Rattus norvegicus

116 known processes

P2ry12

purinergic receptor P2Y, G-protein coupled, 12

(Aliases: P2y12)

P2ry12 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
response to bacterium GO:0009617 200 0.239
aging GO:0007568 241 0.133
defense response GO:0006952 194 0.128
regulation of cell proliferation GO:0042127 359 0.092
vasculature development GO:0001944 70 0.087
blood circulation GO:0008015 183 0.086
g protein coupled receptor signaling pathway GO:0007186 242 0.074
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.074
positive regulation of response to stimulus GO:0048584 285 0.066
response to inorganic substance GO:0010035 377 0.064
circulatory system process GO:0003013 183 0.062
t cell chemotaxis GO:0010818 2 0.060
oxoacid metabolic process GO:0043436 290 0.059
cellular response to endogenous stimulus GO:0071495 377 0.057
central nervous system development GO:0007417 311 0.057
response to nutrient GO:0007584 248 0.057
negative regulation of developmental process GO:0051093 125 0.055
response to estrogen GO:0043627 232 0.055
chemical homeostasis GO:0048878 292 0.055
head development GO:0060322 247 0.054
cellular response to lipid GO:0071396 201 0.054
neuron development GO:0048666 286 0.054
catabolic process GO:0009056 351 0.051
angiogenesis GO:0001525 53 0.050
regulation of neutrophil migration GO:1902622 6 0.049
regulation of protein phosphorylation GO:0001932 183 0.048
cellular amino acid metabolic process GO:0006520 107 0.047
regulation of angiogenesis GO:0045765 39 0.047
cellular catabolic process GO:0044248 295 0.047
inflammatory response GO:0006954 150 0.047
macromolecular complex assembly GO:0065003 273 0.046
response to extracellular stimulus GO:0009991 380 0.045
anatomical structure morphogenesis GO:0009653 298 0.044
inorganic cation transmembrane transport GO:0098662 202 0.044
positive regulation of multicellular organismal process GO:0051240 387 0.043
reproduction GO:0000003 245 0.043
regulation of molecular function GO:0065009 398 0.043
cellular response to growth factor stimulus GO:0071363 162 0.042
regulation of phosphate metabolic process GO:0019220 349 0.042
blood vessel development GO:0001568 69 0.041
response to wounding GO:0009611 254 0.041
small gtpase mediated signal transduction GO:0007264 36 0.041
regulation of cell development GO:0060284 263 0.041
immune system process GO:0002376 204 0.040
regulation of signal transduction GO:0009966 318 0.040
cellular response to oxygen containing compound GO:1901701 386 0.039
locomotion GO:0040011 237 0.039
blood vessel morphogenesis GO:0048514 58 0.039
response to toxic substance GO:0009636 133 0.038
response to growth factor GO:0070848 189 0.038
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.037
cation homeostasis GO:0055080 195 0.037
regulation of nucleic acid templated transcription GO:1903506 380 0.037
negative regulation of response to stimulus GO:0048585 155 0.036
ras protein signal transduction GO:0007265 29 0.036
neuron differentiation GO:0030182 368 0.035
cell activation GO:0001775 97 0.035
response to other organism GO:0051707 220 0.035
regulation of intracellular signal transduction GO:1902531 218 0.035
regulation of phosphorus metabolic process GO:0051174 349 0.034
reproductive process GO:0022414 372 0.034
gastrulation GO:0007369 2 0.033
regulation of chronic inflammatory response to non antigenic stimulus GO:0002880 1 0.032
circulatory system development GO:0072359 134 0.032
response to cytokine GO:0034097 215 0.031
cellular response to nitrogen compound GO:1901699 210 0.031
positive regulation of phosphorus metabolic process GO:0010562 262 0.031
protein complex biogenesis GO:0070271 263 0.031
regulation of phosphorylation GO:0042325 248 0.031
cellular response to organonitrogen compound GO:0071417 197 0.031
positive regulation of phosphate metabolic process GO:0045937 262 0.030
intracellular signal transduction GO:0035556 314 0.030
cellular amine metabolic process GO:0044106 38 0.030
regulation of apoptotic process GO:0042981 335 0.030
regulation of response to stress GO:0080134 126 0.030
developmental growth GO:0048589 100 0.030
negative regulation of cell proliferation GO:0008285 119 0.029
response to external biotic stimulus GO:0043207 221 0.029
cellular response to histamine GO:0071420 3 0.029
vascular process in circulatory system GO:0003018 96 0.029
positive regulation of cell communication GO:0010647 271 0.029
