation of biosynthetic process GO:0009891 319 0.035
blood circulation GO:0008015 183 0.034
cellular component assembly involved in morphogenesis GO:0010927 17 0.034
multicellular organism reproduction GO:0032504 233 0.034
ribonucleoside triphosphate metabolic process GO:0009199 141 0.034
purine containing compound metabolic process GO:0072521 253 0.034
smooth muscle cell proliferation GO:0048659 77 0.034
regulation of cardiac muscle cell contraction GO:0086004 11 0.033
ribose phosphate metabolic process GO:0019693 235 0.033
regulation of organ growth GO:0046620 13 0.033
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.033
cellular response to drug GO:0035690 30 0.033
wound healing GO:0042060 122 0.032
cellular catabolic process GO:0044248 295 0.032
regulation of hormone levels GO:0010817 187 0.032
enzyme linked receptor protein signaling pathway GO:0007167 116 0.032
cellular macromolecular complex assembly GO:0034622 58 0.032
cardiac muscle cell contraction GO:0086003 10 0.032
cellular component biogenesis GO:0044085 368 0.032
macromolecular complex assembly GO:0065003 273 0.031
regulation of secretion by cell GO:1903530 208 0.031
regulation of secretion GO:0051046 224 0.030
muscle filament sliding GO:0030049 2 0.030
negative regulation of cellular metabolic process GO:0031324 281 0.030
negative regulation of gene expression GO:0010629 199 0.030
nucleotide metabolic process GO:0009117 279 0.029
carbohydrate homeostasis GO:0033500 75 0.029
calcium ion homeostasis GO:0055074 162 0.029
regulation of transmembrane transport GO:0034762 122 0.029
nucleobase containing compound catabolic process GO:0034655 152 0.029
regulation of cell differentiation GO:0045595 320 0.028
negative regulation of programmed cell death GO:0043069 183 0.028
ribonucleoside monophosphate metabolic process GO:0009161 88 0.028
synapse organization GO:0050808 46 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
epithelial cell differentiation GO:0030855 71 0.028
cellular nitrogen compound catabolic process GO:0044270 163 0.028
regulation of organ formation GO:0003156 2 0.028
cellular response to insulin stimulus GO:0032869 81 0.027
positive regulation of cellular component organization GO:0051130 200 0.027
regulation of catabolic process GO:0009894 113 0.027
nucleoside monophosphate catabolic process GO:0009125 56 0.026
response to hexose GO:0009746 144 0.026
secretion by cell GO:0032940 248 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.025
programmed cell death GO:0012501 392 0.025
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.025
transmembrane transport GO:0055085 412 0.025
regulation of catalytic activity GO:0050790 304 0.025
regulation of signal transduction GO:0009966 318 0.025
response to glucose GO:0009749 136 0.025
secretion GO:0046903 307 0.024
positive regulation of protein modification process GO:0031401 142 0.024
organophosphate metabolic process GO:0019637 370 0.024
positive regulation of multicellular organismal process GO:0051240 387 0.024
purine nucleoside metabolic process GO:0042278 169 0.024
positive regulation of secretion by cell GO:1903532 128 0.023
regulation of ion transmembrane transport GO:0034765 121 0.023
protein complex assembly GO:0006461 263 0.023
regulation of heart contraction GO:0008016 48 0.023
response to electrical stimulus involved in regulation of muscle adaptation GO:0014878 4 0.023
regulation of heart rate GO:0002027 16 0.023
positive regulation of cell communication GO:0010647 271 0.023
single organism intracellular transport GO:1902582 166 0.023
apoptotic process GO:0006915 381 0.023
regulation of transporter activity GO:0032409 50 0.023
purine ribonucleotide metabolic process GO:0009150 227 0.023
cellular metal ion homeostasis GO:0006875 172 0.022
neuromuscular process GO:0050905 2 0.022
negative regulation of cation channel activity GO:2001258 6 0.022
cellular chemical homeostasis GO:0055082 247 0.022
organ induction GO:0001759 1 0.022
sequestering of metal ion GO:0051238 9 0.021
regulation of mapk cascade GO:0043408 116 0.021
regulation of protein metabolic process GO:0051246 289 0.021
muscle cell proliferation GO:0033002 84 0.021
regulation of cellular component organization GO:0051128 368 0.021
striated muscle cell differentiation GO:0051146 39 0.021
positive regulation of nucleic acid templated transcription GO:1903508 197 0.021
response to muscle stretch GO:0035994 2 0.021
divalent inorganic cation homeostasis GO:0072507 165 0.020
cellular divalent inorganic cation homeostasis GO:0072503 162 0.020
