Rattus norvegicus

13 known processes

Pf4

platelet factor 4

(Aliases: RATPF4A,Pf4a,Cxcl4,PF-4)

Pf4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
programmed cell death GO:0012501 392 0.420
Human
response to bacterium GO:0009617 200 0.299
Rat
response to molecule of bacterial origin GO:0002237 194 0.298
Rat
organophosphate metabolic process GO:0019637 370 0.285
Human
defense response GO:0006952 194 0.202
Rat
response to lipopolysaccharide GO:0032496 191 0.196
Rat
anatomical structure morphogenesis GO:0009653 298 0.193
Human Rat
positive regulation of signaling GO:0023056 270 0.151
Human Rat
nucleic acid templated transcription GO:0097659 379 0.150
Human
response to nutrient levels GO:0031667 370 0.145
Rat
circulatory system development GO:0072359 134 0.144
Human Rat
positive regulation of cell proliferation GO:0008284 249 0.140
Rat
regulation of signal transduction GO:0009966 318 0.125
Human Rat
cellular response to stress GO:0033554 269 0.123
Rat
regulation of rna biosynthetic process GO:2001141 381 0.120
Human
calcium ion homeostasis GO:0055074 162 0.120
Rat
homeostatic process GO:0042592 331 0.119
Rat
positive regulation of response to stimulus GO:0048584 285 0.118
Human Rat
intracellular signal transduction GO:0035556 314 0.117
Human Rat
wound healing GO:0042060 122 0.113
Human Rat
positive regulation of cell differentiation GO:0045597 217 0.112
Human Rat
positive regulation of multicellular organismal process GO:0051240 387 0.101
Human Rat
chemical homeostasis GO:0048878 292 0.100
Rat
rna biosynthetic process GO:0032774 380 0.099
Human
cellular component biogenesis GO:0044085 368 0.098
cellular response to oxygen containing compound GO:1901701 386 0.095
Rat
response to ethanol GO:0045471 162 0.094
inorganic cation transmembrane transport GO:0098662 202 0.094
carbohydrate derivative metabolic process GO:1901135 346 0.093
Human
locomotion GO:0040011 237 0.091
Human Rat
positive regulation of cellular biosynthetic process GO:0031328 295 0.087
Human
rna metabolic process GO:0016070 406 0.086
Human
single organism biosynthetic process GO:0044711 342 0.085
regulation of multicellular organismal development GO:2000026 376 0.083
Human Rat
response to glucocorticoid GO:0051384 223 0.083
Rat
regulation of cell differentiation GO:0045595 320 0.081
Human Rat
regulation of rna metabolic process GO:0051252 391 0.080
Human
negative regulation of cellular biosynthetic process GO:0031327 161 0.079
cellular homeostasis GO:0019725 252 0.073
Rat
cell activation GO:0001775 97 0.072
Human
cell migration GO:0016477 197 0.072
Human Rat
positive regulation of signal transduction GO:0009967 175 0.069
Human Rat
tissue development GO:0009888 252 0.068
transcription dna templated GO:0006351 377 0.067
Human
response to wounding GO:0009611 254 0.067
Human Rat
g protein coupled receptor signaling pathway GO:0007186 242 0.066
ion transmembrane transport GO:0034220 365 0.064
carboxylic acid transport GO:0046942 115 0.063
organic acid transport GO:0015849 116 0.062
cellular metal ion homeostasis GO:0006875 172 0.062
Rat
positive regulation of transport GO:0051050 245 0.061
Rat
secretion GO:0046903 307 0.060
Rat
aging GO:0007568 241 0.059
metal ion transport GO:0030001 289 0.057
Rat
cell adhesion GO:0007155 110 0.053
cellular component assembly GO:0022607 360 0.053
positive regulation of intracellular signal transduction GO:1902533 138 0.052
Human Rat
response to inorganic substance GO:0010035 377 0.052
macromolecular complex assembly GO:0065003 273 0.051
regulation of cellular component organization GO:0051128 368 0.051
Rat
cell cell signaling GO:0007267 335 0.051
lipid transport GO:0006869 61 0.051
response to extracellular stimulus GO:0009991 380 0.051
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.051
Human
transcription from rna polymerase ii promoter GO:0006366 252 0.051
Human
vesicle mediated transport GO:0016192 181 0.050
anion transport GO:0006820 178 0.050
cation transport GO:0006812 382 0.049
Rat
positive regulation of gene expression GO:0010628 244 0.049
Human
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.048
Human
oxoacid metabolic process GO:0043436 290 0.048
