Rattus norvegicus

0 known processes

Phc2

polyhomeotic homolog 2 (Drosophila)

(Aliases: MGC105958)

Phc2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
intracellular signal transduction GO:0035556 314 0.161
regulation of intracellular signal transduction GO:1902531 218 0.126
apoptotic process GO:0006915 381 0.083
positive regulation of cell communication GO:0010647 271 0.080
negative regulation of cell death GO:0060548 229 0.077
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.076
rna metabolic process GO:0016070 406 0.066
positive regulation of signaling GO:0023056 270 0.061
positive regulation of signal transduction GO:0009967 175 0.058
regulation of transcription dna templated GO:0006355 374 0.057
cell projection organization GO:0030030 302 0.055
response to other organism GO:0051707 220 0.055
regulation of alternative mrna splicing via spliceosome GO:0000381 2 0.055
regulation of rna metabolic process GO:0051252 391 0.053
positive regulation of response to stimulus GO:0048584 285 0.050
positive regulation of phosphate metabolic process GO:0045937 262 0.048
neuron development GO:0048666 286 0.046
spindle organization GO:0007051 2 0.046
positive regulation of intracellular signal transduction GO:1902533 138 0.045
regulation of apoptotic process GO:0042981 335 0.045
regulation of rna biosynthetic process GO:2001141 381 0.044
cellular response to stress GO:0033554 269 0.044
regulation of programmed cell death GO:0043067 341 0.042
rna biosynthetic process GO:0032774 380 0.039
positive regulation of humoral immune response GO:0002922 2 0.039
cellular component assembly GO:0022607 360 0.038
regulation of phosphate metabolic process GO:0019220 349 0.037
cellular component biogenesis GO:0044085 368 0.035
negative regulation of cellular biosynthetic process GO:0031327 161 0.034
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.034
neuron differentiation GO:0030182 368 0.034
enzyme linked receptor protein signaling pathway GO:0007167 116 0.033
positive regulation of biosynthetic process GO:0009891 319 0.033
positive regulation of apoptotic process GO:0043065 154 0.033
regulation of response to stress GO:0080134 126 0.033
positive regulation of cell death GO:0010942 184 0.032
defense response to other organism GO:0098542 17 0.031
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.031
regulation of signal transduction GO:0009966 318 0.031
programmed cell death GO:0012501 392 0.030
reproduction GO:0000003 245 0.030
cellular response to growth factor stimulus GO:0071363 162 0.030
negative regulation of cellular metabolic process GO:0031324 281 0.030
catabolic process GO:0009056 351 0.030
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.030
regulation of cellular localization GO:0060341 263 0.028
regulation of molecular function GO:0065009 398 0.028
neuron projection development GO:0031175 273 0.028
response to nutrient levels GO:0031667 370 0.027
negative regulation of rna biosynthetic process GO:1902679 118 0.027
regulation of mrna splicing via spliceosome GO:0048024 3 0.027
negative regulation of macromolecule metabolic process GO:0010605 260 0.027
macromolecular complex subunit organization GO:0043933 339 0.027
transcription from rna polymerase ii promoter GO:0006366 252 0.027
regulation of multicellular organismal development GO:2000026 376 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.026
peptide biosynthetic process GO:0043043 3 0.026
multi multicellular organism process GO:0044706 138 0.026
positive regulation of nucleic acid templated transcription GO:1903508 197 0.026
cellular response to oxygen containing compound GO:1901701 386 0.026
cell adhesion GO:0007155 110 0.025
response to nutrient GO:0007584 248 0.025
regulation of nucleic acid templated transcription GO:1903506 380 0.024
cellular response to reactive oxygen species GO:0034614 55 0.024
transcription dna templated GO:0006351 377 0.024
response to metal ion GO:0010038 253 0.024
macromolecular complex assembly GO:0065003 273 0.024
immune response GO:0006955 104 0.024
purine nucleotide metabolic process GO:0006163 229 0.023
response to mechanical stimulus GO:0009612 134 0.023
response to biotic stimulus GO:0009607 226 0.023
reproductive process GO:0022414 372 0.023
