Rattus norvegicus

36 known processes

Pgam2

phosphoglycerate mutase 2 (muscle)

(Aliases: PGAM-M,D14Mgh1,Pgmut)

Pgam2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
muscle system process GO:0003012 115 0.523
Human
heart contraction GO:0060047 57 0.332
homeostatic process GO:0042592 331 0.287
Rat
oxoacid metabolic process GO:0043436 290 0.274
Human Yeast Mouse
twitch skeletal muscle contraction GO:0014721 3 0.257
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.237
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 4 0.217
ventricular cardiac muscle cell action potential GO:0086005 2 0.203
organic acid metabolic process GO:0006082 292 0.194
Human Yeast Mouse
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.183
regulation of system process GO:0044057 208 0.175
response to metal ion GO:0010038 253 0.169
response to oxygen levels GO:0070482 265 0.167
divalent metal ion transport GO:0070838 132 0.166
response to hypoxia GO:0001666 231 0.163
organic substance catabolic process GO:1901575 316 0.157
Human Yeast Mouse
carboxylic acid metabolic process GO:0019752 289 0.154
Human Yeast Mouse
regeneration GO:0031099 163 0.152
cellular modified amino acid biosynthetic process GO:0042398 18 0.152
cardiac muscle tissue morphogenesis GO:0055008 1 0.151
cellular response to endogenous stimulus GO:0071495 377 0.150
muscle contraction GO:0006936 88 0.149
Human
striated muscle tissue development GO:0014706 58 0.145
organophosphate metabolic process GO:0019637 370 0.137
single organism biosynthetic process GO:0044711 342 0.116
striated muscle contraction GO:0006941 44 0.114
Human
cardiac muscle contraction GO:0060048 27 0.114
cellular response to hormone stimulus GO:0032870 247 0.111
purine nucleotide metabolic process GO:0006163 229 0.106
response to decreased oxygen levels GO:0036293 237 0.103
cation homeostasis GO:0055080 195 0.102
cellular amino acid metabolic process GO:0006520 107 0.100
response to inorganic substance GO:0010035 377 0.098
response to purine containing compound GO:0014074 126 0.095
slow twitch skeletal muscle fiber contraction GO:0031444 2 0.089
regulation of ion transport GO:0043269 245 0.088
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.087
single organism carbohydrate catabolic process GO:0044724 40 0.087
Human Yeast Mouse
carbohydrate derivative metabolic process GO:1901135 346 0.086
cardiac ventricle development GO:0003231 1 0.085
cardiac chamber development GO:0003205 1 0.084
oxidation reduction process GO:0055114 304 0.083
endoplasmic reticulum to cytosol transport GO:1903513 4 0.083
actin filament based movement GO:0030048 16 0.081
cardiac myofibril assembly GO:0055003 1 0.081
carbohydrate catabolic process GO:0016052 40 0.080
Human Yeast Mouse
muscle filament sliding GO:0030049 2 0.077
nucleotide metabolic process GO:0009117 279 0.076
nucleobase containing small molecule metabolic process GO:0055086 316 0.074
negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 1 0.074
ion homeostasis GO:0050801 212 0.072
nucleobase containing compound catabolic process GO:0034655 152 0.070
metal ion transport GO:0030001 289 0.070
voluntary skeletal muscle contraction GO:0003010 3 0.070
chemical homeostasis GO:0048878 292 0.070
cellular ion homeostasis GO:0006873 184 0.069
divalent inorganic cation homeostasis GO:0072507 165 0.066
tissue development GO:0009888 252 0.066
single organism intracellular transport GO:1902582 166 0.066
cation transport GO:0006812 382 0.066
growth GO:0040007 165 0.063
ribonucleoside triphosphate metabolic process GO:0009199 141 0.062
muscle organ morphogenesis GO:0048644 1 0.062
single organism catabolic process GO:0044712 283 0.060
Human Yeast Mouse
negative regulation of neuron differentiation GO:0045665 62 0.059
