Rattus norvegicus

29 known processes

Plb1

phospholipase B1

(Aliases: Phlpb)

Plb1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
muscle system process GO:0003012 115 0.645
carboxylic acid metabolic process GO:0019752 289 0.639
muscle contraction GO:0006936 88 0.386
positive regulation of multicellular organismal process GO:0051240 387 0.354
cellular response to lipid GO:0071396 201 0.346
negative regulation of cellular metabolic process GO:0031324 281 0.337
negative regulation of gene expression GO:0010629 199 0.331
cellular response to organonitrogen compound GO:0071417 197 0.322
response to peptide hormone GO:0043434 278 0.282
negative regulation of metabolic process GO:0009892 331 0.235
rna biosynthetic process GO:0032774 380 0.231
cellular response to hormone stimulus GO:0032870 247 0.229
cation transmembrane transport GO:0098655 263 0.216
cellular response to endogenous stimulus GO:0071495 377 0.216
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.204
response to other organism GO:0051707 220 0.198
response to estrogen GO:0043627 232 0.195
cellular lipid metabolic process GO:0044255 208 0.193
oxoacid metabolic process GO:0043436 290 0.191
cardiovascular system development GO:0072358 134 0.190
regulation of transcription dna templated GO:0006355 374 0.189
response to peptide GO:1901652 292 0.184
organic acid metabolic process GO:0006082 292 0.183
transcription from rna polymerase ii promoter GO:0006366 252 0.183
regulation of rna metabolic process GO:0051252 391 0.179
inorganic cation transmembrane transport GO:0098662 202 0.167
rna metabolic process GO:0016070 406 0.167
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.163
positive regulation of biosynthetic process GO:0009891 319 0.161
regulation of nucleic acid templated transcription GO:1903506 380 0.160
positive regulation of developmental process GO:0051094 283 0.159
negative regulation of cellular biosynthetic process GO:0031327 161 0.151
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.150
regulation of rna biosynthetic process GO:2001141 381 0.148
cellular response to oxygen containing compound GO:1901701 386 0.148
transcription dna templated GO:0006351 377 0.147
regulation of muscle system process GO:0090257 79 0.146
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.144
ion transmembrane transport GO:0034220 365 0.141
cellular ion homeostasis GO:0006873 184 0.139
heart development GO:0007507 72 0.137
response to estradiol GO:0032355 164 0.137
regulation of muscle contraction GO:0006937 53 0.135
cellular metal ion homeostasis GO:0006875 172 0.134
negative regulation of macromolecule metabolic process GO:0010605 260 0.133
cellular response to organic cyclic compound GO:0071407 202 0.132
regulation of neurogenesis GO:0050767 247 0.132
cellular response to steroid hormone stimulus GO:0071383 93 0.129
striated muscle contraction GO:0006941 44 0.119
response to oxygen levels GO:0070482 265 0.115
circulatory system development GO:0072359 134 0.110
positive regulation of rna biosynthetic process GO:1902680 197 0.107
response to cytokine GO:0034097 215 0.107
metal ion transport GO:0030001 289 0.106
inorganic ion transmembrane transport GO:0098660 229 0.103
positive regulation of gene expression GO:0010628 244 0.101
monocarboxylic acid metabolic process GO:0032787 152 0.096
negative regulation of transcription dna templated GO:0045892 116 0.096
regulation of cell development GO:0060284 263 0.095
regulation of multicellular organismal development GO:2000026 376 0.094
enzyme linked receptor protein signaling pathway GO:0007167 116 0.093
blood circulation GO:0008015 183 0.089
response to vitamin GO:0033273 131 0.088
regulation of cell differentiation GO:0045595 320 0.084
nucleic acid templated transcription GO:0097659 379 0.083
circulatory system process GO:0003013 183 0.077
cellular cation homeostasis GO:0030003 180 0.077
transmembrane transport GO:0055085 412 0.075
