Rattus norvegicus

0 known processes

P4ha1

prolyl 4-hydroxylase, alpha polypeptide I

(Aliases: PHalphaI)

P4ha1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein refolding GO:0042026 3 0.160
negative regulation of gene expression GO:0010629 199 0.147
regulation of molecular function GO:0065009 398 0.105
anatomical structure morphogenesis GO:0009653 298 0.096
negative regulation of cellular metabolic process GO:0031324 281 0.084
regulation of catalytic activity GO:0050790 304 0.082
neuron differentiation GO:0030182 368 0.078
regulation of protein metabolic process GO:0051246 289 0.078
protein transport GO:0015031 132 0.076
transcription from rna polymerase ii promoter GO:0006366 252 0.075
protein localization GO:0008104 191 0.072
cellular component biogenesis GO:0044085 368 0.071
macromolecule localization GO:0033036 252 0.070
regulation of rna biosynthetic process GO:2001141 381 0.070
regulation of nucleic acid templated transcription GO:1903506 380 0.069
rna biosynthetic process GO:0032774 380 0.069
cell projection morphogenesis GO:0048858 123 0.069
positive regulation of phosphorus metabolic process GO:0010562 262 0.067
de novo posttranslational protein folding GO:0051084 2 0.064
negative regulation of macromolecule metabolic process GO:0010605 260 0.062
regulation of transcription dna templated GO:0006355 374 0.062
negative regulation of metabolic process GO:0009892 331 0.062
carbohydrate derivative metabolic process GO:1901135 346 0.060
regulation of apoptotic process GO:0042981 335 0.059
regulation of programmed cell death GO:0043067 341 0.057
regulation of rna metabolic process GO:0051252 391 0.056
transmembrane transport GO:0055085 412 0.056
programmed cell death GO:0012501 392 0.055
secretion by cell GO:0032940 248 0.055
regulation of neuron differentiation GO:0045664 208 0.054
regulation of phosphorylation GO:0042325 248 0.054
rna metabolic process GO:0016070 406 0.054
positive regulation of gene expression GO:0010628 244 0.052
negative regulation of protein metabolic process GO:0051248 114 0.052
regulation of phosphorus metabolic process GO:0051174 349 0.051
regulation of cellular protein metabolic process GO:0032268 267 0.050
regulation of multicellular organismal development GO:2000026 376 0.050
intracellular transport GO:0046907 185 0.050
positive regulation of developmental process GO:0051094 283 0.049
cellular component assembly GO:0022607 360 0.049
cellular catabolic process GO:0044248 295 0.048
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.048
positive regulation of cell differentiation GO:0045597 217 0.048
regulation of phosphate metabolic process GO:0019220 349 0.047
response to nutrient levels GO:0031667 370 0.047
tissue development GO:0009888 252 0.046
negative regulation of molecular function GO:0044092 133 0.044
regulation of neurogenesis GO:0050767 247 0.043
oxoacid metabolic process GO:0043436 290 0.042
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.042
nucleic acid templated transcription GO:0097659 379 0.042
apoptotic process GO:0006915 381 0.041
response to hypoxia GO:0001666 231 0.041
purine containing compound metabolic process GO:0072521 253 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.040
response to oxygen levels GO:0070482 265 0.040
membrane organization GO:0061024 94 0.039
positive regulation of response to stimulus GO:0048584 285 0.039
transcription dna templated GO:0006351 377 0.037
regulation of nervous system development GO:0051960 264 0.037
regulation of cell differentiation GO:0045595 320 0.037
organophosphate metabolic process GO:0019637 370 0.037
positive regulation of molecular function GO:0044093 230 0.037
carboxylic acid metabolic process GO:0019752 289 0.037
aromatic compound catabolic process GO:0019439 168 0.037
neuron projection development GO:0031175 273 0.036
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.036
nucleobase containing small molecule metabolic process GO:0055086 316 0.036
positive regulation of cellular biosynthetic process GO:0031328 295 0.036
organic substance catabolic process GO:1901575 316 0.036
catabolic process GO:0009056 351 0.035
regulation of cell development GO:0060284 263 0.035
positive regulation of transcription dna templated GO:0045893 197 0.034
response to extracellular stimulus GO:0009991 380 0.034
negative regulation of apoptotic process GO:0043066 181 0.034
positive regulation of nervous system development GO:0051962 178 0.034
cellular response to hormone stimulus GO:0032870 247 0.033
regulation of cellular component organization GO:0051128 368 0.033
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.033
cellular protein localization GO:0034613 122 0.033
nitrogen compound transport GO:0071705 229 0.032
cardiovascular system development GO:0072358 134 0.032
organic acid metabolic process GO:0006082 292 0.031
purine nucleotide metabolic process GO:0006163 229 0.031
