Rattus norvegicus

53 known processes

Pde11a

phosphodiesterase 11A

Pde11a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of response to stimulus GO:0048584 285 0.163
Rat
regulation of protein modification process GO:0031399 194 0.146
regulation of phosphate metabolic process GO:0019220 349 0.133
Rat
regulation of phosphorus metabolic process GO:0051174 349 0.126
Rat
rna biosynthetic process GO:0032774 380 0.125
negative regulation of cellular metabolic process GO:0031324 281 0.114
Rat
regulation of phosphorylation GO:0042325 248 0.107
regulation of molecular function GO:0065009 398 0.106
positive regulation of multicellular organismal process GO:0051240 387 0.101
Rat
regulation of signal transduction GO:0009966 318 0.095
positive regulation of protein phosphorylation GO:0001934 135 0.092
regulation of cellular protein metabolic process GO:0032268 267 0.092
regulation of catalytic activity GO:0050790 304 0.089
negative regulation of nucleic acid templated transcription GO:1903507 117 0.086
negative regulation of macromolecule metabolic process GO:0010605 260 0.085
regulation of intracellular signal transduction GO:1902531 218 0.084
organonitrogen compound biosynthetic process GO:1901566 167 0.083
Rat
regulation of rna metabolic process GO:0051252 391 0.081
regulation of rna biosynthetic process GO:2001141 381 0.080
rna metabolic process GO:0016070 406 0.078
intracellular signal transduction GO:0035556 314 0.075
Rat
protein complex biogenesis GO:0070271 263 0.074
regulation of nucleic acid templated transcription GO:1903506 380 0.072
positive regulation of cell proliferation GO:0008284 249 0.071
regulation of protein phosphorylation GO:0001932 183 0.069
regulation of protein metabolic process GO:0051246 289 0.069
positive regulation of protein modification process GO:0031401 142 0.066
apoptotic process GO:0006915 381 0.066
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.066
Rat
negative regulation of metabolic process GO:0009892 331 0.064
Rat
regulation of transcription dna templated GO:0006355 374 0.063
protein phosphorylation GO:0006468 345 0.063
transcription dna templated GO:0006351 377 0.061
positive regulation of phosphorus metabolic process GO:0010562 262 0.061
positive regulation of transferase activity GO:0051347 81 0.060
positive regulation of catalytic activity GO:0043085 184 0.059
immune system process GO:0002376 204 0.058
nucleic acid templated transcription GO:0097659 379 0.057
positive regulation of molecular function GO:0044093 230 0.057
positive regulation of developmental process GO:0051094 283 0.057
regulation of membrane potential GO:0042391 110 0.056
positive regulation of phosphate metabolic process GO:0045937 262 0.054
cellular component biogenesis GO:0044085 368 0.054
protein transport GO:0015031 132 0.052
Rat
positive regulation of cell communication GO:0010647 271 0.052
response to corticosteroid GO:0031960 235 0.050
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.048
inflammatory response GO:0006954 150 0.048
Rat
aging GO:0007568 241 0.048
negative regulation of gene expression GO:0010629 199 0.047
macromolecular complex subunit organization GO:0043933 339 0.047
cell motility GO:0048870 202 0.046
regulation of kinase activity GO:0043549 117 0.046
signal transduction by phosphorylation GO:0023014 144 0.045
negative regulation of cell communication GO:0010648 158 0.044
regulation of transferase activity GO:0051338 123 0.043
positive regulation of protein kinase activity GO:0045860 73 0.043
positive regulation of phosphorylation GO:0042327 177 0.042
positive regulation of nervous system development GO:0051962 178 0.042
cell projection organization GO:0030030 302 0.042
negative regulation of cellular biosynthetic process GO:0031327 161 0.042
Rat
response to wounding GO:0009611 254 0.042
Rat
organophosphate metabolic process GO:0019637 370 0.041
central nervous system development GO:0007417 311 0.041
positive regulation of protein metabolic process GO:0051247 178 0.040
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.038
carbohydrate derivative metabolic process GO:1901135 346 0.038
protein complex assembly GO:0006461 263 0.038
transcription from rna polymerase ii promoter GO:0006366 252 0.037
neuron development GO:0048666 286 0.037
positive regulation of signal transduction GO:0009967 175 0.036
regulation of protein kinase activity GO:0045859 105 0.036
negative regulation of biosynthetic process GO:0009890 168 0.035
Rat
regulation of multicellular organismal development GO:2000026 376 0.035
organophosphate biosynthetic process GO:0090407 143 0.035
Rat
positive regulation of neurogenesis GO:0050769 165 0.034
macromolecular complex assembly GO:0065003 273 0.034