positive regulation of cell proliferation GO:0008284 249 0.073
amine metabolic process GO:0009308 38 0.070
anatomical structure morphogenesis GO:0009653 298 0.070
muscle tissue development GO:0060537 58 0.068
sodium ion transmembrane transport GO:0035725 67 0.068
organophosphate metabolic process GO:0019637 370 0.066
regulation of nervous system development GO:0051960 264 0.065
metal ion homeostasis GO:0055065 186 0.065
developmental induction GO:0031128 2 0.065
positive regulation of nucleic acid templated transcription GO:1903508 197 0.065
negative regulation of rna metabolic process GO:0051253 123 0.064
response to metal ion GO:0010038 253 0.063
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.063
macromolecular complex assembly GO:0065003 273 0.063
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.063
response to nutrient levels GO:0031667 370 0.062
heart morphogenesis GO:0003007 3 0.059
organonitrogen compound biosynthetic process GO:1901566 167 0.059
cellular component movement GO:0006928 248 0.058
positive regulation of transcription dna templated GO:0045893 197 0.057
response to bacterium GO:0009617 200 0.056
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.055
immune response GO:0006955 104 0.054
regulation of catalytic activity GO:0050790 304 0.054
negative regulation of biosynthetic process GO:0009890 168 0.053
negative regulation of nucleic acid templated transcription GO:1903507 117 0.052
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.052
response to insulin GO:0032868 133 0.052
positive regulation of nervous system development GO:0051962 178 0.052
immune system process GO:0002376 204 0.051
negative regulation of molecular function GO:0044092 133 0.051
regulation of molecular function GO:0065009 398 0.051
nucleoside phosphate metabolic process GO:0006753 283 0.050
protein complex assembly GO:0006461 263 0.049
cellular ketone metabolic process GO:0042180 51 0.049
cellular divalent inorganic cation homeostasis GO:0072503 162 0.049
nucleobase containing small molecule metabolic process GO:0055086 316 0.049
carbohydrate derivative metabolic process GO:1901135 346 0.047
response to hypoxia GO:0001666 231 0.047
intracellular signal transduction GO:0035556 314 0.046
response to lipopolysaccharide GO:0032496 191 0.046
ribonucleotide metabolic process GO:0009259 231 0.046
cell projection organization GO:0030030 302 0.046
cellular component assembly GO:0022607 360 0.044
positive regulation of rna metabolic process GO:0051254 203 0.043
positive regulation of apoptotic process GO:0043065 154 0.043
regulation of neuron differentiation GO:0045664 208 0.043
regulation of neuron projection development GO:0010975 161 0.043
central nervous system development GO:0007417 311 0.043
cardiac chamber development GO:0003205 1 0.043
cellular homeostasis GO:0019725 252 0.043
cellular response to peptide GO:1901653 133 0.043
purine containing compound metabolic process GO:0072521 253 0.042
intracellular transport GO:0046907 185 0.041
positive regulation of transport GO:0051050 245 0.041
cellular response to peptide hormone stimulus GO:0071375 120 0.041
regulation of ion transport GO:0043269 245 0.041
regulation of heart contraction GO:0008016 48 0.040
response to corticosteroid GO:0031960 235 0.040
cellular response to glucocorticoid stimulus GO:0071385 68 0.040
negative regulation of neurogenesis GO:0050768 78 0.039
actin mediated cell contraction GO:0070252 12 0.039
regulation of cellular protein metabolic process GO:0032268 267 0.039
positive regulation of phosphate metabolic process GO:0045937 262 0.039
cellular response to corticosteroid stimulus GO:0071384 69 0.038
response to external biotic stimulus GO:0043207 221 0.038
response to molecule of bacterial origin GO:0002237 194 0.038
muscle cell differentiation GO:0042692 52 0.037
regulation of cellular localization GO:0060341 263 0.037
