Rattus norvegicus

49 known processes

Pik3r3

phosphoinositide-3-kinase, regulatory subunit 3 (gamma)

Pik3r3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular component biogenesis GO:0044085 368 0.244
regulation of catalytic activity GO:0050790 304 0.230
nucleobase containing small molecule metabolic process GO:0055086 316 0.156
regulation of multicellular organismal development GO:2000026 376 0.155
Rat
regulation of rho gtpase activity GO:0032319 17 0.141
ribonucleotide catabolic process GO:0009261 136 0.133
single organism catabolic process GO:0044712 283 0.125
organophosphate metabolic process GO:0019637 370 0.125
aromatic compound catabolic process GO:0019439 168 0.120
organophosphate catabolic process GO:0046434 148 0.114
intracellular signal transduction GO:0035556 314 0.113
regulation of molecular function GO:0065009 398 0.105
transcription dna templated GO:0006351 377 0.103
purine ribonucleoside metabolic process GO:0046128 168 0.101
cellular catabolic process GO:0044248 295 0.096
embryonic skeletal system development GO:0048706 3 0.095
cellular component assembly GO:0022607 360 0.091
nucleoside phosphate catabolic process GO:1901292 140 0.090
nucleoside triphosphate catabolic process GO:0009143 123 0.090
ribonucleoside metabolic process GO:0009119 174 0.089
purine ribonucleoside catabolic process GO:0046130 124 0.088
purine nucleoside triphosphate catabolic process GO:0009146 122 0.085
negative regulation of metabolic process GO:0009892 331 0.082
Rat
regulation of transcription dna templated GO:0006355 374 0.081
nucleotide catabolic process GO:0009166 139 0.080
purine containing compound catabolic process GO:0072523 138 0.079
cell motility GO:0048870 202 0.075
Rat
neuron differentiation GO:0030182 368 0.071
catabolic process GO:0009056 351 0.070
negative regulation of cellular metabolic process GO:0031324 281 0.069
Rat
ribonucleotide metabolic process GO:0009259 231 0.069
cell projection organization GO:0030030 302 0.067
macromolecular complex subunit organization GO:0043933 339 0.067
purine nucleoside catabolic process GO:0006152 124 0.067
ribose phosphate metabolic process GO:0019693 235 0.067
nucleoside catabolic process GO:0009164 126 0.065
anatomical structure morphogenesis GO:0009653 298 0.065
rna metabolic process GO:0016070 406 0.064
apoptotic process GO:0006915 381 0.064
Rat
neuron development GO:0048666 286 0.063
organelle organization GO:0006996 266 0.062
nucleotide metabolic process GO:0009117 279 0.060
proteolysis GO:0006508 175 0.060
Rat
regulation of nucleic acid templated transcription GO:1903506 380 0.060
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.059
carbohydrate derivative metabolic process GO:1901135 346 0.059
regulation of cellular component organization GO:0051128 368 0.058
neuron projection morphogenesis GO:0048812 122 0.058
glycosyl compound catabolic process GO:1901658 126 0.057
organonitrogen compound catabolic process GO:1901565 179 0.056
ribonucleoside triphosphate catabolic process GO:0009203 122 0.056
ribonucleoside triphosphate metabolic process GO:0009199 141 0.055
macromolecular complex assembly GO:0065003 273 0.055
axonogenesis GO:0007409 71 0.054
nucleoside metabolic process GO:0009116 179 0.054
developmental growth GO:0048589 100 0.053
mesenchymal cell proliferation GO:0010463 4 0.053
purine ribonucleotide metabolic process GO:0009150 227 0.053
female gonad development GO:0008585 53 0.052
positive regulation of nervous system development GO:0051962 178 0.051
regulation of secretion GO:0051046 224 0.051
carboxylic acid metabolic process GO:0019752 289 0.051
heterocycle catabolic process GO:0046700 167 0.050
single organism organelle organization GO:1902589 180 0.049
carbohydrate derivative catabolic process GO:1901136 147 0.048
neuron projection development GO:0031175 273 0.048