regulation of ion transport GO:0043269 245 0.048
Rat
positive regulation of cellular protein metabolic process GO:0032270 167 0.047
cell motility GO:0048870 202 0.047
Human Rat
regulation of protein metabolic process GO:0051246 289 0.047
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.047
Human
regulation of programmed cell death GO:0043067 341 0.046
Human
carboxylic acid metabolic process GO:0019752 289 0.046
cellular catabolic process GO:0044248 295 0.044
response to oxidative stress GO:0006979 186 0.044
reproductive process GO:0022414 372 0.044
monocarboxylic acid transport GO:0015718 52 0.043
biological adhesion GO:0022610 110 0.043
cellular response to growth factor stimulus GO:0071363 162 0.042
immune system process GO:0002376 204 0.042
positive regulation of phosphorus metabolic process GO:0010562 262 0.042
Human
cellular chemical homeostasis GO:0055082 247 0.041
Rat
response to monosaccharide GO:0034284 159 0.041
regulation of intracellular signal transduction GO:1902531 218 0.041
Human Rat
blood coagulation GO:0007596 26 0.041
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.041
striated muscle tissue development GO:0014706 58 0.041
multicellular organism reproduction GO:0032504 233 0.041
chemotaxis GO:0006935 66 0.040
Human Rat
positive regulation of nervous system development GO:0051962 178 0.040
Rat
regulation of response to stress GO:0080134 126 0.040
negative regulation of programmed cell death GO:0043069 183 0.039
Human
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.038
Human
cation transmembrane transport GO:0098655 263 0.038
organelle organization GO:0006996 266 0.038
amine metabolic process GO:0009308 38 0.038
organic acid metabolic process GO:0006082 292 0.037
positive regulation of apoptotic process GO:0043065 154 0.037
muscle tissue development GO:0060537 58 0.036
inorganic ion transmembrane transport GO:0098660 229 0.036
protein complex assembly GO:0006461 263 0.036
regulation of cell proliferation GO:0042127 359 0.035
Human Rat
cellular ion homeostasis GO:0006873 184 0.035
Rat
protein phosphorylation GO:0006468 345 0.035
negative regulation of apoptotic process GO:0043066 181 0.034
Human
response to hexose GO:0009746 144 0.033
cellular divalent inorganic cation homeostasis GO:0072503 162 0.033
Rat
organic anion transport GO:0015711 132 0.033
protein complex subunit organization GO:0071822 302 0.033
positive regulation of developmental process GO:0051094 283 0.033
Human Rat
negative regulation of macromolecule metabolic process GO:0010605 260 0.033
Human
membrane organization GO:0061024 94 0.033
negative regulation of cellular metabolic process GO:0031324 281 0.032
nucleobase containing small molecule metabolic process GO:0055086 316 0.032
Human
macromolecular complex subunit organization GO:0043933 339 0.031
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
Human
negative regulation of cell death GO:0060548 229 0.031
Human
positive regulation of cellular component organization GO:0051130 200 0.031
Rat
regulation of response to external stimulus GO:0032101 106 0.031
Rat
carbohydrate derivative biosynthetic process GO:1901137 124 0.031
central nervous system development GO:0007417 311 0.030
Rat
regulation of calcium ion transmembrane transport GO:1903169 18 0.030
positive regulation of catalytic activity GO:0043085 184 0.030
cellular calcium ion homeostasis GO:0006874 160 0.030
Rat
response to growth factor GO:0070848 189 0.030
regulation of phosphate metabolic process GO:0019220 349 0.029
Human
regulation of response to wounding GO:1903034 69 0.029
response to metal ion GO:0010038 253 0.029
regulation of apoptotic process GO:0042981 335 0.029
Human
cell chemotaxis GO:0060326 31 0.029
Human Rat
organ morphogenesis GO:0009887 75 0.029
response to biotic stimulus GO:0009607 226 0.029
Rat
response to decreased oxygen levels GO:0036293 237 0.029
monocarboxylic acid biosynthetic process GO:0072330 48 0.028
nucleotide metabolic process GO:0009117 279 0.028
Human
lipid metabolic process GO:0006629 283 0.028
positive regulation of biosynthetic process GO:0009891 319 0.028
Human
