Rattus norvegicus

20 known processes

Pcna

proliferating cell nuclear antigen

(Aliases: PCNAR,Pcna/cyclin)

Pcna biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin assembly or disassembly GO:0006333 1 0.569
negative regulation of biosynthetic process GO:0009890 168 0.447
negative regulation of nucleic acid templated transcription GO:1903507 117 0.396
cellular response to peptide hormone stimulus GO:0071375 120 0.376
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.376
cellular response to endogenous stimulus GO:0071495 377 0.343
negative regulation of rna biosynthetic process GO:1902679 118 0.319
response to bacterium GO:0009617 200 0.298
cellular response to oxygen containing compound GO:1901701 386 0.284
response to molecule of bacterial origin GO:0002237 194 0.270
apoptotic process GO:0006915 381 0.265
negative regulation of gene expression GO:0010629 199 0.256
negative regulation of metabolic process GO:0009892 331 0.239
regulation of rna metabolic process GO:0051252 391 0.235
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.234
negative regulation of cellular biosynthetic process GO:0031327 161 0.229
response to peptide GO:1901652 292 0.227
response to peptide hormone GO:0043434 278 0.221
negative regulation of rna metabolic process GO:0051253 123 0.221
regulation of apoptotic process GO:0042981 335 0.215
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.212
regulation of programmed cell death GO:0043067 341 0.212
regulation of nucleic acid templated transcription GO:1903506 380 0.208
mitotic spindle organization GO:0007052 2 0.202
homeostatic process GO:0042592 331 0.197
neuron differentiation GO:0030182 368 0.192
nucleic acid templated transcription GO:0097659 379 0.189
cell type specific apoptotic process GO:0097285 134 0.179
negative regulation of transcription dna templated GO:0045892 116 0.178
muscle tissue development GO:0060537 58 0.177
multicellular organism reproduction GO:0032504 233 0.173
negative regulation of cellular metabolic process GO:0031324 281 0.172
programmed cell death GO:0012501 392 0.170
rna metabolic process GO:0016070 406 0.168
cellular response to insulin stimulus GO:0032869 81 0.165
cellular response to peptide GO:1901653 133 0.162
transcription from rna polymerase ii promoter GO:0006366 252 0.161
cellular lipid metabolic process GO:0044255 208 0.159
cellular response to organonitrogen compound GO:0071417 197 0.158
reproduction GO:0000003 245 0.157
response to temperature stimulus GO:0009266 94 0.157
nucleosome organization GO:0034728 1 0.155
rna biosynthetic process GO:0032774 380 0.153
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.149
regulation of transcription dna templated GO:0006355 374 0.146
negative regulation of macromolecule metabolic process GO:0010605 260 0.140
regulation of rna biosynthetic process GO:2001141 381 0.137
regulation of cellular amine metabolic process GO:0033238 8 0.127
head development GO:0060322 247 0.127
anterior posterior pattern specification GO:0009952 1 0.125
cell cycle GO:0007049 101 0.123
response to extracellular stimulus GO:0009991 380 0.123
response to lipopolysaccharide GO:0032496 191 0.121
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.118
brain development GO:0007420 247 0.118
dna conformation change GO:0071103 10 0.113
dna metabolic process GO:0006259 96 0.113
positive regulation of developmental process GO:0051094 283 0.112
organelle organization GO:0006996 266 0.111
multi organism reproductive process GO:0044703 262 0.110
aging GO:0007568 241 0.104
macromolecule localization GO:0033036 252 0.103
macromolecular complex assembly GO:0065003 273 0.100
negative regulation of apoptotic process GO:0043066 181 0.096
central nervous system development GO:0007417 311 0.095
regulation of catalytic activity GO:0050790 304 0.095
regulation of cell cycle phase transition GO:1901987 12 0.092
single organism reproductive process GO:0044702 297 0.091
regulation of multicellular organismal development GO:2000026 376 0.089
transcription dna templated GO:0006351 377 0.089
macromolecular complex subunit organization GO:0043933 339 0.088
dna replication GO:0006260 37 0.084
regulation of phosphorylation GO:0042325 248 0.084
protein refolding GO:0042026 3 0.083
