Rattus norvegicus

0 known processes

Pdia3

protein disulfide isomerase family A, member 3

(Aliases: ERp57,Grp58,ER60)

Pdia3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of protein metabolic process GO:0051246 289 0.313
protein transport GO:0015031 132 0.291
cellular response to topologically incorrect protein GO:0035967 3 0.264
protein folding GO:0006457 12 0.184
Yeast Rat
transmembrane transport GO:0055085 412 0.175
response to toxic substance GO:0009636 133 0.159
regulation of cell migration GO:0030334 128 0.153
hindbrain morphogenesis GO:0021575 2 0.146
positive regulation of cellular component movement GO:0051272 102 0.135
regulation of hydrolase activity GO:0051336 143 0.131
central nervous system development GO:0007417 311 0.131
cell motility GO:0048870 202 0.128
programmed cell death GO:0012501 392 0.128
Mouse
endoplasmic reticulum unfolded protein response GO:0030968 2 0.127
organic acid metabolic process GO:0006082 292 0.120
regulation of cellular protein metabolic process GO:0032268 267 0.118
localization of cell GO:0051674 202 0.114
maintenance of protein location GO:0045185 7 0.112
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.110
cellular response to unfolded protein GO:0034620 2 0.108
intracellular transport GO:0046907 185 0.107
response to nutrient levels GO:0031667 370 0.103
chaperone mediated protein folding GO:0061077 6 0.102
Rat
regulation of locomotion GO:0040012 148 0.102
er associated ubiquitin dependent protein catabolic process GO:0030433 1 0.102
organic substance catabolic process GO:1901575 316 0.101
positive regulation of multicellular organismal process GO:0051240 387 0.097
blood vessel development GO:0001568 69 0.094
cellular macromolecule localization GO:0070727 122 0.092
apoptotic process GO:0006915 381 0.089
Mouse
synaptic vesicle endocytosis GO:0048488 4 0.087
head development GO:0060322 247 0.085
negative regulation of metabolic process GO:0009892 331 0.084
positive regulation of biosynthetic process GO:0009891 319 0.083
positive regulation of cell migration GO:0030335 96 0.083
regulation of molecular function GO:0065009 398 0.082
protein complex biogenesis GO:0070271 263 0.082
carboxylic acid metabolic process GO:0019752 289 0.081
striated muscle tissue development GO:0014706 58 0.080
cellular protein complex assembly GO:0043623 44 0.078
retinoic acid receptor signaling pathway GO:0048384 7 0.075
growth GO:0040007 165 0.075
positive regulation of cell motility GO:2000147 97 0.073
regulation of programmed cell death GO:0043067 341 0.073
Mouse
cerebellar purkinje cell layer development GO:0021680 2 0.072
cellular catabolic process GO:0044248 295 0.072
neurological system process GO:0050877 219 0.071
cellular protein localization GO:0034613 122 0.070
positive regulation of locomotion GO:0040017 102 0.070
positive regulation of protein metabolic process GO:0051247 178 0.070
anatomical structure morphogenesis GO:0009653 298 0.070
establishment of protein localization GO:0045184 141 0.069
catabolic process GO:0009056 351 0.068
cytoskeleton organization GO:0007010 111 0.068
response to hypoxia GO:0001666 231 0.068
negative regulation of cell death GO:0060548 229 0.066
neuron apoptotic process GO:0051402 88 0.066
organelle organization GO:0006996 266 0.064
regulation of neuron death GO:1901214 115 0.063
reproduction GO:0000003 245 0.062
response to oxygen levels GO:0070482 265 0.061
regulation of phagocytosis GO:0050764 13 0.061
multicellular organismal reproductive process GO:0048609 233 0.060
single organism biosynthetic process GO:0044711 342 0.059
negative regulation of gene expression GO:0010629 199 0.059
antigen processing and presentation GO:0019882 2 0.059
neuromuscular process GO:0050905 2 0.058
positive regulation of hydrolase activity GO:0051345 86 0.057
response to biotic stimulus GO:0009607 226 0.056
positive regulation of cell differentiation GO:0045597 217 0.054
cell migration GO:0016477 197 0.054
membrane repolarization GO:0086009 1 0.053
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.052
regulation of apoptotic process GO:0042981 335 0.052
Mouse
response to inorganic substance GO:0010035 377 0.051
macromolecule catabolic process GO:0009057 58 0.051
cellular response to oxygen containing compound GO:1901701 386 0.051
regulation of ion transport GO:0043269 245 0.051
response to estradiol GO:0032355 164 0.051
response to other organism GO:0051707 220 0.050
pigment biosynthetic process GO:0046148 4 0.050
cellular response to organonitrogen compound GO:0071417 197 0.049