regulation of rna biosynthetic process GO:2001141 381 0.048
purine ribonucleotide catabolic process GO:0009154 136 0.048
protein complex assembly GO:0006461 263 0.046
ribonucleoside catabolic process GO:0042454 126 0.046
purine containing compound metabolic process GO:0072521 253 0.046
purine nucleoside metabolic process GO:0042278 169 0.046
positive regulation of cellular component organization GO:0051130 200 0.045
positive regulation of hydrolase activity GO:0051345 86 0.045
negative regulation of gene expression GO:0010629 199 0.045
Rat
glycosyl compound metabolic process GO:1901657 182 0.045
cell cell signaling GO:0007267 335 0.044
monovalent inorganic cation transport GO:0015672 172 0.044
small gtpase mediated signal transduction GO:0007264 36 0.044
regulation of cell projection organization GO:0031344 175 0.044
heart morphogenesis GO:0003007 3 0.043
olfactory bulb interneuron differentiation GO:0021889 1 0.041
nucleic acid templated transcription GO:0097659 379 0.041
organic substance catabolic process GO:1901575 316 0.041
nucleoside triphosphate metabolic process GO:0009141 144 0.040
multicellular organismal reproductive process GO:0048609 233 0.040
head development GO:0060322 247 0.040
regulation of hydrolase activity GO:0051336 143 0.040
cellular nitrogen compound catabolic process GO:0044270 163 0.040
gtp catabolic process GO:0006184 71 0.039
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.039
glandular epithelial cell differentiation GO:0002067 4 0.039
purine nucleoside triphosphate metabolic process GO:0009144 141 0.039
regulation of mesenchymal cell proliferation GO:0010464 4 0.039
positive regulation of cell development GO:0010720 176 0.038
anterior posterior pattern specification GO:0009952 1 0.038
synaptic transmission GO:0007268 235 0.038
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.037
regulation of phosphorus metabolic process GO:0051174 349 0.037
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.036
purine nucleotide catabolic process GO:0006195 136 0.036
central nervous system development GO:0007417 311 0.036
developmental process involved in reproduction GO:0003006 159 0.035
inorganic cation transmembrane transport GO:0098662 202 0.035
positive regulation of catalytic activity GO:0043085 184 0.035
reproductive structure development GO:0048608 128 0.034
guanosine containing compound catabolic process GO:1901069 71 0.034
regulation of signal transduction GO:0009966 318 0.033
organic acid metabolic process GO:0006082 292 0.033
inorganic ion transmembrane transport GO:0098660 229 0.033
regulation of neurogenesis GO:0050767 247 0.033
positive regulation of gtp catabolic process GO:0033126 48 0.032
nucleobase containing compound catabolic process GO:0034655 152 0.032
organic cyclic compound catabolic process GO:1901361 175 0.031
regulation of exocytosis GO:0017157 37 0.031
positive regulation of transport GO:0051050 245 0.031
positive regulation of neuron differentiation GO:0045666 126 0.031
regulation of small gtpase mediated signal transduction GO:0051056 48 0.031
regulation of phosphate metabolic process GO:0019220 349 0.031
purine nucleotide metabolic process GO:0006163 229 0.030
establishment of vesicle localization GO:0051650 31 0.030
cerebral cortex tangential migration GO:0021800 1 0.030
protein complex biogenesis GO:0070271 263 0.030
cellular component morphogenesis GO:0032989 155 0.030
vesicle mediated transport GO:0016192 181 0.030
rhythmic process GO:0048511 156 0.029
regulation of neuron differentiation GO:0045664 208 0.029
dendrite development GO:0016358 72 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.029
nucleoside phosphate metabolic process GO:0006753 283 0.029
circulatory system development GO:0072359 134 0.028
negative regulation of cellular biosynthetic process GO:0031327 161 0.028
