Rattus norvegicus

18 known processes

Nell2

NEL-like 2 (chicken)

Nell2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
neuron differentiation GO:0030182 368 0.363
secretion GO:0046903 307 0.198
single organism catabolic process GO:0044712 283 0.176
g protein coupled receptor signaling pathway GO:0007186 242 0.163
cellular component biogenesis GO:0044085 368 0.150
nucleobase containing small molecule metabolic process GO:0055086 316 0.143
organophosphate metabolic process GO:0019637 370 0.134
regulation of cellular component organization GO:0051128 368 0.128
regulation of phosphorus metabolic process GO:0051174 349 0.125
carboxylic acid metabolic process GO:0019752 289 0.120
oxoacid metabolic process GO:0043436 290 0.117
neuron development GO:0048666 286 0.110
positive regulation of multicellular organismal process GO:0051240 387 0.108
reproductive process GO:0022414 372 0.101
cellular amino acid metabolic process GO:0006520 107 0.099
response to ketone GO:1901654 182 0.099
nucleotide metabolic process GO:0009117 279 0.097
regulation of catalytic activity GO:0050790 304 0.094
catabolic process GO:0009056 351 0.092
positive regulation of molecular function GO:0044093 230 0.085
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.085
organic substance catabolic process GO:1901575 316 0.084
cellular component assembly GO:0022607 360 0.082
purine containing compound metabolic process GO:0072521 253 0.075
regulation of peptide secretion GO:0002791 82 0.074
cellular catabolic process GO:0044248 295 0.074
positive regulation of phosphate metabolic process GO:0045937 262 0.074
positive regulation of catalytic activity GO:0043085 184 0.070
brain development GO:0007420 247 0.070
regulation of hydrolase activity GO:0051336 143 0.069
intracellular signal transduction GO:0035556 314 0.066
regulation of nervous system development GO:0051960 264 0.066
positive regulation of cell communication GO:0010647 271 0.066
regulation of purine nucleotide metabolic process GO:1900542 115 0.065
nucleoside phosphate metabolic process GO:0006753 283 0.065
ribonucleotide metabolic process GO:0009259 231 0.065
nucleoside triphosphate metabolic process GO:0009141 144 0.061
cellular nitrogen compound catabolic process GO:0044270 163 0.061
response to nutrient levels GO:0031667 370 0.060
synaptic transmission GO:0007268 235 0.058
ribonucleoside triphosphate metabolic process GO:0009199 141 0.058
neuron projection development GO:0031175 273 0.057
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.057
regulation of vesicle mediated transport GO:0060627 81 0.057
neurological system process GO:0050877 219 0.056
regulation of phosphorylation GO:0042325 248 0.055
regulation of secretion GO:0051046 224 0.054
macromolecular complex assembly GO:0065003 273 0.054
purine nucleotide metabolic process GO:0006163 229 0.054
regulation of peptide hormone secretion GO:0090276 80 0.054
positive regulation of transport GO:0051050 245 0.054
divalent metal ion transport GO:0070838 132 0.054
organophosphate catabolic process GO:0046434 148 0.052
response to oxidative stress GO:0006979 186 0.051
regulation of molecular function GO:0065009 398 0.051
secretion by cell GO:0032940 248 0.050
organic acid metabolic process GO:0006082 292 0.050
regulation of neuron differentiation GO:0045664 208 0.050
regulation of cell development GO:0060284 263 0.049
nucleotide catabolic process GO:0009166 139 0.047
regulation of protein metabolic process GO:0051246 289 0.047
rna metabolic process GO:0016070 406 0.047
protein complex biogenesis GO:0070271 263 0.047
purine ribonucleotide metabolic process GO:0009150 227 0.047
carbohydrate derivative metabolic process GO:1901135 346 0.046
organonitrogen compound catabolic process GO:1901565 179 0.045
aromatic compound catabolic process GO:0019439 168 0.045
central nervous system development GO:0007417 311 0.045
protein autophosphorylation GO:0046777 66 0.045
purine ribonucleoside metabolic process GO:0046128 168 0.044
positive regulation of phosphorus metabolic process GO:0010562 262 0.044
positive regulation of cellular component organization GO:0051130 200 0.044