divalent inorganic cation transport GO:0072511 134 0.059
myosin filament assembly GO:0031034 1 0.057
organophosphate biosynthetic process GO:0090407 143 0.057
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.056
metal ion homeostasis GO:0055065 186 0.055
response to camp GO:0051591 91 0.054
calcium ion homeostasis GO:0055074 162 0.054
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.053
muscle tissue development GO:0060537 58 0.052
heart morphogenesis GO:0003007 3 0.052
inorganic cation transmembrane transport GO:0098662 202 0.051
cellular modified amino acid metabolic process GO:0006575 61 0.051
regulation of muscle contraction GO:0006937 53 0.050
cellular chemical homeostasis GO:0055082 247 0.049
muscle cell differentiation GO:0042692 52 0.049
Fly
aromatic compound catabolic process GO:0019439 168 0.049
cellular component morphogenesis GO:0032989 155 0.046
purine nucleoside monophosphate metabolic process GO:0009126 84 0.045
positive regulation of multicellular organismal process GO:0051240 387 0.045
reproductive system development GO:0061458 128 0.045
protein complex subunit organization GO:0071822 302 0.045
hexose metabolic process GO:0019318 58 0.044
carbohydrate metabolic process GO:0005975 130 0.044
myosin filament organization GO:0031033 2 0.042
potassium ion transmembrane transport GO:0071805 71 0.042
sequestering of metal ion GO:0051238 9 0.042
cytosolic calcium ion homeostasis GO:0051480 140 0.041
amine metabolic process GO:0009308 38 0.041
cardiac muscle cell contraction GO:0086003 10 0.040
regulation of cellular component organization GO:0051128 368 0.040
cell projection organization GO:0030030 302 0.039
cellular calcium ion homeostasis GO:0006874 160 0.038
catabolic process GO:0009056 351 0.038
Human Yeast Mouse
regulation of muscle system process GO:0090257 79 0.038
cellular homeostasis GO:0019725 252 0.038
muscle organ development GO:0007517 50 0.038
maintenance of location GO:0051235 17 0.038
regulation of ion homeostasis GO:2000021 63 0.037
ion transmembrane transport GO:0034220 365 0.037
glycosyl compound metabolic process GO:1901657 182 0.037
cellular cation homeostasis GO:0030003 180 0.037
response to nutrient levels GO:0031667 370 0.036
reproductive structure development GO:0048608 128 0.036
regulation of cell differentiation GO:0045595 320 0.036
sarcoplasmic reticulum calcium ion transport GO:0070296 8 0.036
heart process GO:0003015 57 0.035
blood circulation GO:0008015 183 0.035
transmembrane transport GO:0055085 412 0.035
cellular metal ion homeostasis GO:0006875 172 0.035
response to acid chemical GO:0001101 222 0.035
ribonucleoside triphosphate catabolic process GO:0009203 122 0.035
cellular response to stress GO:0033554 269 0.035
response to electrical stimulus GO:0051602 56 0.034
response to extracellular stimulus GO:0009991 380 0.034
cellular amine metabolic process GO:0044106 38 0.034
response to corticosteroid GO:0031960 235 0.034
purine ribonucleoside metabolic process GO:0046128 168 0.033
negative regulation of programmed cell death GO:0043069 183 0.033
negative regulation of organ growth GO:0046621 3 0.033
monovalent inorganic cation transport GO:0015672 172 0.033
purine nucleoside monophosphate catabolic process GO:0009128 55 0.032
cellular component biogenesis GO:0044085 368 0.032
nucleoside monophosphate metabolic process GO:0009123 93 0.032
proteolysis GO:0006508 175 0.032
negative regulation of cardiac muscle tissue development GO:0055026 3 0.031
ribonucleoside metabolic process GO:0009119 174 0.031
regulation of multicellular organismal development GO:2000026 376 0.030
monocarboxylic acid metabolic process GO:0032787 152 0.030
Human Yeast Mouse
macromolecular complex assembly GO:0065003 273 0.030
cellular response to fluid shear stress GO:0071498 4 0.030