positive regulation of developmental process GO:0051094 283 0.049
single organism cell adhesion GO:0098602 46 0.047
circulatory system development GO:0072359 134 0.047
protein targeting GO:0006605 61 0.047
response to ethanol GO:0045471 162 0.047
negative regulation of cell communication GO:0010648 158 0.047
protein localization to organelle GO:0033365 57 0.047
nucleoside phosphate metabolic process GO:0006753 283 0.046
gastrulation GO:0007369 2 0.046
positive regulation of cell development GO:0010720 176 0.046
startle response GO:0001964 2 0.045
cardiovascular system development GO:0072358 134 0.044
response to endoplasmic reticulum stress GO:0034976 10 0.044
circulatory system process GO:0003013 183 0.044
positive regulation of cellular biosynthetic process GO:0031328 295 0.042
regulation of phosphorus metabolic process GO:0051174 349 0.042
cation transport GO:0006812 382 0.042
protein catabolic process GO:0030163 30 0.041
angiogenesis GO:0001525 53 0.041
calcium ion homeostasis GO:0055074 162 0.041
microtubule organizing center organization GO:0031023 1 0.040
intracellular protein transport GO:0006886 79 0.040
chemical homeostasis GO:0048878 292 0.039
cellular amino acid metabolic process GO:0006520 107 0.039
positive regulation of gene expression GO:0010628 244 0.039
actin cytoskeleton organization GO:0030036 73 0.039
protein transmembrane transport GO:0071806 2 0.039
divalent metal ion transport GO:0070838 132 0.038
cellular response to extracellular stimulus GO:0031668 73 0.038
regulation of neuron apoptotic process GO:0043523 83 0.038
macromolecule localization GO:0033036 252 0.038
macromolecular complex subunit organization GO:0043933 339 0.038
positive regulation of molecular function GO:0044093 230 0.038
regulation of cell development GO:0060284 263 0.038
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.037
calcium ion transport GO:0006816 131 0.037
homeostatic process GO:0042592 331 0.037
ubiquitin dependent protein catabolic process GO:0006511 14 0.037
positive regulation of phosphorus metabolic process GO:0010562 262 0.037
response to organophosphorus GO:0046683 102 0.036
regulation of cellular component movement GO:0051270 150 0.035
neuron death GO:0070997 127 0.035
response to oxidative stress GO:0006979 186 0.034
regulation of neuron differentiation GO:0045664 208 0.034
regulation of cellular component organization GO:0051128 368 0.034
positive regulation of cellular component organization GO:0051130 200 0.034
proteolysis GO:0006508 175 0.034
muscle contraction GO:0006936 88 0.034
response to wounding GO:0009611 254 0.034
cytoplasmic transport GO:0016482 115 0.033
regulation of system process GO:0044057 208 0.033
purine nucleotide metabolic process GO:0006163 229 0.033
carbohydrate derivative metabolic process GO:1901135 346 0.033
organophosphate metabolic process GO:0019637 370 0.033
response to decreased oxygen levels GO:0036293 237 0.033
purine ribonucleotide catabolic process GO:0009154 136 0.033
regulation of neuron projection development GO:0010975 161 0.033
positive regulation of cellular protein metabolic process GO:0032270 167 0.033
regulation of homeostatic process GO:0032844 101 0.032
cellular component biogenesis GO:0044085 368 0.032
intracellular signal transduction GO:0035556 314 0.032
chemosensory behavior GO:0007635 2 0.032
organic cyclic compound catabolic process GO:1901361 175 0.031
protein complex subunit organization GO:0071822 302 0.031
cell projection organization GO:0030030 302 0.031
protein localization to nucleus GO:0034504 39 0.031
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.031
lipid metabolic process GO:0006629 283 0.030
response to metal ion GO:0010038 253 0.030
cellular lipid metabolic process GO:0044255 208 0.030
cellular component assembly GO:0022607 360 0.030
protein localization GO:0008104 191 0.030
positive regulation of cell projection organization GO:0031346 111 0.030
cellular response to external stimulus GO:0071496 118 0.030
positive regulation of neurogenesis GO:0050769 165 0.030
single organism organelle organization GO:1902589 180 0.030
cellular amine metabolic process GO:0044106 38 0.029
aging GO:0007568 241 0.029
modification dependent protein catabolic process GO:0019941 14 0.029
cellular response to atp GO:0071318 5 0.029
cellular divalent inorganic cation homeostasis GO:0072503 162 0.029
brain development GO:0007420 247 0.029
cellular response to nitrogen compound GO:1901699 210 0.029
urogenital system development GO:0001655 78 0.028
ion homeostasis GO:0050801 212 0.028
