Rattus norvegicus

52 known processes

Pah

phenylalanine hydroxylase

Pah biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
alpha amino acid metabolic process GO:1901605 71 0.788
organic acid metabolic process GO:0006082 292 0.451
aromatic amino acid family metabolic process GO:0009072 9 0.403
carboxylic acid metabolic process GO:0019752 289 0.344
oxoacid metabolic process GO:0043436 290 0.288
organic substance catabolic process GO:1901575 316 0.277
Fly
alpha amino acid biosynthetic process GO:1901607 23 0.267
cellular amino acid metabolic process GO:0006520 107 0.240
aromatic amino acid family catabolic process GO:0009074 7 0.226
Fly
cellular amino acid biosynthetic process GO:0008652 32 0.226
carboxylic acid catabolic process GO:0046395 49 0.223
Fly
nitrogen cycle metabolic process GO:0071941 5 0.194
urea metabolic process GO:0019627 5 0.192
cellular amino acid catabolic process GO:0009063 21 0.182
Fly
cellular catabolic process GO:0044248 295 0.180
Fly
response to extracellular stimulus GO:0009991 380 0.171
Rat
response to glucocorticoid GO:0051384 223 0.166
Rat
response to nutrient GO:0007584 248 0.166
organic acid biosynthetic process GO:0016053 83 0.163
single organism biosynthetic process GO:0044711 342 0.157
response to metal ion GO:0010038 253 0.152
Rat
response to nutrient levels GO:0031667 370 0.148
Rat
single organism catabolic process GO:0044712 283 0.141
Fly
small molecule catabolic process GO:0044282 59 0.133
Fly
catabolic process GO:0009056 351 0.127
Fly
response to corticosteroid GO:0031960 235 0.124
Rat
response to hypoxia GO:0001666 231 0.117
Rat
cellular lipid metabolic process GO:0044255 208 0.102
Rat
organonitrogen compound catabolic process GO:1901565 179 0.100
Fly
coenzyme metabolic process GO:0006732 86 0.097
response to peptide hormone GO:0043434 278 0.095
Rat
aging GO:0007568 241 0.092
Rat
glutamine family amino acid metabolic process GO:0009064 15 0.091
programmed cell death GO:0012501 392 0.088
sulfur compound metabolic process GO:0006790 70 0.087
fatty acid metabolic process GO:0006631 99 0.087
Rat
apoptotic process GO:0006915 381 0.086
carboxylic acid biosynthetic process GO:0046394 83 0.086
cellular response to oxygen containing compound GO:1901701 386 0.080
Rat
response to peptide GO:1901652 292 0.080
Rat
macromolecular complex assembly GO:0065003 273 0.077
cellular amine metabolic process GO:0044106 38 0.076
response to oxygen levels GO:0070482 265 0.070
Rat
regulation of secretion GO:0051046 224 0.069
regulation of apoptotic process GO:0042981 335 0.068
alpha amino acid catabolic process GO:1901606 20 0.065
Fly
nitrogen compound transport GO:0071705 229 0.062
Rat
cofactor metabolic process GO:0051186 95 0.061
amine metabolic process GO:0009308 38 0.060
response to camp GO:0051591 91 0.060
aromatic compound catabolic process GO:0019439 168 0.058
Fly
response to organophosphorus GO:0046683 102 0.058
response to acid chemical GO:0001101 222 0.056
Rat
regulation of programmed cell death GO:0043067 341 0.055
glycine metabolic process GO:0006544 7 0.053
secretion GO:0046903 307 0.051
response to corticosterone GO:0051412 40 0.051
Rat
cellular response to lipid GO:0071396 201 0.051
cellular response to organonitrogen compound GO:0071417 197 0.051
Rat
carbohydrate metabolic process GO:0005975 130 0.050
cellular ketone metabolic process GO:0042180 51 0.050
lipid catabolic process GO:0016042 46 0.049
regulation of cellular ketone metabolic process GO:0010565 27 0.048
cellular lipid catabolic process GO:0044242 37 0.048
regulation of cellular amino acid metabolic process GO:0006521 2 0.048
cellular response to insulin stimulus GO:0032869 81 0.047
response to inorganic substance GO:0010035 377 0.047
Rat
regulation of secretion by cell GO:1903530 208 0.046
response to transition metal nanoparticle GO:1990267 122 0.046
Rat
positive regulation of cell death GO:0010942 184 0.046
arginine metabolic process GO:0006525 6 0.045
positive regulation of programmed cell death GO:0043068 157 0.045
cellular modified amino acid metabolic process GO:0006575 61 0.045
regulation of cell differentiation GO:0045595 320 0.044
negative regulation of multicellular organismal process GO:0051241 203 0.044
Rat
cation transport GO:0006812 382 0.044
positive regulation of cellular biosynthetic process GO:0031328 295 0.044
macromolecular complex subunit organization GO:0043933 339 0.044
thioester metabolic process GO:0035383 28 0.043
response to estrogen GO:0043627 232 0.043
Rat
cellular response to peptide hormone stimulus GO:0071375 120 0.043
