Rattus norvegicus

25 known processes

Notch4

Notch homolog 4 (Drosophila)

Notch4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hormone transport GO:0009914 121 0.254
ion transmembrane transport GO:0034220 365 0.253
regulation of hormone levels GO:0010817 187 0.239
nitrogen compound transport GO:0071705 229 0.236
positive regulation of signaling GO:0023056 270 0.203
regulation of rna biosynthetic process GO:2001141 381 0.181
peptide secretion GO:0002790 86 0.174
positive regulation of signal transduction GO:0009967 175 0.159
transmembrane transport GO:0055085 412 0.159
signal release GO:0023061 145 0.153
peptide transport GO:0015833 97 0.146
regulation of secretion by cell GO:1903530 208 0.142
regulation of peptide secretion GO:0002791 82 0.135
anatomical structure morphogenesis GO:0009653 298 0.133
positive regulation of cell communication GO:0010647 271 0.130
secretion GO:0046903 307 0.118
secretion by cell GO:0032940 248 0.113
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.111
amide transport GO:0042886 105 0.106
regulation of molecular function GO:0065009 398 0.103
transcription dna templated GO:0006351 377 0.101
inorganic ion transmembrane transport GO:0098660 229 0.100
organic anion transport GO:0015711 132 0.091
positive regulation of response to stimulus GO:0048584 285 0.090
regulation of peptide hormone secretion GO:0090276 80 0.089
hormone secretion GO:0046879 115 0.087
negative regulation of cellular metabolic process GO:0031324 281 0.087
actin filament based process GO:0030029 86 0.084
reproductive process GO:0022414 372 0.083
anion transport GO:0006820 178 0.083
protein phosphorylation GO:0006468 345 0.081
peptide hormone secretion GO:0030072 84 0.080
multi organism reproductive process GO:0044703 262 0.080
negative regulation of signaling GO:0023057 157 0.079
regulation of cellular component organization GO:0051128 368 0.079
monocarboxylic acid transport GO:0015718 52 0.079
carboxylic acid transport GO:0046942 115 0.078
response to extracellular stimulus GO:0009991 380 0.076
regulation of hormone secretion GO:0046883 106 0.073
positive regulation of secretion GO:0051047 140 0.072
neuronal stem cell maintenance GO:0097150 2 0.070
carboxylic acid metabolic process GO:0019752 289 0.070
peptidyl tyrosine phosphorylation GO:0018108 72 0.067
cell motility GO:0048870 202 0.064
developmental process involved in reproduction GO:0003006 159 0.062
localization of cell GO:0051674 202 0.061
regulation of transferase activity GO:0051338 123 0.059
regulation of peptide transport GO:0090087 87 0.058
response to peptide hormone GO:0043434 278 0.058
lipid metabolic process GO:0006629 283 0.057
neuron differentiation GO:0030182 368 0.057
regulation of nucleic acid templated transcription GO:1903506 380 0.056
negative regulation of secretion by cell GO:1903531 72 0.056
lipid transport GO:0006869 61 0.054
immune system process GO:0002376 204 0.054
inorganic cation transmembrane transport GO:0098662 202 0.054
multicellular organismal reproductive process GO:0048609 233 0.054
single organism reproductive process GO:0044702 297 0.053
organic acid transport GO:0015849 116 0.053
cell cell signaling GO:0007267 335 0.053
negative regulation of transport GO:0051051 136 0.053
regulation of protein metabolic process GO:0051246 289 0.053
macromolecular complex subunit organization GO:0043933 339 0.052
positive regulation of phosphate metabolic process GO:0045937 262 0.050
negative regulation of programmed cell death GO:0043069 183 0.049
multicellular organism reproduction GO:0032504 233 0.049
nucleic acid templated transcription GO:0097659 379 0.048
organophosphate biosynthetic process GO:0090407 143 0.047
locomotion GO:0040011 237 0.047
reproduction GO:0000003 245 0.047
rna biosynthetic process GO:0032774 380 0.047
exocytosis GO:0006887 60 0.046
cellular component biogenesis GO:0044085 368 0.046
cellular response to peptide hormone stimulus GO:0071375 120 0.046
neurotransmitter transport GO:0006836 42 0.046
response to nutrient levels GO:0031667 370 0.046
rna metabolic process GO:0016070 406 0.045
insulin secretion GO:0030073 69 0.045
cellular component movement GO:0006928 248 0.045
regulation of secretion GO:0051046 224 0.044
regulation of response to stress GO:0080134 126 0.044
regulation of rna metabolic process GO:0051252 391 0.043
response to ammonium ion GO:0060359 71 0.043
