Rattus norvegicus

33 known processes

Pdha1

pyruvate dehydrogenase (lipoamide) alpha 1

(Aliases: MGC114215,MGC94854)

Pdha1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
acyl coa biosynthetic process GO:0071616 7 0.760
cofactor biosynthetic process GO:0051188 28 0.711
acyl coa metabolic process GO:0006637 28 0.702
carboxylic acid metabolic process GO:0019752 289 0.656
sulfur compound biosynthetic process GO:0044272 19 0.631
oxoacid metabolic process GO:0043436 290 0.595
dicarboxylic acid metabolic process GO:0043648 42 0.529
response to inorganic substance GO:0010035 377 0.403
coenzyme metabolic process GO:0006732 86 0.296
single organism biosynthetic process GO:0044711 342 0.290
regulation of phosphorus metabolic process GO:0051174 349 0.238
organic acid metabolic process GO:0006082 292 0.229
nitrogen compound transport GO:0071705 229 0.206
cofactor metabolic process GO:0051186 95 0.172
homeostatic process GO:0042592 331 0.162
chemical homeostasis GO:0048878 292 0.146
ribonucleoside metabolic process GO:0009119 174 0.123
cellular homeostasis GO:0019725 252 0.106
cation transport GO:0006812 382 0.104
thioester metabolic process GO:0035383 28 0.099
glycosyl compound metabolic process GO:1901657 182 0.098
purine nucleoside metabolic process GO:0042278 169 0.095
programmed cell death GO:0012501 392 0.091
nucleoside metabolic process GO:0009116 179 0.083
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.082
oxidative phosphorylation GO:0006119 4 0.082
energy derivation by oxidation of organic compounds GO:0015980 46 0.082
cellular response to oxygen containing compound GO:1901701 386 0.081
ribonucleoside triphosphate metabolic process GO:0009199 141 0.081
nucleotide metabolic process GO:0009117 279 0.080
negative regulation of molecular function GO:0044092 133 0.079
organophosphate metabolic process GO:0019637 370 0.079
secretion by cell GO:0032940 248 0.077
aging GO:0007568 241 0.076
cellular respiration GO:0045333 21 0.075
acetyl coa biosynthetic process from pyruvate GO:0006086 5 0.073
response to lipopolysaccharide GO:0032496 191 0.066
protein phosphorylation GO:0006468 345 0.064
sulfur compound metabolic process GO:0006790 70 0.063
apoptotic process GO:0006915 381 0.059
response to molecule of bacterial origin GO:0002237 194 0.058
purine ribonucleotide metabolic process GO:0009150 227 0.057
response to peptide GO:1901652 292 0.057
purine ribonucleoside metabolic process GO:0046128 168 0.056
vesicle mediated transport GO:0016192 181 0.056
purine nucleotide metabolic process GO:0006163 229 0.055
cellular chemical homeostasis GO:0055082 247 0.055
cell morphogenesis GO:0000902 142 0.055
cellular response to hormone stimulus GO:0032870 247 0.053
ion homeostasis GO:0050801 212 0.053
response to insulin GO:0032868 133 0.052
regulation of phosphate metabolic process GO:0019220 349 0.052
oxidation reduction process GO:0055114 304 0.052
cellular metal ion homeostasis GO:0006875 172 0.051
nucleobase containing small molecule metabolic process GO:0055086 316 0.050
transmembrane transport GO:0055085 412 0.049
regulation of protein metabolic process GO:0051246 289 0.049
protein dephosphorylation GO:0006470 38 0.048
pyruvate metabolic process GO:0006090 27 0.047
generation of precursor metabolites and energy GO:0006091 62 0.047
response to oxidative stress GO:0006979 186 0.047
rna biosynthetic process GO:0032774 380 0.046
regulation of signal transduction GO:0009966 318 0.046
circulatory system development GO:0072359 134 0.046
2 oxoglutarate metabolic process GO:0006103 6 0.046
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.045
purine containing compound metabolic process GO:0072521 253 0.045
mitotic spindle organization GO:0007052 2 0.045
p38mapk cascade GO:0038066 1 0.045
growth GO:0040007 165 0.043
nucleoside phosphate metabolic process GO:0006753 283 0.043
ribonucleotide metabolic process GO:0009259 231 0.041
positive regulation of secretion by cell GO:1903532 128 0.041
purine nucleoside monophosphate metabolic process GO:0009126 84 0.041
response to interleukin 1 GO:0070555 55 0.041
positive regulation of cell proliferation GO:0008284 249 0.040
protein complex subunit organization GO:0071822 302 0.040
metal ion homeostasis GO:0055065 186 0.040