cellular chemical homeostasis GO:0055082 247 0.044
macromolecular complex subunit organization GO:0043933 339 0.043
regulation of phosphate metabolic process GO:0019220 349 0.043
regulation of protein phosphorylation GO:0001932 183 0.043
positive regulation of signaling GO:0023056 270 0.043
ribose phosphate metabolic process GO:0019693 235 0.043
divalent inorganic cation transport GO:0072511 134 0.042
signal release GO:0023061 145 0.042
purine containing compound catabolic process GO:0072523 138 0.041
positive regulation of response to stimulus GO:0048584 285 0.041
positive regulation of neuron projection development GO:0010976 99 0.041
regulation of cellular amino acid metabolic process GO:0006521 2 0.041
regulation of cellular localization GO:0060341 263 0.040
positive regulation of secretion GO:0051047 140 0.040
regulation of synaptic transmission GO:0050804 141 0.040
positive regulation of signal transduction GO:0009967 175 0.040
multicellular organism reproduction GO:0032504 233 0.039
positive regulation of programmed cell death GO:0043068 157 0.039
cell projection organization GO:0030030 302 0.039
head development GO:0060322 247 0.038
response to extracellular stimulus GO:0009991 380 0.038
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
guanosine containing compound metabolic process GO:1901068 74 0.037
positive regulation of apoptotic process GO:0043065 154 0.037
neuron projection morphogenesis GO:0048812 122 0.037
protein oligomerization GO:0051259 191 0.037
multicellular organismal reproductive process GO:0048609 233 0.037
nucleoside phosphate catabolic process GO:1901292 140 0.036
response to inorganic substance GO:0010035 377 0.036
negative regulation of macromolecule metabolic process GO:0010605 260 0.035
regulation of nucleic acid templated transcription GO:1903506 380 0.035
rna biosynthetic process GO:0032774 380 0.035
vesicle mediated transport GO:0016192 181 0.035
regulation of multicellular organismal development GO:2000026 376 0.035
single organism reproductive process GO:0044702 297 0.035
regulation of rna biosynthetic process GO:2001141 381 0.034
regulation of cellular protein metabolic process GO:0032268 267 0.034
heterocycle catabolic process GO:0046700 167 0.034
multi organism reproductive process GO:0044703 262 0.034
regulation of secretion by cell GO:1903530 208 0.034
regulation of cell differentiation GO:0045595 320 0.033
organic cyclic compound catabolic process GO:1901361 175 0.033
organelle organization GO:0006996 266 0.033
positive regulation of neuron differentiation GO:0045666 126 0.033
cellular ketone metabolic process GO:0042180 51 0.032
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.032
regulation of neuron projection development GO:0010975 161 0.032
positive regulation of neurogenesis GO:0050769 165 0.032
regulation of ion transport GO:0043269 245 0.032
protein phosphorylation GO:0006468 345 0.032
chemical homeostasis GO:0048878 292 0.032
positive regulation of protein metabolic process GO:0051247 178 0.031
glycosyl compound catabolic process GO:1901658 126 0.031
regulation of nucleotide metabolic process GO:0006140 117 0.030
regulation of rna metabolic process GO:0051252 391 0.030
inorganic ion transmembrane transport GO:0098660 229 0.030
nucleoside triphosphate catabolic process GO:0009143 123 0.030
gtp catabolic process GO:0006184 71 0.030
protein homooligomerization GO:0051260 91 0.029
synaptic vesicle exocytosis GO:0016079 15 0.029
regulation of signal transduction GO:0009966 318 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.028
protein complex subunit organization GO:0071822 302 0.028
ion homeostasis GO:0050801 212 0.028
purine ribonucleoside catabolic process GO:0046130 124 0.028
regulation of programmed cell death GO:0043067 341 0.027
ribonucleotide catabolic process GO:0009261 136 0.027
negative regulation of cellular metabolic process GO:0031324 281 0.027
purine nucleoside metabolic process GO:0042278 169 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
homeostatic process GO:0042592 331 0.027
cognition GO:0050890 92 0.027
cell morphogenesis GO:0000902 142 0.027
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.027