negative regulation of macromolecule metabolic process GO:0010605 260 0.042
female pregnancy GO:0007565 122 0.042
cellular component biogenesis GO:0044085 368 0.042
cellular response to nitrogen compound GO:1901699 210 0.042
Rat
regulation of cellular component organization GO:0051128 368 0.042
cellular response to stress GO:0033554 269 0.041
organic cyclic compound catabolic process GO:1901361 175 0.041
Fly
positive regulation of cellular amine metabolic process GO:0033240 3 0.041
serine family amino acid metabolic process GO:0009069 12 0.040
liver development GO:0001889 90 0.040
response to growth factor GO:0070848 189 0.039
Rat
sulfur amino acid metabolic process GO:0000096 9 0.039
catenin import into nucleus GO:0035411 1 0.039
response to insulin GO:0032868 133 0.038
organic acid catabolic process GO:0016054 49 0.038
Fly
regulation of reactive oxygen species metabolic process GO:2000377 26 0.038
extracellular matrix constituent secretion GO:0070278 4 0.037
protein complex assembly GO:0006461 263 0.037
reactive nitrogen species metabolic process GO:2001057 1 0.037
cellular response to glucocorticoid stimulus GO:0071385 68 0.037
regulation of ion transport GO:0043269 245 0.036
small molecule biosynthetic process GO:0044283 124 0.036
positive regulation of apoptotic process GO:0043065 154 0.035
oxidation reduction process GO:0055114 304 0.034
regulation of serine type peptidase activity GO:1902571 1 0.034
central nervous system development GO:0007417 311 0.034
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.034
response to oxidative stress GO:0006979 186 0.033
reproduction GO:0000003 245 0.033
regulation of extracellular matrix constituent secretion GO:0003330 2 0.033
protein complex biogenesis GO:0070271 263 0.033
indolalkylamine metabolic process GO:0006586 5 0.033
negative regulation of cell death GO:0060548 229 0.033
response to carbohydrate GO:0009743 183 0.033
Rat
regulation of catalytic activity GO:0050790 304 0.033
defense response GO:0006952 194 0.032
glycerolipid metabolic process GO:0046486 67 0.032
monocarboxylic acid metabolic process GO:0032787 152 0.032
Rat
reactive oxygen species biosynthetic process GO:1903409 8 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.032
urea cycle GO:0000050 5 0.031
reactive oxygen species metabolic process GO:0072593 37 0.031
negative regulation of gene expression GO:0010629 199 0.031
response to cytokine GO:0034097 215 0.031
cellular response to organic cyclic compound GO:0071407 202 0.031
Rat
monovalent inorganic cation transport GO:0015672 172 0.030
single organism reproductive process GO:0044702 297 0.030
reproductive process GO:0022414 372 0.030
response to molecule of bacterial origin GO:0002237 194 0.030
Rat
hepaticobiliary system development GO:0061008 90 0.030
cellular response to external stimulus GO:0071496 118 0.030
negative regulation of protein metabolic process GO:0051248 114 0.030
response to methanol GO:0033986 1 0.029
response to ketone GO:1901654 182 0.029
Rat
secretion by cell GO:0032940 248 0.029
cellular hormone metabolic process GO:0034754 49 0.029
gland development GO:0048732 155 0.028
multi organism reproductive process GO:0044703 262 0.028
regulation of hormone levels GO:0010817 187 0.027
negative regulation of metabolic process GO:0009892 331 0.027
regulation of protein metabolic process GO:0051246 289 0.027
response to vitamin GO:0033273 131 0.027
regulation of cellular localization GO:0060341 263 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
organonitrogen compound biosynthetic process GO:1901566 167 0.027
cellular response to steroid hormone stimulus GO:0071383 93 0.026
response to other organism GO:0051707 220 0.026
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.026
sulfur compound biosynthetic process GO:0044272 19 0.026
cellular response to camp GO:0071320 26 0.026
anion transport GO:0006820 178 0.026
cellular response to cytokine stimulus GO:0071345 127 0.025
response to purine containing compound GO:0014074 126 0.025
organ regeneration GO:0031100 101 0.025
response to fatty acid GO:0070542 65 0.025
regulation of catabolic process GO:0009894 113 0.025
monocarboxylic acid biosynthetic process GO:0072330 48 0.025
cellular response to endogenous stimulus GO:0071495 377 0.025
Rat
negative regulation of programmed cell death GO:0043069 183 0.025
multi multicellular organism process GO:0044706 138 0.024
negative regulation of cellular metabolic process GO:0031324 281 0.024