negative regulation of signaling GO:0023057 157 0.036
hormone secretion GO:0046879 115 0.036
ventricular cardiac muscle cell action potential GO:0086005 2 0.036
rhythmic process GO:0048511 156 0.035
positive regulation of cellular biosynthetic process GO:0031328 295 0.035
response to ammonium ion GO:0060359 71 0.035
positive regulation of cell differentiation GO:0045597 217 0.035
response to growth factor GO:0070848 189 0.035
cellular response to growth factor stimulus GO:0071363 162 0.035
transmission of nerve impulse GO:0019226 42 0.035
cellular response to acid chemical GO:0071229 75 0.035
neuron projection development GO:0031175 273 0.035
regulation of membrane potential GO:0042391 110 0.035
reproduction GO:0000003 245 0.035
neurological system process GO:0050877 219 0.035
muscle structure development GO:0061061 87 0.034
negative regulation of cell differentiation GO:0045596 99 0.034
aging GO:0007568 241 0.034
cell growth GO:0016049 104 0.033
cell cell signaling GO:0007267 335 0.033
cellular amine metabolic process GO:0044106 38 0.033
monovalent inorganic cation transport GO:0015672 172 0.032
protein complex biogenesis GO:0070271 263 0.032
negative regulation of programmed cell death GO:0043069 183 0.031
action potential GO:0001508 54 0.031
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.030
ribose phosphate metabolic process GO:0019693 235 0.030
homeostatic process GO:0042592 331 0.029
regulation of hormone levels GO:0010817 187 0.029
single organism reproductive process GO:0044702 297 0.029
regulation of phosphate metabolic process GO:0019220 349 0.029
response to fatty acid GO:0070542 65 0.029
cardiac muscle contraction GO:0060048 27 0.029
negative regulation of rna biosynthetic process GO:1902679 118 0.028
cellular component biogenesis GO:0044085 368 0.028
regulation of cellular ketone metabolic process GO:0010565 27 0.028
gland development GO:0048732 155 0.028
regulation of phosphorus metabolic process GO:0051174 349 0.028
carboxylic acid biosynthetic process GO:0046394 83 0.028
chemical homeostasis GO:0048878 292 0.028
calcium ion homeostasis GO:0055074 162 0.028
tissue development GO:0009888 252 0.028
protein maturation GO:0051604 68 0.028
cellular amino acid metabolic process GO:0006520 107 0.028
fat cell proliferation GO:0070341 2 0.028
cation homeostasis GO:0055080 195 0.028
regulation of apoptotic process GO:0042981 335 0.027
regulation of protein localization GO:0032880 81 0.027
regulation of homeostatic process GO:0032844 101 0.027
purine nucleotide metabolic process GO:0006163 229 0.027
regulation of cell projection organization GO:0031344 175 0.027
cellular response to nitrogen compound GO:1901699 210 0.027
response to inorganic substance GO:0010035 377 0.027
cellular response to alkaloid GO:0071312 25 0.027
limb morphogenesis GO:0035108 4 0.026
negative regulation of transporter activity GO:0032410 13 0.026
response to acid chemical GO:0001101 222 0.026
regulation of hydrolase activity GO:0051336 143 0.026
response to tumor necrosis factor GO:0034612 56 0.026
negative regulation of cell communication GO:0010648 158 0.025
single organism biosynthetic process GO:0044711 342 0.025
cellular chemical homeostasis GO:0055082 247 0.025
defense response GO:0006952 194 0.025
ion homeostasis GO:0050801 212 0.024
positive regulation of neurogenesis GO:0050769 165 0.024
neuron differentiation GO:0030182 368 0.024
angiogenesis involved in coronary vascular morphogenesis GO:0060978 3 0.024
negative regulation of cellular protein metabolic process GO:0032269 106 0.024
protein complex subunit organization GO:0071822 302 0.024
heart process GO:0003015 57 0.024
negative regulation of ion transport GO:0043271 51 0.024
response to corticosterone GO:0051412 40 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.023
negative regulation of protein metabolic process GO:0051248 114 0.023
single organism organelle organization GO:1902589 180 0.023
