Rattus norvegicus

46 known processes

Pfkl

phosphofructokinase, liver

Pfkl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
generation of precursor metabolites and energy GO:0006091 62 0.238
oxoacid metabolic process GO:0043436 290 0.209
carbohydrate catabolic process GO:0016052 40 0.159
carbohydrate metabolic process GO:0005975 130 0.140
response to other organism GO:0051707 220 0.133
single organism intracellular transport GO:1902582 166 0.130
response to inorganic substance GO:0010035 377 0.119
oxidation reduction process GO:0055114 304 0.101
single organism biosynthetic process GO:0044711 342 0.094
single organism carbohydrate metabolic process GO:0044723 118 0.090
monocarboxylic acid metabolic process GO:0032787 152 0.089
carbohydrate derivative metabolic process GO:1901135 346 0.088
negative regulation of cell death GO:0060548 229 0.087
single organism carbohydrate catabolic process GO:0044724 40 0.087
negative regulation of apoptotic process GO:0043066 181 0.083
carboxylic acid metabolic process GO:0019752 289 0.083
liver development GO:0001889 90 0.079
nucleotide metabolic process GO:0009117 279 0.079
response to nutrient levels GO:0031667 370 0.079
organic acid metabolic process GO:0006082 292 0.074
gland development GO:0048732 155 0.072
organophosphate metabolic process GO:0019637 370 0.068
organic substance catabolic process GO:1901575 316 0.065
response to metal ion GO:0010038 253 0.064
response to hypoxia GO:0001666 231 0.064
central nervous system development GO:0007417 311 0.064
small molecule biosynthetic process GO:0044283 124 0.064
negative regulation of programmed cell death GO:0043069 183 0.063
purine containing compound catabolic process GO:0072523 138 0.060
response to corticosteroid GO:0031960 235 0.058
nucleobase containing small molecule metabolic process GO:0055086 316 0.058
regulation of programmed cell death GO:0043067 341 0.058
chemical homeostasis GO:0048878 292 0.057
response to external biotic stimulus GO:0043207 221 0.056
regulation of locomotion GO:0040012 148 0.056
catabolic process GO:0009056 351 0.054
g protein coupled receptor signaling pathway GO:0007186 242 0.054
nucleoside phosphate metabolic process GO:0006753 283 0.054
purine containing compound metabolic process GO:0072521 253 0.053
response to peptide GO:1901652 292 0.053
organelle organization GO:0006996 266 0.053
protein phosphorylation GO:0006468 345 0.053
regulation of protein metabolic process GO:0051246 289 0.052
negative regulation of transport GO:0051051 136 0.052
Mouse
response to carbohydrate GO:0009743 183 0.051
Mouse
single organism catabolic process GO:0044712 283 0.051
response to extracellular stimulus GO:0009991 380 0.050
response to glucocorticoid GO:0051384 223 0.049
response to cytokine GO:0034097 215 0.048
membrane organization GO:0061024 94 0.048
organonitrogen compound catabolic process GO:1901565 179 0.047
organonitrogen compound biosynthetic process GO:1901566 167 0.046
intracellular transport GO:0046907 185 0.046
single organism organelle organization GO:1902589 180 0.045
hepaticobiliary system development GO:0061008 90 0.045
protein complex biogenesis GO:0070271 263 0.045
programmed cell death GO:0012501 392 0.043
regulation of ion transport GO:0043269 245 0.042
macromolecular complex subunit organization GO:0043933 339 0.042
protein complex assembly GO:0006461 263 0.041
glycosaminoglycan biosynthetic process GO:0006024 4 0.041
regulation of apoptotic process GO:0042981 335 0.041
pyruvate metabolic process GO:0006090 27 0.041
response to biotic stimulus GO:0009607 226 0.041
regulation of molecular function GO:0065009 398 0.041
cellular component movement GO:0006928 248 0.040
organ regeneration GO:0031100 101 0.040
ribonucleoside triphosphate metabolic process GO:0009199 141 0.040
homeostatic process GO:0042592 331 0.040
cellular chemical homeostasis GO:0055082 247 0.040
purine ribonucleotide catabolic process GO:0009154 136 0.039
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.039
purine ribonucleoside metabolic process GO:0046128 168 0.039
response to oxygen levels GO:0070482 265 0.038
localization of cell GO:0051674 202 0.037