sexual reproduction GO:0019953 148 0.042
organophosphate metabolic process GO:0019637 370 0.042
lipid localization GO:0010876 62 0.042
regulation of catalytic activity GO:0050790 304 0.041
organic acid metabolic process GO:0006082 292 0.041
nucleoside phosphate metabolic process GO:0006753 283 0.041
regulation of cell differentiation GO:0045595 320 0.041
regulation of transcription dna templated GO:0006355 374 0.040
positive regulation of gene expression GO:0010628 244 0.040
monocarboxylic acid metabolic process GO:0032787 152 0.039
protein autophosphorylation GO:0046777 66 0.039
intracellular signal transduction GO:0035556 314 0.039
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.039
cellular metal ion homeostasis GO:0006875 172 0.039
amine metabolic process GO:0009308 38 0.039
cell migration GO:0016477 197 0.038
regulation of activation of jak2 kinase activity GO:0010534 1 0.038
lymphoid progenitor cell differentiation GO:0002320 2 0.038
neurological system process GO:0050877 219 0.038
negative regulation of macromolecule metabolic process GO:0010605 260 0.037
positive regulation of cell migration GO:0030335 96 0.037
negative regulation of metabolic process GO:0009892 331 0.037
cation transport GO:0006812 382 0.037
positive regulation of rna metabolic process GO:0051254 203 0.037
positive regulation of protein kinase activity GO:0045860 73 0.036
cellular response to hormone stimulus GO:0032870 247 0.036
positive regulation of developmental process GO:0051094 283 0.036
regulation of cellular localization GO:0060341 263 0.036
carbohydrate metabolic process GO:0005975 130 0.035
regulation of system process GO:0044057 208 0.035
inflammatory response GO:0006954 150 0.034
pro t cell differentiation GO:0002572 1 0.034
gastrulation GO:0007369 2 0.034
regulation of cell projection organization GO:0031344 175 0.034
cellular calcium ion homeostasis GO:0006874 160 0.033
regulation of kinase activity GO:0043549 117 0.033
regulation of membrane potential GO:0042391 110 0.033
cellular carbohydrate metabolic process GO:0044262 72 0.033
protein oligomerization GO:0051259 191 0.033
positive regulation of cell differentiation GO:0045597 217 0.033
negative regulation of secretion GO:0051048 82 0.033
acid secretion GO:0046717 48 0.032
metal ion transport GO:0030001 289 0.032
single organism carbohydrate metabolic process GO:0044723 118 0.032
cellular response to organonitrogen compound GO:0071417 197 0.032
regulation of cellular protein metabolic process GO:0032268 267 0.032
positive regulation of hormone secretion GO:0046887 65 0.031
gliogenesis GO:0042063 93 0.031
cyclic nucleotide biosynthetic process GO:0009190 63 0.031
oxoacid metabolic process GO:0043436 290 0.031
activation of jak2 kinase activity GO:0042977 2 0.031
positive regulation of secretion by cell GO:1903532 128 0.031
regulation of phosphorus metabolic process GO:0051174 349 0.031
peptidyl amino acid modification GO:0018193 126 0.030
positive regulation of phosphorus metabolic process GO:0010562 262 0.030
bmp signaling pathway GO:0030509 4 0.030
regulation of insulin secretion GO:0050796 65 0.030
positive regulation of fatty acid transport GO:2000193 9 0.030
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.030
regulation of synaptic transmission GO:0050804 141 0.030
positive regulation of rna biosynthetic process GO:1902680 197 0.030
growth GO:0040007 165 0.030
immune response GO:0006955 104 0.030
regulation of protein phosphorylation GO:0001932 183 0.030
carbohydrate biosynthetic process GO:0016051 42 0.030
cellular response to organic cyclic compound GO:0071407 202 0.029
response to transition metal nanoparticle GO:1990267 122 0.029
cation homeostasis GO:0055080 195 0.029
macromolecule localization GO:0033036 252 0.029
regulation of phosphorylation GO:0042325 248 0.029
positive regulation of cell motility GO:2000147 97 0.029
response to light stimulus GO:0009416 52 0.029
positive regulation of protein metabolic process GO:0051247 178 0.029
cellular component assembly GO:0022607 360 0.028
cellular amine metabolic process GO:0044106 38 0.028
cytokine mediated signaling pathway GO:0019221 43 0.028
cell morphogenesis involved in differentiation GO:0000904 119 0.028
regulation of programmed cell death GO:0043067 341 0.028
regulation of protein modification process GO:0031399 194 0.027
