Rattus norvegicus

0 known processes

Plekhg3

pleckstrin homology domain containing, family G (with RhoGef domain) member 3

(Aliases: RGD1308089)

Plekhg3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
anatomical structure morphogenesis GO:0009653 298 0.094
neuron differentiation GO:0030182 368 0.076
regulation of cell differentiation GO:0045595 320 0.066
neuron development GO:0048666 286 0.062
regulation of signal transduction GO:0009966 318 0.061
regulation of cell development GO:0060284 263 0.061
cellular component movement GO:0006928 248 0.056
regulation of anatomical structure morphogenesis GO:0022603 141 0.055
positive regulation of multicellular organismal process GO:0051240 387 0.055
central nervous system development GO:0007417 311 0.052
regulation of molecular function GO:0065009 398 0.052
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.052
regulation of nervous system development GO:0051960 264 0.052
cell projection organization GO:0030030 302 0.049
regulation of neurogenesis GO:0050767 247 0.049
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.048
regulation of cellular component organization GO:0051128 368 0.048
amine metabolic process GO:0009308 38 0.048
intracellular signal transduction GO:0035556 314 0.047
positive regulation of developmental process GO:0051094 283 0.045
regulation of neuron differentiation GO:0045664 208 0.044
regulation of phosphorus metabolic process GO:0051174 349 0.044
organic acid metabolic process GO:0006082 292 0.044
cell morphogenesis involved in differentiation GO:0000904 119 0.044
catabolic process GO:0009056 351 0.043
negative regulation of metabolic process GO:0009892 331 0.043
positive regulation of neurogenesis GO:0050769 165 0.042
regulation of cell projection organization GO:0031344 175 0.042
regulation of neuron projection development GO:0010975 161 0.041
neuron projection development GO:0031175 273 0.041
lipid metabolic process GO:0006629 283 0.040
organophosphate metabolic process GO:0019637 370 0.040
regulation of transcription dna templated GO:0006355 374 0.040
tissue development GO:0009888 252 0.039
head development GO:0060322 247 0.038
cellular response to endogenous stimulus GO:0071495 377 0.038
positive regulation of phosphate metabolic process GO:0045937 262 0.037
cellular amino acid metabolic process GO:0006520 107 0.037
rna biosynthetic process GO:0032774 380 0.036
regulation of rna metabolic process GO:0051252 391 0.036
regulation of multicellular organismal development GO:2000026 376 0.036
positive regulation of cell development GO:0010720 176 0.036
regulation of phosphorylation GO:0042325 248 0.035
transcription dna templated GO:0006351 377 0.035
secretion GO:0046903 307 0.035
positive regulation of cell differentiation GO:0045597 217 0.035
programmed cell death GO:0012501 392 0.035
carboxylic acid metabolic process GO:0019752 289 0.035
regulation of proteasomal protein catabolic process GO:0061136 4 0.035
oxoacid metabolic process GO:0043436 290 0.035
apoptotic process GO:0006915 381 0.035
cellular amine metabolic process GO:0044106 38 0.034
negative regulation of cell communication GO:0010648 158 0.034
regulation of phosphate metabolic process GO:0019220 349 0.034
regulation of rna biosynthetic process GO:2001141 381 0.034
regulation of programmed cell death GO:0043067 341 0.034
regulation of canonical wnt signaling pathway GO:0060828 4 0.033
regulation of cellular amino acid metabolic process GO:0006521 2 0.033
single organism catabolic process GO:0044712 283 0.033
regulation of protein metabolic process GO:0051246 289 0.033
positive regulation of phosphorus metabolic process GO:0010562 262 0.033
protein complex subunit organization GO:0071822 302 0.033
cellular component morphogenesis GO:0032989 155 0.032
regulation of cellular amine metabolic process GO:0033238 8 0.032
regulation of apoptotic process GO:0042981 335 0.032
carbohydrate derivative metabolic process GO:1901135 346 0.031
nucleic acid templated transcription GO:0097659 379 0.031
regulation of intracellular signal transduction GO:1902531 218 0.031
positive regulation of cellular component organization GO:0051130 200 0.031