apoptotic process GO:0006915 381 0.037
single organism membrane organization GO:0044802 74 0.036
ribonucleotide metabolic process GO:0009259 231 0.036
response to peptide hormone GO:0043434 278 0.036
calcium ion homeostasis GO:0055074 162 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.034
organophosphate catabolic process GO:0046434 148 0.034
positive regulation of response to stimulus GO:0048584 285 0.034
nucleoside triphosphate metabolic process GO:0009141 144 0.034
cellular response to hormone stimulus GO:0032870 247 0.034
aging GO:0007568 241 0.034
negative regulation of signaling GO:0023057 157 0.033
Mouse
purine ribonucleoside catabolic process GO:0046130 124 0.033
cellular response to oxygen containing compound GO:1901701 386 0.033
response to heat GO:0009408 60 0.032
cellular amino acid metabolic process GO:0006520 107 0.032
insulin like growth factor receptor signaling pathway GO:0048009 3 0.032
defense response GO:0006952 194 0.032
cell type specific apoptotic process GO:0097285 134 0.031
response to estrogen GO:0043627 232 0.031
cellular catabolic process GO:0044248 295 0.031
regulation of catalytic activity GO:0050790 304 0.031
locomotion GO:0040011 237 0.031
response to monosaccharide GO:0034284 159 0.030
Mouse
purine nucleoside metabolic process GO:0042278 169 0.030
neuron projection development GO:0031175 273 0.029
ribose phosphate metabolic process GO:0019693 235 0.029
metal ion homeostasis GO:0055065 186 0.029
brain development GO:0007420 247 0.029
response to acid chemical GO:0001101 222 0.029
purine ribonucleotide metabolic process GO:0009150 227 0.029
regeneration GO:0031099 163 0.029
olfactory behavior GO:0042048 2 0.029
regulation of hormone levels GO:0010817 187 0.028
Mouse
monosaccharide metabolic process GO:0005996 61 0.028
carbohydrate derivative catabolic process GO:1901136 147 0.028
cation transport GO:0006812 382 0.027
regulation of cellular protein metabolic process GO:0032268 267 0.027
ribonucleoside metabolic process GO:0009119 174 0.027
positive regulation of rna biosynthetic process GO:1902680 197 0.027
neuron differentiation GO:0030182 368 0.027
transmembrane transport GO:0055085 412 0.027
regulation of immune system process GO:0002682 123 0.026
neural crest cell development GO:0014032 2 0.026
cellular ion homeostasis GO:0006873 184 0.026
positive regulation of cellular amine metabolic process GO:0033240 3 0.026
regulation of muscle system process GO:0090257 79 0.026
regulation of membrane potential GO:0042391 110 0.026
tube formation GO:0035148 3 0.025
cellular response to nitrogen compound GO:1901699 210 0.025
amine metabolic process GO:0009308 38 0.025
regulation of cell development GO:0060284 263 0.025
regulation of hydrolase activity GO:0051336 143 0.025
negative regulation of metabolic process GO:0009892 331 0.025
response to decreased oxygen levels GO:0036293 237 0.024
head development GO:0060322 247 0.024
g protein coupled receptor internalization GO:0002031 3 0.024
aromatic compound catabolic process GO:0019439 168 0.024
response to oxidative stress GO:0006979 186 0.024
tissue development GO:0009888 252 0.024
cell motility GO:0048870 202 0.024
protein complex subunit organization GO:0071822 302 0.024
gtp metabolic process GO:0046039 72 0.024
cellular response to external stimulus GO:0071496 118 0.024
nucleoside metabolic process GO:0009116 179 0.023
positive regulation of cell proliferation GO:0008284 249 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.023
nucleoside phosphate catabolic process GO:1901292 140 0.023
response to hexose GO:0009746 144 0.023
Mouse
b cell activation involved in immune response GO:0002312 1 0.023
response to radiation GO:0009314 137 0.023
monovalent inorganic cation transport GO:0015672 172 0.023
cation homeostasis GO:0055080 195 0.023
neurological system process GO:0050877 219 0.023
purine nucleoside triphosphate metabolic process GO:0009144 141 0.023
positive regulation of immune system process GO:0002684 90 0.023
cellular homeostasis GO:0019725 252 0.022
nucleotide catabolic process GO:0009166 139 0.022
gtp catabolic process GO:0006184 71 0.022