negative regulation of follicle stimulating hormone secretion GO:0046882 3 0.027
negative regulation of apoptotic process GO:0043066 181 0.027
phasic smooth muscle contraction GO:0014821 3 0.027
regulation of cellular amine metabolic process GO:0033238 8 0.027
g protein coupled receptor signaling pathway GO:0007186 242 0.026
negative regulation of cell communication GO:0010648 158 0.026
cellular lipid metabolic process GO:0044255 208 0.026
aging GO:0007568 241 0.026
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.026
negative regulation of biosynthetic process GO:0009890 168 0.026
regulation of locomotion GO:0040012 148 0.025
positive regulation of catalytic activity GO:0043085 184 0.025
regulation of multicellular organismal development GO:2000026 376 0.025
cellular response to endogenous stimulus GO:0071495 377 0.025
response to peptide GO:1901652 292 0.025
gamete generation GO:0007276 124 0.025
sensory perception GO:0007600 101 0.025
homeostatic process GO:0042592 331 0.024
chemical homeostasis GO:0048878 292 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.024
cell projection organization GO:0030030 302 0.024
cation transmembrane transport GO:0098655 263 0.024
cellular divalent inorganic cation homeostasis GO:0072503 162 0.024
regulation of response to external stimulus GO:0032101 106 0.023
transcription from rna polymerase ii promoter GO:0006366 252 0.023
neuron development GO:0048666 286 0.023
single organism organelle organization GO:1902589 180 0.023
positive regulation of intracellular signal transduction GO:1902533 138 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
actin cytoskeleton organization GO:0030036 73 0.023
tissue development GO:0009888 252 0.023
negative regulation of cell death GO:0060548 229 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
learning GO:0007612 33 0.023
regulation of cellular amino acid metabolic process GO:0006521 2 0.023
sensory perception of pain GO:0019233 73 0.022
male gamete generation GO:0048232 99 0.022
positive regulation of kinase activity GO:0033674 77 0.022
regulation of signal transduction GO:0009966 318 0.022
multicellular organism growth GO:0035264 1 0.022
detection of stimulus GO:0051606 24 0.022
positive regulation of molecular function GO:0044093 230 0.021
positive regulation of mapk cascade GO:0043410 92 0.021
spermatogenesis GO:0007283 99 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.021
positive regulation of peptide hormone secretion GO:0090277 50 0.021
regulation of transmembrane transport GO:0034762 122 0.021
response to mechanical stimulus GO:0009612 134 0.021
single organism biosynthetic process GO:0044711 342 0.021
biological adhesion GO:0022610 110 0.021
calcium ion homeostasis GO:0055074 162 0.021
regulation of cell migration GO:0030334 128 0.021
ion homeostasis GO:0050801 212 0.020
reproductive structure development GO:0048608 128 0.020
regulation of endothelial cell differentiation GO:0045601 4 0.020
regulation of apoptotic process GO:0042981 335 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
monocarboxylic acid biosynthetic process GO:0072330 48 0.020
cellular response to peptide GO:1901653 133 0.019
programmed cell death GO:0012501 392 0.019
positive regulation of ion transport GO:0043270 94 0.019
regulation of activation of janus kinase activity GO:0010533 1 0.019
digestive tract development GO:0048565 39 0.019
endothelium development GO:0003158 12 0.019
regulation of mapk cascade GO:0043408 116 0.019
cellular response to nitrogen compound GO:1901699 210 0.018
protein homooligomerization GO:0051260 91 0.018
regulation of nervous system development GO:0051960 264 0.018
regulation of protein kinase activity GO:0045859 105 0.018
response to external biotic stimulus GO:0043207 221 0.018
response to nutrient GO:0007584 248 0.018
apoptotic process GO:0006915 381 0.018
mapk cascade GO:0000165 140 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
calcium ion transmembrane transport GO:0070588 70 0.018
adenylate cyclase inhibiting opioid receptor signaling pathway GO:0031635 2 0.018
negative regulation of cellular component organization GO:0051129 83 0.018
regulation of immune system process GO:0002682 123 0.018
neuron projection development GO:0031175 273 0.018
regulation of cell activation GO:0050865 50 0.018
negative regulation of neuron differentiation GO:0045665 62 0.017