cell projection morphogenesis GO:0048858 123 0.028
ras protein signal transduction GO:0007265 29 0.027
tissue development GO:0009888 252 0.027
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.027
cellular amino acid metabolic process GO:0006520 107 0.027
positive regulation of gtpase activity GO:0043547 47 0.027
exocytosis GO:0006887 60 0.027
regulation of cell differentiation GO:0045595 320 0.027
Rat
synaptic growth at neuromuscular junction GO:0051124 1 0.026
regulation of nucleotide catabolic process GO:0030811 65 0.026
regulation of nervous system development GO:0051960 264 0.026
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.026
regulation of purine nucleotide metabolic process GO:1900542 115 0.026
positive regulation of cell differentiation GO:0045597 217 0.026
Rat
protein oligomerization GO:0051259 191 0.026
vesicle organization GO:0016050 29 0.025
gastrulation GO:0007369 2 0.025
brain development GO:0007420 247 0.025
positive regulation of developmental process GO:0051094 283 0.024
Rat
neuron projection guidance GO:0097485 24 0.024
negative regulation of multicellular organismal process GO:0051241 203 0.024
Rat
regulation of anatomical structure morphogenesis GO:0022603 141 0.024
eye morphogenesis GO:0048592 4 0.024
regulation of neuron projection development GO:0010975 161 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.023
Rat
cellular component movement GO:0006928 248 0.023
Rat
embryonic pattern specification GO:0009880 1 0.023
regulation of protein metabolic process GO:0051246 289 0.023
Rat
regulation of cellular component biogenesis GO:0044087 86 0.023
programmed cell death GO:0012501 392 0.023
Rat
positive regulation of cell projection organization GO:0031346 111 0.023
postnatal olfactory bulb interneuron migration GO:0021827 1 0.023
development of primary female sexual characteristics GO:0046545 56 0.023
tangential migration from the subventricular zone to the olfactory bulb GO:0022028 1 0.022
synaptic vesicle endocytosis GO:0048488 4 0.022
transforming growth factor beta3 production GO:0032907 2 0.022
ion homeostasis GO:0050801 212 0.022
sulfur compound metabolic process GO:0006790 70 0.022
negative regulation of developmental process GO:0051093 125 0.022
immune system process GO:0002376 204 0.022
regulation of peptidase activity GO:0052547 55 0.021
neuromuscular synaptic transmission GO:0007274 2 0.021
positive regulation of neuron projection development GO:0010976 99 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
cell part morphogenesis GO:0032990 123 0.021
male mating behavior GO:0060179 3 0.021
regulation of gtpase activity GO:0043087 57 0.021
positive regulation of molecular function GO:0044093 230 0.021
guanosine containing compound metabolic process GO:1901068 74 0.021
lipid metabolic process GO:0006629 283 0.021
regulation of programmed cell death GO:0043067 341 0.021
Rat
single organism membrane organization GO:0044802 74 0.021
tissue morphogenesis GO:0048729 22 0.021
regulation of nucleotide metabolic process GO:0006140 117 0.020
formation of primary germ layer GO:0001704 1 0.020
potassium ion transport GO:0006813 97 0.020
protein tetramerization GO:0051262 38 0.020
regulation of ras gtpase activity GO:0032318 32 0.020
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.019
embryonic skeletal system morphogenesis GO:0048704 3 0.019
carboxylic acid biosynthetic process GO:0046394 83 0.019
rho protein signal transduction GO:0007266 11 0.019
positive regulation of rho gtpase activity GO:0032321 13 0.019
actin filament based process GO:0030029 86 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.019
oxoacid metabolic process GO:0043436 290 0.019
regulation of secretion by cell GO:1903530 208 0.019
ureteric bud development GO:0001657 14 0.019
sexual reproduction GO:0019953 148 0.019
metal ion transport GO:0030001 289 0.019