regulation of calcium ion transport GO:0051924 77 0.028
anion transport GO:0006820 178 0.028
organelle inheritance GO:0048308 2 0.028
regulation of cellular component biogenesis GO:0044087 86 0.027
negative regulation of nervous system development GO:0051961 79 0.027
regulation of cell differentiation GO:0045595 320 0.027
negative regulation of signal transduction GO:0009968 83 0.027
protein complex assembly GO:0006461 263 0.027
regulation of cellular catabolic process GO:0031329 101 0.027
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.027
actin filament based process GO:0030029 86 0.027
cellular response to organic cyclic compound GO:0071407 202 0.026
carbohydrate metabolic process GO:0005975 130 0.026
cellular calcium ion homeostasis GO:0006874 160 0.026
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.026
single organism carbohydrate metabolic process GO:0044723 118 0.026
dna metabolic process GO:0006259 96 0.026
regulation of dna metabolic process GO:0051052 60 0.026
neuron development GO:0048666 286 0.026
nucleobase containing compound catabolic process GO:0034655 152 0.026
multicellular organism growth GO:0035264 1 0.026
regulation of neurogenesis GO:0050767 247 0.025
regulation of catalytic activity GO:0050790 304 0.025
cation homeostasis GO:0055080 195 0.025
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.025
cell morphogenesis involved in differentiation GO:0000904 119 0.025
cytosolic calcium ion homeostasis GO:0051480 140 0.025
regulation of hormone levels GO:0010817 187 0.025
dephosphorylation GO:0016311 98 0.025
protein phosphorylation GO:0006468 345 0.024
metal ion transport GO:0030001 289 0.024
cellular response to biotic stimulus GO:0071216 59 0.024
response to extracellular stimulus GO:0009991 380 0.024
cellular chemical homeostasis GO:0055082 247 0.024
taxis GO:0042330 67 0.024
positive regulation of catalytic activity GO:0043085 184 0.024
vasoconstriction GO:0042310 54 0.024
synaptic transmission GO:0007268 235 0.024
negative regulation of biosynthetic process GO:0009890 168 0.024
positive regulation of dna metabolic process GO:0051054 39 0.024
regulation of protein phosphorylation GO:0001932 183 0.024
heart morphogenesis GO:0003007 3 0.024
cellular ion homeostasis GO:0006873 184 0.023
reproductive system development GO:0061458 128 0.023
response to testosterone GO:0033574 55 0.023
negative regulation of signaling GO:0023057 157 0.023
positive regulation of nervous system development GO:0051962 178 0.023
macromolecular complex assembly GO:0065003 273 0.023
cell type specific apoptotic process GO:0097285 134 0.023
regulation of cell motility GO:2000145 131 0.023
oxoacid metabolic process GO:0043436 290 0.023
regulation of phosphorylation GO:0042325 248 0.023
metal ion homeostasis GO:0055065 186 0.022
response to cytokine GO:0034097 215 0.022
cellular metal ion homeostasis GO:0006875 172 0.022
response to growth factor GO:0070848 189 0.022
single organism membrane organization GO:0044802 74 0.022
multicellular organismal homeostasis GO:0048871 49 0.022
maintenance of location GO:0051235 17 0.022
regulation of signal transduction GO:0009966 318 0.021
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.021
establishment of protein localization to organelle GO:0072594 44 0.021
negative regulation of neurogenesis GO:0050768 78 0.021
single organism reproductive process GO:0044702 297 0.021
blood circulation GO:0008015 183 0.021
regulation of blood pressure GO:0008217 83 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.021
divalent inorganic cation transport GO:0072511 134 0.021
cellular response to stress GO:0033554 269 0.021
negative regulation of cell differentiation GO:0045596 99 0.021
regulation of nervous system development GO:0051960 264 0.021
hair cell differentiation GO:0035315 2 0.021
heart process GO:0003015 57 0.020
response to external biotic stimulus GO:0043207 221 0.020
negative regulation of multicellular organismal process GO:0051241 203 0.020
immune system process GO:0002376 204 0.020
positive regulation of neuron projection development GO:0010976 99 0.020
response to atp GO:0033198 13 0.020
regulation of growth GO:0040008 105 0.020
multicellular organism reproduction GO:0032504 233 0.020
regulation of membrane potential GO:0042391 110 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
multicellular organismal signaling GO:0035637 44 0.020
organic hydroxy compound metabolic process GO:1901615 115 0.019
neuron projection development GO:0031175 273 0.019
