Rattus norvegicus

2 known processes

Oas1a

2'-5' oligoadenylate synthetase 1A

(Aliases: Oas1,MGC93097,Oas1g)

Oas1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to biotic stimulus GO:0009607 226 0.867
response to other organism GO:0051707 220 0.792
response to virus GO:0009615 17 0.704
t cell tolerance induction GO:0002517 3 0.691
immune response GO:0006955 104 0.602
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.590
negative regulation of viral genome replication GO:0045071 1 0.588
response to cytokine GO:0034097 215 0.581
regulation of tolerance induction to nonself antigen GO:0002655 1 0.516
response to external biotic stimulus GO:0043207 221 0.488
negative regulation of innate immune response GO:0045824 4 0.438
positive regulation of multicellular organismal process GO:0051240 387 0.340
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.294
programmed cell death GO:0012501 392 0.292
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.289
positive regulation of lymphocyte migration GO:2000403 1 0.255
cellular response to oxygen containing compound GO:1901701 386 0.202
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.199
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.192
defense response GO:0006952 194 0.189
negative regulation of cell killing GO:0031342 5 0.181
response to lipopolysaccharide GO:0032496 191 0.175
positive regulation of tolerance induction GO:0002645 1 0.167
regulation of signal transduction GO:0009966 318 0.161
cell killing GO:0001906 13 0.137
leukocyte mediated immunity GO:0002443 28 0.135
cellular response to endogenous stimulus GO:0071495 377 0.125
positive regulation of response to external stimulus GO:0032103 51 0.125
positive regulation of response to stimulus GO:0048584 285 0.120
g protein coupled receptor signaling pathway GO:0007186 242 0.117
cellular response to peptide hormone stimulus GO:0071375 120 0.110
inflammatory response GO:0006954 150 0.108
response to bacterium GO:0009617 200 0.107
organophosphate metabolic process GO:0019637 370 0.102
Mouse
reproductive process GO:0022414 372 0.101
positive regulation of cell death GO:0010942 184 0.100
regulation of tolerance induction GO:0002643 2 0.100
negative regulation of response to stimulus GO:0048585 155 0.098
chemical homeostasis GO:0048878 292 0.096
response to exogenous dsrna GO:0043330 3 0.095
cation homeostasis GO:0055080 195 0.093
regulation of defense response GO:0031347 68 0.091
cellular response to nitrogen compound GO:1901699 210 0.086
cellular response to interleukin 1 GO:0071347 37 0.086
carboxylic acid metabolic process GO:0019752 289 0.086
positive regulation of secretion by cell GO:1903532 128 0.086
regulation of immune system process GO:0002682 123 0.083
amine metabolic process GO:0009308 38 0.082
metal ion homeostasis GO:0055065 186 0.081
cellular response to lipid GO:0071396 201 0.081
viral genome replication GO:0019079 2 0.079
organic acid metabolic process GO:0006082 292 0.078
cellular response to organic cyclic compound GO:0071407 202 0.078
regulation of cellular amino acid metabolic process GO:0006521 2 0.077
cellular homeostasis GO:0019725 252 0.071
regulation of programmed cell death GO:0043067 341 0.071
regulation of cellular protein metabolic process GO:0032268 267 0.070
regulation of response to external stimulus GO:0032101 106 0.068
oxoacid metabolic process GO:0043436 290 0.067
response to molecule of bacterial origin GO:0002237 194 0.067
homeostatic process GO:0042592 331 0.066
ion homeostasis GO:0050801 212 0.065
positive regulation of tolerance induction to nonself antigen GO:0002657 1 0.064
nucleotide metabolic process GO:0009117 279 0.062
Mouse
protein phosphorylation GO:0006468 345 0.061
regulation of response to stress GO:0080134 126 0.059
innate immune response GO:0045087 35 0.058
response to extracellular stimulus GO:0009991 380 0.057
negative regulation of immune system process GO:0002683 39 0.056
regulation of protein metabolic process GO:0051246 289 0.056
apoptotic process GO:0006915 381 0.056
cellular response to iron ion starvation GO:0010106 1 0.056
jak stat cascade GO:0007259 26 0.055
immune system process GO:0002376 204 0.055
female pregnancy GO:0007565 122 0.054