cellular component biogenesis GO:0044085 368 0.082
response to purine containing compound GO:0014074 126 0.082
single organism organelle organization GO:1902589 180 0.081
positive regulation of multicellular organismal process GO:0051240 387 0.079
mesenchymal cell proliferation GO:0010463 4 0.079
protein complex assembly GO:0006461 263 0.076
multicellular organismal reproductive process GO:0048609 233 0.074
cellular response to nitrogen compound GO:1901699 210 0.073
cytoskeleton organization GO:0007010 111 0.073
sexual reproduction GO:0019953 148 0.072
gamete generation GO:0007276 124 0.072
positive regulation of cell proliferation GO:0008284 249 0.071
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.070
embryonic pattern specification GO:0009880 1 0.069
amine metabolic process GO:0009308 38 0.068
response to other organism GO:0051707 220 0.067
regulation of protein metabolic process GO:0051246 289 0.067
positive regulation of molecular function GO:0044093 230 0.063
positive regulation of cell differentiation GO:0045597 217 0.061
regulation of molecular function GO:0065009 398 0.061
protein complex biogenesis GO:0070271 263 0.060
regulation of cell proliferation GO:0042127 359 0.060
reproductive process GO:0022414 372 0.060
positive regulation of immune system process GO:0002684 90 0.059
lipid metabolic process GO:0006629 283 0.058
response to nutrient GO:0007584 248 0.057
spermatogenesis GO:0007283 99 0.057
single organism biosynthetic process GO:0044711 342 0.057
nuclear transport GO:0051169 49 0.056
response to inorganic substance GO:0010035 377 0.056
heat acclimation GO:0010286 1 0.055
response to radiation GO:0009314 137 0.054
oxidation reduction process GO:0055114 304 0.054
cellular amine metabolic process GO:0044106 38 0.054
cell projection morphogenesis GO:0048858 123 0.053
nucleocytoplasmic transport GO:0006913 48 0.053
regulation of response to stress GO:0080134 126 0.052
cellular component assembly GO:0022607 360 0.052
positive regulation of biosynthetic process GO:0009891 319 0.051
negative regulation of cell communication GO:0010648 158 0.050
positive regulation of dna metabolic process GO:0051054 39 0.049
response to nutrient levels GO:0031667 370 0.049
chromatin organization GO:0006325 34 0.048
regulation of phosphorus metabolic process GO:0051174 349 0.047
regulation of cellular protein metabolic process GO:0032268 267 0.047
regulation of cell cycle GO:0051726 73 0.047
response to external biotic stimulus GO:0043207 221 0.046
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.046
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.046
neuron death GO:0070997 127 0.045
neuron development GO:0048666 286 0.045
cell cycle checkpoint GO:0000075 2 0.045
positive regulation of apoptotic process GO:0043065 154 0.045
negative regulation of molecular function GO:0044092 133 0.044
heart contraction GO:0060047 57 0.043
cellular response to hormone stimulus GO:0032870 247 0.043
developmental process involved in reproduction GO:0003006 159 0.042
circadian rhythm GO:0007623 88 0.042
intracellular signal transduction GO:0035556 314 0.042
adult locomotory behavior GO:0008344 4 0.041
negative regulation of cell death GO:0060548 229 0.041
immune system process GO:0002376 204 0.040
response to biotic stimulus GO:0009607 226 0.040
chromatin modification GO:0016568 33 0.040
regulation of cellular amino acid metabolic process GO:0006521 2 0.039
negative regulation of programmed cell death GO:0043069 183 0.039
cellular protein catabolic process GO:0044257 19 0.039
negative regulation of cellular protein metabolic process GO:0032269 106 0.039
protein transport GO:0015031 132 0.038
muscle organ development GO:0007517 50 0.037
embryonic axis specification GO:0000578 1 0.037
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.037
response to camp GO:0051591 91 0.037
glucan metabolic process GO:0044042 23 0.037
cell chemotaxis GO:0060326 31 0.037
response to oxidative stress GO:0006979 186 0.036
positive regulation of gene expression GO:0010628 244 0.036
neuron apoptotic process GO:0051402 88 0.036
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.036
regulation of chromosome segregation GO:0051983 1 0.036
response to estrogen GO:0043627 232 0.036
organic substance catabolic process GO:1901575 316 0.036