amine metabolic process GO:0009308 38 0.029
response to nutrient levels GO:0031667 370 0.029
cellular response to cytokine stimulus GO:0071345 127 0.028
cardiovascular system development GO:0072358 134 0.028
regulation of cellular protein metabolic process GO:0032268 267 0.028
t cell tolerance induction GO:0002517 3 0.027
positive regulation of cellular protein metabolic process GO:0032270 167 0.027
response to oxygen levels GO:0070482 265 0.027
apoptotic process GO:0006915 381 0.027
regulation of anatomical structure morphogenesis GO:0022603 141 0.027
response to histamine GO:0034776 3 0.027
ion homeostasis GO:0050801 212 0.027
positive regulation of protein modification process GO:0031401 142 0.026
negative regulation of multicellular organismal process GO:0051241 203 0.026
protein oligomerization GO:0051259 191 0.026
angioblast cell migration GO:0035476 1 0.026
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.025
Human Mouse
positive regulation of cell proliferation GO:0008284 249 0.025
muscle system process GO:0003012 115 0.025
regulation of ion transmembrane transporter activity GO:0032412 48 0.025
regulation of blood vessel size GO:0050880 89 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.025
response to metal ion GO:0010038 253 0.024
positive regulation of transcription dna templated GO:0045893 197 0.024
response to biotic stimulus GO:0009607 226 0.024
positive regulation of protein phosphorylation GO:0001934 135 0.024
lymphocyte chemotaxis GO:0048247 3 0.024
regulation of anatomical structure size GO:0090066 135 0.024
multicellular organismal reproductive process GO:0048609 233 0.024
cellular component biogenesis GO:0044085 368 0.023
immune response GO:0006955 104 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
transmembrane transport GO:0055085 412 0.023
positive regulation of phosphorylation GO:0042327 177 0.023
positive regulation of signaling GO:0023056 270 0.023
intracellular transport GO:0046907 185 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
muscle tissue development GO:0060537 58 0.022
negative regulation of programmed cell death GO:0043069 183 0.022
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.022
regulation of protein modification process GO:0031399 194 0.021
response to lipopolysaccharide GO:0032496 191 0.021
cellular calcium ion homeostasis GO:0006874 160 0.021
calcium ion transport GO:0006816 131 0.021
regulation of cell differentiation GO:0045595 320 0.021
wound healing GO:0042060 122 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
macromolecule localization GO:0033036 252 0.021
brain development GO:0007420 247 0.021
regulation of tube size GO:0035150 89 0.020
striated muscle tissue development GO:0014706 58 0.020
negative regulation of neutrophil apoptotic process GO:0033030 3 0.020
cellular macromolecule localization GO:0070727 122 0.020
cellular homeostasis GO:0019725 252 0.020
telencephalon development GO:0021537 62 0.020
regulation of chronic inflammatory response GO:0002676 3 0.020
neuromuscular process GO:0050905 2 0.020
cardiac muscle contraction GO:0060048 27 0.020
heart contraction GO:0060047 57 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
regulation of system process GO:0044057 208 0.019
proteolysis GO:0006508 175 0.019
regulation of neurogenesis GO:0050767 247 0.019
negative regulation of protein metabolic process GO:0051248 114 0.019
regulation of protein metabolic process GO:0051246 289 0.019
homeostatic process GO:0042592 331 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
regulation of cellular ketone metabolic process GO:0010565 27 0.019
adenosine receptor signaling pathway GO:0001973 7 0.019
regulation of vasculature development GO:1901342 44 0.019
tube morphogenesis GO:0035239 23 0.019
protein complex assembly GO:0006461 263 0.019
cell morphogenesis involved in differentiation GO:0000904 119 0.018
forebrain development GO:0030900 98 0.018
neuron projection development GO:0031175 273 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
regulation of programmed cell death GO:0043067 341 0.018
regulation of neuron projection development GO:0010975 161 0.018
biological adhesion GO:0022610 110 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.017
cytosolic calcium ion homeostasis GO:0051480 140 0.017
negative regulation of apoptotic process GO:0043066 181 0.017