cellular ketone metabolic process GO:0042180 51 0.054
response to vitamin GO:0033273 131 0.053
response to nutrient GO:0007584 248 0.052
regulation of multicellular organismal development GO:2000026 376 0.052
regulation of phosphorus metabolic process GO:0051174 349 0.051
tolerance induction to nonself antigen GO:0002462 2 0.051
nucleoside phosphate metabolic process GO:0006753 283 0.050
Mouse
response to interleukin 1 GO:0070555 55 0.050
positive regulation of cell communication GO:0010647 271 0.050
neurological system process GO:0050877 219 0.049
response to wounding GO:0009611 254 0.048
positive regulation of intracellular signal transduction GO:1902533 138 0.046
regulation of phosphorylation GO:0042325 248 0.045
response to interferon gamma GO:0034341 20 0.045
regulation of cellular amine metabolic process GO:0033238 8 0.045
blood vessel morphogenesis GO:0048514 58 0.044
negative regulation of signaling GO:0023057 157 0.044
cell substrate adhesion GO:0031589 29 0.043
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.043
cellular amino acid metabolic process GO:0006520 107 0.043
cellular amine metabolic process GO:0044106 38 0.043
peptidyl amino acid modification GO:0018193 126 0.042
response to dsrna GO:0043331 9 0.042
intracellular signal transduction GO:0035556 314 0.041
metal ion transport GO:0030001 289 0.041
nucleobase containing small molecule metabolic process GO:0055086 316 0.041
Mouse
negative regulation of metabolic process GO:0009892 331 0.039
rna metabolic process GO:0016070 406 0.039
immune effector process GO:0002252 53 0.039
neuron projection development GO:0031175 273 0.038
regulation of kinase activity GO:0043549 117 0.038
positive regulation of phosphorus metabolic process GO:0010562 262 0.038
regulation of hormone levels GO:0010817 187 0.037
response to glucocorticoid GO:0051384 223 0.036
cellular response to hormone stimulus GO:0032870 247 0.036
blood circulation GO:0008015 183 0.036
regulation of cell development GO:0060284 263 0.035
regulation of cellular ketone metabolic process GO:0010565 27 0.035
reproduction GO:0000003 245 0.034
response to peptide GO:1901652 292 0.033
regulation of protein phosphorylation GO:0001932 183 0.033
protein complex subunit organization GO:0071822 302 0.033
organophosphate biosynthetic process GO:0090407 143 0.033
Mouse
t cell migration GO:0072678 2 0.032
positive regulation of t cell migration GO:2000406 1 0.032
cellular response to nutrient levels GO:0031669 60 0.032
protein oligomerization GO:0051259 191 0.032
regulation of natural killer cell mediated cytotoxicity GO:0042269 6 0.032
regulation of apoptotic process GO:0042981 335 0.032
negative regulation of cell communication GO:0010648 158 0.032
regulation of phosphate metabolic process GO:0019220 349 0.031
response to hexose GO:0009746 144 0.031
single organism biosynthetic process GO:0044711 342 0.031
Mouse
t cell chemotaxis GO:0010818 2 0.031
negative regulation of signal transduction GO:0009968 83 0.031
regulation of viral genome replication GO:0045069 2 0.031
response to peptide hormone GO:0043434 278 0.031
cellular response to external stimulus GO:0071496 118 0.030
response to growth factor GO:0070848 189 0.030
learning or memory GO:0007611 90 0.029
negative regulation of viral process GO:0048525 4 0.029
Mouse
cellular response to molecule of bacterial origin GO:0071219 56 0.028
positive regulation of programmed cell death GO:0043068 157 0.028
circulatory system process GO:0003013 183 0.028
positive regulation of developmental process GO:0051094 283 0.028
protein localization GO:0008104 191 0.028
regulation of protein modification process GO:0031399 194 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.027
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.027
protein complex assembly GO:0006461 263 0.027
regulation of catalytic activity GO:0050790 304 0.027
negative regulation of phosphorus metabolic process GO:0010563 80 0.027
tolerance induction dependent upon immune response GO:0002461 2 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
cellular response to peptide GO:1901653 133 0.026
negative regulation of protein phosphorylation GO:0001933 44 0.026
positive regulation of cellular biosynthetic process GO:0031328 295 0.026