inorganic ion transmembrane transport GO:0098660 229 0.035
positive regulation of nervous system development GO:0051962 178 0.035
cell projection organization GO:0030030 302 0.035
development of primary sexual characteristics GO:0045137 107 0.035
regulation of cell maturation GO:1903429 3 0.035
negative regulation of signaling GO:0023057 157 0.035
mitotic cell cycle GO:0000278 49 0.034
neuron projection development GO:0031175 273 0.034
protein phosphorylation GO:0006468 345 0.034
intracellular protein transport GO:0006886 79 0.034
positive regulation of cell development GO:0010720 176 0.034
positive regulation of programmed cell death GO:0043068 157 0.034
cell cycle process GO:0022402 57 0.033
dephosphorylation GO:0016311 98 0.033
chemotaxis GO:0006935 66 0.033
regulation of response to wounding GO:1903034 69 0.032
response to metal ion GO:0010038 253 0.032
innate immune response GO:0045087 35 0.032
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.031
tissue development GO:0009888 252 0.031
peptidyl amino acid modification GO:0018193 126 0.031
cellular macromolecule localization GO:0070727 122 0.031
positive regulation of cellular protein metabolic process GO:0032270 167 0.031
regulation of phosphate metabolic process GO:0019220 349 0.030
positive regulation of protein phosphorylation GO:0001934 135 0.030
cellular cation homeostasis GO:0030003 180 0.030
positive regulation of protein metabolic process GO:0051247 178 0.030
wound healing GO:0042060 122 0.030
positive regulation of response to stimulus GO:0048584 285 0.030
regulation of cellular localization GO:0060341 263 0.029
immune system development GO:0002520 41 0.029
response to tumor cell GO:0002347 4 0.029
regulation of gene expression epigenetic GO:0040029 10 0.029
regulation of cell differentiation GO:0045595 320 0.029
regulation of cellular ketone metabolic process GO:0010565 27 0.029
cellular response to stress GO:0033554 269 0.029
peptidyl serine modification GO:0018209 34 0.029
cellular response to growth factor stimulus GO:0071363 162 0.028
male gamete generation GO:0048232 99 0.028
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.028
cellular component morphogenesis GO:0032989 155 0.028
localization of cell GO:0051674 202 0.027
positive regulation of cellular biosynthetic process GO:0031328 295 0.027
circadian regulation of gene expression GO:0032922 3 0.027
cell migration GO:0016477 197 0.027
posttranscriptional regulation of gene expression GO:0010608 37 0.027
anatomical structure morphogenesis GO:0009653 298 0.027
chemical homeostasis GO:0048878 292 0.026
cardiovascular system development GO:0072358 134 0.026
carboxylic acid biosynthetic process GO:0046394 83 0.026
positive regulation of cellular amine metabolic process GO:0033240 3 0.026
regulation of behavior GO:0050795 61 0.026
behavior GO:0007610 205 0.025
regulation of neuron death GO:1901214 115 0.025
regulation of signal transduction GO:0009966 318 0.025
dna packaging GO:0006323 4 0.025
positive regulation of neuron projection development GO:0010976 99 0.025
endothelium development GO:0003158 12 0.025
organonitrogen compound biosynthetic process GO:1901566 167 0.025
regulation of hydrolase activity GO:0051336 143 0.024
positive regulation of wound healing GO:0090303 6 0.024
cellular amino acid metabolic process GO:0006520 107 0.024
regulation of cellular component organization GO:0051128 368 0.024
reactive oxygen species metabolic process GO:0072593 37 0.023
somatic stem cell division GO:0048103 2 0.023
reproductive system development GO:0061458 128 0.023
oxoacid metabolic process GO:0043436 290 0.023
positive regulation of lipid catabolic process GO:0050996 4 0.023
regulation of cell development GO:0060284 263 0.023
positive regulation of protein modification process GO:0031401 142 0.023
negative regulation of protein metabolic process GO:0051248 114 0.023
regulation of embryonic development GO:0045995 2 0.023
growth GO:0040007 165 0.022
response to heat GO:0009408 60 0.022
positive regulation of cell projection organization GO:0031346 111 0.022
sensory perception GO:0007600 101 0.022
negative regulation of neuron death GO:1901215 69 0.022
taxis GO:0042330 67 0.022
cell proliferation in forebrain GO:0021846 3 0.022