positive regulation of cellular protein metabolic process GO:0032270 167 0.033
cellular response to hormone stimulus GO:0032870 247 0.033
protein oligomerization GO:0051259 191 0.033
single organism biosynthetic process GO:0044711 342 0.033
Rat
locomotion GO:0040011 237 0.033
cellular response to stress GO:0033554 269 0.032
negative regulation of signaling GO:0023057 157 0.032
positive regulation of intracellular signal transduction GO:1902533 138 0.032
cellular component movement GO:0006928 248 0.031
regulation of system process GO:0044057 208 0.030
Rat
signal release GO:0023061 145 0.030
regulation of cell projection organization GO:0031344 175 0.030
neuron differentiation GO:0030182 368 0.030
brain development GO:0007420 247 0.030
regulation of cell migration GO:0030334 128 0.029
regulation of cell motility GO:2000145 131 0.029
response to growth factor GO:0070848 189 0.029
regulation of cell development GO:0060284 263 0.028
cellular response to oxygen containing compound GO:1901701 386 0.028
cellular ketone metabolic process GO:0042180 51 0.028
positive regulation of cellular component organization GO:0051130 200 0.028
regulation of cellular localization GO:0060341 263 0.028
circulatory system process GO:0003013 183 0.028
Rat
cell type specific apoptotic process GO:0097285 134 0.028
response to lipopolysaccharide GO:0032496 191 0.028
Rat
mapk cascade GO:0000165 140 0.028
regulation of cellular component organization GO:0051128 368 0.028
purine containing compound metabolic process GO:0072521 253 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.027
oxoacid metabolic process GO:0043436 290 0.027
negative regulation of rna metabolic process GO:0051253 123 0.027
positive regulation of signaling GO:0023056 270 0.027
negative regulation of transport GO:0051051 136 0.026
Fly
transmembrane transport GO:0055085 412 0.026
positive regulation of cell development GO:0010720 176 0.026
regulation of cellular amino acid metabolic process GO:0006521 2 0.026
regulation of cell differentiation GO:0045595 320 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.025
cellular response to peptide GO:1901653 133 0.025
regulation of neurogenesis GO:0050767 247 0.025
lipid biosynthetic process GO:0008610 128 0.025
response to glucocorticoid GO:0051384 223 0.025
response to decreased oxygen levels GO:0036293 237 0.025
Rat
response to oxidative stress GO:0006979 186 0.025
nucleobase containing small molecule metabolic process GO:0055086 316 0.025
negative regulation of protein metabolic process GO:0051248 114 0.024
hormone transport GO:0009914 121 0.024
cellular response to growth factor stimulus GO:0071363 162 0.024
cellular response to organic cyclic compound GO:0071407 202 0.024
regulation of apoptotic process GO:0042981 335 0.024
Rat
protein heterooligomerization GO:0051291 89 0.024
negative regulation of signal transduction GO:0009968 83 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
regulation of cellular ketone metabolic process GO:0010565 27 0.023
regulation of secretion GO:0051046 224 0.023
reproduction GO:0000003 245 0.023
cellular component assembly GO:0022607 360 0.023
positive regulation of kinase activity GO:0033674 77 0.023
ribonucleotide metabolic process GO:0009259 231 0.023
cellular response to steroid hormone stimulus GO:0071383 93 0.023
response to nutrient levels GO:0031667 370 0.023
regulation of secretion by cell GO:1903530 208 0.023
response to hexose GO:0009746 144 0.022
regulation of neuron projection development GO:0010975 161 0.022
regulation of mapk cascade GO:0043408 116 0.022
negative regulation of phosphorus metabolic process GO:0010563 80 0.022
Rat
programmed cell death GO:0012501 392 0.022
Rat
protein complex subunit organization GO:0071822 302 0.022
positive regulation of neuron differentiation GO:0045666 126 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.022
catabolic process GO:0009056 351 0.021
cellular response to nitrogen compound GO:1901699 210 0.021
response to bacterium GO:0009617 200 0.021
Rat
blood circulation GO:0008015 183 0.021
Rat
regulation of metal ion transport GO:0010959 118 0.021
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.021
Rat
neuron projection development GO:0031175 273 0.021
positive regulation of cellular biosynthetic process GO:0031328 295 0.021
rhythmic process GO:0048511 156 0.021
reactive oxygen species metabolic process GO:0072593 37 0.021
head development GO:0060322 247 0.020
regulation of blood pressure GO:0008217 83 0.020
metal ion transport GO:0030001 289 0.020
carboxylic acid metabolic process GO:0019752 289 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
response to molecule of bacterial origin GO:0002237 194 0.020
Rat