regulation of cell projection organization GO:0031344 175 0.027
regulation of catabolic process GO:0009894 113 0.027
carbohydrate derivative catabolic process GO:1901136 147 0.026
metal ion transport GO:0030001 289 0.026
apoptotic process GO:0006915 381 0.026
regulation of synapse maturation GO:0090128 2 0.025
glycosyl compound metabolic process GO:1901657 182 0.025
cellular homeostasis GO:0019725 252 0.025
cellular metal ion homeostasis GO:0006875 172 0.025
positive regulation of cellular biosynthetic process GO:0031328 295 0.024
programmed cell death GO:0012501 392 0.024
negative regulation of multicellular organismal process GO:0051241 203 0.024
positive regulation of cell death GO:0010942 184 0.024
regulation of cellular amine metabolic process GO:0033238 8 0.024
cellular ion homeostasis GO:0006873 184 0.024
purine nucleoside triphosphate metabolic process GO:0009144 141 0.024
response to axon injury GO:0048678 59 0.023
nucleobase containing compound catabolic process GO:0034655 152 0.023
protein localization GO:0008104 191 0.023
exocytosis GO:0006887 60 0.023
regulation of insulin secretion GO:0050796 65 0.023
behavior GO:0007610 205 0.023
positive regulation of developmental process GO:0051094 283 0.022
purine nucleoside triphosphate catabolic process GO:0009146 122 0.022
ribonucleoside catabolic process GO:0042454 126 0.022
synaptic vesicle endocytosis GO:0048488 4 0.022
gtp metabolic process GO:0046039 72 0.022
peptidyl amino acid modification GO:0018193 126 0.022
positive regulation of hydrolase activity GO:0051345 86 0.022
reproduction GO:0000003 245 0.022
regulation of cellular component biogenesis GO:0044087 86 0.022
gamete generation GO:0007276 124 0.022
synapse organization GO:0050808 46 0.022
protein complex assembly GO:0006461 263 0.022
oxidation reduction process GO:0055114 304 0.021
regulation of transcription dna templated GO:0006355 374 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
regulation of neurogenesis GO:0050767 247 0.021
regulation of cell motility GO:2000145 131 0.021
cellular amine metabolic process GO:0044106 38 0.021
developmental process involved in reproduction GO:0003006 159 0.021
single organism organelle organization GO:1902589 180 0.021
negative regulation of metabolic process GO:0009892 331 0.021
amine metabolic process GO:0009308 38 0.020
defense response GO:0006952 194 0.020
biological adhesion GO:0022610 110 0.020
purine nucleoside catabolic process GO:0006152 124 0.020
cell adhesion GO:0007155 110 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
reproductive system development GO:0061458 128 0.020
regulation of apoptotic process GO:0042981 335 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.020
negative regulation of secretion GO:0051048 82 0.020
l glutamate import GO:0051938 2 0.020
positive regulation of protein phosphorylation GO:0001934 135 0.020
positive regulation of nervous system development GO:0051962 178 0.019
ras protein signal transduction GO:0007265 29 0.019
positive regulation of cell differentiation GO:0045597 217 0.019
regulation of neuron death GO:1901214 115 0.019
divalent inorganic cation homeostasis GO:0072507 165 0.019
regeneration GO:0031099 163 0.019
growth GO:0040007 165 0.019
hormone secretion GO:0046879 115 0.019
cation homeostasis GO:0055080 195 0.019
positive regulation of gene expression GO:0010628 244 0.019
salivary gland development GO:0007431 3 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.019
single organism behavior GO:0044708 130 0.019
peptide secretion GO:0002790 86 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.019
ribonucleoside triphosphate catabolic process GO:0009203 122 0.019
negative regulation of cell communication GO:0010648 158 0.019
calcium ion homeostasis GO:0055074 162 0.019
positive regulation of phosphorylation GO:0042327 177 0.019
cyclic nucleotide metabolic process GO:0009187 80 0.018
thymine metabolic process GO:0019859 2 0.018
maintenance of protein location in plasma membrane GO:0072660 1 0.018
organelle localization GO:0051640 55 0.018
response to hexose GO:0009746 144 0.018
immune response GO:0006955 104 0.018