acetyl coa biosynthetic process GO:0006085 6 0.040
cation homeostasis GO:0055080 195 0.040
regulation of secretion GO:0051046 224 0.039
cellular divalent inorganic cation homeostasis GO:0072503 162 0.038
cellular response to endogenous stimulus GO:0071495 377 0.038
regulation of secretion by cell GO:1903530 208 0.038
metal ion transport GO:0030001 289 0.038
multi organism reproductive process GO:0044703 262 0.038
atp synthesis coupled electron transport GO:0042773 2 0.037
regulation of cellular protein metabolic process GO:0032268 267 0.037
nucleoside triphosphate metabolic process GO:0009141 144 0.037
negative regulation of phosphate metabolic process GO:0045936 80 0.037
response to light stimulus GO:0009416 52 0.037
spindle organization GO:0007051 2 0.036
regulation of catalytic activity GO:0050790 304 0.036
ion transmembrane transport GO:0034220 365 0.035
cellular ion homeostasis GO:0006873 184 0.035
ribonucleoside monophosphate metabolic process GO:0009161 88 0.035
cellular response to stress GO:0033554 269 0.034
regulation of rna metabolic process GO:0051252 391 0.034
atp metabolic process GO:0046034 72 0.034
regulation of apoptotic process GO:0042981 335 0.033
positive regulation of response to stimulus GO:0048584 285 0.033
reproductive process GO:0022414 372 0.032
regeneration GO:0031099 163 0.032
adult locomotory behavior GO:0008344 4 0.032
response to peptide hormone GO:0043434 278 0.032
thioester biosynthetic process GO:0035384 7 0.031
cellular calcium ion homeostasis GO:0006874 160 0.031
cellular cation homeostasis GO:0030003 180 0.031
regulation of protein phosphorylation GO:0001932 183 0.030
cell projection morphogenesis GO:0048858 123 0.030
positive regulation of biosynthetic process GO:0009891 319 0.029
neuron apoptotic process GO:0051402 88 0.029
regulation of ion transport GO:0043269 245 0.029
response to radiation GO:0009314 137 0.029
secretion GO:0046903 307 0.028
regulation of intracellular signal transduction GO:1902531 218 0.028
positive regulation of signaling GO:0023056 270 0.028
regulation of programmed cell death GO:0043067 341 0.028
regulation of cell proliferation GO:0042127 359 0.028
cellular amino acid metabolic process GO:0006520 107 0.028
ribose phosphate metabolic process GO:0019693 235 0.027
regulation of protein modification process GO:0031399 194 0.027
positive regulation of cell death GO:0010942 184 0.027
response to nutrient levels GO:0031667 370 0.027
negative regulation of phosphorus metabolic process GO:0010563 80 0.027
negative regulation of protein metabolic process GO:0051248 114 0.027
response to cytokine GO:0034097 215 0.027
positive regulation of multicellular organismal process GO:0051240 387 0.026
regulation of cellular component organization GO:0051128 368 0.026
negative regulation of gene expression GO:0010629 199 0.026
aspartate family amino acid biosynthetic process GO:0009067 4 0.026
positive regulation of secretion GO:0051047 140 0.026
cellular response to reactive oxygen species GO:0034614 55 0.026
nucleoside monophosphate metabolic process GO:0009123 93 0.025
cellular response to peptide hormone stimulus GO:0071375 120 0.025
regulation of kinase activity GO:0043549 117 0.025
regulation of membrane potential GO:0042391 110 0.024
cell cell signaling GO:0007267 335 0.024
regulation of phosphorylation GO:0042325 248 0.024
positive regulation of cellular protein metabolic process GO:0032270 167 0.024
carbohydrate derivative metabolic process GO:1901135 346 0.024
negative regulation of cell communication GO:0010648 158 0.024
regulation of nucleotide metabolic process GO:0006140 117 0.024
calcium ion homeostasis GO:0055074 162 0.023
negative regulation of macromolecule metabolic process GO:0010605 260 0.023
cellular response to oxidative stress GO:0034599 76 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
cardiovascular system development GO:0072358 134 0.023
positive regulation of programmed cell death GO:0043068 157 0.023
macromolecular complex assembly GO:0065003 273 0.023
neurotransmitter uptake GO:0001504 3 0.023
regulation of transferase activity GO:0051338 123 0.023
negative regulation of catalytic activity GO:0043086 103 0.023
response to monosaccharide GO:0034284 159 0.022
divalent inorganic cation homeostasis GO:0072507 165 0.022
