Rattus norvegicus

115 known processes

Pitx2

paired-like homeodomain 2

(Aliases: Pitx2c,Ptx2)

Pitx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.311
organic acid metabolic process GO:0006082 292 0.300
oxoacid metabolic process GO:0043436 290 0.257
regulation of ion transport GO:0043269 245 0.176
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.165
response to inorganic substance GO:0010035 377 0.158
secretion by cell GO:0032940 248 0.151
cell cell signaling GO:0007267 335 0.143
cellular lipid metabolic process GO:0044255 208 0.142
macromolecular complex assembly GO:0065003 273 0.140
oxidation reduction process GO:0055114 304 0.137
anion transport GO:0006820 178 0.135
response to wounding GO:0009611 254 0.129
anatomical structure morphogenesis GO:0009653 298 0.128
nitrogen compound transport GO:0071705 229 0.126
regulation of cellular localization GO:0060341 263 0.124
macromolecular complex subunit organization GO:0043933 339 0.121
organelle organization GO:0006996 266 0.116
cellular component biogenesis GO:0044085 368 0.116
response to peptide hormone GO:0043434 278 0.115
regulation of cell proliferation GO:0042127 359 0.106
Mouse
regulation of multicellular organismal development GO:2000026 376 0.104
single organism biosynthetic process GO:0044711 342 0.097
regulation of secretion by cell GO:1903530 208 0.093
protein complex assembly GO:0006461 263 0.092
chemical homeostasis GO:0048878 292 0.082
negative regulation of macromolecule metabolic process GO:0010605 260 0.082
Human
response to peptide GO:1901652 292 0.081
single organism catabolic process GO:0044712 283 0.077
cellular component assembly GO:0022607 360 0.077
cellular response to endogenous stimulus GO:0071495 377 0.076
positive regulation of cell differentiation GO:0045597 217 0.075
transmembrane transport GO:0055085 412 0.074
cellular response to oxygen containing compound GO:1901701 386 0.073
cellular response to hormone stimulus GO:0032870 247 0.073
reproductive process GO:0022414 372 0.073
positive regulation of multicellular organismal process GO:0051240 387 0.072
response to external biotic stimulus GO:0043207 221 0.072
protein oligomerization GO:0051259 191 0.071
organonitrogen compound biosynthetic process GO:1901566 167 0.070
multicellular organism reproduction GO:0032504 233 0.070
response to ethanol GO:0045471 162 0.070
regeneration GO:0031099 163 0.069
regulation of phosphorus metabolic process GO:0051174 349 0.069
regulation of secretion GO:0051046 224 0.068
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.068
lipid metabolic process GO:0006629 283 0.067
cellular chemical homeostasis GO:0055082 247 0.066
regulation of cellular protein metabolic process GO:0032268 267 0.066
response to nutrient levels GO:0031667 370 0.064
cellular amino acid metabolic process GO:0006520 107 0.063
positive regulation of cell proliferation GO:0008284 249 0.062
Mouse
catabolic process GO:0009056 351 0.062
g protein coupled receptor signaling pathway GO:0007186 242 0.062
monocarboxylic acid metabolic process GO:0032787 152 0.062
cardiovascular system development GO:0072358 134 0.061
Zebrafish Mouse
response to lipopolysaccharide GO:0032496 191 0.060
organophosphate metabolic process GO:0019637 370 0.059
cellular catabolic process GO:0044248 295 0.059
response to estrogen GO:0043627 232 0.059
single organism reproductive process GO:0044702 297 0.058
homeostatic process GO:0042592 331 0.058
regulation of cell differentiation GO:0045595 320 0.058
response to extracellular stimulus GO:0009991 380 0.058
positive regulation of phosphate metabolic process GO:0045937 262 0.057
organic substance catabolic process GO:1901575 316 0.057
positive regulation of secretion by cell GO:1903532 128 0.057
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.057
Human
