Rattus norvegicus

37 known processes

Pgk1

phosphoglycerate kinase 1

(Aliases: Pgk,MGC105265)

Pgk1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carbohydrate catabolic process GO:0016052 40 0.977
pyridine containing compound metabolic process GO:0072524 32 0.829
single organism carbohydrate catabolic process GO:0044724 40 0.799
carboxylic acid metabolic process GO:0019752 289 0.765
cofactor metabolic process GO:0051186 95 0.707
nucleobase containing small molecule metabolic process GO:0055086 316 0.691
organic acid metabolic process GO:0006082 292 0.689
single organism biosynthetic process GO:0044711 342 0.674
nucleoside phosphate metabolic process GO:0006753 283 0.647
oxoacid metabolic process GO:0043436 290 0.571
nucleoside triphosphate metabolic process GO:0009141 144 0.514
coenzyme metabolic process GO:0006732 86 0.491
organophosphate metabolic process GO:0019637 370 0.403
carbohydrate derivative metabolic process GO:1901135 346 0.393
response to inorganic substance GO:0010035 377 0.383
monocarboxylic acid metabolic process GO:0032787 152 0.379
nad metabolic process GO:0019674 15 0.365
atp metabolic process GO:0046034 72 0.319
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.314
nucleoside metabolic process GO:0009116 179 0.314
pyruvate metabolic process GO:0006090 27 0.313
nucleotide metabolic process GO:0009117 279 0.279
response to oxidative stress GO:0006979 186 0.275
positive regulation of programmed cell death GO:0043068 157 0.274
positive regulation of cell death GO:0010942 184 0.270
response to camp GO:0051591 91 0.266
positive regulation of apoptotic process GO:0043065 154 0.246
negative regulation of gene expression GO:0010629 199 0.246
monosaccharide metabolic process GO:0005996 61 0.218
purine nucleoside monophosphate metabolic process GO:0009126 84 0.214
response to hypoxia GO:0001666 231 0.210
glycosyl compound metabolic process GO:1901657 182 0.197
regulation of apoptotic process GO:0042981 335 0.195
response to decreased oxygen levels GO:0036293 237 0.181
dicarboxylic acid metabolic process GO:0043648 42 0.180
regulation of programmed cell death GO:0043067 341 0.179
response to nutrient GO:0007584 248 0.172
programmed cell death GO:0012501 392 0.172
catabolic process GO:0009056 351 0.169
acetyl coa metabolic process GO:0006084 17 0.165
regulation of transcription dna templated GO:0006355 374 0.164
nicotinamide nucleotide metabolic process GO:0046496 28 0.157
oxidation reduction process GO:0055114 304 0.149
response to organophosphorus GO:0046683 102 0.148
cellular response to oxygen containing compound GO:1901701 386 0.144
apoptotic process GO:0006915 381 0.144
proteolysis GO:0006508 175 0.143
gluconeogenesis GO:0006094 15 0.141
purine ribonucleotide metabolic process GO:0009150 227 0.140
response to nutrient levels GO:0031667 370 0.139
purine nucleoside monophosphate biosynthetic process GO:0009127 20 0.136
purine nucleotide metabolic process GO:0006163 229 0.135
ribonucleoside triphosphate metabolic process GO:0009199 141 0.128
organic hydroxy compound metabolic process GO:1901615 115 0.126
negative regulation of metabolic process GO:0009892 331 0.118
oxidoreduction coenzyme metabolic process GO:0006733 31 0.114
single organism catabolic process GO:0044712 283 0.114
organophosphate biosynthetic process GO:0090407 143 0.110
organic substance catabolic process GO:1901575 316 0.106
response to oxygen levels GO:0070482 265 0.099
regulation of cellular component organization GO:0051128 368 0.098
nucleic acid templated transcription GO:0097659 379 0.093
pyridine nucleotide metabolic process GO:0019362 28 0.089
glucose metabolic process GO:0006006 52 0.089
cellular catabolic process GO:0044248 295 0.088
response to lipopolysaccharide GO:0032496 191 0.088
acyl coa metabolic process GO:0006637 28 0.088
cellular component assembly GO:0022607 360 0.087
