Rattus norvegicus

0 known processes

Pde6h

phosphodiesterase 6H, cGMP-specific, cone, gamma

(Aliases: Pde6g)

Pde6h biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of neutrophil migration GO:1902622 6 0.231
locomotion GO:0040011 237 0.224
regulation of chemotaxis GO:0050920 29 0.224
response to radiation GO:0009314 137 0.154
positive regulation of chemotaxis GO:0050921 23 0.144
hormone transport GO:0009914 121 0.115
aging GO:0007568 241 0.106
regulation of secretion by cell GO:1903530 208 0.097
cellular cation homeostasis GO:0030003 180 0.090
response to bacterium GO:0009617 200 0.088
homeostatic process GO:0042592 331 0.086
cellular component movement GO:0006928 248 0.079
regulation of ion transport GO:0043269 245 0.075
regulation of cellular localization GO:0060341 263 0.075
chemotaxis GO:0006935 66 0.075
neurological system process GO:0050877 219 0.075
hormone secretion GO:0046879 115 0.073
behavior GO:0007610 205 0.071
regulation of chronic inflammatory response GO:0002676 3 0.071
divalent inorganic cation homeostasis GO:0072507 165 0.070
positive regulation of response to stimulus GO:0048584 285 0.067
cellular metal ion homeostasis GO:0006875 172 0.066
eosinophil migration GO:0072677 3 0.064
response to other organism GO:0051707 220 0.064
regulation of nervous system development GO:0051960 264 0.064
g protein coupled receptor signaling pathway GO:0007186 242 0.064
regulation of secretion GO:0051046 224 0.064
programmed cell death GO:0012501 392 0.063
neuron differentiation GO:0030182 368 0.061
defense response GO:0006952 194 0.061
leukocyte migration GO:0050900 38 0.059
regulation of cellular component movement GO:0051270 150 0.059
intracellular signal transduction GO:0035556 314 0.059
macromolecular complex subunit organization GO:0043933 339 0.059
cell cell signaling GO:0007267 335 0.059
response to estrogen GO:0043627 232 0.058
memory GO:0007613 54 0.057
protein complex subunit organization GO:0071822 302 0.057
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.057
regulation of apoptotic process GO:0042981 335 0.056
regulation of rna biosynthetic process GO:2001141 381 0.055
cellular chemical homeostasis GO:0055082 247 0.055
single organism behavior GO:0044708 130 0.054
transcription dna templated GO:0006351 377 0.053
cellular ion homeostasis GO:0006873 184 0.053
neuron development GO:0048666 286 0.053
regulation of programmed cell death GO:0043067 341 0.052
cellular component assembly GO:0022607 360 0.052
response to peptide GO:1901652 292 0.052
positive regulation of neutrophil chemotaxis GO:0090023 5 0.051
cell motility GO:0048870 202 0.051
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.051
apoptotic process GO:0006915 381 0.051
cellular homeostasis GO:0019725 252 0.050
calcium ion homeostasis GO:0055074 162 0.050
positive regulation of cellular component movement GO:0051272 102 0.049
regulation of hormone levels GO:0010817 187 0.049
secretion GO:0046903 307 0.048
cellular divalent inorganic cation homeostasis GO:0072503 162 0.047
cytoskeleton organization GO:0007010 111 0.047
regulation of nucleic acid templated transcription GO:1903506 380 0.047
regulation of locomotion GO:0040012 148 0.047
cellular response to oxygen containing compound GO:1901701 386 0.047
regulation of cell migration GO:0030334 128 0.046
regulation of neurogenesis GO:0050767 247 0.046
negative regulation of long term synaptic potentiation GO:1900272 1 0.045
regulation of hormone secretion GO:0046883 106 0.044
eosinophil chemotaxis GO:0048245 3 0.044
mast cell migration GO:0097531 4 0.044
taxis GO:0042330 67 0.044
single organism reproductive process GO:0044702 297 0.043
cellular response to organic cyclic compound GO:0071407 202 0.043
response to calcium ion GO:0051592 59 0.043
positive regulation of signaling GO:0023056 270 0.043
regulation of phosphate metabolic process GO:0019220 349 0.042
regulation of multicellular organismal development GO:2000026 376 0.042
regulation of cellular component organization GO:0051128 368 0.041