cofactor metabolic process GO:0051186 95 0.057
rna metabolic process GO:0016070 406 0.056
cellular amine metabolic process GO:0044106 38 0.056
positive regulation of signaling GO:0023056 270 0.056
cellular ketone metabolic process GO:0042180 51 0.056
fatty acid metabolic process GO:0006631 99 0.056
metal ion transport GO:0030001 289 0.055
cation transport GO:0006812 382 0.054
response to corticosteroid GO:0031960 235 0.054
protein phosphorylation GO:0006468 345 0.052
monovalent inorganic cation transport GO:0015672 172 0.052
regulation of protein metabolic process GO:0051246 289 0.052
reproduction GO:0000003 245 0.052
single organism membrane organization GO:0044802 74 0.052
negative regulation of cellular metabolic process GO:0031324 281 0.051
Human
amine metabolic process GO:0009308 38 0.051
protein transport GO:0015031 132 0.051
positive regulation of developmental process GO:0051094 283 0.051
regulation of hormone levels GO:0010817 187 0.051
positive regulation of transport GO:0051050 245 0.050
negative regulation of biosynthetic process GO:0009890 168 0.050
Human
protein complex subunit organization GO:0071822 302 0.049
response to metal ion GO:0010038 253 0.049
regulation of cell development GO:0060284 263 0.048
response to ketone GO:1901654 182 0.048
cytoskeleton organization GO:0007010 111 0.047
response to biotic stimulus GO:0009607 226 0.047
regulation of nucleic acid templated transcription GO:1903506 380 0.047
regulation of phosphate metabolic process GO:0019220 349 0.047
ion homeostasis GO:0050801 212 0.047
protein complex biogenesis GO:0070271 263 0.046
regulation of protein phosphorylation GO:0001932 183 0.046
regulation of rna metabolic process GO:0051252 391 0.045
response to carbohydrate GO:0009743 183 0.045
membrane organization GO:0061024 94 0.045
organic anion transport GO:0015711 132 0.045
striated muscle contraction GO:0006941 44 0.044
cell morphogenesis GO:0000902 142 0.044
Worm Fly
gland development GO:0048732 155 0.044
Mouse
reproductive structure development GO:0048608 128 0.044
ion transmembrane transport GO:0034220 365 0.043
cellular response to growth factor stimulus GO:0071363 162 0.043
peptidyl amino acid modification GO:0018193 126 0.043
organic hydroxy compound metabolic process GO:1901615 115 0.042
secretion GO:0046903 307 0.042
regulation of signal transduction GO:0009966 318 0.041
response to glucocorticoid GO:0051384 223 0.041
negative regulation of developmental process GO:0051093 125 0.041
small molecule catabolic process GO:0044282 59 0.041
positive regulation of biosynthetic process GO:0009891 319 0.040
regulation of phosphorylation GO:0042325 248 0.040
anterior posterior pattern specification GO:0009952 1 0.040
response to bacterium GO:0009617 200 0.040
cellular cation homeostasis GO:0030003 180 0.040
single organism organelle organization GO:1902589 180 0.040
positive regulation of transcription dna templated GO:0045893 197 0.039
regulation of response to stress GO:0080134 126 0.039
cellular response to stress GO:0033554 269 0.039
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.039
Human
positive regulation of response to stimulus GO:0048584 285 0.039
multicellular organismal movement GO:0050879 17 0.039
cytosolic calcium ion homeostasis GO:0051480 140 0.038
regulation of response to external stimulus GO:0032101 106 0.038
liver development GO:0001889 90 0.038
cellular response to alcohol GO:0097306 87 0.038
cellular component morphogenesis GO:0032989 155 0.037
Worm Fly
cellular calcium ion homeostasis GO:0006874 160 0.037
positive regulation of cellular biosynthetic process GO:0031328 295 0.037
negative regulation of cellular biosynthetic process GO:0031327 161 0.037
Human
muscle system process GO:0003012 115 0.037
multi organism reproductive process GO:0044703 262 0.037