negative regulation of gene expression GO:0010629 199 0.017
positive regulation of long term synaptic potentiation GO:1900273 4 0.017
cellular chemical homeostasis GO:0055082 247 0.017
axon development GO:0061564 96 0.017
organophosphate catabolic process GO:0046434 148 0.017
cellular cation homeostasis GO:0030003 180 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
transcription from rna polymerase ii promoter GO:0006366 252 0.017
gliogenesis GO:0042063 93 0.017
regulation of blood circulation GO:1903522 110 0.017
regulation of rna biosynthetic process GO:2001141 381 0.017
multicellular organism growth GO:0035264 1 0.017
multi organism reproductive process GO:0044703 262 0.017
cellular response to alcohol GO:0097306 87 0.017
positive regulation of mapk cascade GO:0043410 92 0.017
motor neuron axon guidance GO:0008045 1 0.017
lymphocyte migration GO:0072676 3 0.017
purine ribonucleoside metabolic process GO:0046128 168 0.017
organic acid metabolic process GO:0006082 292 0.017
macrophage chemotaxis GO:0048246 2 0.016
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.016
response to alkaloid GO:0043279 132 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
organ morphogenesis GO:0009887 75 0.016
carbohydrate derivative metabolic process GO:1901135 346 0.016
multicellular organism reproduction GO:0032504 233 0.016
negative regulation of cell differentiation GO:0045596 99 0.016
purine nucleoside catabolic process GO:0006152 124 0.016
metanephric tubule morphogenesis GO:0072173 2 0.016
organic cyclic compound catabolic process GO:1901361 175 0.016
neutrophil apoptotic process GO:0001781 4 0.016
choline transport GO:0015871 4 0.016
sequestering of metal ion GO:0051238 9 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
g protein coupled purinergic receptor signaling pathway GO:0035588 8 0.015
negative regulation of chronic inflammatory response GO:0002677 2 0.015
acute inflammatory response GO:0002526 58 0.015
positive regulation of blood circulation GO:1903524 65 0.015
programmed cell death GO:0012501 392 0.015
regulation of neuron differentiation GO:0045664 208 0.015
regeneration GO:0031099 163 0.015
response to oxidative stress GO:0006979 186 0.015
response to purine containing compound GO:0014074 126 0.014
single organism biosynthetic process GO:0044711 342 0.014
regulation of response to external stimulus GO:0032101 106 0.014
regulation of transporter activity GO:0032409 50 0.014
sequestering of calcium ion GO:0051208 8 0.014
vasodilation GO:0042311 44 0.014
regulation of catabolic process GO:0009894 113 0.014
protein transport GO:0015031 132 0.014
regulation of synaptic plasticity GO:0048167 70 0.014
regulation of cellular component movement GO:0051270 150 0.014
response to carbohydrate GO:0009743 183 0.014
growth GO:0040007 165 0.014
negative regulation of innate immune response GO:0045824 4 0.014
response to glucocorticoid GO:0051384 223 0.014
protein phosphorylation GO:0006468 345 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
positive regulation of intracellular signal transduction GO:1902533 138 0.014
positive regulation of molecular function GO:0044093 230 0.014
female sex differentiation GO:0046660 59 0.014
potassium ion transport GO:0006813 97 0.014
regulation of cellular localization GO:0060341 263 0.014
single organismal cell cell adhesion GO:0016337 42 0.013
regulation of transmembrane transporter activity GO:0022898 49 0.013
cellular protein localization GO:0034613 122 0.013
negative regulation of cell communication GO:0010648 158 0.013
positive regulation of developmental process GO:0051094 283 0.013
rna biosynthetic process GO:0032774 380 0.013
positive regulation of cellular biosynthetic process GO:0031328 295 0.013
cellular component movement GO:0006928 248 0.013
organ formation GO:0048645 3 0.013
negative regulation of signaling GO:0023057 157 0.013
platelet aggregation GO:0070527 4 0.013
axonogenesis GO:0007409 71 0.013
adenylate cyclase inhibiting serotonin receptor signaling pathway GO:0007198 1 0.013
leukocyte activation GO:0045321 76 0.013
cell part morphogenesis GO:0032990 123 0.013
single organism reproductive process GO:0044702 297 0.013
response to mechanical stimulus GO:0009612 134 0.013
rho protein signal transduction GO:0007266 11 0.013
adult locomotory behavior GO:0008344 4 0.013
carboxylic acid metabolic process GO:0019752 289 0.013