mesoderm development GO:0007498 2 0.020
regulation of apoptotic process GO:0042981 335 0.020
cytosolic calcium ion homeostasis GO:0051480 140 0.020
regulation of metal ion transport GO:0010959 118 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.020
neuromuscular synaptic transmission GO:0007274 2 0.020
proteolysis GO:0006508 175 0.020
sequestering of calcium ion GO:0051208 8 0.019
maintenance of location GO:0051235 17 0.019
gamete generation GO:0007276 124 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.019
nucleoside catabolic process GO:0009164 126 0.019
intracellular transport GO:0046907 185 0.019
ventricular cardiac muscle cell action potential GO:0086005 2 0.019
ribonucleoside monophosphate catabolic process GO:0009158 55 0.018
response to camp GO:0051591 91 0.018
organophosphate biosynthetic process GO:0090407 143 0.018
multi organism reproductive process GO:0044703 262 0.018
tube development GO:0035295 89 0.018
regulation of growth GO:0040008 105 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
axis specification GO:0009798 4 0.018
negative regulation of cellular biosynthetic process GO:0031327 161 0.018
negative regulation of ion transmembrane transporter activity GO:0032413 12 0.018
cellular cation homeostasis GO:0030003 180 0.018
cellular response to growth factor stimulus GO:0071363 162 0.018
intracellular signal transduction GO:0035556 314 0.018
actomyosin structure organization GO:0031032 22 0.018
transcription from rna polymerase ii promoter GO:0006366 252 0.018
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.017
skeletal muscle contraction GO:0003009 17 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
cell projection morphogenesis GO:0048858 123 0.017
reproduction GO:0000003 245 0.017
organelle assembly GO:0070925 22 0.017
response to carbohydrate GO:0009743 183 0.017
neuron development GO:0048666 286 0.017
epithelium development GO:0060429 96 0.017
response to oxygen levels GO:0070482 265 0.017
glycosyl compound metabolic process GO:1901657 182 0.017
negative regulation of macromolecule metabolic process GO:0010605 260 0.017
negative regulation of phosphorus metabolic process GO:0010563 80 0.017
cellular response to mechanical stimulus GO:0071260 48 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
cellular homeostasis GO:0019725 252 0.016
nucleoside triphosphate metabolic process GO:0009141 144 0.016
amine metabolic process GO:0009308 38 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
cell morphogenesis involved in differentiation GO:0000904 119 0.016
reproductive process GO:0022414 372 0.016
response to corticosteroid GO:0031960 235 0.015
response to extracellular stimulus GO:0009991 380 0.015
organic cyclic compound catabolic process GO:1901361 175 0.015
neuron differentiation GO:0030182 368 0.015
positive regulation of catalytic activity GO:0043085 184 0.015
negative regulation of transport GO:0051051 136 0.015
regulation of ion transport GO:0043269 245 0.015
carbohydrate metabolic process GO:0005975 130 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
purine nucleoside monophosphate metabolic process GO:0009126 84 0.015
purine nucleoside triphosphate catabolic process GO:0009146 122 0.015
regulation of homeostatic process GO:0032844 101 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.015
protein complex subunit organization GO:0071822 302 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
regulation of cellular catabolic process GO:0031329 101 0.015
adult locomotory behavior GO:0008344 4 0.014
inorganic ion transmembrane transport GO:0098660 229 0.014
metal ion homeostasis GO:0055065 186 0.014
response to estrogen GO:0043627 232 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
response to hypoxia GO:0001666 231 0.014
organ morphogenesis GO:0009887 75 0.014
single organism reproductive process GO:0044702 297 0.014
cellular amine metabolic process GO:0044106 38 0.014
negative regulation of transporter activity GO:0032410 13 0.014
regulation of cardiac muscle contraction GO:0055117 17 0.014
developmental process involved in reproduction GO:0003006 159 0.014
regulation of cytoskeleton organization GO:0051493 49 0.014
regulation of actin filament based process GO:0032970 42 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
transcription dna templated GO:0006351 377 0.014
purine nucleotide catabolic process GO:0006195 136 0.013
positive regulation of cell development GO:0010720 176 0.013
cell cell signaling GO:0007267 335 0.013