positive regulation of cellular biosynthetic process GO:0031328 295 0.023
cellular amine metabolic process GO:0044106 38 0.023
cytoskeleton organization GO:0007010 111 0.023
protein complex biogenesis GO:0070271 263 0.022
regulation of cellular ketone metabolic process GO:0010565 27 0.022
positive regulation of rna metabolic process GO:0051254 203 0.022
organelle organization GO:0006996 266 0.022
cellular amino acid metabolic process GO:0006520 107 0.021
response to oxidative stress GO:0006979 186 0.021
amine metabolic process GO:0009308 38 0.021
defense response GO:0006952 194 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.020
response to cytokine GO:0034097 215 0.020
cellular response to tumor necrosis factor GO:0071356 46 0.020
multicellular organism growth GO:0035264 1 0.020
nucleoside metabolic process GO:0009116 179 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
aging GO:0007568 241 0.019
regulation of phosphorus metabolic process GO:0051174 349 0.019
positive regulation of jnk cascade GO:0046330 13 0.019
cellular response to cytokine stimulus GO:0071345 127 0.019
regulation of neurogenesis GO:0050767 247 0.019
cellular macromolecule localization GO:0070727 122 0.019
regulation of nervous system development GO:0051960 264 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
negative regulation of rna metabolic process GO:0051253 123 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
positive regulation of protein metabolic process GO:0051247 178 0.018
positive regulation of cellular amine metabolic process GO:0033240 3 0.018
positive regulation of programmed cell death GO:0043068 157 0.018
regulation of cell development GO:0060284 263 0.018
protein localization GO:0008104 191 0.018
regulation of cellular component organization GO:0051128 368 0.018
response to inorganic substance GO:0010035 377 0.018
protein complex subunit organization GO:0071822 302 0.017
stress activated protein kinase signaling cascade GO:0031098 37 0.017
multicellular organismal reproductive process GO:0048609 233 0.017
g protein coupled receptor signaling pathway GO:0007186 242 0.017
protein complex assembly GO:0006461 263 0.017
multi organism reproductive process GO:0044703 262 0.017
organic substance catabolic process GO:1901575 316 0.017
intracellular transport GO:0046907 185 0.017
response to lipopolysaccharide GO:0032496 191 0.017
cellular ketone metabolic process GO:0042180 51 0.017
regulation of cell projection organization GO:0031344 175 0.017
brain development GO:0007420 247 0.016
sensory organ development GO:0007423 74 0.016
negative regulation of transcription dna templated GO:0045892 116 0.016
tissue development GO:0009888 252 0.016
nucleoside phosphate metabolic process GO:0006753 283 0.016
response to growth factor GO:0070848 189 0.016
nucleic acid templated transcription GO:0097659 379 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
cellular response to oxidative stress GO:0034599 76 0.016
ribonucleotide metabolic process GO:0009259 231 0.016
positive regulation of cell proliferation GO:0008284 249 0.016
macromolecule localization GO:0033036 252 0.016
positive regulation of cell development GO:0010720 176 0.016
defense response to gram negative bacterium GO:0050829 3 0.015
regulation of cellular amine metabolic process GO:0033238 8 0.015
vesicle mediated transport GO:0016192 181 0.015
response to tumor necrosis factor GO:0034612 56 0.015
cell part morphogenesis GO:0032990 123 0.015
positive regulation of molecular function GO:0044093 230 0.015
response to ketone GO:1901654 182 0.015
regulation of cellular amino acid metabolic process GO:0006521 2 0.015
response to external biotic stimulus GO:0043207 221 0.015
regulation of cellular response to stress GO:0080135 49 0.015
regulation of response to external stimulus GO:0032101 106 0.015
single organism intracellular transport GO:1902582 166 0.015
purine containing compound metabolic process GO:0072521 253 0.014
response to estrogen GO:0043627 232 0.014
negative regulation of developmental process GO:0051093 125 0.014
negative regulation of programmed cell death GO:0043069 183 0.014
head development GO:0060322 247 0.014
cell type specific apoptotic process GO:0097285 134 0.014
ras protein signal transduction GO:0007265 29 0.014
purine nucleotide catabolic process GO:0006195 136 0.014