response to glucose GO:0009749 136 0.021
Mouse
multi multicellular organism process GO:0044706 138 0.021
behavior GO:0007610 205 0.021
secretion GO:0046903 307 0.021
Mouse
cellular amine metabolic process GO:0044106 38 0.021
purine nucleotide biosynthetic process GO:0006164 83 0.021
glycosyl compound metabolic process GO:1901657 182 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.021
cytosolic calcium ion homeostasis GO:0051480 140 0.020
heart morphogenesis GO:0003007 3 0.020
positive regulation of cell migration GO:0030335 96 0.020
regulation of cellular localization GO:0060341 263 0.020
Mouse
positive regulation of cellular component movement GO:0051272 102 0.020
metal ion transport GO:0030001 289 0.020
cellular response to abiotic stimulus GO:0071214 85 0.019
cellular response to peptide GO:1901653 133 0.019
negative regulation of secretion GO:0051048 82 0.019
Mouse
cell cycle checkpoint GO:0000075 2 0.019
macromolecular complex assembly GO:0065003 273 0.019
response to ammonium ion GO:0060359 71 0.019
cellular response to stress GO:0033554 269 0.019
ribonucleoside catabolic process GO:0042454 126 0.019
neuron development GO:0048666 286 0.019
cell projection organization GO:0030030 302 0.019
positive regulation of biosynthetic process GO:0009891 319 0.019
response to bacterium GO:0009617 200 0.019
response to wounding GO:0009611 254 0.019
cellular ketone metabolic process GO:0042180 51 0.019
regulation of ion transmembrane transport GO:0034765 121 0.018
chemosensory behavior GO:0007635 2 0.018
cellular cation homeostasis GO:0030003 180 0.018
ribose phosphate biosynthetic process GO:0046390 87 0.018
single fertilization GO:0007338 3 0.018
regulation of purine nucleotide metabolic process GO:1900542 115 0.018
protein oligomerization GO:0051259 191 0.018
regulation of cell differentiation GO:0045595 320 0.018
negative regulation of cellular metabolic process GO:0031324 281 0.018
establishment of protein localization GO:0045184 141 0.018
regulation of the force of heart contraction by chemical signal GO:0003057 2 0.017
peptide secretion GO:0002790 86 0.017
Mouse
cellular carbohydrate metabolic process GO:0044262 72 0.017
negative regulation of gene expression GO:0010629 199 0.017
nucleotide biosynthetic process GO:0009165 98 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
female pregnancy GO:0007565 122 0.017
single organism cellular localization GO:1902580 102 0.017
positive regulation of multicellular organismal process GO:0051240 387 0.017
negative regulation of molecular function GO:0044092 133 0.017
nucleoside triphosphate catabolic process GO:0009143 123 0.017
single organism behavior GO:0044708 130 0.017
purine containing compound biosynthetic process GO:0072522 85 0.017
anatomical structure morphogenesis GO:0009653 298 0.017
positive regulation of locomotion GO:0040017 102 0.017
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
reproduction GO:0000003 245 0.016
response to alkaloid GO:0043279 132 0.016
cellular calcium ion homeostasis GO:0006874 160 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
regulation of metal ion transport GO:0010959 118 0.016
multicellular organism reproduction GO:0032504 233 0.016
regulation of mitochondrion organization GO:0010821 7 0.016
aminoglycan biosynthetic process GO:0006023 4 0.016
negative regulation of rna splicing GO:0033119 3 0.016
regulation of phosphorus metabolic process GO:0051174 349 0.016
ribonucleoside triphosphate catabolic process GO:0009203 122 0.016
regulation of homeostatic process GO:0032844 101 0.016
regulation of cellular component movement GO:0051270 150 0.016
positive regulation of phosphorus metabolic process GO:0010562 262 0.016
immune system process GO:0002376 204 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
smooth muscle cell proliferation GO:0048659 77 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.016
positive regulation of gene expression GO:0010628 244 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
neural crest cell differentiation GO:0014033 2 0.016
glycogen metabolic process GO:0005977 23 0.016
response to insulin GO:0032868 133 0.016