regulation of cell differentiation GO:0045595 320 0.040
negative regulation of cell death GO:0060548 229 0.040
response to estradiol GO:0032355 164 0.040
negative regulation of chronic inflammatory response GO:0002677 2 0.039
transmembrane transport GO:0055085 412 0.039
secretion by cell GO:0032940 248 0.039
positive regulation of nervous system development GO:0051962 178 0.039
development of primary sexual characteristics GO:0045137 107 0.039
anatomical structure morphogenesis GO:0009653 298 0.039
positive regulation of immune system process GO:0002684 90 0.038
regulation of response to wounding GO:1903034 69 0.038
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.038
phasic smooth muscle contraction GO:0014821 3 0.038
regulation of peptide hormone secretion GO:0090276 80 0.038
response to growth factor GO:0070848 189 0.038
protein complex biogenesis GO:0070271 263 0.037
neutrophil apoptotic process GO:0001781 4 0.037
cellular calcium ion homeostasis GO:0006874 160 0.036
regulation of behavior GO:0050795 61 0.036
transcription from rna polymerase ii promoter GO:0006366 252 0.036
positive regulation of behavior GO:0048520 38 0.036
positive regulation of neutrophil migration GO:1902624 6 0.036
lymphocyte chemotaxis GO:0048247 3 0.035
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.035
regulation of neutrophil chemotaxis GO:0090022 5 0.035
positive regulation of rna metabolic process GO:0051254 203 0.034
negative regulation of secretion by cell GO:1903531 72 0.034
response to lipopolysaccharide GO:0032496 191 0.033
regulation of anatomical structure size GO:0090066 135 0.033
chemical homeostasis GO:0048878 292 0.033
ion homeostasis GO:0050801 212 0.033
cell migration GO:0016477 197 0.033
negative regulation of cell communication GO:0010648 158 0.032
regulation of cell motility GO:2000145 131 0.032
tissue development GO:0009888 252 0.032
synaptic transmission GO:0007268 235 0.032
regulation of cell development GO:0060284 263 0.032
eye morphogenesis GO:0048592 4 0.032
rna metabolic process GO:0016070 406 0.032
cognition GO:0050890 92 0.032
negative regulation of neutrophil apoptotic process GO:0033030 3 0.031
single organism organelle organization GO:1902589 180 0.031
response to fatty acid GO:0070542 65 0.031
rna biosynthetic process GO:0032774 380 0.031
macromolecular complex assembly GO:0065003 273 0.031
brain development GO:0007420 247 0.030
vascular process in circulatory system GO:0003018 96 0.030
response to carbohydrate GO:0009743 183 0.030
regulation of fat cell proliferation GO:0070344 1 0.029
signal release GO:0023061 145 0.029
response to peptide hormone GO:0043434 278 0.029
localization of cell GO:0051674 202 0.029
negative regulation of apoptotic process GO:0043066 181 0.029
negative regulation of biosynthetic process GO:0009890 168 0.029
regulation of response to external stimulus GO:0032101 106 0.028
positive regulation of multicellular organismal process GO:0051240 387 0.028
regulation of phosphorus metabolic process GO:0051174 349 0.028
response to biotic stimulus GO:0009607 226 0.028
positive regulation of cell motility GO:2000147 97 0.028
positive regulation of leukocyte migration GO:0002687 21 0.027
positive regulation of transport GO:0051050 245 0.027
learning or memory GO:0007611 90 0.027
positive regulation of phosphate metabolic process GO:0045937 262 0.027
multicellular organism reproduction GO:0032504 233 0.027
cation homeostasis GO:0055080 195 0.027
cell chemotaxis GO:0060326 31 0.027
nucleic acid templated transcription GO:0097659 379 0.026
regulation of blood vessel size GO:0050880 89 0.025
positive regulation of nucleic acid templated transcription GO:1903508 197 0.025
cellular response to endogenous stimulus GO:0071495 377 0.025
response to camp GO:0051591 91 0.025
urogenital system development GO:0001655 78 0.025
regulation of neural precursor cell proliferation GO:2000177 16 0.025
metal ion homeostasis GO:0055065 186 0.025
positive regulation of neurogenesis GO:0050769 165 0.025
cellular component biogenesis GO:0044085 368 0.025