macromolecular complex subunit organization GO:0043933 339 0.023
single organism behavior GO:0044708 130 0.023
positive regulation of programmed cell death GO:0043068 157 0.023
cellular response to cytokine stimulus GO:0071345 127 0.023
response to ethanol GO:0045471 162 0.023
regulation of signal transduction GO:0009966 318 0.023
cellular calcium ion homeostasis GO:0006874 160 0.023
regulation of organ formation GO:0003156 2 0.022
positive regulation of neuron differentiation GO:0045666 126 0.022
organic cyclic compound catabolic process GO:1901361 175 0.022
proteolysis GO:0006508 175 0.022
regulation of protein metabolic process GO:0051246 289 0.022
positive regulation of homeostatic process GO:0032846 49 0.022
smooth muscle contraction GO:0006939 37 0.022
bmp signaling pathway GO:0030509 4 0.021
regulation of establishment of protein localization GO:0070201 69 0.021
regulation of sodium ion transmembrane transporter activity GO:2000649 4 0.021
cytosolic calcium ion homeostasis GO:0051480 140 0.021
potassium ion transmembrane transport GO:0071805 71 0.021
heart contraction GO:0060047 57 0.021
blood vessel development GO:0001568 69 0.021
renal system development GO:0072001 67 0.020
response to extracellular stimulus GO:0009991 380 0.020
cytoplasmic transport GO:0016482 115 0.020
neuron development GO:0048666 286 0.020
fatty acid metabolic process GO:0006631 99 0.020
negative regulation of cell death GO:0060548 229 0.020
cell morphogenesis involved in differentiation GO:0000904 119 0.020
negative regulation of transport GO:0051051 136 0.020
regulation of cell proliferation GO:0042127 359 0.020
hematopoietic or lymphoid organ development GO:0048534 36 0.020
single organism intracellular transport GO:1902582 166 0.020
positive regulation of signaling GO:0023056 270 0.020
regulation of ion homeostasis GO:2000021 63 0.020
appendage morphogenesis GO:0035107 4 0.020
l glutamate import GO:0051938 2 0.020
urogenital system development GO:0001655 78 0.019
nucleotide metabolic process GO:0009117 279 0.019
regulation of programmed cell death GO:0043067 341 0.019
striated muscle tissue development GO:0014706 58 0.019
cardiac ventricle development GO:0003231 1 0.019
organ morphogenesis GO:0009887 75 0.019
protein phosphorylation GO:0006468 345 0.019
gonad development GO:0008406 104 0.019
response to camp GO:0051591 91 0.019
apoptotic process GO:0006915 381 0.019
regulation of cellular component movement GO:0051270 150 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
positive regulation of ion transport GO:0043270 94 0.018
negative regulation of multicellular organismal process GO:0051241 203 0.018
response to alkaloid GO:0043279 132 0.018
dephosphorylation GO:0016311 98 0.018
regulation of ion transmembrane transport GO:0034765 121 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
organelle organization GO:0006996 266 0.018
regulation of blood pressure GO:0008217 83 0.017
secretion GO:0046903 307 0.017
developmental process involved in reproduction GO:0003006 159 0.017
vasculature development GO:0001944 70 0.017
purine ribonucleotide metabolic process GO:0009150 227 0.017
protein oligomerization GO:0051259 191 0.017
response to reactive oxygen species GO:0000302 120 0.017
cell part morphogenesis GO:0032990 123 0.017
cyclic nucleotide metabolic process GO:0009187 80 0.017
regulation of canonical wnt signaling pathway GO:0060828 4 0.017
growth GO:0040007 165 0.017
cellular response to tumor necrosis factor GO:0071356 46 0.017
inflammatory response GO:0006954 150 0.017
positive regulation of cell death GO:0010942 184 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.017
glial cell differentiation GO:0010001 65 0.017
positive regulation of cellular component organization GO:0051130 200 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
negative regulation of protein maturation GO:1903318 47 0.016