organ formation GO:0048645 3 0.019
cellular macromolecule localization GO:0070727 122 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
response to inorganic substance GO:0010035 377 0.019
Rat
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
female sex differentiation GO:0046660 59 0.018
regulation of purine nucleotide catabolic process GO:0033121 65 0.018
divalent inorganic cation homeostasis GO:0072507 165 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.018
neural crest cell development GO:0014032 2 0.018
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 3 0.018
positive regulation of nucleotide catabolic process GO:0030813 53 0.018
embryonic morphogenesis GO:0048598 14 0.018
multicellular organism growth GO:0035264 1 0.018
protein maturation GO:0051604 68 0.018
Rat
regulation of rna metabolic process GO:0051252 391 0.018
regulation of apoptotic process GO:0042981 335 0.018
Rat
single organism reproductive process GO:0044702 297 0.017
small molecule biosynthetic process GO:0044283 124 0.017
mesoderm development GO:0007498 2 0.017
positive regulation of gene expression GO:0010628 244 0.017
Rat
axon development GO:0061564 96 0.017
ovulation cycle process GO:0022602 50 0.017
negative regulation of cellular protein metabolic process GO:0032269 106 0.017
Rat
cellular response to organic cyclic compound GO:0071407 202 0.017
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 4 0.017
development of primary sexual characteristics GO:0045137 107 0.017
regulation of cell development GO:0060284 263 0.017
Rat
salivary gland development GO:0007431 3 0.017
regulation of nucleoside metabolic process GO:0009118 66 0.017
cytoskeleton dependent cytokinesis GO:0061640 2 0.017
tube formation GO:0035148 3 0.017
rna biosynthetic process GO:0032774 380 0.017
reproduction GO:0000003 245 0.016
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.016
regulation of proteolysis GO:0030162 66 0.016
Rat
ovarian follicle development GO:0001541 31 0.016
morphogenesis of embryonic epithelium GO:0016331 3 0.016
germ cell migration GO:0008354 1 0.016
axis specification GO:0009798 4 0.016
cell adhesion GO:0007155 110 0.016
Rat
cerebral cortex tangential migration using cell cell interactions GO:0021823 1 0.016
synaptic vesicle transport GO:0048489 23 0.016
myeloid leukocyte activation GO:0002274 36 0.016
regulation of canonical wnt signaling pathway GO:0060828 4 0.016
response to decreased oxygen levels GO:0036293 237 0.016
sensory organ development GO:0007423 74 0.016
camera type eye development GO:0043010 48 0.016
regulation of embryonic development GO:0045995 2 0.015
positive regulation of multicellular organismal process GO:0051240 387 0.015
biological adhesion GO:0022610 110 0.015
Rat
negative regulation of biosynthetic process GO:0009890 168 0.015
negative regulation of monooxygenase activity GO:0032769 3 0.015
positive regulation of nucleoside metabolic process GO:0045979 55 0.015
cation homeostasis GO:0055080 195 0.015
vesicle localization GO:0051648 33 0.015
adult locomotory behavior GO:0008344 4 0.015
male gamete generation GO:0048232 99 0.015
regulation of gtp catabolic process GO:0033124 58 0.015
cell cell signaling involved in cell fate commitment GO:0045168 2 0.015
cellular amine metabolic process GO:0044106 38 0.015
ion transmembrane transport GO:0034220 365 0.015
regulation of developmental growth GO:0048638 45 0.015
regulation of cellular localization GO:0060341 263 0.015
specification of organ identity GO:0010092 2 0.015
hematopoietic progenitor cell differentiation GO:0002244 2 0.015
positive regulation of neurogenesis GO:0050769 165 0.014
regulation of catabolic process GO:0009894 113 0.014
intracellular transport GO:0046907 185 0.014
alpha amino acid metabolic process GO:1901605 71 0.014
epithelial cell differentiation GO:0030855 71 0.014