cellular response to peptide hormone stimulus GO:0071375 120 0.036
regulation of cellular amine metabolic process GO:0033238 8 0.036
regulation of cellular component organization GO:0051128 368 0.036
cellular divalent inorganic cation homeostasis GO:0072503 162 0.036
cellular component movement GO:0006928 248 0.036
Mouse Worm
regulation of transcription dna templated GO:0006355 374 0.036
heart development GO:0007507 72 0.035
Zebrafish Mouse
macromolecule localization GO:0033036 252 0.035
lipid localization GO:0010876 62 0.035
response to growth factor GO:0070848 189 0.035
intracellular signal transduction GO:0035556 314 0.035
regulation of organelle organization GO:0033043 80 0.035
negative regulation of rna metabolic process GO:0051253 123 0.034
Human
regulation of cellular amino acid metabolic process GO:0006521 2 0.034
inorganic ion transmembrane transport GO:0098660 229 0.034
behavior GO:0007610 205 0.034
multicellular organismal reproductive process GO:0048609 233 0.034
response to toxic substance GO:0009636 133 0.034
negative regulation of multicellular organismal process GO:0051241 203 0.034
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.034
Human
response to insulin GO:0032868 133 0.034
heart morphogenesis GO:0003007 3 0.034
Mouse
regulation of wound healing GO:0061041 14 0.033
divalent inorganic cation homeostasis GO:0072507 165 0.033
positive regulation of ion transport GO:0043270 94 0.033
developmental process involved in reproduction GO:0003006 159 0.033
cellular response to organonitrogen compound GO:0071417 197 0.032
response to hydrogen peroxide GO:0042542 89 0.032
regulation of nervous system development GO:0051960 264 0.032
positive regulation of protein phosphorylation GO:0001934 135 0.032
cation homeostasis GO:0055080 195 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.032
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.032
apoptotic process GO:0006915 381 0.032
response to oxygen levels GO:0070482 265 0.031
regulation of membrane potential GO:0042391 110 0.031
positive regulation of cell development GO:0010720 176 0.031
response to estradiol GO:0032355 164 0.031
response to other organism GO:0051707 220 0.031
response to monosaccharide GO:0034284 159 0.031
glycerolipid metabolic process GO:0046486 67 0.031
carboxylic acid transport GO:0046942 115 0.030
organ regeneration GO:0031100 101 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
amine transport GO:0015837 57 0.030
potassium ion transport GO:0006813 97 0.030
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.030
Human
wound healing GO:0042060 122 0.030
sensory organ development GO:0007423 74 0.030
Human Zebrafish Mouse
cellular response to peptide GO:1901653 133 0.029
brain development GO:0007420 247 0.029
cell part morphogenesis GO:0032990 123 0.029
Worm Fly
negative regulation of metabolic process GO:0009892 331 0.029
Human
organic cyclic compound catabolic process GO:1901361 175 0.029
hepaticobiliary system development GO:0061008 90 0.029
lipid biosynthetic process GO:0008610 128 0.029
regulation of neurogenesis GO:0050767 247 0.029
positive regulation of cell communication GO:0010647 271 0.029
heterocycle catabolic process GO:0046700 167 0.028
cellular homeostasis GO:0019725 252 0.028
cation transmembrane transport GO:0098655 263 0.028
cellular ion homeostasis GO:0006873 184 0.028
positive regulation of mapk cascade GO:0043410 92 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
nucleobase containing small molecule metabolic process GO:0055086 316 0.027
neuron development GO:0048666 286 0.027
Worm Fly
rna biosynthetic process GO:0032774 380 0.027
muscle structure development GO:0061061 87 0.027
Mouse
regulation of anatomical structure morphogenesis GO:0022603 141 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.027