nucleoside phosphate metabolic process GO:0006753 283 0.030
carboxylic acid biosynthetic process GO:0046394 83 0.030
calcium ion transport GO:0006816 131 0.030
ribose phosphate metabolic process GO:0019693 235 0.030
heterocycle catabolic process GO:0046700 167 0.029
positive regulation of rna biosynthetic process GO:1902680 197 0.029
positive regulation of potassium ion transmembrane transport GO:1901381 4 0.029
negative regulation of signal transduction GO:0009968 83 0.029
actin mediated cell contraction GO:0070252 12 0.028
response to organophosphorus GO:0046683 102 0.028
response to insulin GO:0032868 133 0.028
urogenital system development GO:0001655 78 0.028
apoptotic process GO:0006915 381 0.028
aging GO:0007568 241 0.027
response to oxidative stress GO:0006979 186 0.027
central nervous system development GO:0007417 311 0.027
positive regulation of developmental process GO:0051094 283 0.027
glycerolipid metabolic process GO:0046486 67 0.027
sequestering of calcium ion GO:0051208 8 0.027
response to glucocorticoid GO:0051384 223 0.027
regulation of rna metabolic process GO:0051252 391 0.026
cellular component assembly involved in morphogenesis GO:0010927 17 0.026
intracellular signal transduction GO:0035556 314 0.026
negative regulation of transport GO:0051051 136 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
regulation of cellular localization GO:0060341 263 0.026
regulation of heart contraction GO:0008016 48 0.025
ventricular cardiac muscle cell development GO:0055015 2 0.025
regulation of cardiac muscle contraction GO:0055117 17 0.025
regulation of rna biosynthetic process GO:2001141 381 0.025
nucleoside metabolic process GO:0009116 179 0.025
cation transmembrane transport GO:0098655 263 0.025
developmental growth GO:0048589 100 0.025
response to peptide hormone GO:0043434 278 0.024
purine nucleoside metabolic process GO:0042278 169 0.024
organonitrogen compound biosynthetic process GO:1901566 167 0.024
cellular amino acid biosynthetic process GO:0008652 32 0.024
cardiac muscle cell action potential involved in contraction GO:0086002 2 0.024
neuron differentiation GO:0030182 368 0.024
negative regulation of signaling GO:0023057 157 0.023
polysaccharide metabolic process GO:0005976 25 0.023
positive regulation of peptide hormone secretion GO:0090277 50 0.023
regulation of peptide hormone secretion GO:0090276 80 0.023
nucleoside triphosphate metabolic process GO:0009141 144 0.023
circulatory system process GO:0003013 183 0.023
negative regulation of ion transport GO:0043271 51 0.023
negative regulation of apoptotic process GO:0043066 181 0.023
brain development GO:0007420 247 0.022
multicellular organism reproduction GO:0032504 233 0.022
protein complex assembly GO:0006461 263 0.022
heart development GO:0007507 72 0.022
ribonucleoside monophosphate catabolic process GO:0009158 55 0.022
ribonucleoside monophosphate metabolic process GO:0009161 88 0.022
response to heat GO:0009408 60 0.022
nucleoside catabolic process GO:0009164 126 0.022
actin cytoskeleton organization GO:0030036 73 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.022
cellular divalent inorganic cation homeostasis GO:0072503 162 0.022
lipid metabolic process GO:0006629 283 0.022
head development GO:0060322 247 0.022
peptide transport GO:0015833 97 0.022
purine containing compound metabolic process GO:0072521 253 0.022
glycosyl compound catabolic process GO:1901658 126 0.022
cellular component assembly GO:0022607 360 0.021
response to electrical stimulus involved in regulation of muscle adaptation GO:0014878 4 0.021
kidney development GO:0001822 67 0.021
regulation of response to stress GO:0080134 126 0.021
regulation of organ growth GO:0046620 13 0.021
cellular response to oxygen containing compound GO:1901701 386 0.021