regulation of cell motility GO:2000145 131 0.017
regulation of neurogenesis GO:0050767 247 0.017
t cell differentiation GO:0030217 9 0.017
mesoderm development GO:0007498 2 0.017
cellular ion homeostasis GO:0006873 184 0.017
platelet derived growth factor receptor alpha signaling pathway GO:0035790 1 0.017
regulation of ion transport GO:0043269 245 0.017
detection of calcium ion GO:0005513 1 0.017
regulation of receptor activity GO:0010469 29 0.017
regulation of cellular component biogenesis GO:0044087 86 0.016
response to radiation GO:0009314 137 0.016
membrane depolarization GO:0051899 32 0.016
leukocyte activation GO:0045321 76 0.016
regulation of heart rate GO:0002027 16 0.016
regulated secretory pathway GO:0045055 17 0.016
protein complex subunit organization GO:0071822 302 0.016
divalent inorganic cation transport GO:0072511 134 0.016
cellular chemical homeostasis GO:0055082 247 0.016
positive regulation of protein phosphorylation GO:0001934 135 0.016
synaptic vesicle endocytosis GO:0048488 4 0.016
positive regulation of locomotion GO:0040017 102 0.016
fatty acid transport GO:0015908 25 0.016
negative regulation of innate immune response GO:0045824 4 0.016
regulation of neuron differentiation GO:0045664 208 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
regulation of cellular carbohydrate metabolic process GO:0010675 39 0.016
response to metal ion GO:0010038 253 0.015
positive regulation of biosynthetic process GO:0009891 319 0.015
positive regulation of peptide secretion GO:0002793 52 0.015
regulation of intracellular signal transduction GO:1902531 218 0.015
response to molecule of fungal origin GO:0002238 3 0.015
vesicle mediated transport GO:0016192 181 0.015
protein complex assembly GO:0006461 263 0.015
positive regulation of serotonin secretion GO:0014064 1 0.015
regulation of cellular ketone metabolic process GO:0010565 27 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
negative regulation of molecular function GO:0044092 133 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
adult locomotory behavior GO:0008344 4 0.015
regulation of epithelial cell migration GO:0010632 17 0.015
nucleotide metabolic process GO:0009117 279 0.015
cellular cation homeostasis GO:0030003 180 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
regulation of ion transmembrane transport GO:0034765 121 0.014
defense response GO:0006952 194 0.014
modified amino acid transport GO:0072337 12 0.014
negative regulation of hormone secretion GO:0046888 46 0.014
activation of protein kinase activity GO:0032147 47 0.014
response to cgmp GO:0070305 3 0.014
taxis GO:0042330 67 0.014
cytoskeleton organization GO:0007010 111 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
regulation of fatty acid transport GO:2000191 10 0.014
metal ion homeostasis GO:0055065 186 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
purine containing compound metabolic process GO:0072521 253 0.014
negative regulation of amine transport GO:0051953 24 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
protein complex biogenesis GO:0070271 263 0.014
neuron death GO:0070997 127 0.014
actin filament bundle organization GO:0061572 19 0.014
saliva secretion GO:0046541 3 0.014
positive regulation of receptor activity GO:2000273 4 0.014
acute inflammatory response GO:0002526 58 0.014
regulation of immunoglobulin secretion GO:0051023 1 0.014
negative regulation of luteinizing hormone secretion GO:0033685 4 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.014
olfactory behavior GO:0042048 2 0.014
salivary gland development GO:0007431 3 0.014
alcohol metabolic process GO:0006066 77 0.013
monovalent inorganic cation transport GO:0015672 172 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
neuropeptide signaling pathway GO:0007218 29 0.013
cell activation GO:0001775 97 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
negative regulation of multicellular organismal process GO:0051241 203 0.013
regulation of organelle organization GO:0033043 80 0.013
positive regulation of map kinase activity GO:0043406 46 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.013
positive regulation of transport GO:0051050 245 0.013
peptidyl tyrosine modification GO:0018212 72 0.013
positive regulation of neurogenesis GO:0050769 165 0.013
positive regulation of transferase activity GO:0051347 81 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