regulation of nervous system development GO:0051960 264 0.020
positive regulation of cellular component movement GO:0051272 102 0.020
secretion GO:0046903 307 0.020
nucleoside phosphate metabolic process GO:0006753 283 0.020
amine metabolic process GO:0009308 38 0.020
cellular homeostasis GO:0019725 252 0.020
negative regulation of transcription dna templated GO:0045892 116 0.020
transmission of nerve impulse GO:0019226 42 0.019
nucleoside phosphate biosynthetic process GO:1901293 102 0.019
Rat
cellular response to endogenous stimulus GO:0071495 377 0.019
activation of protein kinase activity GO:0032147 47 0.019
intracellular transport GO:0046907 185 0.019
Rat
cellular amino acid metabolic process GO:0006520 107 0.019
cellular amine metabolic process GO:0044106 38 0.019
positive regulation of gene expression GO:0010628 244 0.019
cation transport GO:0006812 382 0.019
positive regulation of biosynthetic process GO:0009891 319 0.018
regulation of programmed cell death GO:0043067 341 0.018
Rat
regulation of locomotion GO:0040012 148 0.018
negative regulation of programmed cell death GO:0043069 183 0.018
positive regulation of interleukin 1 beta secretion GO:0050718 3 0.018
bmp signaling pathway GO:0030509 4 0.018
positive regulation of cell differentiation GO:0045597 217 0.018
positive regulation of neuron projection development GO:0010976 99 0.018
protein maturation GO:0051604 68 0.018
protein localization GO:0008104 191 0.018
Rat
cell cell signaling GO:0007267 335 0.018
negative regulation of rna biosynthetic process GO:1902679 118 0.018
positive regulation of cell projection organization GO:0031346 111 0.018
cellular response to cytokine stimulus GO:0071345 127 0.017
cellular response to reactive oxygen species GO:0034614 55 0.017
localization of cell GO:0051674 202 0.017
positive regulation of apoptotic process GO:0043065 154 0.017
Rat
regulation of ion homeostasis GO:2000021 63 0.017
cardiovascular system development GO:0072358 134 0.017
cellular response to external stimulus GO:0071496 118 0.017
negative regulation of cell death GO:0060548 229 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
circulatory system development GO:0072359 134 0.017
response to monosaccharide GO:0034284 159 0.017
epithelial cell differentiation GO:0030855 71 0.017
Rat
dephosphorylation GO:0016311 98 0.017
cytoplasmic transport GO:0016482 115 0.017
Rat
regulation of protein serine threonine kinase activity GO:0071900 64 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
regulation of neuron apoptotic process GO:0043523 83 0.016
negative regulation of molecular function GO:0044092 133 0.016
reproductive process GO:0022414 372 0.016
nucleotide metabolic process GO:0009117 279 0.016
cellular response to organonitrogen compound GO:0071417 197 0.016
multi organism reproductive process GO:0044703 262 0.016
response to reactive oxygen species GO:0000302 120 0.016
regulation of neuron death GO:1901214 115 0.016
cellular macromolecule localization GO:0070727 122 0.016
Rat
positive regulation of cellular amine metabolic process GO:0033240 3 0.016
anatomical structure morphogenesis GO:0009653 298 0.016
divalent metal ion transport GO:0070838 132 0.016
g protein coupled receptor signaling pathway GO:0007186 242 0.016
organ regeneration GO:0031100 101 0.015
organic hydroxy compound biosynthetic process GO:1901617 51 0.015
interleukin 1 beta secretion GO:0050702 3 0.015
ras protein signal transduction GO:0007265 29 0.015
sex differentiation GO:0007548 113 0.015
macromolecule localization GO:0033036 252 0.015
Rat
regulation of hormone levels GO:0010817 187 0.015
response to glucose GO:0009749 136 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
cellular component morphogenesis GO:0032989 155 0.015
response to peptide GO:1901652 292 0.015
gastrulation GO:0007369 2 0.015
calcium ion transport GO:0006816 131 0.015
synaptic transmission GO:0007268 235 0.015
lipid metabolic process GO:0006629 283 0.015
response to oxygen levels GO:0070482 265 0.015
Rat
regulation of ion transmembrane transport GO:0034765 121 0.015
regulation of neuron differentiation GO:0045664 208 0.014
negative regulation of phosphate metabolic process GO:0045936 80 0.014
Rat
divalent inorganic cation transport GO:0072511 134 0.014
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
neuron projection morphogenesis GO:0048812 122 0.014
positive regulation of cell motility GO:2000147 97 0.014
cellular lipid metabolic process GO:0044255 208 0.014
regulation of interleukin 1 beta secretion GO:0050706 3 0.014
regulation of homeostatic process GO:0032844 101 0.014
tissue development GO:0009888 252 0.014
Rat
negative regulation of multicellular organismal process GO:0051241 203 0.014