cell morphogenesis GO:0000902 142 0.031
single organism intracellular transport GO:1902582 166 0.031
regulation of hydrolase activity GO:0051336 143 0.031
regulation of response to stress GO:0080134 126 0.030
single organism catabolic process GO:0044712 283 0.030
protein complex subunit organization GO:0071822 302 0.030
reproduction GO:0000003 245 0.030
regulation of secretion by cell GO:1903530 208 0.030
cellular response to stress GO:0033554 269 0.029
response to decreased oxygen levels GO:0036293 237 0.029
cell projection organization GO:0030030 302 0.029
positive regulation of cellular component organization GO:0051130 200 0.029
cell cell signaling GO:0007267 335 0.029
organelle organization GO:0006996 266 0.029
negative regulation of cellular protein metabolic process GO:0032269 106 0.028
ribonucleotide catabolic process GO:0009261 136 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.028
organophosphate catabolic process GO:0046434 148 0.028
heterocycle catabolic process GO:0046700 167 0.028
cellular macromolecule localization GO:0070727 122 0.027
regulation of anatomical structure size GO:0090066 135 0.027
cellular amino acid metabolic process GO:0006520 107 0.027
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.026
circulatory system development GO:0072359 134 0.026
blood vessel development GO:0001568 69 0.026
positive regulation of phosphate metabolic process GO:0045937 262 0.026
protein complex biogenesis GO:0070271 263 0.026
positive regulation of cell development GO:0010720 176 0.026
nucleotide metabolic process GO:0009117 279 0.025
chaperone mediated protein folding requiring cofactor GO:0051085 2 0.025
glycosyl compound catabolic process GO:1901658 126 0.025
macromolecular complex assembly GO:0065003 273 0.025
single organism biosynthetic process GO:0044711 342 0.024
nucleoside metabolic process GO:0009116 179 0.024
negative regulation of biosynthetic process GO:0009890 168 0.024
circulatory system process GO:0003013 183 0.024
regulation of protein modification process GO:0031399 194 0.024
positive regulation of biosynthetic process GO:0009891 319 0.024
vesicle mediated transport GO:0016192 181 0.023
cellular nitrogen compound catabolic process GO:0044270 163 0.023
positive regulation of neuron differentiation GO:0045666 126 0.023
response to growth factor GO:0070848 189 0.023
secretion GO:0046903 307 0.023
protein phosphorylation GO:0006468 345 0.023
nucleoside phosphate metabolic process GO:0006753 283 0.023
positive regulation of multicellular organismal process GO:0051240 387 0.023
signal release GO:0023061 145 0.022
purine ribonucleoside metabolic process GO:0046128 168 0.022
taxis GO:0042330 67 0.022
macromolecular complex subunit organization GO:0043933 339 0.022
regulation of hormone levels GO:0010817 187 0.022
protein targeting GO:0006605 61 0.022
g protein coupled receptor signaling pathway GO:0007186 242 0.021
epithelium development GO:0060429 96 0.021
negative regulation of cellular biosynthetic process GO:0031327 161 0.021
response to nutrient GO:0007584 248 0.021
reproductive process GO:0022414 372 0.021
immune response GO:0006955 104 0.021
cell adhesion GO:0007155 110 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
response to wounding GO:0009611 254 0.021
central nervous system development GO:0007417 311 0.021
neuron development GO:0048666 286 0.021
defense response GO:0006952 194 0.021
negative regulation of protein processing GO:0010955 47 0.021
intracellular signal transduction GO:0035556 314 0.021
cell part morphogenesis GO:0032990 123 0.020
cellular amine metabolic process GO:0044106 38 0.020
glycosyl compound metabolic process GO:1901657 182 0.020
organonitrogen compound catabolic process GO:1901565 179 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.020
purine nucleoside metabolic process GO:0042278 169 0.020
multicellular organism reproduction GO:0032504 233 0.020
regulation of cell projection organization GO:0031344 175 0.020
nucleoside catabolic process GO:0009164 126 0.020
nucleobase containing compound catabolic process GO:0034655 152 0.020
regulation of cell proliferation GO:0042127 359 0.019
regulation of secretion GO:0051046 224 0.019
purine containing compound catabolic process GO:0072523 138 0.019
cellular response to oxygen containing compound GO:1901701 386 0.019
ribonucleoside metabolic process GO:0009119 174 0.019
negative regulation of catalytic activity GO:0043086 103 0.019
vascular process in circulatory system GO:0003018 96 0.019
peptide metabolic process GO:0006518 32 0.019
proteolysis GO:0006508 175 0.019
cell morphogenesis involved in differentiation GO:0000904 119 0.019
negative regulation of cell death GO:0060548 229 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
nucleoside phosphate catabolic process GO:1901292 140 0.019
protein transmembrane transport GO:0071806 2 0.018
