Rattus norvegicus

0 known processes

Pcsk4

proprotein convertase subtilisin/kexin type 4

Pcsk4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell cell signaling GO:0007267 335 0.257
secretion by cell GO:0032940 248 0.141
Mouse Rat
rna biosynthetic process GO:0032774 380 0.135
regulation of nucleic acid templated transcription GO:1903506 380 0.133
nitrogen compound transport GO:0071705 229 0.124
cognition GO:0050890 92 0.105
regulation of transcription dna templated GO:0006355 374 0.103
response to nutrient levels GO:0031667 370 0.103
Rat
inorganic ion transmembrane transport GO:0098660 229 0.101
regulation of blood circulation GO:1903522 110 0.095
neurological system process GO:0050877 219 0.092
cation transport GO:0006812 382 0.089
inorganic cation transmembrane transport GO:0098662 202 0.086
metal ion transport GO:0030001 289 0.077
nucleic acid templated transcription GO:0097659 379 0.072
potassium ion transport GO:0006813 97 0.071
apoptotic process GO:0006915 381 0.071
regulation of peptide secretion GO:0002791 82 0.067
organic substance catabolic process GO:1901575 316 0.067
potassium ion transmembrane transport GO:0071805 71 0.066
cellular chemical homeostasis GO:0055082 247 0.064
synaptic transmission GO:0007268 235 0.062
transcription dna templated GO:0006351 377 0.062
negative regulation of nucleic acid templated transcription GO:1903507 117 0.061
secretion GO:0046903 307 0.060
Mouse Rat
glutamate receptor signaling pathway GO:0007215 43 0.059
anatomical structure morphogenesis GO:0009653 298 0.057
regulation of rna metabolic process GO:0051252 391 0.056
lipid metabolic process GO:0006629 283 0.054
hormone transport GO:0009914 121 0.053
regulation of peptide transport GO:0090087 87 0.052
regulation of rna biosynthetic process GO:2001141 381 0.051
protein complex assembly GO:0006461 263 0.051
regulation of cell differentiation GO:0045595 320 0.050
cellular ion homeostasis GO:0006873 184 0.048
regulation of cellular component organization GO:0051128 368 0.047
acid secretion GO:0046717 48 0.047
ion transmembrane transport GO:0034220 365 0.046
cellular homeostasis GO:0019725 252 0.045
signal release GO:0023061 145 0.045
regulation of phosphorylation GO:0042325 248 0.045
organophosphate metabolic process GO:0019637 370 0.045
regulation of secretion GO:0051046 224 0.044
Rat
response to peptide hormone GO:0043434 278 0.044
Rat
transmembrane transport GO:0055085 412 0.043
peptide transport GO:0015833 97 0.043
anion transport GO:0006820 178 0.042
regulation of ion transport GO:0043269 245 0.041
negative regulation of metabolic process GO:0009892 331 0.040
homeostatic process GO:0042592 331 0.039
regulation of membrane potential GO:0042391 110 0.039
rna metabolic process GO:0016070 406 0.038
regulation of molecular function GO:0065009 398 0.038
positive regulation of cell death GO:0010942 184 0.037
positive regulation of amine transport GO:0051954 26 0.036
cellular potassium ion transport GO:0071804 72 0.036
regulation of apoptotic process GO:0042981 335 0.036
g protein coupled receptor signaling pathway GO:0007186 242 0.036
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.035
regulation of cell development GO:0060284 263 0.035
cation homeostasis GO:0055080 195 0.035
regulation of hormone secretion GO:0046883 106 0.035
positive regulation of developmental process GO:0051094 283 0.035
peptide hormone secretion GO:0030072 84 0.035
reproductive process GO:0022414 372 0.035
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 162 0.034
response to fatty acid GO:0070542 65 0.034
Rat
regulation of catalytic activity GO:0050790 304 0.034
negative regulation of transcription dna templated GO:0045892 116 0.034
regulation of peptide hormone secretion GO:0090276 80 0.033
regulation of multicellular organismal development GO:2000026 376 0.032
regulation of intracellular signal transduction GO:1902531 218 0.032
divalent inorganic cation transport GO:0072511 134 0.032
macromolecular complex assembly GO:0065003 273 0.032
reproduction GO:0000003 245 0.031