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.084
regulation of cell proliferation GO:0042127 359 0.081
response to reactive oxygen species GO:0000302 120 0.080
ribonucleoside biosynthetic process GO:0042455 25 0.079
response to estrogen GO:0043627 232 0.078
ribonucleoside monophosphate metabolic process GO:0009161 88 0.077
regulation of neurogenesis GO:0050767 247 0.075
purine nucleotide biosynthetic process GO:0006164 83 0.075
nucleoside monophosphate metabolic process GO:0009123 93 0.074
single organism organelle organization GO:1902589 180 0.073
alpha amino acid metabolic process GO:1901605 71 0.072
purine nucleoside metabolic process GO:0042278 169 0.072
regulation of rna biosynthetic process GO:2001141 381 0.071
dicarboxylic acid catabolic process GO:0043649 1 0.071
rna biosynthetic process GO:0032774 380 0.069
hexose metabolic process GO:0019318 58 0.067
brain development GO:0007420 247 0.067
muscle structure development GO:0061061 87 0.064
purine containing compound metabolic process GO:0072521 253 0.064
negative regulation of rna metabolic process GO:0051253 123 0.063
negative regulation of apoptotic process GO:0043066 181 0.062
cellular response to peptide hormone stimulus GO:0071375 120 0.061
response to carbohydrate GO:0009743 183 0.061
skeletal muscle tissue regeneration GO:0043403 10 0.060
carbohydrate biosynthetic process GO:0016051 42 0.060
purine nucleoside triphosphate metabolic process GO:0009144 141 0.060
positive regulation of phosphorus metabolic process GO:0010562 262 0.059
response to purine containing compound GO:0014074 126 0.058
ion transmembrane transport GO:0034220 365 0.057
purine ribonucleoside metabolic process GO:0046128 168 0.056
regulation of neuron death GO:1901214 115 0.056
single organism reproductive process GO:0044702 297 0.056
protein complex subunit organization GO:0071822 302 0.056
regulation of nucleic acid templated transcription GO:1903506 380 0.054
nadh metabolic process GO:0006734 10 0.054
response to peptide GO:1901652 292 0.054
response to extracellular stimulus GO:0009991 380 0.054
response to hydrogen peroxide GO:0042542 89 0.053
response to molecule of bacterial origin GO:0002237 194 0.053
cofactor biosynthetic process GO:0051188 28 0.053
neuron apoptotic process GO:0051402 88 0.053
mitochondrion organization GO:0007005 35 0.051
membrane organization GO:0061024 94 0.050
regulation of molecular function GO:0065009 398 0.049
small molecule biosynthetic process GO:0044283 124 0.049
anatomical structure morphogenesis GO:0009653 298 0.049
response to estradiol GO:0032355 164 0.048
macromolecular complex assembly GO:0065003 273 0.047
cellular component biogenesis GO:0044085 368 0.046
head development GO:0060322 247 0.046
metal ion transport GO:0030001 289 0.046
establishment of protein localization GO:0045184 141 0.046
purine ribonucleoside biosynthetic process GO:0046129 21 0.045
cellular response to peptide GO:1901653 133 0.045
rna metabolic process GO:0016070 406 0.045
purine nucleoside biosynthetic process GO:0042451 21 0.042
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.042
organelle organization GO:0006996 266 0.042
negative regulation of cellular metabolic process GO:0031324 281 0.041
negative regulation of macromolecule metabolic process GO:0010605 260 0.041
response to acid chemical GO:0001101 222 0.041
ribonucleoside metabolic process GO:0009119 174 0.041
myoblast fusion GO:0007520 2 0.040
ribose phosphate metabolic process GO:0019693 235 0.040
sulfur compound biosynthetic process GO:0044272 19 0.039
positive regulation of cell proliferation GO:0008284 249 0.039
carbohydrate derivative biosynthetic process GO:1901137 124 0.039
central nervous system development GO:0007417 311 0.039
ribonucleotide metabolic process GO:0009259 231 0.039
reproductive process GO:0022414 372 0.039