positive regulation of cell development GO:0010720 176 0.018
cellular divalent inorganic cation homeostasis GO:0072503 162 0.018
purine ribonucleotide catabolic process GO:0009154 136 0.018
lipid catabolic process GO:0016042 46 0.018
fatty acid metabolic process GO:0006631 99 0.017
ribonucleoside metabolic process GO:0009119 174 0.017
response to monosaccharide GO:0034284 159 0.017
locomotion GO:0040011 237 0.017
spindle organization GO:0007051 2 0.017
response to glucocorticoid GO:0051384 223 0.017
peptide hormone secretion GO:0030072 84 0.017
response to hydrogen peroxide GO:0042542 89 0.017
regulation of ion homeostasis GO:2000021 63 0.017
response to carbohydrate GO:0009743 183 0.017
cell morphogenesis involved in differentiation GO:0000904 119 0.017
tissue development GO:0009888 252 0.017
actin filament based process GO:0030029 86 0.017
response to temperature stimulus GO:0009266 94 0.016
positive regulation of nucleotide metabolic process GO:0045981 91 0.016
neuropeptide signaling pathway GO:0007218 29 0.016
regulation of kinase activity GO:0043549 117 0.016
nucleoside metabolic process GO:0009116 179 0.016
neuronal action potential GO:0019228 35 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
cellular response to alkaloid GO:0071312 25 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
negative regulation of molecular function GO:0044092 133 0.016
positive regulation of catabolic process GO:0009896 78 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
feeding behavior GO:0007631 53 0.016
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.016
negative regulation of transport GO:0051051 136 0.016
sexual reproduction GO:0019953 148 0.016
single organism biosynthetic process GO:0044711 342 0.015
response to glucose GO:0009749 136 0.015
establishment of organelle localization GO:0051656 37 0.015
cellular component morphogenesis GO:0032989 155 0.015
inflammatory response GO:0006954 150 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
axis specification GO:0009798 4 0.015
regulation of meiotic cell cycle GO:0051445 3 0.015
regulation of hormone levels GO:0010817 187 0.015
cell projection assembly GO:0030031 21 0.015
enzyme linked receptor protein signaling pathway GO:0007167 116 0.015
guanosine containing compound catabolic process GO:1901069 71 0.015
negative regulation of catalytic activity GO:0043086 103 0.015
protein homotrimerization GO:0070207 15 0.015
synaptic growth at neuromuscular junction GO:0051124 1 0.015
regulation of membrane potential GO:0042391 110 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
positive regulation of synapse maturation GO:0090129 2 0.014
regulation of nucleotide catabolic process GO:0030811 65 0.014
regulation of response to stress GO:0080134 126 0.014
mapk cascade GO:0000165 140 0.014
response to metal ion GO:0010038 253 0.014
negative regulation of cellular protein metabolic process GO:0032269 106 0.014
positive regulation of nucleotide catabolic process GO:0030813 53 0.014
regulation of camp metabolic process GO:0030814 43 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
negative regulation of protein maturation GO:1903318 47 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
macromolecule localization GO:0033036 252 0.014
negative regulation of neuron differentiation GO:0045665 62 0.014
cyclic nucleotide biosynthetic process GO:0009190 63 0.014
regulation of cell migration GO:0030334 128 0.014
cell part morphogenesis GO:0032990 123 0.014
response to oxygen levels GO:0070482 265 0.014
negative regulation of nervous system development GO:0051961 79 0.014
activation of protein kinase b activity GO:0032148 3 0.014
positive regulation of protein modification process GO:0031401 142 0.014
detection of calcium ion GO:0005513 1 0.014
insulin secretion GO:0030073 69 0.014
proteolysis GO:0006508 175 0.014
regulation of hormone secretion GO:0046883 106 0.014
regulation of map kinase activity GO:0043405 53 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
eye morphogenesis GO:0048592 4 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
metal ion homeostasis GO:0055065 186 0.013