Mouse
sexual reproduction GO:0019953 148 0.031
Mouse
organophosphate biosynthetic process GO:0090407 143 0.031
response to extracellular stimulus GO:0009991 380 0.031
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.031
insulin secretion GO:0030073 69 0.030
response to cytokine GO:0034097 215 0.030
Rat
negative regulation of response to stimulus GO:0048585 155 0.030
regulation of insulin secretion GO:0050796 65 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
transcription from rna polymerase ii promoter GO:0006366 252 0.030
catabolic process GO:0009056 351 0.029
programmed cell death GO:0012501 392 0.029
central nervous system development GO:0007417 311 0.029
Rat
cellular response to endogenous stimulus GO:0071495 377 0.029
Rat
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.029
regulation of signal transduction GO:0009966 318 0.028
Rat
tissue development GO:0009888 252 0.028
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
negative regulation of cell communication GO:0010648 158 0.028
response to monosaccharide GO:0034284 159 0.028
Rat
startle response GO:0001964 2 0.028
prepulse inhibition GO:0060134 1 0.028
negative regulation of secretion GO:0051048 82 0.028
peptide secretion GO:0002790 86 0.028
ribonucleotide metabolic process GO:0009259 231 0.027
regulation of programmed cell death GO:0043067 341 0.027
cyclic nucleotide metabolic process GO:0009187 80 0.027
regulation of synaptic transmission GO:0050804 141 0.027
organic anion transport GO:0015711 132 0.026
cation transmembrane transport GO:0098655 263 0.026
cellular lipid metabolic process GO:0044255 208 0.026
response to metal ion GO:0010038 253 0.026
Rat
locomotion GO:0040011 237 0.025
Rat
response to glucose GO:0009749 136 0.025
Rat
metal ion homeostasis GO:0055065 186 0.025
ionotropic glutamate receptor signaling pathway GO:0035235 34 0.025
positive regulation of cell differentiation GO:0045597 217 0.025
regulation of cellular localization GO:0060341 263 0.025
Rat
positive regulation of phosphorylation GO:0042327 177 0.025
regulation of neurotransmitter uptake GO:0051580 1 0.024
cell type specific apoptotic process GO:0097285 134 0.024
regulation of response to food GO:0032095 11 0.024
neuron death GO:0070997 127 0.024
brain development GO:0007420 247 0.023
Rat
circulatory system process GO:0003013 183 0.023
chemical homeostasis GO:0048878 292 0.023
heart process GO:0003015 57 0.023
positive regulation of multicellular organismal process GO:0051240 387 0.023
localization of cell GO:0051674 202 0.023
Rat
neuron differentiation GO:0030182 368 0.022
Fly
negative regulation of cell death GO:0060548 229 0.022
membrane organization GO:0061024 94 0.022
regulation of nucleotide metabolic process GO:0006140 117 0.022
cellular component biogenesis GO:0044085 368 0.022
glutamate secretion GO:0014047 19 0.022
negative regulation of cellular metabolic process GO:0031324 281 0.022
response to inorganic substance GO:0010035 377 0.021
Rat
regulation of neuron apoptotic process GO:0043523 83 0.021
hormone secretion GO:0046879 115 0.021
cellular response to oxygen containing compound GO:1901701 386 0.021
intracellular signal transduction GO:0035556 314 0.021
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.021
negative regulation of collagen biosynthetic process GO:0032966 4 0.020
regulation of neurogenesis GO:0050767 247 0.020
lipid transport GO:0006869 61 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
positive regulation of cellular component organization GO:0051130 200 0.020
somatostatin receptor signaling pathway GO:0038169 4 0.020
cellular cation homeostasis GO:0030003 180 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.019
single organism membrane organization GO:0044802 74 0.019
behavioral response to nicotine GO:0035095 2 0.019
camera type eye development GO:0043010 48 0.019
divalent inorganic cation homeostasis GO:0072507 165 0.019
negative regulation of hormone secretion GO:0046888 46 0.019
macromolecular complex subunit organization GO:0043933 339 0.019