regulation of peptide secretion GO:0002791 82 0.016
Mouse
reproductive system development GO:0061458 128 0.016
ion transmembrane transport GO:0034220 365 0.016
regulation of cell proliferation GO:0042127 359 0.015
cellular metal ion homeostasis GO:0006875 172 0.015
transcription dna templated GO:0006351 377 0.015
response to nutrient GO:0007584 248 0.015
regulation of rna biosynthetic process GO:2001141 381 0.015
heterocycle catabolic process GO:0046700 167 0.015
purine nucleotide metabolic process GO:0006163 229 0.015
cellular response to endogenous stimulus GO:0071495 377 0.015
action potential GO:0001508 54 0.015
proteolysis GO:0006508 175 0.015
peptide transport GO:0015833 97 0.015
Mouse
regulation of dna metabolic process GO:0051052 60 0.015
divalent inorganic cation homeostasis GO:0072507 165 0.015
immune response GO:0006955 104 0.015
ion homeostasis GO:0050801 212 0.015
positive regulation of developmental process GO:0051094 283 0.015
regulation of response to external stimulus GO:0032101 106 0.015
ribonucleotide catabolic process GO:0009261 136 0.015
endoplasmic reticulum organization GO:0007029 1 0.015
negative regulation of cell communication GO:0010648 158 0.015
Mouse
regulation of blood pressure GO:0008217 83 0.015
regulation of nucleotide catabolic process GO:0030811 65 0.014
neuronal action potential GO:0019228 35 0.014
regulation of synaptic transmission GO:0050804 141 0.014
cellular lipid metabolic process GO:0044255 208 0.014
multicellular organismal signaling GO:0035637 44 0.014
cellular response to peptide hormone stimulus GO:0071375 120 0.014
regulation of blood circulation GO:1903522 110 0.014
regulation of multicellular organismal development GO:2000026 376 0.014
nucleic acid templated transcription GO:0097659 379 0.014
response to amino acid GO:0043200 75 0.014
adult locomotory behavior GO:0008344 4 0.014
response to temperature stimulus GO:0009266 94 0.014
organic cyclic compound catabolic process GO:1901361 175 0.014
cellular component biogenesis GO:0044085 368 0.014
response to growth factor GO:0070848 189 0.014
forebrain development GO:0030900 98 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
regulation of secretion by cell GO:1903530 208 0.014
Mouse
cellular response to insulin stimulus GO:0032869 81 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.014
positive regulation of protein metabolic process GO:0051247 178 0.014
cellular response to organic cyclic compound GO:0071407 202 0.014
response to starvation GO:0042594 59 0.014
vesicle mediated transport GO:0016192 181 0.013
regulation of cellular component organization GO:0051128 368 0.013
epithelium development GO:0060429 96 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.013
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
ribonucleoside monophosphate metabolic process GO:0009161 88 0.013
positive regulation of nucleotide metabolic process GO:0045981 91 0.013
lipid metabolic process GO:0006629 283 0.013
circulatory system process GO:0003013 183 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.013
fertilization GO:0009566 3 0.013
ras protein signal transduction GO:0007265 29 0.013
sulfur compound biosynthetic process GO:0044272 19 0.013
regulation of cell motility GO:2000145 131 0.013
positive regulation of cellular biosynthetic process GO:0031328 295 0.013
positive regulation of cell communication GO:0010647 271 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
transmission of nerve impulse GO:0019226 42 0.013
neural tube formation GO:0001841 1 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
protein heterooligomerization GO:0051291 89 0.013
spermatogenesis GO:0007283 99 0.013
glucose metabolic process GO:0006006 52 0.013
muscle system process GO:0003012 115 0.013
sensory organ development GO:0007423 74 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
regulation of behavior GO:0050795 61 0.012
negative regulation of ion transport GO:0043271 51 0.012
synaptic growth at neuromuscular junction GO:0051124 1 0.012
nucleoside phosphate biosynthetic process GO:1901293 102 0.012
innate immune response GO:0045087 35 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