cellular response to organonitrogen compound GO:0071417 197 0.038
response to glucose GO:0009749 136 0.038
negative regulation of cellular biosynthetic process GO:0031327 161 0.038
response to alkaloid GO:0043279 132 0.038
negative regulation of neuron death GO:1901215 69 0.037
protein complex biogenesis GO:0070271 263 0.037
regulation of nervous system development GO:0051960 264 0.037
organonitrogen compound biosynthetic process GO:1901566 167 0.037
cellular ketone metabolic process GO:0042180 51 0.037
response to other organism GO:0051707 220 0.036
localization of cell GO:0051674 202 0.036
cellular response to endogenous stimulus GO:0071495 377 0.036
response to bacterium GO:0009617 200 0.036
developmental process involved in reproduction GO:0003006 159 0.035
transcription dna templated GO:0006351 377 0.035
anatomical structure formation involved in morphogenesis GO:0048646 83 0.035
cellular carbohydrate metabolic process GO:0044262 72 0.034
positive regulation of cellular biosynthetic process GO:0031328 295 0.034
negative regulation of hydrogen peroxide biosynthetic process GO:0010730 2 0.034
cellular response to hormone stimulus GO:0032870 247 0.033
regulation of mitochondrion organization GO:0010821 7 0.033
energy derivation by oxidation of organic compounds GO:0015980 46 0.032
liver development GO:0001889 90 0.031
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.030
regulation of cell differentiation GO:0045595 320 0.030
acetyl coa biosynthetic process from pyruvate GO:0006086 5 0.030
positive regulation of cellular component organization GO:0051130 200 0.030
response to ammonium ion GO:0060359 71 0.030
aspartate family amino acid biosynthetic process GO:0009067 4 0.030
behavior GO:0007610 205 0.029
purine ribonucleoside monophosphate biosynthetic process GO:0009168 20 0.029
response to peptide hormone GO:0043434 278 0.029
response to hexose GO:0009746 144 0.029
neuron differentiation GO:0030182 368 0.028
regulation of phosphorus metabolic process GO:0051174 349 0.028
syncytium formation by plasma membrane fusion GO:0000768 3 0.028
transcription from rna polymerase ii promoter GO:0006366 252 0.027
growth GO:0040007 165 0.027
cation transmembrane transport GO:0098655 263 0.027
adp metabolic process GO:0046031 8 0.027
regulation of hydrogen peroxide biosynthetic process GO:0010728 2 0.027
gland development GO:0048732 155 0.027
single organism behavior GO:0044708 130 0.026
macromolecular complex subunit organization GO:0043933 339 0.026
cellular response to stress GO:0033554 269 0.026
cellular amine metabolic process GO:0044106 38 0.026
regulation of catalytic activity GO:0050790 304 0.026
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.026
regulation of rna metabolic process GO:0051252 391 0.025
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.025
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 31 0.025
transmembrane transport GO:0055085 412 0.024
response to biotic stimulus GO:0009607 226 0.024
cell type specific apoptotic process GO:0097285 134 0.024
negative regulation of growth GO:0045926 37 0.024
cellular homeostasis GO:0019725 252 0.024
oxidative phosphorylation GO:0006119 4 0.024
regulation of cell growth GO:0001558 85 0.024
amine metabolic process GO:0009308 38 0.024
purine nucleoside catabolic process GO:0006152 124 0.023
multi organism reproductive process GO:0044703 262 0.023
regulation of cellular ketone metabolic process GO:0010565 27 0.023
cellular response to oxygen levels GO:0071453 60 0.023
positive regulation of neurogenesis GO:0050769 165 0.022
purine ribonucleotide biosynthetic process GO:0009152 81 0.022
activation of cysteine type endopeptidase activity GO:0097202 4 0.022
alpha amino acid catabolic process GO:1901606 20 0.022
carbohydrate metabolic process GO:0005975 130 0.022