negative regulation of cell development GO:0010721 82 0.019
cellular modified amino acid metabolic process GO:0006575 61 0.019
response to monosaccharide GO:0034284 159 0.019
purine ribonucleoside catabolic process GO:0046130 124 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
cellular macromolecular complex assembly GO:0034622 58 0.019
cellular response to nutrient levels GO:0031669 60 0.019
protein processing GO:0016485 68 0.019
regulation of ion homeostasis GO:2000021 63 0.019
divalent inorganic cation homeostasis GO:0072507 165 0.019
carbohydrate derivative biosynthetic process GO:1901137 124 0.019
positive regulation of signaling GO:0023056 270 0.019
Mouse
heterocycle catabolic process GO:0046700 167 0.019
nitrogen compound transport GO:0071705 229 0.019
single organism intracellular transport GO:1902582 166 0.019
regulation of rna metabolic process GO:0051252 391 0.018
regulation of cellular ketone metabolic process GO:0010565 27 0.018
cellular component movement GO:0006928 248 0.018
reactive oxygen species metabolic process GO:0072593 37 0.018
positive regulation of transferase activity GO:0051347 81 0.018
rna biosynthetic process GO:0032774 380 0.018
cellular ketone metabolic process GO:0042180 51 0.018
regulation of anatomical structure morphogenesis GO:0022603 141 0.018
positive regulation of cell death GO:0010942 184 0.018
Mouse
negative regulation of response to stimulus GO:0048585 155 0.018
ear development GO:0043583 21 0.018
positive regulation of transport GO:0051050 245 0.018
cell part morphogenesis GO:0032990 123 0.018
purine nucleoside triphosphate metabolic process GO:0009144 141 0.018
regulation of blood circulation GO:1903522 110 0.018
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.018
regulation of behavior GO:0050795 61 0.018
posttranscriptional regulation of gene expression GO:0010608 37 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
regulation of cell substrate adhesion GO:0010810 18 0.018
ion transmembrane transport GO:0034220 365 0.018
regulation of metal ion transport GO:0010959 118 0.018
multi multicellular organism process GO:0044706 138 0.017
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 2 0.017
cellular response to metal ion GO:0071248 55 0.017
response to nutrient GO:0007584 248 0.017
muscle system process GO:0003012 115 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.017
sensory organ development GO:0007423 74 0.016
regulation of cell proliferation GO:0042127 359 0.016
reproductive process GO:0022414 372 0.016
positive regulation of cellular component biogenesis GO:0044089 55 0.016
cellular homeostasis GO:0019725 252 0.016
regulation of cell projection organization GO:0031344 175 0.016
endocytosis GO:0006897 84 0.016
carbohydrate derivative catabolic process GO:1901136 147 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.016
transmission of nerve impulse GO:0019226 42 0.016
cell cycle GO:0007049 101 0.016
positive regulation of phosphate metabolic process GO:0045937 262 0.016
negative regulation of cellular metabolic process GO:0031324 281 0.016
positive regulation of neuron differentiation GO:0045666 126 0.016
regulation of blood vessel size GO:0050880 89 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
positive regulation of phagocytosis GO:0050766 9 0.015
regulation of phosphate metabolic process GO:0019220 349 0.015
autophagy GO:0006914 19 0.015
regulation of catabolic process GO:0009894 113 0.015
gland development GO:0048732 155 0.015
response to starvation GO:0042594 59 0.015
protein homooligomerization GO:0051260 91 0.015
regulation of organelle organization GO:0033043 80 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
response to bacterium GO:0009617 200 0.015
regulation of immune system process GO:0002682 123 0.015
cell cell signaling GO:0007267 335 0.015
nucleobase containing small molecule metabolic process GO:0055086 316 0.015
neuron differentiation GO:0030182 368 0.015
alpha amino acid metabolic process GO:1901605 71 0.014
positive regulation of growth GO:0045927 55 0.014
blood vessel morphogenesis GO:0048514 58 0.014
bone development GO:0060348 25 0.014
sex differentiation GO:0007548 113 0.014
muscle tissue development GO:0060537 58 0.014
organic anion transport GO:0015711 132 0.014
negative regulation of cellular biosynthetic process GO:0031327 161 0.014
mechanoreceptor differentiation GO:0042490 2 0.014
response to lipopolysaccharide GO:0032496 191 0.014
cellular response to growth factor stimulus GO:0071363 162 0.014
sexual reproduction GO:0019953 148 0.014