single organism organelle organization GO:1902589 180 0.014
positive regulation of phosphorus metabolic process GO:0010562 262 0.014
protein phosphorylation GO:0006468 345 0.014
amide transport GO:0042886 105 0.013
transforming growth factor beta receptor signaling pathway GO:0007179 18 0.013
peptide transport GO:0015833 97 0.013
cell cycle checkpoint GO:0000075 2 0.013
ribose phosphate metabolic process GO:0019693 235 0.013
regulation of catalytic activity GO:0050790 304 0.013
positive regulation of protein phosphorylation GO:0001934 135 0.013
positive regulation of nervous system development GO:0051962 178 0.013
cellular response to abiotic stimulus GO:0071214 85 0.013
carboxylic acid metabolic process GO:0019752 289 0.013
small gtpase mediated signal transduction GO:0007264 36 0.013
cellular catabolic process GO:0044248 295 0.013
cytoplasmic transport GO:0016482 115 0.013
response to extracellular stimulus GO:0009991 380 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
regulation of peptide transport GO:0090087 87 0.013
mitotic spindle organization GO:0007052 2 0.013
negative regulation of nucleic acid templated transcription GO:1903507 117 0.013
defense response to fungus GO:0050832 1 0.013
protein oligomerization GO:0051259 191 0.013
cellular response to endogenous stimulus GO:0071495 377 0.013
neuron death GO:0070997 127 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
response to hydrogen peroxide GO:0042542 89 0.012
central nervous system development GO:0007417 311 0.012
positive regulation of catalytic activity GO:0043085 184 0.012
nitrogen compound transport GO:0071705 229 0.012
amide biosynthetic process GO:0043604 10 0.012
insulin receptor signaling pathway GO:0008286 24 0.012
single organism catabolic process GO:0044712 283 0.012
proteolysis GO:0006508 175 0.012
negative regulation of innate immune response GO:0045824 4 0.012
purine nucleoside metabolic process GO:0042278 169 0.012
regulation of neuron projection development GO:0010975 161 0.012
positive regulation of cell differentiation GO:0045597 217 0.012
negative regulation of response to stimulus GO:0048585 155 0.012
response to peptide hormone GO:0043434 278 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
nucleotide catabolic process GO:0009166 139 0.012
oxoacid metabolic process GO:0043436 290 0.012
negative regulation of gene expression GO:0010629 199 0.011
response to amino acid GO:0043200 75 0.011
positive regulation of cell projection organization GO:0031346 111 0.011
rho protein signal transduction GO:0007266 11 0.011
regulation of cell proliferation GO:0042127 359 0.011
response to transforming growth factor beta GO:0071559 46 0.011
regulation of mapk cascade GO:0043408 116 0.011
activation of cysteine type endopeptidase activity GO:0097202 4 0.011
female sex differentiation GO:0046660 59 0.011
negative regulation of metabolic process GO:0009892 331 0.011
regulation of cell differentiation GO:0045595 320 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
secretion GO:0046903 307 0.011
biological adhesion GO:0022610 110 0.011
regulation of hormone levels GO:0010817 187 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
response to estradiol GO:0032355 164 0.011
response to decreased oxygen levels GO:0036293 237 0.011
response to oxygen levels GO:0070482 265 0.011
regulation of odontogenesis GO:0042481 4 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.010
positive regulation of cellular component organization GO:0051130 200 0.010
ribonucleoside metabolic process GO:0009119 174 0.010
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.010
organic acid metabolic process GO:0006082 292 0.010
regulation of stress activated mapk cascade GO:0032872 23 0.010
negative regulation of signaling GO:0023057 157 0.010
glycosyl compound metabolic process GO:1901657 182 0.010
carbohydrate derivative metabolic process GO:1901135 346 0.010

Phc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.013
muscular disease DOID:0080000 0 0.013
muscle tissue disease DOID:66 0 0.013
musculoskeletal system disease DOID:17 0 0.013
sensory system disease DOID:0050155 0 0.012
nervous system disease DOID:863 0 0.012
eye disease DOID:5614 0 0.012
eye and adnexa disease DOID:1492 0 0.012