glycosyl compound metabolic process GO:1901657 182 0.014
ribose phosphate metabolic process GO:0019693 235 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
cytoskeleton organization GO:0007010 111 0.013
vascular process in circulatory system GO:0003018 96 0.013
Rat
defense response GO:0006952 194 0.013
Rat
neurological system process GO:0050877 219 0.013
Rat
establishment of protein localization GO:0045184 141 0.013
Rat
female pregnancy GO:0007565 122 0.013
regulation of cell proliferation GO:0042127 359 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
Rat
positive regulation of mapk cascade GO:0043410 92 0.013
multi multicellular organism process GO:0044706 138 0.013
regulation of purine nucleotide metabolic process GO:1900542 115 0.013
Rat
regulation of immune system process GO:0002682 123 0.013
carbohydrate metabolic process GO:0005975 130 0.013
organic substance catabolic process GO:1901575 316 0.013
interleukin 1 secretion GO:0050701 3 0.013
regulation of blood circulation GO:1903522 110 0.013
Rat
purine ribonucleotide metabolic process GO:0009150 227 0.013
sensory perception GO:0007600 101 0.013
proteolysis GO:0006508 175 0.013
response to external biotic stimulus GO:0043207 221 0.013
Rat
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
alcohol metabolic process GO:0006066 77 0.012
ion homeostasis GO:0050801 212 0.012
cellular protein localization GO:0034613 122 0.012
Rat
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
Rat
response to other organism GO:0051707 220 0.012
Rat
cellular response to oxidative stress GO:0034599 76 0.012
chemical homeostasis GO:0048878 292 0.012
maintenance of location GO:0051235 17 0.012
response to metal ion GO:0010038 253 0.012
positive regulation of cell migration GO:0030335 96 0.012
peptidyl amino acid modification GO:0018193 126 0.012
purine nucleotide metabolic process GO:0006163 229 0.012
response to extracellular stimulus GO:0009991 380 0.012
single organism reproductive process GO:0044702 297 0.012
action potential GO:0001508 54 0.012
positive regulation of cellular component biogenesis GO:0044089 55 0.012
cell migration GO:0016477 197 0.012
protein homooligomerization GO:0051260 91 0.012
regulation of muscle system process GO:0090257 79 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
response to interleukin 1 GO:0070555 55 0.012
regulation of hydrolase activity GO:0051336 143 0.012
organic acid metabolic process GO:0006082 292 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.011
Rat
gonad development GO:0008406 104 0.011
regulation of hormone secretion GO:0046883 106 0.011
protein targeting GO:0006605 61 0.011
Rat
salivary gland development GO:0007431 3 0.011
single organism catabolic process GO:0044712 283 0.011
cell morphogenesis GO:0000902 142 0.011
organelle organization GO:0006996 266 0.011
Rat
eye morphogenesis GO:0048592 4 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
regulation of lipid metabolic process GO:0019216 68 0.011
cell adhesion GO:0007155 110 0.011
regulation of transmembrane transport GO:0034762 122 0.011
intracellular protein transport GO:0006886 79 0.011
Rat
positive regulation of cell death GO:0010942 184 0.011
Rat
cellular divalent inorganic cation homeostasis GO:0072503 162 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
positive regulation of interleukin 1 secretion GO:0050716 3 0.011
cytokine mediated signaling pathway GO:0019221 43 0.011
axis specification GO:0009798 4 0.011
response to inorganic substance GO:0010035 377 0.011
regulation of reactive oxygen species metabolic process GO:2000377 26 0.011
negative regulation of response to stimulus GO:0048585 155 0.011
response to hypoxia GO:0001666 231 0.011
Rat
circadian regulation of gene expression GO:0032922 3 0.011
regulation of ion transport GO:0043269 245 0.011
negative regulation of secretion GO:0051048 82 0.011
carbohydrate derivative catabolic process GO:1901136 147 0.011
neuron death GO:0070997 127 0.011
response to nutrient GO:0007584 248 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
salivary gland morphogenesis GO:0007435 1 0.010
wound healing GO:0042060 122 0.010
negative regulation of homeostatic process GO:0032845 47 0.010
response to cytokine GO:0034097 215 0.010
cell cell signaling involved in cell fate commitment GO:0045168 2 0.010
lipid storage GO:0019915 1 0.010
organonitrogen compound catabolic process GO:1901565 179 0.010
ribose phosphate biosynthetic process GO:0046390 87 0.010
Rat
multicellular organism growth GO:0035264 1 0.010
gliogenesis GO:0042063 93 0.010

Pde11a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.015
musculoskeletal system disease DOID:17 0 0.011
disease of anatomical entity DOID:7 0 0.011