long chain fatty acid transport GO:0015909 14 0.028
negative regulation of biosynthetic process GO:0009890 168 0.028
Human
response to hypoxia GO:0001666 231 0.028
apoptotic process GO:0006915 381 0.027
Human
positive regulation of molecular function GO:0044093 230 0.027
organic substance catabolic process GO:1901575 316 0.027
cell projection organization GO:0030030 302 0.027
Rat
organophosphate biosynthetic process GO:0090407 143 0.027
divalent inorganic cation homeostasis GO:0072507 165 0.027
Rat
response to other organism GO:0051707 220 0.027
Rat
regulation of catalytic activity GO:0050790 304 0.027
multicellular organismal reproductive process GO:0048609 233 0.026
mapk cascade GO:0000165 140 0.026
regulation of cellular ketone metabolic process GO:0010565 27 0.026
synaptic transmission GO:0007268 235 0.026
regulation of molecular function GO:0065009 398 0.026
protein oligomerization GO:0051259 191 0.025
anterior posterior pattern specification GO:0009952 1 0.025
regulation of locomotion GO:0040012 148 0.025
Rat
single organism cell adhesion GO:0098602 46 0.025
fatty acid biosynthetic process GO:0006633 33 0.025
cellular amine metabolic process GO:0044106 38 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.025
Human
cellular amino acid metabolic process GO:0006520 107 0.024
regulation of phosphorus metabolic process GO:0051174 349 0.024
Human
regulation of body fluid levels GO:0050878 90 0.024
Human
regulation of cell development GO:0060284 263 0.024
Rat
positive regulation of protein metabolic process GO:0051247 178 0.024
response to peptide GO:1901652 292 0.024
regulation of phosphorylation GO:0042325 248 0.024
positive regulation of hydrolase activity GO:0051345 86 0.024
response to acid chemical GO:0001101 222 0.024
cellular lipid metabolic process GO:0044255 208 0.024
granulocyte chemotaxis GO:0071621 15 0.023
Rat
single organism organelle organization GO:1902589 180 0.023
cellular component morphogenesis GO:0032989 155 0.023
protein complex biogenesis GO:0070271 263 0.022
positive regulation of cellular amine metabolic process GO:0033240 3 0.022
positive regulation of neurogenesis GO:0050769 165 0.022
Rat
organic hydroxy compound metabolic process GO:1901615 115 0.022
carbohydrate derivative catabolic process GO:1901136 147 0.022
carboxylic acid biosynthetic process GO:0046394 83 0.022
leukotriene biosynthetic process GO:0019370 3 0.022
response to carbohydrate GO:0009743 183 0.022
regulation of calcium ion transport GO:0051924 77 0.022
transmembrane transport GO:0055085 412 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.021
protein processing GO:0016485 68 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
response to vitamin GO:0033273 131 0.021
Rat
regulation of cellular amino acid metabolic process GO:0006521 2 0.021
regulation of anatomical structure morphogenesis GO:0022603 141 0.021
Human Rat
fatty acid transport GO:0015908 25 0.020
regulation of synaptic transmission GO:0050804 141 0.020
cellular ketone metabolic process GO:0042180 51 0.020
response to external biotic stimulus GO:0043207 221 0.020
Rat
inflammatory response GO:0006954 150 0.020
Rat
organonitrogen compound biosynthetic process GO:1901566 167 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
Human
glycosyl compound metabolic process GO:1901657 182 0.020
response to amino acid GO:0043200 75 0.020
multi organism reproductive process GO:0044703 262 0.020
nucleobase containing compound catabolic process GO:0034655 152 0.020
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.020
ribose phosphate metabolic process GO:0019693 235 0.020
Human
negative regulation of rna biosynthetic process GO:1902679 118 0.019
reproduction GO:0000003 245 0.019
multi multicellular organism process GO:0044706 138 0.019
divalent metal ion transport GO:0070838 132 0.019
negative regulation of rna metabolic process GO:0051253 123 0.019
reactive oxygen species metabolic process GO:0072593 37 0.019
regulation of nervous system development GO:0051960 264 0.019
Rat
neuron death GO:0070997 127 0.019
Rat
secretion by cell GO:0032940 248 0.019
Rat
response to camp GO:0051591 91 0.019