cellular component assembly GO:0022607 360 0.030
organic substance catabolic process GO:1901575 316 0.030
negative regulation of multicellular organismal process GO:0051241 203 0.030
single organism organelle organization GO:1902589 180 0.029
nucleobase containing small molecule metabolic process GO:0055086 316 0.029
cellular component biogenesis GO:0044085 368 0.029
cell motility GO:0048870 202 0.029
negative regulation of cellular metabolic process GO:0031324 281 0.029
brain development GO:0007420 247 0.029
positive regulation of nervous system development GO:0051962 178 0.029
mesoderm development GO:0007498 2 0.029
cellular response to oxygen containing compound GO:1901701 386 0.029
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.028
positive regulation of signaling GO:0023056 270 0.028
cellular lipid metabolic process GO:0044255 208 0.028
response to peptide hormone GO:0043434 278 0.028
regulation of protein modification process GO:0031399 194 0.027
glycosyl compound catabolic process GO:1901658 126 0.027
organic cyclic compound catabolic process GO:1901361 175 0.027
regulation of nucleic acid templated transcription GO:1903506 380 0.026
negative regulation of macromolecule metabolic process GO:0010605 260 0.026
nucleoside metabolic process GO:0009116 179 0.026
regulation of cellular protein metabolic process GO:0032268 267 0.026
regulation of cell proliferation GO:0042127 359 0.026
response to extracellular stimulus GO:0009991 380 0.026
cell morphogenesis GO:0000902 142 0.026
organonitrogen compound catabolic process GO:1901565 179 0.026
single organism biosynthetic process GO:0044711 342 0.025
response to nutrient levels GO:0031667 370 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.025
axon development GO:0061564 96 0.025
rna metabolic process GO:0016070 406 0.025
positive regulation of apoptotic process GO:0043065 154 0.025
positive regulation of biosynthetic process GO:0009891 319 0.025
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.025
response to oxygen levels GO:0070482 265 0.025
cellular catabolic process GO:0044248 295 0.025
positive regulation of cell projection organization GO:0031346 111 0.025
cell migration GO:0016477 197 0.024
positive regulation of cellular amine metabolic process GO:0033240 3 0.024
nucleobase containing compound catabolic process GO:0034655 152 0.024
carbohydrate derivative catabolic process GO:1901136 147 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
cellular ketone metabolic process GO:0042180 51 0.024
cell cell signaling GO:0007267 335 0.024
purine containing compound metabolic process GO:0072521 253 0.024
localization of cell GO:0051674 202 0.024
transcription from rna polymerase ii promoter GO:0006366 252 0.024
synaptic transmission GO:0007268 235 0.024
positive regulation of cell death GO:0010942 184 0.023
positive regulation of neuron differentiation GO:0045666 126 0.023
purine ribonucleoside metabolic process GO:0046128 168 0.023
behavior GO:0007610 205 0.023
response to acid chemical GO:0001101 222 0.023
ribonucleotide metabolic process GO:0009259 231 0.023
negative regulation of signal transduction GO:0009968 83 0.023
organelle organization GO:0006996 266 0.022
nitrogen compound transport GO:0071705 229 0.022
small gtpase mediated signal transduction GO:0007264 36 0.022
regulation of system process GO:0044057 208 0.022
gastrulation GO:0007369 2 0.022
ribose phosphate metabolic process GO:0019693 235 0.022
nucleotide metabolic process GO:0009117 279 0.022
positive regulation of neuron projection development GO:0010976 99 0.022
negative regulation of molecular function GO:0044092 133 0.021
signal release GO:0023061 145 0.021
cellular response to growth factor stimulus GO:0071363 162 0.021
cell part morphogenesis GO:0032990 123 0.021
cellular response to organonitrogen compound GO:0071417 197 0.021
regulation of cellular ketone metabolic process GO:0010565 27 0.021
cation transport GO:0006812 382 0.021
heterocycle catabolic process GO:0046700 167 0.021
positive regulation of intracellular signal transduction GO:1902533 138 0.021