carbohydrate phosphorylation GO:0046835 16 0.012
regulation of anatomical structure size GO:0090066 135 0.012
peptidyl amino acid modification GO:0018193 126 0.012
rhythmic process GO:0048511 156 0.012
response to ketone GO:1901654 182 0.012
regulation of protein maturation GO:1903317 50 0.012
blood circulation GO:0008015 183 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 4 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
neuron neuron synaptic transmission GO:0007270 60 0.012
anion transport GO:0006820 178 0.012
regulation of cell migration GO:0030334 128 0.012
regulation of transcription dna templated GO:0006355 374 0.012
sexual reproduction GO:0019953 148 0.012
regulation of immunoglobulin production GO:0002637 4 0.012
negative regulation of neuron death GO:1901215 69 0.012
nitrogen compound transport GO:0071705 229 0.011
Mouse
axis specification GO:0009798 4 0.011
cell cycle GO:0007049 101 0.011
multi organism reproductive process GO:0044703 262 0.011
regulation of system process GO:0044057 208 0.011
positive regulation of cell motility GO:2000147 97 0.011
negative regulation of macromolecule metabolic process GO:0010605 260 0.011
cellular response to oxygen levels GO:0071453 60 0.011
negative regulation of stress activated protein kinase signaling cascade GO:0070303 4 0.011
positive regulation of b cell mediated immunity GO:0002714 2 0.011
response to estradiol GO:0032355 164 0.011
sex differentiation GO:0007548 113 0.011
developmental process involved in reproduction GO:0003006 159 0.011
negative regulation of protein metabolic process GO:0051248 114 0.011
neural crest cell migration GO:0001755 1 0.011
negative regulation of proteolysis GO:0045861 41 0.011
regulation of cell projection organization GO:0031344 175 0.011
cellular glucan metabolic process GO:0006073 23 0.011
cell migration GO:0016477 197 0.011
response to activity GO:0014823 73 0.011
regulation of nucleotide metabolic process GO:0006140 117 0.011
energy derivation by oxidation of organic compounds GO:0015980 46 0.011
ribonucleotide biosynthetic process GO:0009260 85 0.011
rna biosynthetic process GO:0032774 380 0.011
regulation of neuron differentiation GO:0045664 208 0.011
hormone secretion GO:0046879 115 0.011
Mouse
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.011
response to interleukin 1 GO:0070555 55 0.011
positive regulation of organelle organization GO:0010638 48 0.011
regulation of rna metabolic process GO:0051252 391 0.011
reproductive process GO:0022414 372 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 16 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
negative regulation of cell proliferation GO:0008285 119 0.010
negative regulation of cellular protein metabolic process GO:0032269 106 0.010
purine nucleoside catabolic process GO:0006152 124 0.010
regulation of hormone secretion GO:0046883 106 0.010
Mouse
positive regulation of cell development GO:0010720 176 0.010
cytoplasmic transport GO:0016482 115 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
cell cell signaling GO:0007267 335 0.010
Mouse
single organism reproductive process GO:0044702 297 0.010
sensory perception GO:0007600 101 0.010
purine nucleoside triphosphate catabolic process GO:0009146 122 0.010
cellular response to hexose stimulus GO:0071331 65 0.010
behavioral response to ethanol GO:0048149 1 0.010
vesicle organization GO:0016050 29 0.010
rna metabolic process GO:0016070 406 0.010
response to uv c GO:0010225 2 0.010
reactive oxygen species biosynthetic process GO:1903409 8 0.010

Pfkl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
gastrointestinal system cancer DOID:3119 0 0.027
cancer DOID:162 0 0.027
disease of cellular proliferation DOID:14566 0 0.027
organ system cancer DOID:0050686 0 0.027
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
colon carcinoma DOID:1520 0 0.019
large intestine cancer DOID:5672 0 0.019
colon cancer DOID:219 0 0.019
intestinal cancer DOID:10155 0 0.019
colorectal cancer DOID:9256 0 0.019
breast cancer DOID:1612 0 0.012
thoracic cancer DOID:5093 0 0.012
central nervous system disease DOID:331 0 0.011