regulation of camp biosynthetic process GO:0030817 38 0.013
synaptic transmission GO:0007268 235 0.013
synaptic vesicle transport GO:0048489 23 0.013
desensitization of g protein coupled receptor protein signaling pathway GO:0002029 10 0.013
response to muscle stretch GO:0035994 2 0.013
response to wounding GO:0009611 254 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.012
positive regulation of immunoglobulin production GO:0002639 4 0.012
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
synaptic vesicle localization GO:0097479 24 0.012
response to biotic stimulus GO:0009607 226 0.012
prostaglandin secretion GO:0032310 6 0.012
gastric motility GO:0035482 3 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
cell projection morphogenesis GO:0048858 123 0.012
divalent metal ion transport GO:0070838 132 0.012
organ regeneration GO:0031100 101 0.012
neuron neuron synaptic transmission GO:0007270 60 0.012
negative regulation of vesicle fusion GO:0031339 2 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
positive regulation of multicellular organismal process GO:0051240 387 0.012
macromolecular complex assembly GO:0065003 273 0.012
positive regulation of endothelial cell differentiation GO:0045603 2 0.012
regulation of immunoglobulin production GO:0002637 4 0.012
response to growth factor GO:0070848 189 0.012
lipid storage GO:0019915 1 0.011
motor neuron axon guidance GO:0008045 1 0.011
cell junction organization GO:0034330 21 0.011
anion transmembrane transport GO:0098656 77 0.011
ossification GO:0001503 70 0.011
cellular response to drug GO:0035690 30 0.011
release of cytochrome c from mitochondria GO:0001836 8 0.011
response to food GO:0032094 27 0.011
response to ethanol GO:0045471 162 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
mesodermal cell differentiation GO:0048333 1 0.011
response to acid chemical GO:0001101 222 0.011
cellular catabolic process GO:0044248 295 0.011
response to hexose GO:0009746 144 0.011
glial cell differentiation GO:0010001 65 0.011
lymphocyte activation involved in immune response GO:0002285 3 0.011
regulation of regulated secretory pathway GO:1903305 7 0.011
female pregnancy GO:0007565 122 0.011
immune effector process GO:0002252 53 0.011
cellular homeostasis GO:0019725 252 0.011
response to laminar fluid shear stress GO:0034616 9 0.011
single organism behavior GO:0044708 130 0.011
neuron projection morphogenesis GO:0048812 122 0.011
organelle localization GO:0051640 55 0.011
regulation of dendrite development GO:0050773 59 0.011
regulation of exocytosis GO:0017157 37 0.011
cellular response to alkaloid GO:0071312 25 0.011
response to amine GO:0014075 46 0.011
positive regulation of insulin secretion GO:0032024 36 0.011
positive regulation of cell development GO:0010720 176 0.011
synaptic transmission glutamatergic GO:0035249 33 0.011
morphogenesis of a polarized epithelium GO:0001738 1 0.011
regulation of protein serine threonine kinase activity GO:0071900 64 0.010
gastric inhibitory peptide signaling pathway GO:0038192 1 0.010
entrainment of circadian clock GO:0009649 3 0.010
regulation of rho gtpase activity GO:0032319 17 0.010
cellular response to oxygen containing compound GO:1901701 386 0.010
response to other organism GO:0051707 220 0.010
response to estradiol GO:0032355 164 0.010
enzyme linked receptor protein signaling pathway GO:0007167 116 0.010
positive regulation of cell projection organization GO:0031346 111 0.010
organic hydroxy compound metabolic process GO:1901615 115 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.010
glucose metabolic process GO:0006006 52 0.010
membrane organization GO:0061024 94 0.010
cell migration involved in kidney development GO:0035787 2 0.010
signal transduction by phosphorylation GO:0023014 144 0.010
prostaglandin transport GO:0015732 8 0.010
cellular component morphogenesis GO:0032989 155 0.010
positive regulation of protein modification process GO:0031401 142 0.010
circulatory system process GO:0003013 183 0.010

Notch4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
disease of cellular proliferation DOID:14566 0 0.020
neuromuscular disease DOID:440 0 0.019
neuropathy DOID:870 0 0.019
gastrointestinal system disease DOID:77 0 0.016
cardiovascular system disease DOID:1287 0 0.014
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012