reproductive system development GO:0061458 128 0.019
response to hypoxia GO:0001666 231 0.019
response to biotic stimulus GO:0009607 226 0.018
Rat
purine containing compound metabolic process GO:0072521 253 0.018
regulation of phosphate metabolic process GO:0019220 349 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
cell projection organization GO:0030030 302 0.018
amide transport GO:0042886 105 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
negative regulation of response to food GO:0032096 7 0.018
regulation of transferase activity GO:0051338 123 0.018
response to peptide GO:1901652 292 0.018
Rat
carboxylic acid transport GO:0046942 115 0.017
carbohydrate derivative metabolic process GO:1901135 346 0.017
regulation of neuron death GO:1901214 115 0.017
positive regulation of phosphorus metabolic process GO:0010562 262 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
circadian regulation of gene expression GO:0032922 3 0.017
regulation of mapk cascade GO:0043408 116 0.017
organic hydroxy compound biosynthetic process GO:1901617 51 0.017
regulation of nervous system development GO:0051960 264 0.016
carboxylic acid metabolic process GO:0019752 289 0.016
regulation of appetite GO:0032098 8 0.016
adult locomotory behavior GO:0008344 4 0.016
leukocyte activation GO:0045321 76 0.016
neurotransmitter uptake GO:0001504 3 0.016
positive regulation of glutamate secretion GO:0014049 8 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.016
ribose phosphate metabolic process GO:0019693 235 0.016
single organism catabolic process GO:0044712 283 0.016
organonitrogen compound biosynthetic process GO:1901566 167 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
positive regulation of cell projection organization GO:0031346 111 0.015
eye development GO:0001654 50 0.015
calcium ion transport GO:0006816 131 0.015
positive regulation of apoptotic process GO:0043065 154 0.015
cellular component assembly GO:0022607 360 0.015
neuron neuron synaptic transmission GO:0007270 60 0.015
positive regulation of rna metabolic process GO:0051254 203 0.015
blood circulation GO:0008015 183 0.015
response to oxygen levels GO:0070482 265 0.015
monocarboxylic acid transport GO:0015718 52 0.015
cellular response to lipid GO:0071396 201 0.015
muscle contraction GO:0006936 88 0.014
regulation of cell proliferation GO:0042127 359 0.014
regulation of synaptic plasticity GO:0048167 70 0.014
mechanoreceptor differentiation GO:0042490 2 0.014
nucleobase containing small molecule metabolic process GO:0055086 316 0.014
positive regulation of ion transport GO:0043270 94 0.014
positive regulation of biosynthetic process GO:0009891 319 0.014
protein complex biogenesis GO:0070271 263 0.014
cytosolic calcium ion transport GO:0060401 39 0.014
glycerolipid metabolic process GO:0046486 67 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.014
Rat
regulation of neuron projection development GO:0010975 161 0.014
respiratory system development GO:0060541 45 0.014
negative regulation of signaling GO:0023057 157 0.014
single organism biosynthetic process GO:0044711 342 0.014
fatty acid derivative metabolic process GO:1901568 38 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
neuron development GO:0048666 286 0.013
Fly
regulation of cell projection organization GO:0031344 175 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.013
regulation of catabolic process GO:0009894 113 0.013
response to carbohydrate GO:0009743 183 0.013
Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
purine ribonucleotide metabolic process GO:0009150 227 0.013
regulation of protein metabolic process GO:0051246 289 0.013
neuronal action potential GO:0019228 35 0.013
cellular metal ion homeostasis GO:0006875 172 0.013
regulation of neuronal synaptic plasticity GO:0048168 31 0.013
response to calcium ion GO:0051592 59 0.013
Rat
fatty acid transport GO:0015908 25 0.013
calcium ion homeostasis GO:0055074 162 0.013
amine transport GO:0015837 57 0.013
negative regulation of rna metabolic process GO:0051253 123 0.013