ribonucleoside triphosphate metabolic process GO:0009199 141 0.018
establishment of protein localization GO:0045184 141 0.018
regulation of protein maturation GO:1903317 50 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
regulation of immune response GO:0050776 55 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
cellular response to cytokine stimulus GO:0071345 127 0.018
negative regulation of cellular amide metabolic process GO:0034249 1 0.018
axis specification GO:0009798 4 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
amine metabolic process GO:0009308 38 0.018
negative regulation of transcription dna templated GO:0045892 116 0.018
blood circulation GO:0008015 183 0.018
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.018
organic cyclic compound catabolic process GO:1901361 175 0.018
growth GO:0040007 165 0.018
neuron projection morphogenesis GO:0048812 122 0.018
protein oligomerization GO:0051259 191 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
biological adhesion GO:0022610 110 0.017
regulation of system process GO:0044057 208 0.017
single organism cellular localization GO:1902580 102 0.017
regulation of blood circulation GO:1903522 110 0.017
nucleoside monophosphate metabolic process GO:0009123 93 0.017
regulation of cellular ketone metabolic process GO:0010565 27 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
locomotion GO:0040011 237 0.017
negative regulation of cell proliferation GO:0008285 119 0.017
purine ribonucleoside catabolic process GO:0046130 124 0.017
cellular homeostasis GO:0019725 252 0.017
single organism reproductive process GO:0044702 297 0.017
positive regulation of cell communication GO:0010647 271 0.017
regulation of protein phosphorylation GO:0001932 183 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
regulation of immune system process GO:0002682 123 0.016
cellular response to topologically incorrect protein GO:0035967 3 0.016
positive regulation of immune system process GO:0002684 90 0.016
positive regulation of phosphorylation GO:0042327 177 0.016
response to radiation GO:0009314 137 0.016
response to corticosteroid GO:0031960 235 0.016
cellular response to lipid GO:0071396 201 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
establishment of protein localization to organelle GO:0072594 44 0.016
ribonucleoside triphosphate catabolic process GO:0009203 122 0.016
axon development GO:0061564 96 0.015
regulation of canonical wnt signaling pathway GO:0060828 4 0.015
regulation of signal transduction GO:0009966 318 0.015
muscle system process GO:0003012 115 0.015
purine nucleoside monophosphate catabolic process GO:0009128 55 0.015
response to inorganic substance GO:0010035 377 0.015
protein processing GO:0016485 68 0.015
ribonucleotide metabolic process GO:0009259 231 0.015
synaptic transmission GO:0007268 235 0.015
protein localization to organelle GO:0033365 57 0.015
response to ethanol GO:0045471 162 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
cellular ketone metabolic process GO:0042180 51 0.015
regulation of neuron projection development GO:0010975 161 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
regulation of fat cell differentiation GO:0045598 3 0.015
regulation of cellular localization GO:0060341 263 0.015
gastrulation GO:0007369 2 0.015
positive regulation of signaling GO:0023056 270 0.014
nucleotide catabolic process GO:0009166 139 0.014
polysaccharide metabolic process GO:0005976 25 0.014
brain development GO:0007420 247 0.014
peptidyl amino acid modification GO:0018193 126 0.014
amide transport GO:0042886 105 0.014
carbohydrate derivative catabolic process GO:1901136 147 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
response to glucose GO:0009749 136 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
negative regulation of peptidase activity GO:0010466 38 0.014
cellular component morphogenesis GO:0032989 155 0.014
response to bacterium GO:0009617 200 0.014
response to estrogen GO:0043627 232 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
positive regulation of protein phosphorylation GO:0001934 135 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.014
cytoplasmic transport GO:0016482 115 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
heart morphogenesis GO:0003007 3 0.014
actin filament based process GO:0030029 86 0.014
homeostatic process GO:0042592 331 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
ras protein signal transduction GO:0007265 29 0.013
response to hexose GO:0009746 144 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.013
glycogen metabolic process GO:0005977 23 0.013
positive regulation of cellular component biogenesis GO:0044089 55 0.013
organ morphogenesis GO:0009887 75 0.013
negative regulation of rna biosynthetic process GO:1902679 118 0.013
ion transmembrane transport GO:0034220 365 0.013