organic acid metabolic process GO:0006082 292 0.024
central nervous system development GO:0007417 311 0.024
positive regulation of response to external stimulus GO:0032103 51 0.024
lymphocyte migration GO:0072676 3 0.024
regulation of neuron differentiation GO:0045664 208 0.024
oxoacid metabolic process GO:0043436 290 0.024
angioblast cell migration GO:0035476 1 0.024
response to monosaccharide GO:0034284 159 0.024
mast cell chemotaxis GO:0002551 4 0.024
sex differentiation GO:0007548 113 0.023
blood circulation GO:0008015 183 0.023
regulation of tube size GO:0035150 89 0.023
regulation of metal ion transport GO:0010959 118 0.023
amine metabolic process GO:0009308 38 0.023
heart process GO:0003015 57 0.023
negative regulation of programmed cell death GO:0043069 183 0.022
cytosolic calcium ion homeostasis GO:0051480 140 0.022
regeneration GO:0031099 163 0.022
response to molecule of bacterial origin GO:0002237 194 0.022
second messenger mediated signaling GO:0019932 51 0.022
regulation of transcription dna templated GO:0006355 374 0.022
cellular amine metabolic process GO:0044106 38 0.022
positive regulation of cell development GO:0010720 176 0.022
negative regulation of multicellular organismal process GO:0051241 203 0.022
muscle system process GO:0003012 115 0.022
multicellular organism growth GO:0035264 1 0.021
growth GO:0040007 165 0.021
head development GO:0060322 247 0.021
regulation of peptide secretion GO:0002791 82 0.021
regulation of inflammatory response GO:0050727 48 0.021
regulation of leukocyte migration GO:0002685 24 0.021
circulatory system process GO:0003013 183 0.021
response to purine containing compound GO:0014074 126 0.021
negative regulation of cell proliferation GO:0008285 119 0.021
peptide secretion GO:0002790 86 0.021
cellular amino acid metabolic process GO:0006520 107 0.021
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.020
response to oxygen levels GO:0070482 265 0.020
nitrogen compound transport GO:0071705 229 0.020
negative regulation of transport GO:0051051 136 0.020
response to inorganic substance GO:0010035 377 0.020
response to ketone GO:1901654 182 0.020
regulation of cell proliferation GO:0042127 359 0.020
cellular ketone metabolic process GO:0042180 51 0.020
muscle contraction GO:0006936 88 0.020
divalent inorganic cation transport GO:0072511 134 0.020
cellular response to lipid GO:0071396 201 0.020
positive regulation of developmental process GO:0051094 283 0.020
positive regulation of cell communication GO:0010647 271 0.020
negative regulation of hormone secretion GO:0046888 46 0.020
calcium ion import GO:0070509 22 0.020
histamine secretion GO:0001821 8 0.019
developmental process involved in reproduction GO:0003006 159 0.019
muscle cell proliferation GO:0033002 84 0.019
regulation of signal transduction GO:0009966 318 0.019
reproductive process GO:0022414 372 0.019
chronic inflammatory response to non antigenic stimulus GO:0002545 1 0.019
reproduction GO:0000003 245 0.019
positive regulation of cellular biosynthetic process GO:0031328 295 0.019
cell projection organization GO:0030030 302 0.019
erk1 and erk2 cascade GO:0070371 48 0.019
regulation of amine transport GO:0051952 54 0.019
negative regulation of cellular metabolic process GO:0031324 281 0.019
development of primary female sexual characteristics GO:0046545 56 0.019
negative regulation of secretion GO:0051048 82 0.019
t cell chemotaxis GO:0010818 2 0.018
response to metal ion GO:0010038 253 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
tissue morphogenesis GO:0048729 22 0.018
cellular response to glucose stimulus GO:0071333 65 0.018
sensory perception GO:0007600 101 0.018
peristalsis GO:0030432 2 0.018
amide transport GO:0042886 105 0.018
response to hypoxia GO:0001666 231 0.018
organelle organization GO:0006996 266 0.018
glandular epithelial cell differentiation GO:0002067 4 0.018
carboxylic acid metabolic process GO:0019752 289 0.018
positive regulation of biosynthetic process GO:0009891 319 0.017
t cell tolerance induction GO:0002517 3 0.017