positive regulation of interferon gamma production GO:0032729 2 0.022
response to ketone GO:1901654 182 0.022
positive regulation of transcription dna templated GO:0045893 197 0.022
regulation of phosphate metabolic process GO:0019220 349 0.022
regulation of neuron projection development GO:0010975 161 0.022
regulation of cellular protein metabolic process GO:0032268 267 0.022
neuron projection development GO:0031175 273 0.022
regulation of protein metabolic process GO:0051246 289 0.021
membrane depolarization during action potential GO:0086010 1 0.021
lactate metabolic process GO:0006089 3 0.021
oxaloacetate metabolic process GO:0006107 6 0.021
negative regulation of nervous system development GO:0051961 79 0.021
macromolecule localization GO:0033036 252 0.021
positive regulation of cell projection organization GO:0031346 111 0.021
reproduction GO:0000003 245 0.021
positive regulation of developmental process GO:0051094 283 0.021
protein processing GO:0016485 68 0.021
intracellular protein transport GO:0006886 79 0.021
response to toxic substance GO:0009636 133 0.020
cell motility GO:0048870 202 0.020
monovalent inorganic cation transport GO:0015672 172 0.020
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.020
protein heterooligomerization GO:0051291 89 0.020
cellular amino acid biosynthetic process GO:0008652 32 0.020
negative regulation of protein processing GO:0010955 47 0.020
homeostatic process GO:0042592 331 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.020
positive regulation of cell differentiation GO:0045597 217 0.020
negative regulation of neurogenesis GO:0050768 78 0.020
response to monosaccharide GO:0034284 159 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.020
nucleotide biosynthetic process GO:0009165 98 0.020
cellular amino acid metabolic process GO:0006520 107 0.019
negative regulation of cell death GO:0060548 229 0.019
organonitrogen compound catabolic process GO:1901565 179 0.019
positive regulation of protein metabolic process GO:0051247 178 0.019
regulation of hydrolase activity GO:0051336 143 0.019
negative regulation of programmed cell death GO:0043069 183 0.019
inorganic ion transmembrane transport GO:0098660 229 0.019
response to corticosterone GO:0051412 40 0.019
generation of precursor metabolites and energy GO:0006091 62 0.019
negative regulation of multicellular organismal process GO:0051241 203 0.019
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 1 0.019
chemical homeostasis GO:0048878 292 0.019
response to glucocorticoid GO:0051384 223 0.018
carbohydrate homeostasis GO:0033500 75 0.018
ribonucleotide biosynthetic process GO:0009260 85 0.018
response to tumor cell GO:0002347 4 0.018
response to ethanol GO:0045471 162 0.018
cyclic purine nucleotide metabolic process GO:0052652 62 0.018
purine containing compound biosynthetic process GO:0072522 85 0.018
positive regulation of rna biosynthetic process GO:1902680 197 0.018
glial cell apoptotic process GO:0034349 8 0.018
regulation of hormone levels GO:0010817 187 0.018
purine nucleoside diphosphate metabolic process GO:0009135 9 0.018
cytoplasmic transport GO:0016482 115 0.018
protein complex assembly GO:0006461 263 0.017
neuron development GO:0048666 286 0.017
response to starvation GO:0042594 59 0.017
response to external biotic stimulus GO:0043207 221 0.017
secretion GO:0046903 307 0.017
positive regulation of nucleic acid templated transcription GO:1903508 197 0.017
organic acid biosynthetic process GO:0016053 83 0.017
nitrogen compound transport GO:0071705 229 0.017
lipid metabolic process GO:0006629 283 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.017
anion transmembrane transport GO:0098656 77 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
glutamate catabolic process GO:0006538 1 0.017
organ regeneration GO:0031100 101 0.017
male gamete generation GO:0048232 99 0.017