positive regulation of synaptic transmission GO:0050806 62 0.019
neurological system process GO:0050877 219 0.019
regulation of hydrolase activity GO:0051336 143 0.019
cardiovascular system development GO:0072358 134 0.018
Human Rat
positive regulation of cell development GO:0010720 176 0.018
Rat
chronic inflammatory response GO:0002544 16 0.018
cellular component movement GO:0006928 248 0.018
Human Rat
cation homeostasis GO:0055080 195 0.018
Rat
actin filament based process GO:0030029 86 0.018
catabolic process GO:0009056 351 0.018
regulation of cellular amine metabolic process GO:0033238 8 0.018
purine containing compound metabolic process GO:0072521 253 0.018
Human
regulation of cellular localization GO:0060341 263 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
positive regulation of response to external stimulus GO:0032103 51 0.018
Rat
ribonucleoside triphosphate metabolic process GO:0009199 141 0.018
signal transduction by phosphorylation GO:0023014 144 0.017
cellular response to oxygen levels GO:0071453 60 0.017
response to glucose GO:0009749 136 0.017
lipid biosynthetic process GO:0008610 128 0.017
positive regulation of neuron differentiation GO:0045666 126 0.017
Rat
glycerolipid metabolic process GO:0046486 67 0.017
response to activity GO:0014823 73 0.017
nucleoside phosphate metabolic process GO:0006753 283 0.017
Human
ion homeostasis GO:0050801 212 0.017
Rat
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.016
metal ion homeostasis GO:0055065 186 0.016
Rat
skeletal muscle cell differentiation GO:0035914 2 0.016
growth GO:0040007 165 0.016
glycosyl compound catabolic process GO:1901658 126 0.016
anatomical structure formation involved in morphogenesis GO:0048646 83 0.016
Human Rat
neutrophil migration GO:1990266 12 0.016
Rat
negative regulation of gene expression GO:0010629 199 0.016
proteolysis GO:0006508 175 0.016
regulation of chemotaxis GO:0050920 29 0.016
Rat
positive regulation of programmed cell death GO:0043068 157 0.016
nucleoside metabolic process GO:0009116 179 0.016
regulation of transcription dna templated GO:0006355 374 0.016
Human
negative regulation of metabolic process GO:0009892 331 0.016
Human
heterocycle catabolic process GO:0046700 167 0.016
response to transition metal nanoparticle GO:1990267 122 0.015
single organismal cell cell adhesion GO:0016337 42 0.015
regulation of cell adhesion GO:0030155 52 0.015
developmental growth GO:0048589 100 0.015
nucleotide catabolic process GO:0009166 139 0.015
regulation of inflammatory response GO:0050727 48 0.015
cellular response to oxidative stress GO:0034599 76 0.015
digestive system development GO:0055123 41 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.015
Human
nucleoside phosphate catabolic process GO:1901292 140 0.015
protein localization GO:0008104 191 0.015
Rat
neuron differentiation GO:0030182 368 0.015
Rat
regulation of neurogenesis GO:0050767 247 0.015
Rat
regulation of vesicle mediated transport GO:0060627 81 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.014
peptidyl amino acid modification GO:0018193 126 0.014
response to insulin GO:0032868 133 0.014
head development GO:0060322 247 0.014
Rat
positive regulation of ion transport GO:0043270 94 0.014
Rat
gliogenesis GO:0042063 93 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.014
muscle structure development GO:0061061 87 0.014
aromatic compound catabolic process GO:0019439 168 0.014
single organism catabolic process GO:0044712 283 0.014
cytokine biosynthetic process GO:0042089 3 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
peptide transport GO:0015833 97 0.014
cellular macromolecule localization GO:0070727 122 0.014
negative regulation of multicellular organismal process GO:0051241 203 0.013
Human Rat
response to zinc ion GO:0010043 39 0.013
positive regulation of cell motility GO:2000147 97 0.013
Rat
calcium ion transmembrane transport GO:0070588 70 0.013
cellular response to hypoxia GO:0071456 51 0.013
positive regulation of cell communication GO:0010647 271 0.013
Human Rat
regulation of hormone levels GO:0010817 187 0.013
muscle organ development GO:0007517 50 0.013