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.026
regulation of rna metabolic process GO:0051252 391 0.026
regulation of homotypic cell cell adhesion GO:0034110 4 0.026
lymphocyte migration GO:0072676 3 0.025
negative regulation of cell death GO:0060548 229 0.025
regulation of cellular component organization GO:0051128 368 0.025
positive regulation of signaling GO:0023056 270 0.025
multi multicellular organism process GO:0044706 138 0.025
glucose homeostasis GO:0042593 75 0.025
cellular ion homeostasis GO:0006873 184 0.025
response to metal ion GO:0010038 253 0.025
negative regulation of programmed cell death GO:0043069 183 0.025
multi organism reproductive process GO:0044703 262 0.024
neuron differentiation GO:0030182 368 0.024
cellular response to metal ion GO:0071248 55 0.024
protein complex biogenesis GO:0070271 263 0.024
regulation of lymphocyte migration GO:2000401 1 0.024
response to acid chemical GO:0001101 222 0.024
vascular process in circulatory system GO:0003018 96 0.024
macromolecule localization GO:0033036 252 0.023
regulation of natural killer cell mediated immunity GO:0002715 6 0.023
regulation of nervous system development GO:0051960 264 0.023
multicellular organism reproduction GO:0032504 233 0.023
single organism reproductive process GO:0044702 297 0.023
macromolecular complex assembly GO:0065003 273 0.023
positive regulation of erythrocyte aggregation GO:0034120 1 0.023
regulation of purine nucleotide metabolic process GO:1900542 115 0.023
regulation of acute inflammatory response GO:0002673 23 0.022
positive regulation of homotypic cell cell adhesion GO:0034112 2 0.022
positive regulation of phosphate metabolic process GO:0045937 262 0.022
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 8 0.022
response to oxygen levels GO:0070482 265 0.022
single organism carbohydrate metabolic process GO:0044723 118 0.022
negative regulation of macromolecule metabolic process GO:0010605 260 0.021
carbohydrate metabolic process GO:0005975 130 0.021
transcription dna templated GO:0006351 377 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
nucleoside phosphate biosynthetic process GO:1901293 102 0.021
Mouse
regulation of cell killing GO:0031341 12 0.021
regulation of cell adhesion GO:0030155 52 0.021
negative regulation of developmental process GO:0051093 125 0.021
positive regulation of cellular amine metabolic process GO:0033240 3 0.021
biological adhesion GO:0022610 110 0.021
aging GO:0007568 241 0.020
positive regulation of immune system process GO:0002684 90 0.020
negative regulation of phosphate metabolic process GO:0045936 80 0.020
peptide secretion GO:0002790 86 0.020
cellular protein localization GO:0034613 122 0.020
proteolysis GO:0006508 175 0.019
protein transport GO:0015031 132 0.019
sensory perception GO:0007600 101 0.019
purine containing compound biosynthetic process GO:0072522 85 0.019
Mouse
negative regulation of catalytic activity GO:0043086 103 0.019
multicellular organismal reproductive process GO:0048609 233 0.019
divalent inorganic cation transport GO:0072511 134 0.018
maternal process involved in female pregnancy GO:0060135 38 0.018
cytosolic calcium ion homeostasis GO:0051480 140 0.018
negative regulation of defense response GO:0031348 19 0.018
cyclic nucleotide metabolic process GO:0009187 80 0.018
response to axon injury GO:0048678 59 0.018
regulation of rna biosynthetic process GO:2001141 381 0.018
regulation of lymphocyte mediated immunity GO:0002706 11 0.018
regulation of peptide secretion GO:0002791 82 0.018
regulation of cell differentiation GO:0045595 320 0.018
central nervous system development GO:0007417 311 0.018
regulation of cellular localization GO:0060341 263 0.018
negative regulation of leukocyte mediated immunity GO:0002704 6 0.018
peptide transport GO:0015833 97 0.018
response to nutrient levels GO:0031667 370 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
acute phase response GO:0006953 20 0.017
brain development GO:0007420 247 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
cellular chemical homeostasis GO:0055082 247 0.017
muscle system process GO:0003012 115 0.017
positive regulation of signal transduction GO:0009967 175 0.017