spermatogenesis GO:0007283 99 0.014
learning or memory GO:0007611 90 0.014
angiogenesis GO:0001525 53 0.014
nucleoside phosphate biosynthetic process GO:1901293 102 0.014
cellular macromolecular complex assembly GO:0034622 58 0.014
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.014
positive regulation of secretion GO:0051047 140 0.014
localization of cell GO:0051674 202 0.014
Rat
behavior GO:0007610 205 0.014
heart development GO:0007507 72 0.014
gtp metabolic process GO:0046039 72 0.014
lipid biosynthetic process GO:0008610 128 0.014
mesonephros development GO:0001823 14 0.014
striated muscle tissue development GO:0014706 58 0.014
Rat
epithelium development GO:0060429 96 0.014
homeostatic process GO:0042592 331 0.013
regeneration GO:0031099 163 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
positive regulation of catabolic process GO:0009896 78 0.013
embryonic cranial skeleton morphogenesis GO:0048701 2 0.013
negative regulation of signaling GO:0023057 157 0.013
regulation of cellular amino acid metabolic process GO:0006521 2 0.013
positive regulation of cellular biosynthetic process GO:0031328 295 0.013
positive regulation of ras gtpase activity GO:0032320 28 0.013
potassium ion transmembrane transport GO:0071805 71 0.013
protein processing GO:0016485 68 0.013
Rat
cellular response to stress GO:0033554 269 0.013
signal release GO:0023061 145 0.013
actin cytoskeleton organization GO:0030036 73 0.013
negative regulation of macromolecule metabolic process GO:0010605 260 0.013
Rat
cell migration GO:0016477 197 0.013
Rat
gonad development GO:0008406 104 0.013
atp catabolic process GO:0006200 54 0.013
mesonephric tubule development GO:0072164 14 0.013
membrane docking GO:0022406 6 0.013
negative regulation of osteoblast differentiation GO:0045668 2 0.013
negative regulation of neuron differentiation GO:0045665 62 0.013
secretion by cell GO:0032940 248 0.013
defecation GO:0030421 1 0.013
mesoderm morphogenesis GO:0048332 1 0.013
embryo development GO:0009790 49 0.013
response to wounding GO:0009611 254 0.013
negative regulation of molecular function GO:0044092 133 0.013
transmembrane transport GO:0055085 412 0.013
protein homotetramerization GO:0051289 25 0.013
neural crest cell differentiation GO:0014033 2 0.013
positive regulation of rna biosynthetic process GO:1902680 197 0.012
epithelial tube formation GO:0072175 3 0.012
glycerophospholipid metabolic process GO:0006650 47 0.012
secretion GO:0046903 307 0.012
regulation of ras protein signal transduction GO:0046578 45 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.012
muscle tissue development GO:0060537 58 0.012
Rat
anatomical structure formation involved in morphogenesis GO:0048646 83 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.012
regulation of ion transport GO:0043269 245 0.012
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 4 0.012
anion transport GO:0006820 178 0.012
hemopoiesis GO:0030097 34 0.012
cation transport GO:0006812 382 0.012
mesoderm formation GO:0001707 1 0.012
sex differentiation GO:0007548 113 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
regulation of phosphorylation GO:0042325 248 0.012
cytoskeleton organization GO:0007010 111 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.012
regulation of cell motility GO:2000145 131 0.012
Rat
blood vessel development GO:0001568 69 0.012
regulation of cellular ketone metabolic process GO:0010565 27 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.012
regulation of endopeptidase activity GO:0052548 51 0.012
negative regulation of nervous system development GO:0051961 79 0.012
activation of cysteine type endopeptidase activity GO:0097202 4 0.012
single organism intracellular transport GO:1902582 166 0.012
response to monosaccharide GO:0034284 159 0.012
Rat
mesodermal cell differentiation GO:0048333 1 0.012