organic acid metabolic process GO:0006082 292 0.013
cellular component morphogenesis GO:0032989 155 0.012
spermatogenesis GO:0007283 99 0.012
Mouse
cellular response to nitrogen compound GO:1901699 210 0.012
positive regulation of programmed cell death GO:0043068 157 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
response to glucocorticoid GO:0051384 223 0.012
Rat
sequestering of metal ion GO:0051238 9 0.012
cellular response to cytokine stimulus GO:0071345 127 0.012
amine metabolic process GO:0009308 38 0.012
response to hexose GO:0009746 144 0.012
Rat
regulation of synaptic transmission glutamatergic GO:0051966 26 0.012
positive regulation of catecholamine secretion GO:0033605 13 0.012
synaptic transmission dopaminergic GO:0001963 11 0.012
regulation of hormone levels GO:0010817 187 0.012
Rat
purine ribonucleotide catabolic process GO:0009154 136 0.012
phospholipid biosynthetic process GO:0008654 29 0.012
positive regulation of neurotransmitter secretion GO:0001956 9 0.012
cellular response to organonitrogen compound GO:0071417 197 0.012
camp metabolic process GO:0046058 63 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.012
small gtpase mediated signal transduction GO:0007264 36 0.012
response to acid chemical GO:0001101 222 0.012
Rat
lens fiber cell differentiation GO:0070306 3 0.012
organ regeneration GO:0031100 101 0.012
respiratory gaseous exchange GO:0007585 4 0.012
male gamete generation GO:0048232 99 0.012
Mouse
endocytosis GO:0006897 84 0.012
positive regulation of nervous system development GO:0051962 178 0.012
regulation of secretion by cell GO:1903530 208 0.012
Rat
metanephric tubule morphogenesis GO:0072173 2 0.011
negative regulation of molecular function GO:0044092 133 0.011
positive regulation of mapk cascade GO:0043410 92 0.011
immune system process GO:0002376 204 0.011
regulation of neuron differentiation GO:0045664 208 0.011
positive regulation of hormone secretion GO:0046887 65 0.011
sensory perception GO:0007600 101 0.011
response to reactive oxygen species GO:0000302 120 0.011
somatostatin signaling pathway GO:0038170 4 0.011
regulation of anatomical structure size GO:0090066 135 0.011
protein localization GO:0008104 191 0.011
Rat
protein phosphorylation GO:0006468 345 0.011
negative regulation of gene expression GO:0010629 199 0.011
positive regulation of camp metabolic process GO:0030816 31 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.011
dna templated transcription initiation GO:0006352 4 0.011
cellular glucose homeostasis GO:0001678 66 0.011
striated muscle contraction GO:0006941 44 0.011
alcohol biosynthetic process GO:0046165 38 0.011
negative regulation of secretion by cell GO:1903531 72 0.011
response to ketone GO:1901654 182 0.011
regulation of lyase activity GO:0051339 22 0.011
camp biosynthetic process GO:0006171 47 0.011
action potential GO:0001508 54 0.011
membrane depolarization GO:0051899 32 0.011
regulation of cellular catabolic process GO:0031329 101 0.011
regeneration GO:0031099 163 0.011
positive regulation of cell communication GO:0010647 271 0.011
Rat
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 5 0.010
response to external biotic stimulus GO:0043207 221 0.010
Rat
cellular response to external stimulus GO:0071496 118 0.010
cellular amine metabolic process GO:0044106 38 0.010
organic acid transport GO:0015849 116 0.010
divalent metal ion transport GO:0070838 132 0.010
monocarboxylic acid metabolic process GO:0032787 152 0.010
cellular calcium ion homeostasis GO:0006874 160 0.010
gastrulation GO:0007369 2 0.010

Pcsk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.119
disease of anatomical entity DOID:7 0 0.119
sensory system disease DOID:0050155 0 0.039
eye and adnexa disease DOID:1492 0 0.039
eye disease DOID:5614 0 0.039
retinal disease DOID:5679 0 0.039
brain disease DOID:936 0 0.023
epilepsy syndrome DOID:1826 0 0.023
central nervous system disease DOID:331 0 0.023
disease of metabolism DOID:0014667 0 0.023
inherited metabolic disorder DOID:655 0 0.023