positive regulation of extracellular matrix constituent secretion GO:0003331 2 0.024
proteolysis GO:0006508 175 0.024
brain development GO:0007420 247 0.024
Rat
response to alkaloid GO:0043279 132 0.024
Rat
organic anion transport GO:0015711 132 0.023
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.023
cellular response to hormone stimulus GO:0032870 247 0.023
regulation of phosphate metabolic process GO:0019220 349 0.023
protein complex subunit organization GO:0071822 302 0.023
response to hexose GO:0009746 144 0.023
Rat
single organism carbohydrate metabolic process GO:0044723 118 0.023
cell projection organization GO:0030030 302 0.022
response to toxic substance GO:0009636 133 0.022
Rat
regulation of cellular protein metabolic process GO:0032268 267 0.022
cellular nitrogen compound catabolic process GO:0044270 163 0.022
tube development GO:0035295 89 0.022
negative regulation of cellular protein metabolic process GO:0032269 106 0.022
regulation of cell development GO:0060284 263 0.022
positive regulation of neuron differentiation GO:0045666 126 0.022
response to ethanol GO:0045471 162 0.022
Rat
dicarboxylic acid metabolic process GO:0043648 42 0.021
Rat
behavior GO:0007610 205 0.021
Rat Fly
protein phosphorylation GO:0006468 345 0.021
response to mercury ion GO:0046689 15 0.021
vesicle mediated transport GO:0016192 181 0.021
Rat Fly
hormone metabolic process GO:0042445 69 0.021
response to amino acid GO:0043200 75 0.021
anatomical structure morphogenesis GO:0009653 298 0.021
protein homooligomerization GO:0051260 91 0.021
heterocycle catabolic process GO:0046700 167 0.021
cellular component assembly GO:0022607 360 0.021
regulation of molecular function GO:0065009 398 0.021
macromolecule catabolic process GO:0009057 58 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
innate immune response GO:0045087 35 0.020
response to monosaccharide GO:0034284 159 0.020
Rat
ribonucleoside metabolic process GO:0009119 174 0.020
negative regulation of serine type peptidase activity GO:1902572 1 0.020
kidney development GO:0001822 67 0.020
serine family amino acid biosynthetic process GO:0009070 4 0.020
acyl coa metabolic process GO:0006637 28 0.020
organic acid transport GO:0015849 116 0.020
response to reactive oxygen species GO:0000302 120 0.020
positive regulation of transcription dna templated GO:0045893 197 0.020
insulin secretion GO:0030073 69 0.019
urogenital system development GO:0001655 78 0.019
response to temperature stimulus GO:0009266 94 0.019
positive regulation of phosphate metabolic process GO:0045937 262 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
indole containing compound metabolic process GO:0042430 11 0.018
cellular response to metal ion GO:0071248 55 0.018
Rat
benzene containing compound metabolic process GO:0042537 22 0.018
Rat
negative regulation of cell communication GO:0010648 158 0.018
blood circulation GO:0008015 183 0.018
response to triglyceride GO:0034014 3 0.018
response to decreased oxygen levels GO:0036293 237 0.018
Rat
negative regulation of catalytic activity GO:0043086 103 0.018
regulation of rna biosynthetic process GO:2001141 381 0.017
indolalkylamine catabolic process GO:0046218 5 0.017
positive regulation of extracellular matrix organization GO:1903055 4 0.017
digestive system development GO:0055123 41 0.017
response to mineralocorticoid GO:0051385 49 0.017
Rat
carbohydrate derivative metabolic process GO:1901135 346 0.017
Rat
protein localization GO:0008104 191 0.017
negative regulation of developmental process GO:0051093 125 0.017
regeneration GO:0031099 163 0.017
diterpenoid metabolic process GO:0016101 33 0.017
regulation of blood vessel size GO:0050880 89 0.017
skeletal system development GO:0001501 41 0.017
positive regulation of immunoglobulin production GO:0002639 4 0.017
positive regulation of secretion GO:0051047 140 0.016
cellular biogenic amine catabolic process GO:0042402 9 0.016
regulation of neuron differentiation GO:0045664 208 0.016
protein oligomerization GO:0051259 191 0.016
response to activity GO:0014823 73 0.016
Rat
locomotion GO:0040011 237 0.016
regulation of neurogenesis GO:0050767 247 0.016
isoprenoid metabolic process GO:0006720 45 0.016
Rat
regulation of neuron projection development GO:0010975 161 0.016
positive regulation of molecular function GO:0044093 230 0.016
organic hydroxy compound metabolic process GO:1901615 115 0.016
Rat
nucleoside metabolic process GO:0009116 179 0.016
rna metabolic process GO:0016070 406 0.016
cellular response to peptide GO:1901653 133 0.016