peptidyl serine phosphorylation GO:0018105 33 0.021
blood circulation GO:0008015 183 0.021
chromatin remodeling GO:0006338 3 0.021
regulation of neurogenesis GO:0050767 247 0.021
protein complex subunit organization GO:0071822 302 0.021
positive regulation of intracellular signal transduction GO:1902533 138 0.021
glycogen metabolic process GO:0005977 23 0.021
regulation of mrna splicing via spliceosome GO:0048024 3 0.021
regulation of defense response GO:0031347 68 0.021
mrna metabolic process GO:0016071 20 0.021
positive regulation of cellular component organization GO:0051130 200 0.020
positive regulation of rna biosynthetic process GO:1902680 197 0.020
embryonic digestive tract development GO:0048566 3 0.020
regeneration GO:0031099 163 0.019
histone methylation GO:0016571 3 0.019
response to organophosphorus GO:0046683 102 0.019
inflammatory response GO:0006954 150 0.019
response to insulin GO:0032868 133 0.019
response to growth factor GO:0070848 189 0.019
regulation of microtubule cytoskeleton organization GO:0070507 14 0.019
protein oligomerization GO:0051259 191 0.019
response to oxygen levels GO:0070482 265 0.019
neurological system process GO:0050877 219 0.019
small gtpase mediated signal transduction GO:0007264 36 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
cytosolic calcium ion homeostasis GO:0051480 140 0.019
negative regulation of catalytic activity GO:0043086 103 0.018
regulation of immune system process GO:0002682 123 0.018
negative regulation of response to stimulus GO:0048585 155 0.018
positive regulation of hydrolase activity GO:0051345 86 0.018
positive regulation of cell death GO:0010942 184 0.018
response to glucose GO:0009749 136 0.018
response to hydrogen peroxide GO:0042542 89 0.018
intracellular receptor signaling pathway GO:0030522 35 0.018
cellular protein localization GO:0034613 122 0.018
developmental growth GO:0048589 100 0.018
nucleobase containing small molecule metabolic process GO:0055086 316 0.018
male gonad development GO:0008584 59 0.018
multicellular organism growth GO:0035264 1 0.018
axis specification GO:0009798 4 0.017
carbohydrate derivative biosynthetic process GO:1901137 124 0.017
response to acid chemical GO:0001101 222 0.017
male sex differentiation GO:0046661 64 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
ion transmembrane transport GO:0034220 365 0.017
mapk cascade GO:0000165 140 0.017
regulation of epithelial cell proliferation GO:0050678 49 0.016
response to hypoxia GO:0001666 231 0.016
microtubule cytoskeleton organization GO:0000226 25 0.016
regulation of protein kinase activity GO:0045859 105 0.016
cell cell signaling GO:0007267 335 0.016
reactive oxygen species biosynthetic process GO:1903409 8 0.016
mrna processing GO:0006397 14 0.016
response to mechanical stimulus GO:0009612 134 0.016
immune response GO:0006955 104 0.016
positive regulation of catalytic activity GO:0043085 184 0.016
heart development GO:0007507 72 0.016
response to cadmium ion GO:0046686 35 0.016
response to light stimulus GO:0009416 52 0.016
intracellular transport GO:0046907 185 0.016
nucleobase containing compound catabolic process GO:0034655 152 0.016
ion homeostasis GO:0050801 212 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
nucleoside phosphate biosynthetic process GO:1901293 102 0.015
response to wounding GO:0009611 254 0.015
striated muscle tissue development GO:0014706 58 0.015
transforming growth factor beta3 production GO:0032907 2 0.015
regulation of neuron apoptotic process GO:0043523 83 0.015
cellular chemical homeostasis GO:0055082 247 0.015
negative regulation of chromosome organization GO:2001251 1 0.015
cytoplasmic transport GO:0016482 115 0.015
positive chemotaxis GO:0050918 9 0.015
response to monosaccharide GO:0034284 159 0.015
negative regulation of transport GO:0051051 136 0.015
regulation of response to tumor cell GO:0002834 3 0.015
positive regulation of neuron differentiation GO:0045666 126 0.015
regulation of dna metabolic process GO:0051052 60 0.014
histone modification GO:0016570 30 0.014
positive regulation of neurogenesis GO:0050769 165 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
catabolic process GO:0009056 351 0.014
olfactory behavior GO:0042048 2 0.014