actin filament based process GO:0030029 86 0.027
aromatic compound catabolic process GO:0019439 168 0.027
response to ammonium ion GO:0060359 71 0.027
calcium ion homeostasis GO:0055074 162 0.027
purine containing compound metabolic process GO:0072521 253 0.027
coenzyme metabolic process GO:0006732 86 0.026
cellular response to lipid GO:0071396 201 0.026
dicarboxylic acid metabolic process GO:0043648 42 0.026
carbohydrate homeostasis GO:0033500 75 0.026
response to molecule of bacterial origin GO:0002237 194 0.026
response to hexose GO:0009746 144 0.026
transcription from rna polymerase ii promoter GO:0006366 252 0.026
inorganic cation transmembrane transport GO:0098662 202 0.025
regulation of calcium ion transport GO:0051924 77 0.025
positive regulation of phosphorylation GO:0042327 177 0.025
positive regulation of protein metabolic process GO:0051247 178 0.025
purine nucleotide metabolic process GO:0006163 229 0.025
intracellular transport GO:0046907 185 0.025
tissue development GO:0009888 252 0.025
Zebrafish Mouse
organ morphogenesis GO:0009887 75 0.025
regulation of metal ion transport GO:0010959 118 0.025
cell projection organization GO:0030030 302 0.024
Worm Fly
epithelial cell proliferation GO:0050673 54 0.024
neurological system process GO:0050877 219 0.024
aging GO:0007568 241 0.024
metal ion homeostasis GO:0055065 186 0.024
positive regulation of protein modification process GO:0031401 142 0.024
organic acid transport GO:0015849 116 0.023
cellular response to organic cyclic compound GO:0071407 202 0.023
regulation of molecular function GO:0065009 398 0.023
Mouse
regulation of protein modification process GO:0031399 194 0.023
response to decreased oxygen levels GO:0036293 237 0.023
nicotinamide nucleotide metabolic process GO:0046496 28 0.023
negative regulation of cell death GO:0060548 229 0.022
growth GO:0040007 165 0.022
programmed cell death GO:0012501 392 0.022
hematopoietic progenitor cell differentiation GO:0002244 2 0.022
nucleoside phosphate metabolic process GO:0006753 283 0.022
single organism intracellular transport GO:1902582 166 0.022
positive regulation of secretion GO:0051047 140 0.022
single organism carbohydrate metabolic process GO:0044723 118 0.022
protein heterooligomerization GO:0051291 89 0.022
response to glucose GO:0009749 136 0.022
protein homooligomerization GO:0051260 91 0.022
cellular metal ion homeostasis GO:0006875 172 0.022
purine ribonucleotide metabolic process GO:0009150 227 0.021
carboxylic acid catabolic process GO:0046395 49 0.021
anatomical structure formation involved in morphogenesis GO:0048646 83 0.021
Zebrafish Mouse
regulation of programmed cell death GO:0043067 341 0.021
calcium ion transport GO:0006816 131 0.021
neuron projection development GO:0031175 273 0.021
Worm Fly
organophosphate biosynthetic process GO:0090407 143 0.021
divalent metal ion transport GO:0070838 132 0.021
organic acid catabolic process GO:0016054 49 0.020
gliogenesis GO:0042063 93 0.020
signal release GO:0023061 145 0.020
axis specification GO:0009798 4 0.020
Mouse
ossification GO:0001503 70 0.020
positive regulation of cellular protein metabolic process GO:0032270 167 0.020
salivary gland development GO:0007431 3 0.020
multi multicellular organism process GO:0044706 138 0.020
vesicle mediated transport GO:0016192 181 0.020
establishment of protein localization GO:0045184 141 0.020
lipid catabolic process GO:0016042 46 0.020
transcription dna templated GO:0006351 377 0.020
organophosphate catabolic process GO:0046434 148 0.020
cell morphogenesis involved in differentiation GO:0000904 119 0.019
Worm Fly
synaptic transmission GO:0007268 235 0.019
phospholipid metabolic process GO:0006644 61 0.019
regulation of cell cycle GO:0051726 73 0.019
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