cytosolic calcium ion homeostasis GO:0051480 140 0.012
transcription from rna polymerase ii promoter GO:0006366 252 0.012
regulation of protein modification process GO:0031399 194 0.012
Rat
molting cycle GO:0042303 3 0.011
chemical homeostasis GO:0048878 292 0.011
divalent inorganic cation transport GO:0072511 134 0.011
growth GO:0040007 165 0.011
mesonephric epithelium development GO:0072163 14 0.011
regulation of organ formation GO:0003156 2 0.011
negative regulation of transcription dna templated GO:0045892 116 0.011
single organism biosynthetic process GO:0044711 342 0.011
negative regulation of programmed cell death GO:0043069 183 0.011
Rat
skin morphogenesis GO:0043589 2 0.011
organonitrogen compound biosynthetic process GO:1901566 167 0.011
reproductive process GO:0022414 372 0.011
endomembrane system organization GO:0010256 48 0.011
multicellular organism reproduction GO:0032504 233 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
forebrain development GO:0030900 98 0.011
positive regulation of programmed cell death GO:0043068 157 0.011
positive regulation of intracellular signal transduction GO:1902533 138 0.011
protein localization GO:0008104 191 0.011
axon cargo transport GO:0008088 1 0.011
positive regulation of transcription dna templated GO:0045893 197 0.011
regulation of cell morphogenesis GO:0022604 77 0.011
wnt signaling pathway planar cell polarity pathway GO:0060071 2 0.011
thalamus development GO:0021794 2 0.011
positive regulation of focal adhesion assembly GO:0051894 2 0.011
circadian sleep wake cycle process GO:0022410 21 0.011
regulation of cell maturation GO:1903429 3 0.011
rna localization GO:0006403 4 0.011
protein heterooligomerization GO:0051291 89 0.011
establishment of planar polarity GO:0001736 1 0.011
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.011
digestive tract morphogenesis GO:0048546 8 0.011
neural crest cell migration GO:0001755 1 0.011
male sex differentiation GO:0046661 64 0.011
epiboly GO:0090504 2 0.011
artery development GO:0060840 3 0.011
protein complex subunit organization GO:0071822 302 0.011
regulation of dendrite development GO:0050773 59 0.011
negative regulation of cell cycle phase transition GO:1901988 4 0.011
regulation of system process GO:0044057 208 0.011
Rat
neurological system process GO:0050877 219 0.011
negative regulation of cell communication GO:0010648 158 0.011
regulation of hormone levels GO:0010817 187 0.011
regulation of growth GO:0040008 105 0.011
cell morphogenesis GO:0000902 142 0.010
positive regulation of cell death GO:0010942 184 0.010
cellular protein localization GO:0034613 122 0.010
defense response GO:0006952 194 0.010
growth plate cartilage development GO:0003417 2 0.010
hair cycle GO:0042633 3 0.010
sympathetic nervous system development GO:0048485 1 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.010
positive regulation of interleukin 1 secretion GO:0050716 3 0.010
taxis GO:0042330 67 0.010
blood vessel morphogenesis GO:0048514 58 0.010
cell morphogenesis involved in differentiation GO:0000904 119 0.010
positive regulation of cell proliferation GO:0008284 249 0.010
positive regulation of ion transport GO:0043270 94 0.010
regulated secretory pathway GO:0045055 17 0.010
negative regulation of neuron apoptotic process GO:0043524 45 0.010
somatic stem cell maintenance GO:0035019 2 0.010

Pik3r3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
nervous system disease DOID:863 0 0.023
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
organ system cancer DOID:0050686 0 0.020
disease of metabolism DOID:0014667 0 0.016
inherited metabolic disorder DOID:655 0 0.016
vascular disease DOID:178 0 0.014
cardiovascular system disease DOID:1287 0 0.014
central nervous system disease DOID:331 0 0.013
gastrointestinal system cancer DOID:3119 0 0.012