cell type specific apoptotic process GO:0097285 134 0.016
response to radiation GO:0009314 137 0.016
locomotion GO:0040011 237 0.016
positive regulation of fat cell proliferation GO:0070346 1 0.016
regulation of protein complex assembly GO:0043254 33 0.016
digestive tract development GO:0048565 39 0.016
glycosyl compound metabolic process GO:1901657 182 0.016
reproductive structure development GO:0048608 128 0.016
positive regulation of response to stimulus GO:0048584 285 0.016
response to monosaccharide GO:0034284 159 0.016
negative regulation of cell development GO:0010721 82 0.016
insulin like growth factor receptor signaling pathway GO:0048009 3 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.015
cellular response to ketone GO:1901655 51 0.015
protein processing GO:0016485 68 0.015
protein transport GO:0015031 132 0.015
organic acid biosynthetic process GO:0016053 83 0.015
immune system development GO:0002520 41 0.015
regulation of intracellular transport GO:0032386 65 0.015
positive regulation of cardiac muscle cell proliferation GO:0060045 4 0.015
response to decreased oxygen levels GO:0036293 237 0.015
response to hexose GO:0009746 144 0.015
response to electrical stimulus GO:0051602 56 0.015
regulation of transmembrane transport GO:0034762 122 0.015
cellular response to stress GO:0033554 269 0.015
multicellular organismal reproductive process GO:0048609 233 0.015
positive regulation of brown fat cell proliferation GO:0070349 1 0.015
cell cycle GO:0007049 101 0.015
positive regulation of neuron projection development GO:0010976 99 0.015
kidney development GO:0001822 67 0.015
regulation of system process GO:0044057 208 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
ras protein signal transduction GO:0007265 29 0.015
multicellular organismal signaling GO:0035637 44 0.015
coronary vasculature morphogenesis GO:0060977 3 0.014
regulation of amine transport GO:0051952 54 0.014
regulation of catecholamine secretion GO:0050433 32 0.014
inflammatory response to antigenic stimulus GO:0002437 18 0.014
heterocycle catabolic process GO:0046700 167 0.014
regulation of cellular component organization GO:0051128 368 0.014
gamete generation GO:0007276 124 0.014
regulation of vasculature development GO:1901342 44 0.014
protein dephosphorylation GO:0006470 38 0.014
organic hydroxy compound metabolic process GO:1901615 115 0.014
icosanoid metabolic process GO:0006690 38 0.014
embryonic appendage morphogenesis GO:0035113 4 0.014
response to biotic stimulus GO:0009607 226 0.014
negative regulation of catalytic activity GO:0043086 103 0.014
axis specification GO:0009798 4 0.014
embryonic limb morphogenesis GO:0030326 4 0.014
learning or memory GO:0007611 90 0.014
muscle cell proliferation GO:0033002 84 0.014
organic substance catabolic process GO:1901575 316 0.014
positive regulation of cellular amine metabolic process GO:0033240 3 0.014
cellular potassium ion transport GO:0071804 72 0.014
dna metabolic process GO:0006259 96 0.014
positive regulation of cell projection organization GO:0031346 111 0.014
cellular response to insulin stimulus GO:0032869 81 0.014
multicellular organism growth GO:0035264 1 0.014
small molecule biosynthetic process GO:0044283 124 0.014
glomerular mesangium development GO:0072109 4 0.013
regulation of cellular amine metabolic process GO:0033238 8 0.013
reproductive system development GO:0061458 128 0.013
response to ketone GO:1901654 182 0.013
establishment of protein localization GO:0045184 141 0.013
response to vitamin a GO:0033189 36 0.013
glomerular mesangial cell proliferation GO:0072110 4 0.013
negative regulation of developmental process GO:0051093 125 0.013
organ induction GO:0001759 1 0.013
mapk cascade GO:0000165 140 0.013
macromolecule localization GO:0033036 252 0.013
cellular component morphogenesis GO:0032989 155 0.013
multicellular organism reproduction GO:0032504 233 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