response to growth factor GO:0070848 189 0.021
transmembrane transport GO:0055085 412 0.021
regulation of protein phosphorylation GO:0001932 183 0.021
positive regulation of signal transduction GO:0009967 175 0.020
single organism reproductive process GO:0044702 297 0.020
epithelium development GO:0060429 96 0.020
response to decreased oxygen levels GO:0036293 237 0.020
purine ribonucleotide metabolic process GO:0009150 227 0.020
purine nucleotide metabolic process GO:0006163 229 0.020
response to peptide GO:1901652 292 0.020
regulation of membrane potential GO:0042391 110 0.020
nucleoside phosphate catabolic process GO:1901292 140 0.020
positive regulation of transport GO:0051050 245 0.020
positive regulation of molecular function GO:0044093 230 0.020
motor neuron axon guidance GO:0008045 1 0.020
negative regulation of canonical wnt signaling pathway GO:0090090 4 0.020
positive regulation of programmed cell death GO:0043068 157 0.020
purine ribonucleoside catabolic process GO:0046130 124 0.020
response to inorganic substance GO:0010035 377 0.020
aromatic compound catabolic process GO:0019439 168 0.020
protein phosphorylation GO:0006468 345 0.020
cell projection morphogenesis GO:0048858 123 0.020
single organism behavior GO:0044708 130 0.020
ribonucleoside metabolic process GO:0009119 174 0.019
response to glucocorticoid GO:0051384 223 0.019
gliogenesis GO:0042063 93 0.019
macromolecule localization GO:0033036 252 0.019
regulation of cellular catabolic process GO:0031329 101 0.019
negative regulation of cellular protein metabolic process GO:0032269 106 0.019
cellular response to nitrogen compound GO:1901699 210 0.019
purine ribonucleotide catabolic process GO:0009154 136 0.019
tube development GO:0035295 89 0.019
positive regulation of cell communication GO:0010647 271 0.019
nucleoside phosphate metabolic process GO:0006753 283 0.019
chemical homeostasis GO:0048878 292 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
oxidation reduction process GO:0055114 304 0.019
nucleoside catabolic process GO:0009164 126 0.019
protein complex assembly GO:0006461 263 0.019
locomotion GO:0040011 237 0.019
negative regulation of response to stimulus GO:0048585 155 0.019
positive regulation of response to stimulus GO:0048584 285 0.018
positive regulation of gene expression GO:0010628 244 0.018
negative regulation of biosynthetic process GO:0009890 168 0.018
positive regulation of catalytic activity GO:0043085 184 0.018
regeneration GO:0031099 163 0.018
macromolecular complex subunit organization GO:0043933 339 0.018
negative regulation of signaling GO:0023057 157 0.018
negative regulation of cellular component organization GO:0051129 83 0.018
purine nucleoside catabolic process GO:0006152 124 0.018
ras protein signal transduction GO:0007265 29 0.018
nucleotide catabolic process GO:0009166 139 0.018
positive regulation of phosphorylation GO:0042327 177 0.018
negative regulation of cell proliferation GO:0008285 119 0.018
regulation of hydrolase activity GO:0051336 143 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.018
response to wounding GO:0009611 254 0.018
positive regulation of cellular biosynthetic process GO:0031328 295 0.018
negative regulation of nervous system development GO:0051961 79 0.018
proteolysis GO:0006508 175 0.017
heart morphogenesis GO:0003007 3 0.017
homeostatic process GO:0042592 331 0.017
regulation of cellular localization GO:0060341 263 0.017
response to carbohydrate GO:0009743 183 0.017
regulation of catalytic activity GO:0050790 304 0.017
regulation of secretion GO:0051046 224 0.017
cellular response to hormone stimulus GO:0032870 247 0.017
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.017
gonad development GO:0008406 104 0.017
response to estrogen GO:0043627 232 0.017
regulation of dendrite development GO:0050773 59 0.016
secretion by cell GO:0032940 248 0.016
regulation of hormone levels GO:0010817 187 0.016
regulation of catabolic process GO:0009894 113 0.016
ion transmembrane transport GO:0034220 365 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.016
negative regulation of developmental process GO:0051093 125 0.016