regulation of transcription dna templated GO:0006355 374 0.016
ossification GO:0001503 70 0.016
Rat
negative regulation of molecular function GO:0044092 133 0.016
response to glucose GO:0009749 136 0.016
Rat
chemical homeostasis GO:0048878 292 0.016
Rat
response to vitamin e GO:0033197 24 0.015
glycosyl compound metabolic process GO:1901657 182 0.015
Rat
positive regulation of biosynthetic process GO:0009891 319 0.015
response to starvation GO:0042594 59 0.015
regulation of immunoglobulin production GO:0002637 4 0.015
g protein coupled receptor signaling pathway GO:0007186 242 0.015
cell cell signaling GO:0007267 335 0.015
Rat
lipid metabolic process GO:0006629 283 0.015
Rat
regulation of anatomical structure size GO:0090066 135 0.015
cell adhesion GO:0007155 110 0.015
response to vitamin b6 GO:0034516 1 0.015
cellular response to alcohol GO:0097306 87 0.015
cellular response to extracellular stimulus GO:0031668 73 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
negative regulation of transport GO:0051051 136 0.015
cellular macromolecule localization GO:0070727 122 0.015
acetyl coa metabolic process GO:0006084 17 0.015
positive regulation of lipid catabolic process GO:0050996 4 0.015
regulation of multicellular organismal development GO:2000026 376 0.015
positive regulation of cellular component organization GO:0051130 200 0.015
regulation of cell projection organization GO:0031344 175 0.015
negative regulation of serine type endopeptidase activity GO:1900004 1 0.015
intracellular signal transduction GO:0035556 314 0.015
embryonic skeletal system development GO:0048706 3 0.015
organic hydroxy compound transport GO:0015850 77 0.014
positive regulation of multicellular organismal process GO:0051240 387 0.014
cellular response to interferon gamma GO:0071346 14 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
Rat
negative regulation of biosynthetic process GO:0009890 168 0.014
organophosphate biosynthetic process GO:0090407 143 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.014
telencephalon development GO:0021537 62 0.014
Rat
negative regulation of signaling GO:0023057 157 0.014
response to interferon gamma GO:0034341 20 0.014
peptide hormone secretion GO:0030072 84 0.014
response to dexamethasone GO:0071548 49 0.014
response to muscle activity involved in regulation of muscle adaptation GO:0014873 2 0.014
glucose metabolic process GO:0006006 52 0.014
multicellular organism growth GO:0035264 1 0.014
dna metabolic process GO:0006259 96 0.014
axis specification GO:0009798 4 0.014
heart morphogenesis GO:0003007 3 0.013
regulation of nervous system development GO:0051960 264 0.013
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.013
regulation of serine type endopeptidase activity GO:1900003 1 0.013
response to platinum ion GO:0070541 4 0.013
response to vitamin a GO:0033189 36 0.013
cellular response to corticosteroid stimulus GO:0071384 69 0.013
divalent inorganic cation transport GO:0072511 134 0.013
angiotensin mediated drinking behavior GO:0003051 2 0.013
hormone secretion GO:0046879 115 0.013
nucleoside phosphate metabolic process GO:0006753 283 0.013
regulation of transferase activity GO:0051338 123 0.013
regulation of hydrolase activity GO:0051336 143 0.013
bile acid biosynthetic process GO:0006699 3 0.013
hormone transport GO:0009914 121 0.013
cell growth GO:0016049 104 0.013
response to external biotic stimulus GO:0043207 221 0.013
Rat
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.013
amide biosynthetic process GO:0043604 10 0.013
response to testosterone GO:0033574 55 0.013
neuron projection development GO:0031175 273 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
amide transport GO:0042886 105 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
protein homotetramerization GO:0051289 25 0.013
cellular response to glucose stimulus GO:0071333 65 0.013
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.013
insecticide metabolic process GO:0017143 4 0.013
cation transmembrane transport GO:0098655 263 0.013
divalent metal ion transport GO:0070838 132 0.013
response to estradiol GO:0032355 164 0.013
Rat
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.013
negative regulation of response to stimulus GO:0048585 155 0.012
nucleic acid templated transcription GO:0097659 379 0.012
single organism intracellular transport GO:1902582 166 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
immunoglobulin mediated immune response GO:0016064 4 0.012
triglyceride metabolic process GO:0006641 21 0.012