intracellular signal transduction GO:0035556 314 0.022
negative regulation of metabolic process GO:0009892 331 0.022
regulation of nucleic acid templated transcription GO:1903506 380 0.022
regulation of molecular function GO:0065009 398 0.022
regulation of cellular amino acid metabolic process GO:0006521 2 0.022
regulation of p38mapk cascade GO:1900744 1 0.022
aerobic respiration GO:0009060 13 0.022
centrosome organization GO:0051297 1 0.021
negative regulation of cellular component organization GO:0051129 83 0.021
regulation of peptide transport GO:0090087 87 0.021
fatty acid metabolic process GO:0006631 99 0.021
positive regulation of cell communication GO:0010647 271 0.021
positive regulation of intracellular signal transduction GO:1902533 138 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
negative regulation of cellular biosynthetic process GO:0031327 161 0.021
microtubule organizing center organization GO:0031023 1 0.021
neuron death GO:0070997 127 0.020
response to bacterium GO:0009617 200 0.020
double strand break repair GO:0006302 1 0.020
positive regulation of dna recombination GO:0045911 1 0.020
regulation of purine nucleotide metabolic process GO:1900542 115 0.020
female pregnancy GO:0007565 122 0.020
alpha amino acid metabolic process GO:1901605 71 0.020
amide transport GO:0042886 105 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
anatomical structure morphogenesis GO:0009653 298 0.019
heart development GO:0007507 72 0.019
response to hydrogen peroxide GO:0042542 89 0.019
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.019
acetyl coa metabolic process GO:0006084 17 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
cellular response to peptide GO:1901653 133 0.018
response to extracellular stimulus GO:0009991 380 0.018
response to transition metal nanoparticle GO:1990267 122 0.018
positive regulation of hydrolase activity GO:0051345 86 0.018
negative regulation of neurogenesis GO:0050768 78 0.018
negative regulation of endopeptidase activity GO:0010951 36 0.018
response to carbohydrate GO:0009743 183 0.018
protein autophosphorylation GO:0046777 66 0.017
negative regulation of transport GO:0051051 136 0.017
regulation of hydrolase activity GO:0051336 143 0.017
cellular response to organonitrogen compound GO:0071417 197 0.017
regulation of cellular localization GO:0060341 263 0.017
reproduction GO:0000003 245 0.017
negative regulation of cell death GO:0060548 229 0.017
single organism intracellular transport GO:1902582 166 0.016
organophosphate catabolic process GO:0046434 148 0.016
glucose homeostasis GO:0042593 75 0.016
rna metabolic process GO:0016070 406 0.016
cell redox homeostasis GO:0045454 1 0.016
inflammatory response GO:0006954 150 0.016
carboxylic acid catabolic process GO:0046395 49 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
calcium ion transport GO:0006816 131 0.016
cation transmembrane transport GO:0098655 263 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
single organism behavior GO:0044708 130 0.016
cellular amide metabolic process GO:0043603 44 0.016
divalent metal ion transport GO:0070838 132 0.016
tissue development GO:0009888 252 0.016
regulation of transcription dna templated GO:0006355 374 0.015
response to decreased oxygen levels GO:0036293 237 0.015
response to external biotic stimulus GO:0043207 221 0.015
maternal process involved in female pregnancy GO:0060135 38 0.015
cellular protein localization GO:0034613 122 0.015
cellular response to insulin stimulus GO:0032869 81 0.015
nucleic acid transport GO:0050657 3 0.015
protein oligomerization GO:0051259 191 0.015
wnt signaling pathway GO:0016055 17 0.015
response to nutrient GO:0007584 248 0.015
dephosphorylation GO:0016311 98 0.015
cellular component biogenesis GO:0044085 368 0.015
peptide transport GO:0015833 97 0.015
macromolecular complex subunit organization GO:0043933 339 0.015
posttranscriptional regulation of gene expression GO:0010608 37 0.015
positive regulation of molecular function GO:0044093 230 0.015
purine nucleoside triphosphate metabolic process GO:0009144 141 0.015
monocarboxylic acid metabolic process GO:0032787 152 0.014
positive regulation of developmental process GO:0051094 283 0.014