cellular macromolecule localization GO:0070727 122 0.016
anion transport GO:0006820 178 0.016
aging GO:0007568 241 0.016
multicellular organism reproduction GO:0032504 233 0.016
peptidyl tyrosine phosphorylation GO:0018108 72 0.016
multicellular organismal reproductive process GO:0048609 233 0.016
ribonucleoside catabolic process GO:0042454 126 0.016
cellular nitrogen compound catabolic process GO:0044270 163 0.016
single organism intracellular transport GO:1902582 166 0.016
cytoplasmic transport GO:0016482 115 0.016
reproduction GO:0000003 245 0.016
purine nucleoside metabolic process GO:0042278 169 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.015
intracellular transport GO:0046907 185 0.015
regulation of cell morphogenesis GO:0022604 77 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.015
positive regulation of protein metabolic process GO:0051247 178 0.015
response to glucose GO:0009749 136 0.015
purine nucleoside triphosphate metabolic process GO:0009144 141 0.015
regulation of secretion by cell GO:1903530 208 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
positive regulation of protein phosphorylation GO:0001934 135 0.015
negative regulation of gene expression GO:0010629 199 0.015
nucleoside triphosphate metabolic process GO:0009141 144 0.015
protein localization GO:0008104 191 0.015
growth GO:0040007 165 0.015
response to nutrient GO:0007584 248 0.015
anterior posterior pattern specification GO:0009952 1 0.015
enzyme linked receptor protein signaling pathway GO:0007167 116 0.015
cellular protein localization GO:0034613 122 0.015
regulation of mesenchymal cell proliferation GO:0010464 4 0.015
blood circulation GO:0008015 183 0.015
reproductive process GO:0022414 372 0.015
negative regulation of protein metabolic process GO:0051248 114 0.015
protein complex biogenesis GO:0070271 263 0.015
organophosphate catabolic process GO:0046434 148 0.015
regulation of mapk cascade GO:0043408 116 0.015
reproductive structure development GO:0048608 128 0.015
negative regulation of cell differentiation GO:0045596 99 0.015
ribonucleoside triphosphate metabolic process GO:0009199 141 0.014
membrane organization GO:0061024 94 0.014
response to hexose GO:0009746 144 0.014
regulation of kinase activity GO:0043549 117 0.014
actin filament based process GO:0030029 86 0.014
positive regulation of cellular protein metabolic process GO:0032270 167 0.014
action potential GO:0001508 54 0.014
response to monosaccharide GO:0034284 159 0.014
female sex differentiation GO:0046660 59 0.014
peptidyl amino acid modification GO:0018193 126 0.014
cellular response to peptide GO:1901653 133 0.014
circulatory system development GO:0072359 134 0.014
transmission of nerve impulse GO:0019226 42 0.014
mapk cascade GO:0000165 140 0.014
cytoskeleton organization GO:0007010 111 0.014
establishment of tissue polarity GO:0007164 2 0.014
response to oxidative stress GO:0006979 186 0.014
positive regulation of rna metabolic process GO:0051254 203 0.014
neurological system process GO:0050877 219 0.014
single organism membrane organization GO:0044802 74 0.014
dendrite development GO:0016358 72 0.014
negative regulation of cell development GO:0010721 82 0.014
cell communication involved in cardiac conduction GO:0086065 2 0.014
circulatory system process GO:0003013 183 0.014
macromolecular complex assembly GO:0065003 273 0.014
regulation of cell growth GO:0001558 85 0.014
response to insulin GO:0032868 133 0.014
limb morphogenesis GO:0035108 4 0.013
response to other organism GO:0051707 220 0.013
positive regulation of nucleic acid templated transcription GO:1903508 197 0.013
positive regulation of protein modification process GO:0031401 142 0.013
metal ion transport GO:0030001 289 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.013
organonitrogen compound biosynthetic process GO:1901566 167 0.013
synaptic growth at neuromuscular junction GO:0051124 1 0.013
negative regulation of osteoblast differentiation GO:0045668 2 0.013
sex differentiation GO:0007548 113 0.013
regulation of anatomical structure size GO:0090066 135 0.013
response to ketone GO:1901654 182 0.013