glucose homeostasis GO:0042593 75 0.019
regulation of growth GO:0040008 105 0.019
purine nucleoside metabolic process GO:0042278 169 0.019
response to nutrient GO:0007584 248 0.019
response to cytokine GO:0034097 215 0.019
positive regulation of nervous system development GO:0051962 178 0.019
hormone secretion GO:0046879 115 0.019
muscle contraction GO:0006936 88 0.019
regulation of apoptotic process GO:0042981 335 0.019
regulation of transferase activity GO:0051338 123 0.019
bone development GO:0060348 25 0.019
Human Mouse
blood circulation GO:0008015 183 0.019
Zebrafish
developmental growth GO:0048589 100 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.018
non canonical wnt signaling pathway GO:0035567 3 0.018
cytoplasmic transport GO:0016482 115 0.018
cellular macromolecule localization GO:0070727 122 0.018
reproductive system development GO:0061458 128 0.018
negative regulation of protein metabolic process GO:0051248 114 0.018
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.018
Human
regulation of intracellular signal transduction GO:1902531 218 0.018
regulation of ion transmembrane transport GO:0034765 121 0.018
positive regulation of intracellular signal transduction GO:1902533 138 0.018
cellular modified amino acid metabolic process GO:0006575 61 0.018
divalent inorganic cation transport GO:0072511 134 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
response to hypoxia GO:0001666 231 0.018
regulation of lipid metabolic process GO:0019216 68 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
actin cytoskeleton organization GO:0030036 73 0.017
nucleoside triphosphate metabolic process GO:0009141 144 0.017
cellular response to insulin stimulus GO:0032869 81 0.017
nucleotide metabolic process GO:0009117 279 0.017
sulfur compound metabolic process GO:0006790 70 0.017
appendage morphogenesis GO:0035107 4 0.017
Mouse
hormone transport GO:0009914 121 0.017
organic hydroxy compound transport GO:0015850 77 0.017
response to temperature stimulus GO:0009266 94 0.017
negative regulation of transcription dna templated GO:0045892 116 0.017
Human
protein localization GO:0008104 191 0.017
negative regulation of cell communication GO:0010648 158 0.017
embryonic appendage morphogenesis GO:0035113 4 0.017
Mouse
positive regulation of neurogenesis GO:0050769 165 0.017
skeletal system development GO:0001501 41 0.017
Human Zebrafish Mouse
response to transition metal nanoparticle GO:1990267 122 0.017
response to alkaloid GO:0043279 132 0.017
negative regulation of nucleic acid templated transcription GO:1903507 117 0.017
Human
regulation of response to wounding GO:1903034 69 0.017
eye morphogenesis GO:0048592 4 0.017
Human Zebrafish
muscle tissue development GO:0060537 58 0.017
Mouse
response to reactive oxygen species GO:0000302 120 0.017
female pregnancy GO:0007565 122 0.016
action potential GO:0001508 54 0.016
purine nucleoside monophosphate metabolic process GO:0009126 84 0.016
glial cell differentiation GO:0010001 65 0.016
regulation of anatomical structure size GO:0090066 135 0.016
alpha amino acid metabolic process GO:1901605 71 0.016
regulation of transmembrane transporter activity GO:0022898 49 0.016
catecholamine secretion GO:0050432 33 0.016
carbohydrate metabolic process GO:0005975 130 0.016
amide transport GO:0042886 105 0.016
ribonucleoside monophosphate metabolic process GO:0009161 88 0.016
forebrain development GO:0030900 98 0.016
Mouse
musculoskeletal movement GO:0050881 17 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.016
positive regulation of lipid catabolic process GO:0050996 4 0.016
regulation of rna biosynthetic process GO:2001141 381 0.016
positive regulation of rna metabolic process GO:0051254 203 0.015
hormone metabolic process GO:0042445 69 0.015
regulation of hormone secretion GO:0046883 106 0.015