regulation of chromosome segregation GO:0051983 1 0.021
cellular response to insulin stimulus GO:0032869 81 0.021
cellular ketone metabolic process GO:0042180 51 0.020
single organism organelle organization GO:1902589 180 0.020
establishment of tissue polarity GO:0007164 2 0.020
response to estrogen GO:0043627 232 0.020
negative regulation of muscle hypertrophy GO:0014741 3 0.020
organelle organization GO:0006996 266 0.020
positive regulation of cell proliferation GO:0008284 249 0.020
response to estradiol GO:0032355 164 0.020
cytoskeleton organization GO:0007010 111 0.020
regulation of cellular amine metabolic process GO:0033238 8 0.020
protein tetramerization GO:0051262 38 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.020
cofactor metabolic process GO:0051186 95 0.020
enzyme linked receptor protein signaling pathway GO:0007167 116 0.020
response to wounding GO:0009611 254 0.019
cellular response to abiotic stimulus GO:0071214 85 0.019
cellular response to organonitrogen compound GO:0071417 197 0.019
circulatory system development GO:0072359 134 0.019
single organism reproductive process GO:0044702 297 0.019
multi organism reproductive process GO:0044703 262 0.019
atp metabolic process GO:0046034 72 0.019
lipid transport GO:0006869 61 0.019
cardiocyte differentiation GO:0035051 22 0.019
single organism carbohydrate metabolic process GO:0044723 118 0.019
anatomical structure formation involved in morphogenesis GO:0048646 83 0.018
Fly
negative regulation of metabolic process GO:0009892 331 0.018
developmental process involved in reproduction GO:0003006 159 0.018
multi multicellular organism process GO:0044706 138 0.018
action potential GO:0001508 54 0.018
reproduction GO:0000003 245 0.018
cellular response to peptide hormone stimulus GO:0071375 120 0.018
organic cyclic compound catabolic process GO:1901361 175 0.018
skeletal muscle tissue regeneration GO:0043403 10 0.018
regulation of release of sequestered calcium ion into cytosol GO:0051279 18 0.018
erythrocyte differentiation GO:0030218 1 0.018
Rat
ribonucleotide metabolic process GO:0009259 231 0.018
purine nucleoside triphosphate metabolic process GO:0009144 141 0.017
inner ear receptor cell differentiation GO:0060113 2 0.017
cardiac muscle cell development GO:0055013 16 0.017
macromolecule catabolic process GO:0009057 58 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
muscle structure development GO:0061061 87 0.017
Fly
response to hexose GO:0009746 144 0.017
negative regulation of cell death GO:0060548 229 0.017
cardiovascular system development GO:0072358 134 0.017
multicellular organismal signaling GO:0035637 44 0.017
gonad development GO:0008406 104 0.017
purine nucleoside triphosphate catabolic process GO:0009146 122 0.017
organophosphate catabolic process GO:0046434 148 0.017
negative regulation of cardiac muscle tissue growth GO:0055022 3 0.017
regulation of cell development GO:0060284 263 0.017
negative regulation of sequestering of calcium ion GO:0051283 25 0.017
negative regulation of cell differentiation GO:0045596 99 0.017
metaphase anaphase transition of mitotic cell cycle GO:0007091 1 0.017
ribonucleoside catabolic process GO:0042454 126 0.017
response to activity GO:0014823 73 0.017
cellular macromolecule localization GO:0070727 122 0.016
generation of precursor metabolites and energy GO:0006091 62 0.016
Human Yeast Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.016
purine ribonucleotide catabolic process GO:0009154 136 0.016
regulation of secretion by cell GO:1903530 208 0.016
regulation of stem cell differentiation GO:2000736 2 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
cellular protein localization GO:0034613 122 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