organic cyclic compound catabolic process GO:1901361 175 0.017
nucleoside phosphate catabolic process GO:1901292 140 0.017
negative regulation of cell development GO:0010721 82 0.016
anterior posterior pattern specification GO:0009952 1 0.016
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.016
regulation of multicellular organismal development GO:2000026 376 0.016
heart morphogenesis GO:0003007 3 0.016
mitotic dna damage checkpoint GO:0044773 1 0.016
aging GO:0007568 241 0.016
cellular response to hypoxia GO:0071456 51 0.016
cellular response to organic cyclic compound GO:0071407 202 0.016
cell migration GO:0016477 197 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
cell cycle GO:0007049 101 0.016
cell adhesion GO:0007155 110 0.016
carboxylic acid catabolic process GO:0046395 49 0.016
glutamine family amino acid metabolic process GO:0009064 15 0.016
response to metal ion GO:0010038 253 0.016
locomotion GO:0040011 237 0.016
ribonucleotide catabolic process GO:0009261 136 0.016
multicellular organism reproduction GO:0032504 233 0.016
protein localization GO:0008104 191 0.015
regulation of cell development GO:0060284 263 0.015
sexual reproduction GO:0019953 148 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
cellular protein localization GO:0034613 122 0.015
negative regulation of developmental process GO:0051093 125 0.015
purine nucleotide catabolic process GO:0006195 136 0.015
forebrain development GO:0030900 98 0.015
protein transport GO:0015031 132 0.015
protein maturation GO:0051604 68 0.015
cellular ion homeostasis GO:0006873 184 0.015
chemosensory behavior GO:0007635 2 0.014
negative regulation of cell communication GO:0010648 158 0.014
chromosome segregation GO:0007059 2 0.014
response to vitamin GO:0033273 131 0.014
reactive oxygen species metabolic process GO:0072593 37 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
positive regulation of neuron projection development GO:0010976 99 0.014
epithelium development GO:0060429 96 0.014
single organism cellular localization GO:1902580 102 0.014
regulation of endopeptidase activity GO:0052548 51 0.014
development of primary sexual characteristics GO:0045137 107 0.014
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 4 0.014
response to amine GO:0014075 46 0.014
regulation of proteolysis GO:0030162 66 0.014
regulation of growth GO:0040008 105 0.014
cation homeostasis GO:0055080 195 0.014
ion homeostasis GO:0050801 212 0.014
regulation of dendrite development GO:0050773 59 0.014
coenzyme biosynthetic process GO:0009108 22 0.014
camp metabolic process GO:0046058 63 0.014
cellular response to lipid GO:0071396 201 0.013
glutamine family amino acid biosynthetic process GO:0009084 2 0.013
thioester metabolic process GO:0035383 28 0.013
cell projection organization GO:0030030 302 0.013
negative regulation of transcription dna templated GO:0045892 116 0.013
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
cellular macromolecule localization GO:0070727 122 0.013
anion transport GO:0006820 178 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
regulation of cellular localization GO:0060341 263 0.013
positive regulation of neuron differentiation GO:0045666 126 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
regulation of reactive oxygen species metabolic process GO:2000377 26 0.013
regulation of anatomical structure size GO:0090066 135 0.013
response to wounding GO:0009611 254 0.013
phosphatidylinositol dephosphorylation GO:0046856 4 0.013
pyrimidine ribonucleotide biosynthetic process GO:0009220 5 0.013
cellular chemical homeostasis GO:0055082 247 0.013
positive regulation of molecular function GO:0044093 230 0.013
hormone secretion GO:0046879 115 0.013
single organism membrane organization GO:0044802 74 0.012
regeneration GO:0031099 163 0.012
positive regulation of cell development GO:0010720 176 0.012