rna biosynthetic process GO:0032774 380 0.012
regulation of rna metabolic process GO:0051252 391 0.012
organophosphate catabolic process GO:0046434 148 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
protein transport GO:0015031 132 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
tryptophan metabolic process GO:0006568 5 0.012
cell migration GO:0016477 197 0.012
response to food GO:0032094 27 0.012
terpenoid metabolic process GO:0006721 37 0.012
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.012
ion homeostasis GO:0050801 212 0.012
cation homeostasis GO:0055080 195 0.012
head development GO:0060322 247 0.012
Rat
response to wounding GO:0009611 254 0.012
purine ribonucleoside metabolic process GO:0046128 168 0.012
response to lead ion GO:0010288 33 0.012
monocarboxylic acid catabolic process GO:0072329 28 0.012
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure GO:0001999 1 0.012
regulation of insulin secretion GO:0050796 65 0.012
response to bacterium GO:0009617 200 0.012
Rat
regulation of tube size GO:0035150 89 0.012
intracellular protein transport GO:0006886 79 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
regulation of protein modification process GO:0031399 194 0.011
nucleobase containing compound catabolic process GO:0034655 152 0.011
macromolecule localization GO:0033036 252 0.011
rhythmic process GO:0048511 156 0.011
Rat
fertilization GO:0009566 3 0.011
protein localization to organelle GO:0033365 57 0.011
multicellular organismal reproductive process GO:0048609 233 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
regulation of cell growth GO:0001558 85 0.011
cell type specific apoptotic process GO:0097285 134 0.011
anterior posterior pattern specification GO:0009952 1 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
positive regulation of phosphorus metabolic process GO:0010562 262 0.011
organophosphate metabolic process GO:0019637 370 0.011
regulation of organelle organization GO:0033043 80 0.011
regulation of kinase activity GO:0043549 117 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
cellular response to acid chemical GO:0071229 75 0.011
gonad development GO:0008406 104 0.011
vitamin transport GO:0051180 14 0.011
positive regulation of immunoglobulin mediated immune response GO:0002891 2 0.011
localization of cell GO:0051674 202 0.011
purine nucleoside metabolic process GO:0042278 169 0.011
response to chromate GO:0046687 3 0.011
sulfur amino acid biosynthetic process GO:0000097 5 0.011
lipid storage GO:0019915 1 0.011
negative regulation of cellular biosynthetic process GO:0031327 161 0.011
negative regulation of cellular component organization GO:0051129 83 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
cellular metal ion homeostasis GO:0006875 172 0.011
lipid biosynthetic process GO:0008610 128 0.011
amine catabolic process GO:0009310 9 0.011
metal ion transport GO:0030001 289 0.011
positive regulation of catabolic process GO:0009896 78 0.011
transmission of nerve impulse GO:0019226 42 0.011
positive regulation of cell communication GO:0010647 271 0.011
jak stat cascade GO:0007259 26 0.011
regulation of mapk cascade GO:0043408 116 0.011
renal system development GO:0072001 67 0.011
glutamate metabolic process GO:0006536 3 0.011
negative regulation of growth GO:0045926 37 0.010
chromosome segregation GO:0007059 2 0.010
regulation of cell proliferation GO:0042127 359 0.010
negative regulation of rna biosynthetic process GO:1902679 118 0.010
establishment of protein localization GO:0045184 141 0.010
positive regulation of protein metabolic process GO:0051247 178 0.010
regulation of intracellular signal transduction GO:1902531 218 0.010
regulation of protein phosphorylation GO:0001932 183 0.010
ras protein signal transduction GO:0007265 29 0.010
negative regulation of rna metabolic process GO:0051253 123 0.010
response to vitamin d GO:0033280 34 0.010
renin angiotensin regulation of aldosterone production GO:0002018 3 0.010
signal release GO:0023061 145 0.010
carbohydrate homeostasis GO:0033500 75 0.010
Rat
positive regulation of cellular catabolic process GO:0031331 71 0.010
dicarboxylic acid transport GO:0006835 34 0.010

Pah disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.025
Human
inherited metabolic disorder DOID:655 0 0.025
Human
disease of anatomical entity DOID:7 0 0.011
nervous system disease DOID:863 0 0.011
congenital adrenal hyperplasia DOID:0050811 0 0.011
lipid metabolism disorder DOID:3146 0 0.011
steroid inherited metabolic disorder DOID:1701 0 0.011