cellular component morphogenesis GO:0032989 155 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
enzyme linked receptor protein signaling pathway GO:0007167 116 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
anatomical structure homeostasis GO:0060249 29 0.013
axon development GO:0061564 96 0.013
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 10 0.013
single organism cellular localization GO:1902580 102 0.013
positive regulation of organelle organization GO:0010638 48 0.013
centrosome organization GO:0051297 1 0.013
heart contraction GO:0060047 57 0.013
reproductive structure development GO:0048608 128 0.013
neuronal action potential GO:0019228 35 0.013
cell adhesion GO:0007155 110 0.013
digestive tract development GO:0048565 39 0.013
nucleoside triphosphate catabolic process GO:0009143 123 0.013
aromatic compound catabolic process GO:0019439 168 0.013
organic acid transport GO:0015849 116 0.013
regeneration GO:0031099 163 0.013
positive regulation of phosphorylation GO:0042327 177 0.013
positive regulation of protein modification process GO:0031401 142 0.013
centrosome cycle GO:0007098 1 0.013
organonitrogen compound catabolic process GO:1901565 179 0.012
positive regulation of blood circulation GO:1903524 65 0.012
tissue development GO:0009888 252 0.012
cardiocyte differentiation GO:0035051 22 0.012
positive regulation of peptide secretion GO:0002793 52 0.012
olfactory behavior GO:0042048 2 0.012
regulation of protein modification process GO:0031399 194 0.012
nucleotide metabolic process GO:0009117 279 0.012
response to molecule of bacterial origin GO:0002237 194 0.012
heart development GO:0007507 72 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
inner ear receptor cell differentiation GO:0060113 2 0.012
developmental growth GO:0048589 100 0.012
response to camp GO:0051591 91 0.012
negative regulation of protein metabolic process GO:0051248 114 0.012
positive regulation of cell communication GO:0010647 271 0.012
Mouse
positive regulation of cytoplasmic transport GO:1903651 32 0.012
protein oligomerization GO:0051259 191 0.012
regulation of cellular component size GO:0032535 51 0.012
cell chemotaxis GO:0060326 31 0.012
vesicle mediated transport GO:0016192 181 0.011
purine containing compound metabolic process GO:0072521 253 0.011
regulation of response to external stimulus GO:0032101 106 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
regulation of muscle system process GO:0090257 79 0.011
regulation of multicellular organismal development GO:2000026 376 0.011
response to vitamin GO:0033273 131 0.011
regulation of tube size GO:0035150 89 0.011
epithelial cell differentiation GO:0030855 71 0.011
peptidyl amino acid modification GO:0018193 126 0.011
negative regulation of developmental process GO:0051093 125 0.011
regulation of dna replication GO:0006275 29 0.011
regulation of cellular localization GO:0060341 263 0.011
cell morphogenesis GO:0000902 142 0.011
amine metabolic process GO:0009308 38 0.011
regulation of transferase activity GO:0051338 123 0.011
regulation of secretion GO:0051046 224 0.011
positive regulation of catabolic process GO:0009896 78 0.011
response to ketone GO:1901654 182 0.011
er nucleus signaling pathway GO:0006984 3 0.011
regulation of kinase activity GO:0043549 117 0.011
cellular protein catabolic process GO:0044257 19 0.011
locomotion GO:0040011 237 0.011
rho protein signal transduction GO:0007266 11 0.011
response to purine containing compound GO:0014074 126 0.011
peptide transport GO:0015833 97 0.011
tube development GO:0035295 89 0.011
positive regulation of rna metabolic process GO:0051254 203 0.010
behavior GO:0007610 205 0.010
transcription dna templated GO:0006351 377 0.010
negative regulation of apoptotic process GO:0043066 181 0.010
cellular response to transforming growth factor beta stimulus GO:0071560 41 0.010
lipid biosynthetic process GO:0008610 128 0.010
development of primary sexual characteristics GO:0045137 107 0.010
hair follicle development GO:0001942 2 0.010
ras protein signal transduction GO:0007265 29 0.010
organophosphate catabolic process GO:0046434 148 0.010
cellular amide metabolic process GO:0043603 44 0.010
golgi vesicle transport GO:0048193 22 0.010
response to peptide GO:1901652 292 0.010

Pdia3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
musculoskeletal system disease DOID:17 0 0.021
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
central nervous system disease DOID:331 0 0.013
sensory system disease DOID:0050155 0 0.012