organic hydroxy compound biosynthetic process GO:1901617 51 0.015
regulation of cellular component movement GO:0051270 150 0.015
Mouse
dna metabolic process GO:0006259 96 0.015
cellular response to corticosteroid stimulus GO:0071384 69 0.015
muscle organ development GO:0007517 50 0.015
Mouse
sexual reproduction GO:0019953 148 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
regulation of mapk cascade GO:0043408 116 0.015
regulation of epithelial cell proliferation GO:0050678 49 0.015
regulation of kinase activity GO:0043549 117 0.015
neuron differentiation GO:0030182 368 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
mesoderm development GO:0007498 2 0.015
Zebrafish
negative regulation of wound healing GO:0061045 8 0.015
cell adhesion GO:0007155 110 0.015
response to acid chemical GO:0001101 222 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
regulation of dopamine secretion GO:0014059 15 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
response to oxidative stress GO:0006979 186 0.015
negative regulation of cell differentiation GO:0045596 99 0.015
lipid transport GO:0006869 61 0.015
negative regulation of cell proliferation GO:0008285 119 0.015
neural crest cell development GO:0014032 2 0.015
Mouse
positive regulation of kinase activity GO:0033674 77 0.015
negative regulation of molecular function GO:0044092 133 0.015
negative regulation of ion transport GO:0043271 51 0.015
nucleoside phosphate biosynthetic process GO:1901293 102 0.015
monocarboxylic acid transport GO:0015718 52 0.015
head development GO:0060322 247 0.015
pyridine containing compound metabolic process GO:0072524 32 0.015
regulation of cellular component biogenesis GO:0044087 86 0.015
nucleoside monophosphate metabolic process GO:0009123 93 0.014
alcohol metabolic process GO:0006066 77 0.014
nucleotide biosynthetic process GO:0009165 98 0.014
chemosensory behavior GO:0007635 2 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
negative regulation of cardiac muscle tissue development GO:0055026 3 0.014
small gtpase mediated signal transduction GO:0007264 36 0.014
negative regulation of apoptotic process GO:0043066 181 0.014
neuron projection morphogenesis GO:0048812 122 0.014
Worm Fly
enzyme linked receptor protein signaling pathway GO:0007167 116 0.014
central nervous system development GO:0007417 311 0.014
neuron neuron synaptic transmission GO:0007270 60 0.014
skeletal muscle contraction GO:0003009 17 0.014
regulation of transmembrane transport GO:0034762 122 0.014
response to dexamethasone GO:0071548 49 0.014
nucleoside metabolic process GO:0009116 179 0.014
response to vitamin GO:0033273 131 0.014
ribonucleotide metabolic process GO:0009259 231 0.014
positive regulation of blood coagulation GO:0030194 4 0.014
rhythmic process GO:0048511 156 0.014
peptidyl tyrosine modification GO:0018212 72 0.014
ras protein signal transduction GO:0007265 29 0.014
regulation of peptide transport GO:0090087 87 0.014
negative regulation of transport GO:0051051 136 0.014
cellular response to carbohydrate stimulus GO:0071322 72 0.014
regulation of homotypic cell cell adhesion GO:0034110 4 0.014
positive regulation of cellular component organization GO:0051130 200 0.013
negative regulation of gene expression GO:0010629 199 0.013
Human
cell cycle process GO:0022402 57 0.013
indole containing compound metabolic process GO:0042430 11 0.013
circulatory system process GO:0003013 183 0.013
Zebrafish
circulatory system development GO:0072359 134 0.013
Zebrafish Mouse
positive regulation of fatty acid beta oxidation GO:0032000 4 0.013
olfactory behavior GO:0042048 2 0.013
synaptic transmission gabaergic GO:0051932 22 0.013
regulation of actin filament based process GO:0032970 42 0.013
steroid metabolic process GO:0008202 73 0.013