proline transport GO:0015824 3 0.016
response to amino acid GO:0043200 75 0.016
wound healing GO:0042060 122 0.016
regulation of neuron projection development GO:0010975 161 0.016
negative regulation of transporter activity GO:0032410 13 0.016
regulation of cell projection organization GO:0031344 175 0.016
neuron projection morphogenesis GO:0048812 122 0.016
response to peptide GO:1901652 292 0.016
regulation of molecular function GO:0065009 398 0.015
organic acid biosynthetic process GO:0016053 83 0.015
regulation of neuron differentiation GO:0045664 208 0.015
regulation of striated muscle contraction GO:0006942 21 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
negative regulation of ion transmembrane transporter activity GO:0032413 12 0.015
protein complex biogenesis GO:0070271 263 0.015
small molecule biosynthetic process GO:0044283 124 0.015
sulfur compound metabolic process GO:0006790 70 0.015
purine ribonucleoside monophosphate biosynthetic process GO:0009168 20 0.015
organic hydroxy compound metabolic process GO:1901615 115 0.015
glycerol transport GO:0015793 2 0.015
calcium ion transmembrane transport GO:0070588 70 0.015
secretion GO:0046903 307 0.015
regulation of skeletal muscle tissue regeneration GO:0043416 2 0.015
cellular glucan metabolic process GO:0006073 23 0.015
tissue regeneration GO:0042246 36 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
nucleobase biosynthetic process GO:0046112 2 0.015
regulation of blood circulation GO:1903522 110 0.015
reproductive process GO:0022414 372 0.015
actin filament based process GO:0030029 86 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.015
intracellular transport GO:0046907 185 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.014
negative regulation of epithelial cell proliferation GO:0050680 16 0.014
cellular protein complex assembly GO:0043623 44 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.014
regulation of cell proliferation GO:0042127 359 0.014
positive regulation of receptor activity GO:2000273 4 0.014
cardiac cell development GO:0055006 16 0.014
striated muscle cell development GO:0055002 26 0.014
glycogen metabolic process GO:0005977 23 0.014
negative regulation of cell development GO:0010721 82 0.014
response to reactive oxygen species GO:0000302 120 0.014
amide transport GO:0042886 105 0.014
negative regulation of cell proliferation GO:0008285 119 0.014
transcription dna templated GO:0006351 377 0.014
rna metabolic process GO:0016070 406 0.014
potassium ion transport GO:0006813 97 0.014
negative regulation of nervous system development GO:0051961 79 0.013
rna biosynthetic process GO:0032774 380 0.013
regulation of programmed cell death GO:0043067 341 0.013
inorganic ion transmembrane transport GO:0098660 229 0.013
cell cycle checkpoint GO:0000075 2 0.013
cellular response to nitrogen compound GO:1901699 210 0.013
purine containing compound catabolic process GO:0072523 138 0.013
regulation of apoptotic process GO:0042981 335 0.013
response to ketone GO:1901654 182 0.013
regulation of anatomical structure size GO:0090066 135 0.013
mitotic sister chromatid separation GO:0051306 1 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
negative regulation of heart growth GO:0061117 3 0.013
tissue morphogenesis GO:0048729 22 0.013
regulation of mitotic sister chromatid segregation GO:0033047 1 0.013
ribose phosphate biosynthetic process GO:0046390 87 0.013
regulation of cellular ketone metabolic process GO:0010565 27 0.013
phospholipid biosynthetic process GO:0008654 29 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
male gamete generation GO:0048232 99 0.013
regulation of establishment of planar polarity GO:0090175 2 0.013
sexual reproduction GO:0019953 148 0.012
regulation of notch signaling pathway GO:0008593 3 0.012