calcium ion transport GO:0006816 131 0.017
response to tumor necrosis factor GO:0034612 56 0.017
regulation of t cell migration GO:2000404 1 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
carbohydrate homeostasis GO:0033500 75 0.017
positive regulation of catalytic activity GO:0043085 184 0.017
regulation of secretion by cell GO:1903530 208 0.017
positive regulation of behavior GO:0048520 38 0.016
negative regulation of cellular protein metabolic process GO:0032269 106 0.016
cellular component assembly GO:0022607 360 0.016
cellular metal ion homeostasis GO:0006875 172 0.016
positive regulation of leukocyte mediated immunity GO:0002705 13 0.016
cellular cation homeostasis GO:0030003 180 0.016
response to temperature stimulus GO:0009266 94 0.016
cytolysis GO:0019835 4 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
regulation of protein kinase activity GO:0045859 105 0.016
response to estrogen GO:0043627 232 0.016
regulation of system process GO:0044057 208 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
cellular response to stress GO:0033554 269 0.016
positive regulation of rna biosynthetic process GO:1902680 197 0.016
secretion GO:0046903 307 0.016
regulation of membrane potential GO:0042391 110 0.016
leukocyte activation GO:0045321 76 0.016
cell adhesion GO:0007155 110 0.016
hormone secretion GO:0046879 115 0.015
exocytosis GO:0006887 60 0.015
positive regulation of transport GO:0051050 245 0.015
peptidyl tyrosine modification GO:0018212 72 0.015
response to tumor cell GO:0002347 4 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
Mouse
macromolecular complex subunit organization GO:0043933 339 0.015
response to carbohydrate GO:0009743 183 0.015
acute inflammatory response GO:0002526 58 0.015
nitrogen compound transport GO:0071705 229 0.015
carbohydrate derivative metabolic process GO:1901135 346 0.015
response to monosaccharide GO:0034284 159 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
regulation of smooth muscle cell migration GO:0014910 36 0.014
myeloid leukocyte activation GO:0002274 36 0.014
negative regulation of protein metabolic process GO:0051248 114 0.014
cellular response to iron iii ion GO:0071283 3 0.014
positive regulation of cell development GO:0010720 176 0.014
behavior GO:0007610 205 0.014
cellular response to extracellular stimulus GO:0031668 73 0.014
regulation of transferase activity GO:0051338 123 0.014
organonitrogen compound biosynthetic process GO:1901566 167 0.014
Mouse
regulation of tube size GO:0035150 89 0.014
regulation of immune response GO:0050776 55 0.014
programmed necrotic cell death GO:0097300 2 0.014
defense response to gram positive bacterium GO:0050830 2 0.014
muscle cell proliferation GO:0033002 84 0.014
peptidyl tyrosine phosphorylation GO:0018108 72 0.014
positive regulation of peptide hormone secretion GO:0090277 50 0.014
positive regulation of gene expression GO:0010628 244 0.014
amide transport GO:0042886 105 0.014
t cell mediated cytotoxicity GO:0001913 5 0.014
regulation of neuron death GO:1901214 115 0.014
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.014
glucagon secretion GO:0070091 5 0.014
natural killer cell mediated cytotoxicity GO:0042267 6 0.013
response to glucose GO:0009749 136 0.013
regulation of immune response to tumor cell GO:0002837 3 0.013
response to activity GO:0014823 73 0.013
transcription from rna polymerase ii promoter GO:0006366 252 0.013
cellular component biogenesis GO:0044085 368 0.013
regulation of angiogenesis GO:0045765 39 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
response to corticosteroid GO:0031960 235 0.013
regulation of adaptive immune response GO:0002819 8 0.013
positive regulation of t cell mediated immunity GO:0002711 4 0.013
negative regulation of immune response GO:0050777 15 0.013
regulation of jak stat cascade GO:0046425 21 0.013
cellular response to hexose stimulus GO:0071331 65 0.013
negative regulation of molecular function GO:0044092 133 0.013
regulation of immune effector process GO:0002697 32 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
cellular calcium ion homeostasis GO:0006874 160 0.013
positive regulation of camp mediated signaling GO:0043950 2 0.013