cellular amide metabolic process GO:0043603 44 0.013
multicellular organism growth GO:0035264 1 0.013
neuronal action potential GO:0019228 35 0.013
cell fate determination GO:0001709 2 0.013
muscle cell proliferation GO:0033002 84 0.013
regulation of developmental growth GO:0048638 45 0.013
response to testosterone GO:0033574 55 0.013
positive regulation of growth GO:0045927 55 0.013
gonad development GO:0008406 104 0.013
serotonin receptor signaling pathway GO:0007210 10 0.013
glycerophospholipid metabolic process GO:0006650 47 0.013
carbohydrate derivative catabolic process GO:1901136 147 0.013
negative regulation of organ growth GO:0046621 3 0.013
cyclic nucleotide biosynthetic process GO:0009190 63 0.012
cell cycle GO:0007049 101 0.012
dopamine secretion GO:0014046 15 0.012
fatty acid catabolic process GO:0009062 26 0.012
regulation of catalytic activity GO:0050790 304 0.012
negative regulation of cell cycle phase transition GO:1901988 4 0.012
embryonic pattern specification GO:0009880 1 0.012
regulation of protein transport GO:0051223 68 0.012
benzene containing compound metabolic process GO:0042537 22 0.012
positive regulation of cell death GO:0010942 184 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
response to starvation GO:0042594 59 0.012
reactive oxygen species metabolic process GO:0072593 37 0.012
negative regulation of neurogenesis GO:0050768 78 0.012
neural crest cell differentiation GO:0014033 2 0.012
Mouse
acyl coa metabolic process GO:0006637 28 0.012
biological adhesion GO:0022610 110 0.012
purine containing compound catabolic process GO:0072523 138 0.012
sequestering of metal ion GO:0051238 9 0.012
cellular response to lipopolysaccharide GO:0071222 55 0.012
spindle organization GO:0007051 2 0.012
regulation of canonical wnt signaling pathway GO:0060828 4 0.012
nucleoside phosphate catabolic process GO:1901292 140 0.012
locomotion GO:0040011 237 0.012
Mouse Worm
limb morphogenesis GO:0035108 4 0.012
Mouse
cell growth GO:0016049 104 0.012
positive regulation of protein transport GO:0051222 41 0.012
purine containing compound biosynthetic process GO:0072522 85 0.012
cellular protein localization GO:0034613 122 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
cell activation GO:0001775 97 0.012
cell cycle checkpoint GO:0000075 2 0.012
sensory perception GO:0007600 101 0.012
purine ribonucleotide catabolic process GO:0009154 136 0.012
hair cell differentiation GO:0035315 2 0.012
organonitrogen compound catabolic process GO:1901565 179 0.012
lipid storage GO:0019915 1 0.012
response to mechanical stimulus GO:0009612 134 0.012
positive regulation of transferase activity GO:0051347 81 0.012
regulation of transporter activity GO:0032409 50 0.012
regulation of muscle contraction GO:0006937 53 0.011
nucleic acid templated transcription GO:0097659 379 0.011
regulation of protein kinase activity GO:0045859 105 0.011
gamete generation GO:0007276 124 0.011
negative regulation of response to external stimulus GO:0032102 37 0.011
positive regulation of molecular function GO:0044093 230 0.011
Mouse
regulation of stem cell differentiation GO:2000736 2 0.011
morphogenesis of embryonic epithelium GO:0016331 3 0.011
Zebrafish
sex differentiation GO:0007548 113 0.011
positive regulation of catalytic activity GO:0043085 184 0.011
peptide hormone secretion GO:0030072 84 0.011

Pitx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
nervous system disease DOID:863 0 0.047
disease of anatomical entity DOID:7 0 0.047
sensory system disease DOID:0050155 0 0.033
musculoskeletal system disease DOID:17 0 0.027
cardiovascular system disease DOID:1287 0 0.020
disease of metabolism DOID:0014667 0 0.015
inherited metabolic disorder DOID:655 0 0.014
muscular disease DOID:0080000 0 0.011
myopathy DOID:423 0 0.011
muscle tissue disease DOID:66 0 0.011