negative regulation of molecular function GO:0044092 133 0.013
ribonucleotide biosynthetic process GO:0009260 85 0.013
behavior GO:0007610 205 0.013
Rat
pseudopodium organization GO:0031268 3 0.013
skeletal muscle tissue development GO:0007519 31 0.013
response to oxygen levels GO:0070482 265 0.013
positive regulation of rna metabolic process GO:0051254 203 0.013
Human
positive regulation of cell projection organization GO:0031346 111 0.013
Rat
regulation of membrane potential GO:0042391 110 0.013
taxis GO:0042330 67 0.013
Human Rat
purine nucleoside metabolic process GO:0042278 169 0.013
immune system development GO:0002520 41 0.013
Human
regulation of ion transmembrane transport GO:0034765 121 0.013
icosanoid metabolic process GO:0006690 38 0.013
regulation of neuron differentiation GO:0045664 208 0.013
Rat
immune response GO:0006955 104 0.012
response to nutrient GO:0007584 248 0.012
Rat
carbohydrate homeostasis GO:0033500 75 0.012
tissue remodeling GO:0048771 40 0.012
positive regulation of secretion GO:0051047 140 0.012
regulation of smooth muscle cell proliferation GO:0048660 75 0.012
glutathione metabolic process GO:0006749 15 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
acute inflammatory response GO:0002526 58 0.012
Rat
actin cytoskeleton organization GO:0030036 73 0.012
regulation of cation channel activity GO:2001257 23 0.012
negative regulation of nucleic acid templated transcription GO:1903507 117 0.012
lipid localization GO:0010876 62 0.012
regulation of cellular protein metabolic process GO:0032268 267 0.012
regulation of proteolysis GO:0030162 66 0.012
actin filament organization GO:0007015 42 0.012
nucleoside triphosphate metabolic process GO:0009141 144 0.012
localization of cell GO:0051674 202 0.012
Human Rat
negative regulation of developmental process GO:0051093 125 0.011
Human Rat
neuron projection development GO:0031175 273 0.011
Rat
ribonucleotide metabolic process GO:0009259 231 0.011
Human
regulation of protein modification process GO:0031399 194 0.011
regulation of ion transmembrane transporter activity GO:0032412 48 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
Human
female pregnancy GO:0007565 122 0.011
cytosolic calcium ion homeostasis GO:0051480 140 0.011
Rat
protein homooligomerization GO:0051260 91 0.011
alcohol metabolic process GO:0006066 77 0.011
purine ribonucleotide metabolic process GO:0009150 227 0.011
Human
multicellular organismal homeostasis GO:0048871 49 0.011
macromolecule localization GO:0033036 252 0.011
Rat
cell substrate adhesion GO:0031589 29 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
hemopoiesis GO:0030097 34 0.011
Human
single organism reproductive process GO:0044702 297 0.011
organophosphate catabolic process GO:0046434 148 0.011
skeletal muscle organ development GO:0060538 33 0.011
response to cytokine GO:0034097 215 0.011
Human Rat
positive regulation of cell death GO:0010942 184 0.011
action potential GO:0001508 54 0.011
sexual reproduction GO:0019953 148 0.011
endomembrane system organization GO:0010256 48 0.011
regulation of defense response GO:0031347 68 0.011
cytoskeleton organization GO:0007010 111 0.011
positive regulation of protein modification process GO:0031401 142 0.010
heart development GO:0007507 72 0.010
cellular cation homeostasis GO:0030003 180 0.010
Rat
regulation of growth GO:0040008 105 0.010
regulation of kinase activity GO:0043549 117 0.010
single organism membrane organization GO:0044802 74 0.010
positive regulation of phosphate metabolic process GO:0045937 262 0.010
Human
connective tissue development GO:0061448 33 0.010
negative regulation of innate immune response GO:0045824 4 0.010
regulation of nucleotide metabolic process GO:0006140 117 0.010
Human
axis specification GO:0009798 4 0.010
regulation of hormone secretion GO:0046883 106 0.010
cellular response to organic cyclic compound GO:0071407 202 0.010

Pf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
vascular disease DOID:178 0 0.021
cardiovascular system disease DOID:1287 0 0.021
disease of anatomical entity DOID:7 0 0.021
artery disease DOID:0050828 0 0.021
nervous system disease DOID:863 0 0.016