response to glucose GO:0009749 136 0.017
bile acid and bile salt transport GO:0015721 12 0.017
cellular response to cytokine stimulus GO:0071345 127 0.017
protein homooligomerization GO:0051260 91 0.017
epithelium development GO:0060429 96 0.017
neuron projection development GO:0031175 273 0.017
carbohydrate homeostasis GO:0033500 75 0.017
organic hydroxy compound metabolic process GO:1901615 115 0.017
regulation of system process GO:0044057 208 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
regulation of defense response GO:0031347 68 0.016
regulation of insulin secretion GO:0050796 65 0.016
response to hexose GO:0009746 144 0.016
chronic inflammatory response GO:0002544 16 0.016
axon development GO:0061564 96 0.016
peptide hormone secretion GO:0030072 84 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
inflammatory response GO:0006954 150 0.016
response to decreased oxygen levels GO:0036293 237 0.016
metanephric epithelium development GO:0072207 4 0.016
gastrulation GO:0007369 2 0.016
ovulation cycle process GO:0022602 50 0.015
response to nutrient levels GO:0031667 370 0.015
response to ethanol GO:0045471 162 0.015
sensory perception of light stimulus GO:0050953 3 0.015
response to alkaloid GO:0043279 132 0.015
positive regulation of lymphocyte activation GO:0051251 25 0.015
negative regulation of developmental process GO:0051093 125 0.015
positive regulation of gene expression GO:0010628 244 0.015
myeloid leukocyte migration GO:0097529 20 0.015
sensory perception of pain GO:0019233 73 0.015
protein phosphorylation GO:0006468 345 0.015
response to cytokine GO:0034097 215 0.015
positive regulation of cell migration GO:0030335 96 0.015
metanephric tubule development GO:0072170 4 0.015
eye development GO:0001654 50 0.015
positive regulation of phosphorylation GO:0042327 177 0.015
positive regulation of angiogenesis GO:0045766 28 0.015
neutrophil chemotaxis GO:0030593 11 0.015
sensory organ development GO:0007423 74 0.015
reproductive structure development GO:0048608 128 0.015
regulation of cellular protein metabolic process GO:0032268 267 0.014
regulation of cellular amine metabolic process GO:0033238 8 0.014
cellular response to hexose stimulus GO:0071331 65 0.014
peptide transport GO:0015833 97 0.014
positive regulation of hormone secretion GO:0046887 65 0.014
regulation of organ formation GO:0003156 2 0.014
t cell migration GO:0072678 2 0.014
regulation of neutrophil apoptotic process GO:0033029 4 0.014
response to acid chemical GO:0001101 222 0.014
positive regulation of transcription dna templated GO:0045893 197 0.014
cell fate determination GO:0001709 2 0.014
protein complex assembly GO:0006461 263 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
negative regulation of metabolic process GO:0009892 331 0.014
actin cytoskeleton organization GO:0030036 73 0.014
positive regulation of locomotion GO:0040017 102 0.014
response to corticosteroid GO:0031960 235 0.014
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
positive regulation of cellular amine metabolic process GO:0033240 3 0.013
neuropeptide signaling pathway GO:0007218 29 0.013
cellular response to stress GO:0033554 269 0.013
regulation of neuron projection development GO:0010975 161 0.013
monocarboxylic acid metabolic process GO:0032787 152 0.013
regulation of cell projection organization GO:0031344 175 0.013
developmental induction GO:0031128 2 0.013
cation transport GO:0006812 382 0.013
cytokine production GO:0001816 61 0.013
regulation of organic acid transport GO:0032890 35 0.013
regulation of saliva secretion GO:0046877 3 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
regulation of angiogenesis GO:0045765 39 0.013
response to organophosphorus GO:0046683 102 0.013
regulation of synaptic transmission GO:0050804 141 0.013
cellular response to hormone stimulus GO:0032870 247 0.013
sexual reproduction GO:0019953 148 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.013
multi multicellular organism process GO:0044706 138 0.013
insulin secretion GO:0030073 69 0.013