development of primary male sexual characteristics GO:0046546 59 0.014
reproductive structure development GO:0048608 128 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
palate development GO:0060021 2 0.014
regulation of protein modification process GO:0031399 194 0.013
tube development GO:0035295 89 0.013
rna localization GO:0006403 4 0.013
positive regulation of phosphorus metabolic process GO:0010562 262 0.013
endothelial cell differentiation GO:0045446 9 0.013
regulation of mitotic cell cycle GO:0007346 27 0.013
response to hyperoxia GO:0055093 45 0.013
response to alkaloid GO:0043279 132 0.013
regulation of microtubule based process GO:0032886 14 0.013
mitotic cell cycle checkpoint GO:0007093 1 0.013
olfactory learning GO:0008355 1 0.013
protein homooligomerization GO:0051260 91 0.013
mitotic cell cycle process GO:1903047 35 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
spinal cord development GO:0021510 27 0.012
organic hydroxy compound metabolic process GO:1901615 115 0.012
cation transmembrane transport GO:0098655 263 0.012
hematopoietic progenitor cell differentiation GO:0002244 2 0.012
cellular ketone metabolic process GO:0042180 51 0.012
protein localization GO:0008104 191 0.012
regulation of dopamine metabolic process GO:0042053 5 0.012
extracellular transport GO:0006858 1 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
response to increased oxygen levels GO:0036296 45 0.012
regulation of neuron projection development GO:0010975 161 0.012
regulation of mesenchymal cell proliferation GO:0010464 4 0.012
regulation of kinase activity GO:0043549 117 0.012
gonad development GO:0008406 104 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
macromolecule catabolic process GO:0009057 58 0.012
epithelial cell proliferation GO:0050673 54 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
locomotion GO:0040011 237 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
spindle organization GO:0007051 2 0.012
covalent chromatin modification GO:0016569 30 0.012
energy derivation by oxidation of organic compounds GO:0015980 46 0.012
sex differentiation GO:0007548 113 0.012
positive regulation of cellular component biogenesis GO:0044089 55 0.012
nucleoside phosphate metabolic process GO:0006753 283 0.012
microtubule based process GO:0007017 36 0.012
response to electrical stimulus GO:0051602 56 0.012
organ regeneration GO:0031100 101 0.012
cellular homeostasis GO:0019725 252 0.011
cytoskeleton dependent cytokinesis GO:0061640 2 0.011
cellular response to abiotic stimulus GO:0071214 85 0.011
single organism carbohydrate metabolic process GO:0044723 118 0.011
endothelial cell proliferation GO:0001935 20 0.011
germ cell development GO:0007281 25 0.011
single organism behavior GO:0044708 130 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.011
circulatory system process GO:0003013 183 0.011
muscle system process GO:0003012 115 0.011
heterocycle catabolic process GO:0046700 167 0.011
regulation of cell projection organization GO:0031344 175 0.011
chromosome segregation GO:0007059 2 0.011
response to ketone GO:1901654 182 0.011
cell motility GO:0048870 202 0.011
energy reserve metabolic process GO:0006112 25 0.011
ras protein signal transduction GO:0007265 29 0.011
synaptic growth at neuromuscular junction GO:0051124 1 0.011
negative regulation of signal transduction GO:0009968 83 0.011
potassium ion transport GO:0006813 97 0.010
rna transport GO:0050658 3 0.010
negative regulation of neuron apoptotic process GO:0043524 45 0.010
regulation of intracellular signal transduction GO:1902531 218 0.010
response to carbohydrate GO:0009743 183 0.010
regulation of proteolysis GO:0030162 66 0.010
carbohydrate metabolic process GO:0005975 130 0.010
regulation of intracellular transport GO:0032386 65 0.010
response to cytokine GO:0034097 215 0.010
calcium ion transmembrane transport GO:0070588 70 0.010
regulation of purine nucleotide metabolic process GO:1900542 115 0.010
response to reactive oxygen species GO:0000302 120 0.010
signal transduction by phosphorylation GO:0023014 144 0.010

Pcna disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 0 0.022
disease of anatomical entity DOID:7 0 0.022
nervous system disease DOID:863 0 0.022
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016