purine containing compound metabolic process GO:0072521 253 0.012
Mouse
response to transition metal nanoparticle GO:1990267 122 0.012
single organism cellular localization GO:1902580 102 0.012
negative regulation of jak stat cascade GO:0046426 3 0.012
regulation of cell proliferation GO:0042127 359 0.012
regulation of hydrolase activity GO:0051336 143 0.012
muscle contraction GO:0006936 88 0.012
regulation of blood vessel size GO:0050880 89 0.012
cell cell signaling GO:0007267 335 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
insecticide metabolic process GO:0017143 4 0.012
positive regulation of cytokine production GO:0001819 42 0.012
cellular response to lipoteichoic acid GO:0071223 1 0.012
olfactory behavior GO:0042048 2 0.012
organ regeneration GO:0031100 101 0.012
negative regulation of lymphocyte mediated immunity GO:0002707 5 0.012
response to purine containing compound GO:0014074 126 0.012
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.012
positive regulation of hormone secretion GO:0046887 65 0.012
positive regulation of neurogenesis GO:0050769 165 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
gamete generation GO:0007276 124 0.012
negative regulation of cellular metabolic process GO:0031324 281 0.012
regulation of innate immune response GO:0045088 15 0.012
cellular response to acid chemical GO:0071229 75 0.011
regulation of camp metabolic process GO:0030814 43 0.011
defense response to other organism GO:0098542 17 0.011
regulation of leukocyte mediated cytotoxicity GO:0001910 10 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.011
response to inorganic substance GO:0010035 377 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
response to hypoxia GO:0001666 231 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.011
regulation of neuron differentiation GO:0045664 208 0.011
regulation of peptide hormone secretion GO:0090276 80 0.011
regulation of necroptotic process GO:0060544 2 0.011
neuron development GO:0048666 286 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
negative regulation of phosphorylation GO:0042326 57 0.011
regulation of nucleic acid templated transcription GO:1903506 380 0.011
positive regulation of peptide secretion GO:0002793 52 0.011
regulation of insulin secretion GO:0050796 65 0.011
regulation of neuron projection development GO:0010975 161 0.011
cellular glucose homeostasis GO:0001678 66 0.011
response to radiation GO:0009314 137 0.011
negative regulation of gene expression GO:0010629 199 0.011
response to ethanol GO:0045471 162 0.010
response to toxic substance GO:0009636 133 0.010
platelet aggregation GO:0070527 4 0.010
defense response to gram negative bacterium GO:0050829 3 0.010
carbohydrate derivative biosynthetic process GO:1901137 124 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.010
response to vitamin d GO:0033280 34 0.010
positive regulation of nervous system development GO:0051962 178 0.010
ion transmembrane transport GO:0034220 365 0.010
glucose metabolic process GO:0006006 52 0.010
alpha amino acid metabolic process GO:1901605 71 0.010
single organism intracellular transport GO:1902582 166 0.010
secretion by cell GO:0032940 248 0.010
cell type specific apoptotic process GO:0097285 134 0.010
phospholipid metabolic process GO:0006644 61 0.010
signal transduction by phosphorylation GO:0023014 144 0.010
positive regulation of transcription dna templated GO:0045893 197 0.010
neuron apoptotic process GO:0051402 88 0.010
positive regulation of necrotic cell death GO:0010940 4 0.010
response to stilbenoid GO:0035634 1 0.010
positive regulation of protein kinase activity GO:0045860 73 0.010

Oas1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
urinary system disease DOID:18 0 0.039
disease of anatomical entity DOID:7 0 0.039
carbohydrate metabolism disease DOID:0050013 0 0.018
acquired metabolic disease DOID:0060158 0 0.018
diabetes mellitus DOID:9351 0 0.018
type 1 diabetes mellitus DOID:9744 0 0.018
glucose metabolism disease DOID:4194 0 0.018
disease of metabolism DOID:0014667 0 0.018
focal segmental glomerulosclerosis DOID:1312 0 0.013
kidney disease DOID:557 0 0.013
glomerulosclerosis DOID:0050851 0 0.013
nephritis DOID:10952 0 0.013
glomerulonephritis DOID:2921 0 0.013