forebrain development GO:0030900 98 0.013
neuromuscular process GO:0050905 2 0.013
cellular response to monosaccharide stimulus GO:0071326 67 0.013
muscle structure development GO:0061061 87 0.012
regulation of homeostatic process GO:0032844 101 0.012
dna metabolic process GO:0006259 96 0.012
positive regulation of secretion by cell GO:1903532 128 0.012
neural precursor cell proliferation GO:0061351 23 0.012
response to external biotic stimulus GO:0043207 221 0.012
positive regulation of brown fat cell proliferation GO:0070349 1 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.012
multi organism reproductive process GO:0044703 262 0.012
positive regulation of rna biosynthetic process GO:1902680 197 0.012
adenohypophysis development GO:0021984 2 0.012
metal ion transport GO:0030001 289 0.012
tolerance induction dependent upon immune response GO:0002461 2 0.012
positive regulation of peptide hormone secretion GO:0090277 50 0.012
glucose homeostasis GO:0042593 75 0.012
regulation of immune system process GO:0002682 123 0.012
epithelial cell proliferation GO:0050673 54 0.012
macrophage chemotaxis GO:0048246 2 0.012
ribonucleotide catabolic process GO:0009261 136 0.012
gamete generation GO:0007276 124 0.012
regulation of phosphorylation GO:0042325 248 0.012
positive regulation of mapk cascade GO:0043410 92 0.012
cellular macromolecular complex assembly GO:0034622 58 0.012
intracellular transport GO:0046907 185 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
response to extracellular stimulus GO:0009991 380 0.011
regulation of vascular permeability GO:0043114 10 0.011
regulation of body fluid levels GO:0050878 90 0.011
macromolecule localization GO:0033036 252 0.011
blood vessel development GO:0001568 69 0.011
positive regulation of neural precursor cell proliferation GO:2000179 10 0.011
cellular glucose homeostasis GO:0001678 66 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
organic acid transport GO:0015849 116 0.011
ribose phosphate metabolic process GO:0019693 235 0.011
positive regulation of granulocyte chemotaxis GO:0071624 6 0.011
axonogenesis GO:0007409 71 0.011
response to reactive oxygen species GO:0000302 120 0.011
protein oligomerization GO:0051259 191 0.011
actin filament based process GO:0030029 86 0.011
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.011
regulation of cellular extravasation GO:0002691 2 0.011
visual perception GO:0007601 3 0.011
positive regulation of cell death GO:0010942 184 0.011
female sex differentiation GO:0046660 59 0.011
neutrophil migration GO:1990266 12 0.011
ossification GO:0001503 70 0.011
positive regulation of fat cell proliferation GO:0070346 1 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
purine ribonucleotide metabolic process GO:0009150 227 0.010
neutrophil homeostasis GO:0001780 4 0.010
sterol catabolic process GO:0016127 1 0.010
gonad development GO:0008406 104 0.010
urinary bladder smooth muscle contraction GO:0014832 4 0.010
multicellular organismal reproductive process GO:0048609 233 0.010
regulation of rna metabolic process GO:0051252 391 0.010
fat cell proliferation GO:0070341 2 0.010
regulation of cytokine production GO:0001817 56 0.010
positive regulation of peptide secretion GO:0002793 52 0.010
response to activity GO:0014823 73 0.010
small gtpase mediated signal transduction GO:0007264 36 0.010
organic cyclic compound catabolic process GO:1901361 175 0.010
positive regulation of molecular function GO:0044093 230 0.010
cellular protein complex assembly GO:0043623 44 0.010

Pde6h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.273
eye disease DOID:5614 0 0.273
disease of anatomical entity DOID:7 0 0.273
sensory system disease DOID:0050155 0 0.273
retinal disease DOID:5679 0 0.273
eye and adnexa disease DOID:1492 0 0.273
cone rod dystrophy DOID:0050572 0 0.107
retinal degeneration DOID:8466 0 0.107
night blindness DOID:8499 0 0.076
retinitis pigmentosa DOID:10584 0 0.049
musculoskeletal system disease DOID:17 0 0.023
endocrine system disease DOID:28 0 0.012