behavior GO:0007610 205 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
response to other organism GO:0051707 220 0.013
negative regulation of cell communication GO:0010648 158 0.013
negative regulation of phosphate metabolic process GO:0045936 80 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
salivary gland morphogenesis GO:0007435 1 0.013
cardiac chamber development GO:0003205 1 0.013
lipid metabolic process GO:0006629 283 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
neurotransmitter transport GO:0006836 42 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
carbohydrate metabolic process GO:0005975 130 0.013
protein complex assembly GO:0006461 263 0.013
purine nucleoside triphosphate metabolic process GO:0009144 141 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
axonogenesis GO:0007409 71 0.013
response to carbohydrate GO:0009743 183 0.012
cellular component movement GO:0006928 248 0.012
adult locomotory behavior GO:0008344 4 0.012
single organism organelle organization GO:1902589 180 0.012
response to biotic stimulus GO:0009607 226 0.012
small molecule biosynthetic process GO:0044283 124 0.012
cation transport GO:0006812 382 0.012
cartilage development involved in endochondral bone morphogenesis GO:0060351 3 0.012
carbohydrate derivative biosynthetic process GO:1901137 124 0.012
protein maturation GO:0051604 68 0.012
regulation of response to wounding GO:1903034 69 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
regeneration GO:0031099 163 0.012
neuron death GO:0070997 127 0.012
salivary gland development GO:0007431 3 0.012
signal transduction by phosphorylation GO:0023014 144 0.012
nucleoside triphosphate catabolic process GO:0009143 123 0.012
cellular chemical homeostasis GO:0055082 247 0.012
response to mechanical stimulus GO:0009612 134 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
negative regulation of signaling GO:0023057 157 0.012
negative regulation of protein maturation GO:1903318 47 0.012
regulation of peptidase activity GO:0052547 55 0.012
response to metal ion GO:0010038 253 0.011
negative regulation of developmental process GO:0051093 125 0.011
establishment of protein localization to membrane GO:0090150 16 0.011
dendrite development GO:0016358 72 0.011
neural crest cell development GO:0014032 2 0.011
purine nucleotide catabolic process GO:0006195 136 0.011
renal system development GO:0072001 67 0.011
embryonic pattern specification GO:0009880 1 0.011
nucleoside triphosphate metabolic process GO:0009141 144 0.011
b cell activation involved in immune response GO:0002312 1 0.011
positive regulation of apoptotic process GO:0043065 154 0.011
response to ketone GO:1901654 182 0.011
anterior posterior pattern specification GO:0009952 1 0.011
cytokinetic process GO:0032506 1 0.011
response to acid chemical GO:0001101 222 0.011
cellular response to nitrogen compound GO:1901699 210 0.011
developmental process involved in reproduction GO:0003006 159 0.011
alpha amino acid metabolic process GO:1901605 71 0.011
regulation of membrane potential GO:0042391 110 0.011
regulation of blood vessel size GO:0050880 89 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
regulation of immune effector process GO:0002697 32 0.011
response to heat GO:0009408 60 0.011
negative regulation of cell development GO:0010721 82 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
nucleoside monophosphate catabolic process GO:0009125 56 0.011
cell type specific apoptotic process GO:0097285 134 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
neurological system process GO:0050877 219 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
anion transport GO:0006820 178 0.011
positive regulation of cell death GO:0010942 184 0.010
ribonucleoside catabolic process GO:0042454 126 0.010
immune effector process GO:0002252 53 0.010
carboxylic acid biosynthetic process GO:0046394 83 0.010
cellular response to organic cyclic compound GO:0071407 202 0.010
inflammatory response GO:0006954 150 0.010
regulation of cell migration GO:0030334 128 0.010
regulation of vesicle mediated transport GO:0060627 81 0.010
negative regulation of proteolysis GO:0045861 41 0.010
response to temperature stimulus GO:0009266 94 0.010
angiogenesis GO:0001525 53 0.010
positive regulation of immunoglobulin production GO:0002639 4 0.010
vasoconstriction GO:0042310 54 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
organic anion transport GO:0015711 132 0.010
heart development GO:0007507 72 0.010
protein targeting to membrane GO:0006612 11 0.010
oxidation reduction process GO:0055114 304 0.010
spermatogenesis GO:0007283 99 0.010
cation homeostasis GO:0055080 195 0.010

P4ha1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
musculoskeletal system disease DOID:17 0 0.033
connective tissue disease DOID:65 0 0.030
sensory system disease DOID:0050155 0 0.012
nervous system disease DOID:863 0 0.012