muscle tissue morphogenesis GO:0060415 1 0.013
lipid storage GO:0019915 1 0.013
smooth muscle cell proliferation GO:0048659 77 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.013
negative regulation of cell proliferation GO:0008285 119 0.013
positive regulation of molecular function GO:0044093 230 0.013
acid secretion GO:0046717 48 0.013
reproductive process GO:0022414 372 0.013
actin cytoskeleton organization GO:0030036 73 0.012
regulation of smooth muscle contraction GO:0006940 29 0.012
cardiac muscle cell contraction GO:0086003 10 0.012
secretion by cell GO:0032940 248 0.012
negative regulation of apoptotic process GO:0043066 181 0.012
cellular response to alcohol GO:0097306 87 0.012
regulation of neuron death GO:1901214 115 0.012
regulation of neuron apoptotic process GO:0043523 83 0.012
divalent inorganic cation homeostasis GO:0072507 165 0.012
regeneration GO:0031099 163 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
response to wounding GO:0009611 254 0.012
response to amino acid GO:0043200 75 0.012
regulation of blood circulation GO:1903522 110 0.012
regulation of ion transmembrane transporter activity GO:0032412 48 0.012
regulation of transmembrane transporter activity GO:0022898 49 0.012
nucleotide biosynthetic process GO:0009165 98 0.012
gliogenesis GO:0042063 93 0.012
organophosphate biosynthetic process GO:0090407 143 0.012
response to oxidative stress GO:0006979 186 0.012
positive regulation of immune response GO:0050778 42 0.012
hemopoiesis GO:0030097 34 0.011
defense response to gram negative bacterium GO:0050829 3 0.011
negative regulation of secretion GO:0051048 82 0.011
response to mechanical stimulus GO:0009612 134 0.011
circadian rhythm GO:0007623 88 0.011
negative regulation of ion transmembrane transporter activity GO:0032413 12 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
negative regulation of neuron differentiation GO:0045665 62 0.011
response to carbohydrate GO:0009743 183 0.011
small gtpase mediated signal transduction GO:0007264 36 0.011
negative regulation of signal transduction GO:0009968 83 0.011
mammary gland development GO:0030879 38 0.011
positive regulation of cell development GO:0010720 176 0.011
neuronal action potential GO:0019228 35 0.011
synaptic transmission glutamatergic GO:0035249 33 0.011
epithelium development GO:0060429 96 0.011
positive regulation of ion transmembrane transport GO:0034767 24 0.011
catecholamine transport GO:0051937 37 0.011
muscle organ morphogenesis GO:0048644 1 0.011
calcium ion transport GO:0006816 131 0.011
behavior GO:0007610 205 0.011
brain development GO:0007420 247 0.011
maintenance of location GO:0051235 17 0.011
multi multicellular organism process GO:0044706 138 0.011
regulation of gtpase activity GO:0043087 57 0.010
memory GO:0007613 54 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
actin filament based process GO:0030029 86 0.010
response to transition metal nanoparticle GO:1990267 122 0.010
spermatogenesis GO:0007283 99 0.010
catabolic process GO:0009056 351 0.010
response to axon injury GO:0048678 59 0.010
regulation of brown fat cell proliferation GO:0070347 1 0.010
dna replication GO:0006260 37 0.010
regulation of fatty acid metabolic process GO:0019217 18 0.010
forebrain development GO:0030900 98 0.010
response to heat GO:0009408 60 0.010
negative regulation of hormone secretion GO:0046888 46 0.010
cellular response to molecule of bacterial origin GO:0071219 56 0.010
regulation of transferase activity GO:0051338 123 0.010
positive regulation of cell communication GO:0010647 271 0.010

Plb1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
musculoskeletal system disease DOID:17 0 0.048
nervous system disease DOID:863 0 0.031
cardiovascular system disease DOID:1287 0 0.021
heart disease DOID:114 0 0.011
myopathy DOID:423 0 0.010
muscular disease DOID:0080000 0 0.010
muscle tissue disease DOID:66 0 0.010