intracellular transport GO:0046907 185 0.014
neurological system process GO:0050877 219 0.014
cellular response to nitrogen compound GO:1901699 210 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
regulation of rna biosynthetic process GO:2001141 381 0.014
response to activity GO:0014823 73 0.014
response to reactive oxygen species GO:0000302 120 0.014
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.014
central nervous system development GO:0007417 311 0.014
protein complex assembly GO:0006461 263 0.014
negative regulation of phosphorylation GO:0042326 57 0.014
single organism organelle organization GO:1902589 180 0.014
anion transport GO:0006820 178 0.014
organic anion transport GO:0015711 132 0.014
single organism reproductive process GO:0044702 297 0.014
signal release GO:0023061 145 0.013
cell part morphogenesis GO:0032990 123 0.013
nucleic acid templated transcription GO:0097659 379 0.013
amine metabolic process GO:0009308 38 0.013
negative regulation of cell differentiation GO:0045596 99 0.013
multicellular organism reproduction GO:0032504 233 0.013
organ regeneration GO:0031100 101 0.013
cellular amine metabolic process GO:0044106 38 0.013
response to other organism GO:0051707 220 0.013
positive regulation of ion transport GO:0043270 94 0.013
cellular ketone metabolic process GO:0042180 51 0.013
response to hypoxia GO:0001666 231 0.013
muscle system process GO:0003012 115 0.013
anion transmembrane transport GO:0098656 77 0.013
ras protein signal transduction GO:0007265 29 0.012
nucleocytoplasmic transport GO:0006913 48 0.012
positive regulation of immune system process GO:0002684 90 0.012
response to glucocorticoid GO:0051384 223 0.012
protein complex biogenesis GO:0070271 263 0.012
cell projection organization GO:0030030 302 0.012
action potential GO:0001508 54 0.012
adenine nucleotide transport GO:0051503 2 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.012
regulation of anatomical structure size GO:0090066 135 0.012
regulation of neurogenesis GO:0050767 247 0.012
negative regulation of cell development GO:0010721 82 0.012
sexual reproduction GO:0019953 148 0.012
regulation of atp biosynthetic process GO:2001169 2 0.012
regulation of protein kinase activity GO:0045859 105 0.012
cellular response to alcohol GO:0097306 87 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
organic hydroxy compound transport GO:0015850 77 0.011
response to corticosteroid GO:0031960 235 0.011
synaptic transmission GO:0007268 235 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
anatomical structure homeostasis GO:0060249 29 0.011
response to biotic stimulus GO:0009607 226 0.011
behavior GO:0007610 205 0.011
autophagic cell death GO:0048102 4 0.011
response to growth factor GO:0070848 189 0.011
cell adhesion GO:0007155 110 0.011
response to toxic substance GO:0009636 133 0.011
programmed necrotic cell death GO:0097300 2 0.011
transcription from rna polymerase ii promoter GO:0006366 252 0.011
negative regulation of apoptotic process GO:0043066 181 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
regulation of neuron projection development GO:0010975 161 0.011
immune system process GO:0002376 204 0.011
regulation of blood vessel endothelial cell migration GO:0043535 4 0.011
rhythmic process GO:0048511 156 0.011
necroptotic process GO:0070266 2 0.011
macromolecule localization GO:0033036 252 0.011
positive regulation of cell development GO:0010720 176 0.010
cellular macromolecule localization GO:0070727 122 0.010
biological adhesion GO:0022610 110 0.010
response to hexose GO:0009746 144 0.010
negative regulation of programmed cell death GO:0043069 183 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.010
chromosome segregation GO:0007059 2 0.010
response to glucose GO:0009749 136 0.010

Pdha1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.291
amino acid metabolic disorder DOID:9252 0 0.291
inherited metabolic disorder DOID:655 0 0.291
organic acidemia DOID:0060159 0 0.291
disease of anatomical entity DOID:7 0 0.057
nervous system disease DOID:863 0 0.057
sensory system disease DOID:0050155 0 0.019
eye and adnexa disease DOID:1492 0 0.019
eye disease DOID:5614 0 0.019
retinal disease DOID:5679 0 0.013
maple syrup urine disease DOID:9269 0 0.011