receptor mediated endocytosis GO:0006898 42 0.012
chylomicron remodeling GO:0034371 1 0.012
neuron development GO:0048666 286 0.012
negative regulation of release of sequestered calcium ion into cytosol GO:0051280 4 0.012
cell projection morphogenesis GO:0048858 123 0.012
glucan metabolic process GO:0044042 23 0.012
renal system development GO:0072001 67 0.012
sex differentiation GO:0007548 113 0.012
defense response GO:0006952 194 0.012
peptide secretion GO:0002790 86 0.012
positive regulation of blood circulation GO:1903524 65 0.012
nucleoside monophosphate catabolic process GO:0009125 56 0.012
regulation of nervous system development GO:0051960 264 0.012
negative regulation of molecular function GO:0044092 133 0.012
regulation of epithelial cell proliferation GO:0050678 49 0.012
regulation of anatomical structure morphogenesis GO:0022603 141 0.012
regulation of endocytosis GO:0030100 42 0.012
microtubule cytoskeleton organization GO:0000226 25 0.012
protein homotetramerization GO:0051289 25 0.012
nucleotide catabolic process GO:0009166 139 0.011
purine nucleoside catabolic process GO:0006152 124 0.011
regulation of metal ion transport GO:0010959 118 0.011
neuronal action potential GO:0019228 35 0.011
insulin like growth factor receptor signaling pathway GO:0048009 3 0.011
regulation of transmembrane transporter activity GO:0022898 49 0.011
dna metabolic process GO:0006259 96 0.011
acyl coa metabolic process GO:0006637 28 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
response to muscle activity involved in regulation of muscle adaptation GO:0014873 2 0.011
chromosome segregation GO:0007059 2 0.011
cellular potassium ion transport GO:0071804 72 0.011
regulation of catalytic activity GO:0050790 304 0.011
cytosolic calcium ion transport GO:0060401 39 0.011
positive regulation of biosynthetic process GO:0009891 319 0.011
pigment biosynthetic process GO:0046148 4 0.011
lipid biosynthetic process GO:0008610 128 0.011
regulation of transporter activity GO:0032409 50 0.010
negative regulation of neurogenesis GO:0050768 78 0.010
regulation of neurogenesis GO:0050767 247 0.010
response to ethanol GO:0045471 162 0.010
myofibril assembly GO:0030239 6 0.010
regulation of mitotic sister chromatid separation GO:0010965 1 0.010
programmed cell death GO:0012501 392 0.010
negative regulation of cell communication GO:0010648 158 0.010
nucleoside monophosphate biosynthetic process GO:0009124 28 0.010
regulation of catabolic process GO:0009894 113 0.010
mechanoreceptor differentiation GO:0042490 2 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.010
cold acclimation GO:0009631 1 0.010
positive regulation of cellular amine metabolic process GO:0033240 3 0.010
appendage morphogenesis GO:0035107 4 0.010
negative regulation of multicellular organismal process GO:0051241 203 0.010
cellular response to peptide GO:1901653 133 0.010

Pgam2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.590
muscle tissue disease DOID:66 0 0.590
musculoskeletal system disease DOID:17 0 0.590
disease of anatomical entity DOID:7 0 0.590
heart disease DOID:114 0 0.547
intrinsic cardiomyopathy DOID:0060036 0 0.547
cardiovascular system disease DOID:1287 0 0.547
myopathy DOID:423 0 0.547
cardiomyopathy DOID:0050700 0 0.547
dilated cardiomyopathy DOID:12930 0 0.218
long qt syndrome DOID:2843 0 0.142
congenital heart disease DOID:1682 0 0.113
heart septal defect DOID:1681 0 0.113
hypertrophic cardiomyopathy DOID:11984 0 0.041
disease of metabolism DOID:0014667 0 0.035
heart conduction disease DOID:10273 0 0.030
muscular dystrophy DOID:9884 0 0.021
renal tubular transport disease DOID:447 0 0.019
kidney disease DOID:557 0 0.019
urinary system disease DOID:18 0 0.019
acquired metabolic disease DOID:0060158 0 0.011