cell type specific apoptotic process GO:0097285 134 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
protein localization GO:0008104 191 0.013
positive regulation of cell death GO:0010942 184 0.012
negative regulation of protein modification process GO:0031400 52 0.012
ion transmembrane transport GO:0034220 365 0.012
negative regulation of macromolecule metabolic process GO:0010605 260 0.012
divalent metal ion transport GO:0070838 132 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
startle response GO:0001964 2 0.012
negative regulation of molecular function GO:0044092 133 0.012
cell projection organization GO:0030030 302 0.012
organic hydroxy compound transport GO:0015850 77 0.012
regulation of ion transport GO:0043269 245 0.012
regulation of response to wounding GO:1903034 69 0.012
cellular response to biotic stimulus GO:0071216 59 0.012
regulation of hydrolase activity GO:0051336 143 0.012
tissue development GO:0009888 252 0.012
positive regulation of neuron differentiation GO:0045666 126 0.012
negative regulation of metabolic process GO:0009892 331 0.012
axis specification GO:0009798 4 0.012
regulation of kinase activity GO:0043549 117 0.012
inflammatory response to antigenic stimulus GO:0002437 18 0.012
cation transmembrane transport GO:0098655 263 0.011
response to monosaccharide GO:0034284 159 0.011
negative regulation of cellular metabolic process GO:0031324 281 0.011
response to acid chemical GO:0001101 222 0.011
kidney development GO:0001822 67 0.011
positive regulation of interleukin 1 beta secretion GO:0050718 3 0.011
cellular response to lipopolysaccharide GO:0071222 55 0.011
response to radiation GO:0009314 137 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
regulation of respiratory gaseous exchange GO:0043576 2 0.011
single organism catabolic process GO:0044712 283 0.011
transcription dna templated GO:0006351 377 0.011
protein homooligomerization GO:0051260 91 0.011
regulation of multicellular organismal development GO:2000026 376 0.011
t cell migration GO:0072678 2 0.011
regulation of defense response GO:0031347 68 0.011
sensory perception GO:0007600 101 0.011
regulation of catalytic activity GO:0050790 304 0.011
regulation of small gtpase mediated signal transduction GO:0051056 48 0.011
purine nucleoside triphosphate metabolic process GO:0009144 141 0.011
purine containing compound metabolic process GO:0072521 253 0.011
cellular nitrogen compound catabolic process GO:0044270 163 0.011
cell migration GO:0016477 197 0.011
cellular ketone metabolic process GO:0042180 51 0.011
astrocyte activation GO:0048143 4 0.011
cellular component assembly GO:0022607 360 0.011
regulation of secretion GO:0051046 224 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
negative regulation of cellular protein metabolic process GO:0032269 106 0.011
response to testosterone GO:0033574 55 0.011
glucose homeostasis GO:0042593 75 0.011
positive regulation of rna biosynthetic process GO:1902680 197 0.011
regulation of transcription dna templated GO:0006355 374 0.010
nucleotide catabolic process GO:0009166 139 0.010
regulation of cell motility GO:2000145 131 0.010
regulation of alpha beta t cell activation GO:0046634 2 0.010
muscle contraction GO:0006936 88 0.010
organic substance catabolic process GO:1901575 316 0.010
odontogenesis GO:0042476 32 0.010
sensory perception of bitter taste GO:0050913 4 0.010
negative regulation of vascular permeability GO:0043116 3 0.010
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 4 0.010
catecholamine secretion GO:0050432 33 0.010
response to corticosteroid GO:0031960 235 0.010
ribonucleoside triphosphate catabolic process GO:0009203 122 0.010
heterocycle catabolic process GO:0046700 167 0.010
regulation of rna metabolic process GO:0051252 391 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
heart process GO:0003015 57 0.010
rna metabolic process GO:0016070 406 0.010
regulation of membrane potential GO:0042391 110 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
respiratory gaseous exchange GO:0007585 4 0.010
l glutamate import GO:0051938 2 0.010
cellular response to external stimulus GO:0071496 118 0.010
regulation of growth GO:0040008 105 0.010
regulation of cell projection organization GO:0031344 175 0.010

P2ry12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
sensory system disease DOID:0050155 0 0.016
disease of metabolism DOID:0014667 0 0.013