cellular response to extracellular stimulus GO:0031668 73 0.012
negative regulation of hydrogen peroxide metabolic process GO:0010727 2 0.012
sex differentiation GO:0007548 113 0.012
regulation of lipid metabolic process GO:0019216 68 0.012
response to gravity GO:0009629 13 0.012
response to insulin GO:0032868 133 0.012
organophosphate catabolic process GO:0046434 148 0.012
hormone transport GO:0009914 121 0.012
single organism carbohydrate metabolic process GO:0044723 118 0.012
immune system development GO:0002520 41 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
positive regulation of rna metabolic process GO:0051254 203 0.012
positive regulation of response to stimulus GO:0048584 285 0.012
glycosyl compound catabolic process GO:1901658 126 0.012
atp catabolic process GO:0006200 54 0.012
neuron death GO:0070997 127 0.012
purine containing compound catabolic process GO:0072523 138 0.012
thioester biosynthetic process GO:0035384 7 0.012
reactive oxygen species biosynthetic process GO:1903409 8 0.011
cardiac chamber development GO:0003205 1 0.011
ribonucleoside triphosphate catabolic process GO:0009203 122 0.011
secretion by cell GO:0032940 248 0.011
gamete generation GO:0007276 124 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.011
purine ribonucleoside diphosphate biosynthetic process GO:0009180 9 0.011
nucleotide phosphorylation GO:0046939 8 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
acyl coa biosynthetic process GO:0071616 7 0.011
hippocampus development GO:0021766 30 0.011
somatic cell dna recombination GO:0016444 2 0.011
response to cytokine GO:0034097 215 0.011
regulation of peptidase activity GO:0052547 55 0.011
negative regulation of cell differentiation GO:0045596 99 0.011
inflammatory response GO:0006954 150 0.011
regulation of cell projection organization GO:0031344 175 0.011
ribonucleoside catabolic process GO:0042454 126 0.011
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.011
female pregnancy GO:0007565 122 0.011
pyrimidine nucleotide biosynthetic process GO:0006221 9 0.011
regulation of response to tumor cell GO:0002834 3 0.011
regulation of ion transmembrane transport GO:0034765 121 0.011
b cell mediated immunity GO:0019724 4 0.011
purine nucleoside monophosphate catabolic process GO:0009128 55 0.011
response to transition metal nanoparticle GO:1990267 122 0.011
response to corticosteroid GO:0031960 235 0.011
positive regulation of transport GO:0051050 245 0.010
cellular cation homeostasis GO:0030003 180 0.010
cellular response to external stimulus GO:0071496 118 0.010
neurological system process GO:0050877 219 0.010
telencephalon development GO:0021537 62 0.010
aerobic respiration GO:0009060 13 0.010
positive regulation of multicellular organismal process GO:0051240 387 0.010
multi multicellular organism process GO:0044706 138 0.010
behavioral response to ethanol GO:0048149 1 0.010
regulation of system process GO:0044057 208 0.010
sulfur compound metabolic process GO:0006790 70 0.010
reproductive system development GO:0061458 128 0.010
cellular response to insulin stimulus GO:0032869 81 0.010
regulation of signal transduction GO:0009966 318 0.010
cell cell signaling GO:0007267 335 0.010
signal release GO:0023061 145 0.010
positive regulation of camp metabolic process GO:0030816 31 0.010
regulation of purine nucleotide metabolic process GO:1900542 115 0.010
developmental growth GO:0048589 100 0.010
positive regulation of nervous system development GO:0051962 178 0.010
regulation of transferase activity GO:0051338 123 0.010
response to fatty acid GO:0070542 65 0.010
immune response GO:0006955 104 0.010
positive regulation of cellular protein metabolic process GO:0032270 167 0.010

Pgk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.019
central nervous system disease DOID:331 0 0.018