gonad development GO:0008406 104 0.013
cellular response to peptide GO:1901653 133 0.013
erythrocyte differentiation GO:0030218 1 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
cell projection organization GO:0030030 302 0.013
positive regulation of nervous system development GO:0051962 178 0.013
sulfur compound metabolic process GO:0006790 70 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
regulation of cell growth GO:0001558 85 0.013
lipid storage GO:0019915 1 0.013
divalent metal ion transport GO:0070838 132 0.013
regulation of cellular localization GO:0060341 263 0.013
myoblast fusion GO:0007520 2 0.013
microtubule based process GO:0007017 36 0.013
regulation of transferase activity GO:0051338 123 0.013
hematopoietic progenitor cell differentiation GO:0002244 2 0.013
nucleotide catabolic process GO:0009166 139 0.013
positive regulation of cytoskeleton organization GO:0051495 26 0.013
regulation of sarcomere organization GO:0060297 2 0.012
nucleoside metabolic process GO:0009116 179 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
cell morphogenesis GO:0000902 142 0.012
ribonucleoside catabolic process GO:0042454 126 0.012
response to transition metal nanoparticle GO:1990267 122 0.012
slow twitch skeletal muscle fiber contraction GO:0031444 2 0.012
response to hydrogen peroxide GO:0042542 89 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
protein processing GO:0016485 68 0.012
sensory perception GO:0007600 101 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
regulation of nervous system development GO:0051960 264 0.012
ion transmembrane transport GO:0034220 365 0.012
regulation of transmembrane transporter activity GO:0022898 49 0.012
regulation of ryanodine sensitive calcium release channel activity GO:0060314 5 0.012
male gamete generation GO:0048232 99 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
syncytium formation GO:0006949 4 0.012
single organism catabolic process GO:0044712 283 0.012
cellular response to stress GO:0033554 269 0.012
synaptic transmission GO:0007268 235 0.012
cellular response to peptide hormone stimulus GO:0071375 120 0.011
negative regulation of transcription regulatory region dna binding GO:2000678 2 0.011
developmental growth GO:0048589 100 0.011
multicellular organismal signaling GO:0035637 44 0.011
regulation of protein modification process GO:0031399 194 0.011
hormone metabolic process GO:0042445 69 0.011
peptide secretion GO:0002790 86 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
protein polymerization GO:0051258 22 0.011
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.011
regulation of neuron apoptotic process GO:0043523 83 0.011
purine containing compound catabolic process GO:0072523 138 0.011
protein homotetramerization GO:0051289 25 0.011
response to hyperoxia GO:0055093 45 0.011
purine ribonucleotide catabolic process GO:0009154 136 0.011
negative regulation of phosphorylation GO:0042326 57 0.011
neuron apoptotic process GO:0051402 88 0.011
synaptic vesicle transport GO:0048489 23 0.011
neurological system process GO:0050877 219 0.011
sexual reproduction GO:0019953 148 0.011
response to ph GO:0009268 27 0.011
regulation of intracellular transport GO:0032386 65 0.010
cellular response to alkaloid GO:0071312 25 0.010
regulation of vesicle mediated transport GO:0060627 81 0.010
cytoplasmic transport GO:0016482 115 0.010
ventricular cardiac muscle cell development GO:0055015 2 0.010
heart growth GO:0060419 20 0.010
tissue regeneration GO:0042246 36 0.010
positive regulation of cellular amine metabolic process GO:0033240 3 0.010
central nervous system development GO:0007417 311 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010

Myl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.940
muscular disease DOID:0080000 0 0.940
heart disease DOID:114 0 0.940
cardiomyopathy DOID:0050700 0 0.940
disease of anatomical entity DOID:7 0 0.940
intrinsic cardiomyopathy DOID:0060036 0 0.940
cardiovascular system disease DOID:1287 0 0.940
musculoskeletal system disease DOID:17 0 0.940
muscle tissue disease DOID:66 0 0.940
dilated cardiomyopathy DOID:12930 0 0.708
hypertrophic cardiomyopathy DOID:11984 0 0.345
congenital heart disease DOID:1682 0 0.187
heart septal defect DOID:1681 0 0.187
atrial heart septal defect DOID:1882 0 0.084
muscular dystrophy DOID:9884 0 0.080
central nervous system disease DOID:331 0 0.018
nervous system disease DOID:863 0 0.018
disease of cellular proliferation DOID:14566 0 0.016
heart conduction disease DOID:10273 0 0.011