ensheathment of neurons GO:0007272 40 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
response to mineralocorticoid GO:0051385 49 0.013
regulation of protein serine threonine kinase activity GO:0071900 64 0.013
cation transport GO:0006812 382 0.013
beta alanine metabolic process GO:0019482 3 0.013
calcium ion transport GO:0006816 131 0.013
cellular response to organonitrogen compound GO:0071417 197 0.013
regulation of protein modification process GO:0031399 194 0.013
nucleic acid templated transcription GO:0097659 379 0.013
positive regulation of rna metabolic process GO:0051254 203 0.013
multi multicellular organism process GO:0044706 138 0.013
cell motility GO:0048870 202 0.013
transmission of nerve impulse GO:0019226 42 0.013
cellular cation homeostasis GO:0030003 180 0.013
regulation of protein kinase activity GO:0045859 105 0.013
synaptic vesicle transport GO:0048489 23 0.013
long term synaptic potentiation GO:0060291 21 0.013
cyclic purine nucleotide metabolic process GO:0052652 62 0.013
cellular response to glucose stimulus GO:0071333 65 0.012
embryonic pattern specification GO:0009880 1 0.012
response to starvation GO:0042594 59 0.012
intracellular transport GO:0046907 185 0.012
peptidyl tyrosine phosphorylation GO:0018108 72 0.012
response to cadmium ion GO:0046686 35 0.012
actin filament organization GO:0007015 42 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
negative regulation of developmental process GO:0051093 125 0.012
regulation of organelle organization GO:0033043 80 0.012
positive regulation of cellular catabolic process GO:0031331 71 0.012
vesicle localization GO:0051648 33 0.012
heart morphogenesis GO:0003007 3 0.012
cell cycle GO:0007049 101 0.012
peptidyl tyrosine modification GO:0018212 72 0.012
positive regulation of dendritic spine morphogenesis GO:0061003 3 0.012
positive regulation of locomotion GO:0040017 102 0.012
cell cycle checkpoint GO:0000075 2 0.012
sequestering of metal ion GO:0051238 9 0.012
multicellular organism growth GO:0035264 1 0.012
male gamete generation GO:0048232 99 0.012
wound healing GO:0042060 122 0.011
neuromuscular process GO:0050905 2 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
anterior posterior pattern specification GO:0009952 1 0.011
organophosphate biosynthetic process GO:0090407 143 0.011
transcription dna templated GO:0006351 377 0.011
regulation of exocytosis GO:0017157 37 0.011
single organism intracellular transport GO:1902582 166 0.011
response to vitamin GO:0033273 131 0.011
actin cytoskeleton organization GO:0030036 73 0.011
amide transport GO:0042886 105 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
positive regulation of gtp catabolic process GO:0033126 48 0.011
salivary gland morphogenesis GO:0007435 1 0.011
organic acid catabolic process GO:0016054 49 0.011
activation of protein kinase activity GO:0032147 47 0.011
carbohydrate metabolic process GO:0005975 130 0.011
regulation of homeostatic process GO:0032844 101 0.011
positive regulation of peptide hormone secretion GO:0090277 50 0.011
axon development GO:0061564 96 0.011
positive regulation of hormone secretion GO:0046887 65 0.011
immune system process GO:0002376 204 0.011
regulation of gtpase activity GO:0043087 57 0.011
peptide transport GO:0015833 97 0.011
cellular macromolecule localization GO:0070727 122 0.010
developmental growth GO:0048589 100 0.010
actin crosslink formation GO:0051764 3 0.010
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
regulation of cell proliferation GO:0042127 359 0.010
regulation of gtp catabolic process GO:0033124 58 0.010
nucleoside catabolic process GO:0009164 126 0.010
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.010
digestion GO:0007586 26 0.010
fertilization GO:0009566 3 0.010
negative regulation of phosphorus metabolic process GO:0010563 80 0.010
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.010

Nell2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
synucleinopathy DOID:0050890 0 0.017
central nervous system disease DOID:331 0 0.017
nervous system disease DOID:863 0 0.017
neurodegenerative disease DOID:1289 0 0.017
disease of anatomical entity DOID:7 0 0.017
parkinson s disease DOID:14330 0 0.017