calcium ion homeostasis GO:0055074 162 0.013
regulation of synaptic transmission GO:0050804 141 0.013
purine containing compound catabolic process GO:0072523 138 0.013
response to estradiol GO:0032355 164 0.013
regulation of establishment of planar polarity GO:0090175 2 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
positive regulation of mapk cascade GO:0043410 92 0.013
axonogenesis GO:0007409 71 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.013
negative regulation of catalytic activity GO:0043086 103 0.013
neuron death GO:0070997 127 0.013
metal ion homeostasis GO:0055065 186 0.013
peptidyl tyrosine modification GO:0018212 72 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.013
cell cycle GO:0007049 101 0.013
regulation of axonogenesis GO:0050770 37 0.012
purine nucleotide catabolic process GO:0006195 136 0.012
negative regulation of cellular biosynthetic process GO:0031327 161 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.012
cardiovascular system development GO:0072358 134 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
neuronal action potential GO:0019228 35 0.012
chromosome segregation GO:0007059 2 0.012
cellular response to stress GO:0033554 269 0.012
cellular chemical homeostasis GO:0055082 247 0.012
developmental process involved in reproduction GO:0003006 159 0.012
ribonucleoside triphosphate catabolic process GO:0009203 122 0.012
chemotaxis GO:0006935 66 0.012
eye morphogenesis GO:0048592 4 0.012
small molecule biosynthetic process GO:0044283 124 0.012
response to vitamin GO:0033273 131 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
forebrain development GO:0030900 98 0.012
ossification GO:0001503 70 0.012
coenzyme metabolic process GO:0006732 86 0.012
regulation of transferase activity GO:0051338 123 0.012
neuron projection morphogenesis GO:0048812 122 0.012
establishment of protein localization GO:0045184 141 0.012
development of primary sexual characteristics GO:0045137 107 0.012
negative regulation of rna biosynthetic process GO:1902679 118 0.012
regulation of g0 to g1 transition GO:0070316 3 0.012
carboxylic acid biosynthetic process GO:0046394 83 0.012
response to corticosteroid GO:0031960 235 0.011
anatomical structure formation involved in morphogenesis GO:0048646 83 0.011
negative regulation of phosphorus metabolic process GO:0010563 80 0.011
axis specification GO:0009798 4 0.011
response to metal ion GO:0010038 253 0.011
organic hydroxy compound metabolic process GO:1901615 115 0.011
carbohydrate derivative biosynthetic process GO:1901137 124 0.011
negative regulation of phosphate metabolic process GO:0045936 80 0.011
reproductive system development GO:0061458 128 0.011
lipid biosynthetic process GO:0008610 128 0.011
regulation of nucleotide catabolic process GO:0030811 65 0.011
regulation of response to stress GO:0080134 126 0.011
hormone secretion GO:0046879 115 0.011
energy derivation by oxidation of organic compounds GO:0015980 46 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
morphogenesis of a polarized epithelium GO:0001738 1 0.011
nucleoside triphosphate catabolic process GO:0009143 123 0.011
ion homeostasis GO:0050801 212 0.011
monovalent inorganic cation transport GO:0015672 172 0.011
ribonucleotide catabolic process GO:0009261 136 0.011
organ morphogenesis GO:0009887 75 0.011
negative regulation of neurogenesis GO:0050768 78 0.011
cellular homeostasis GO:0019725 252 0.011
multicellular organism growth GO:0035264 1 0.011
signal transduction by phosphorylation GO:0023014 144 0.011
single organism cellular localization GO:1902580 102 0.011
regulation of response to external stimulus GO:0032101 106 0.011
wound healing GO:0042060 122 0.011
monocarboxylic acid metabolic process GO:0032787 152 0.011
cellular cation homeostasis GO:0030003 180 0.011
developmental growth GO:0048589 100 0.011
divalent inorganic cation homeostasis GO:0072507 165 0.011
response to external biotic stimulus GO:0043207 221 0.011
positive regulation of mesenchymal cell proliferation GO:0002053 4 0.011
actin cytoskeleton organization GO:0030036 73 0.011
regulation of gtpase activity GO:0043087 57 0.011
regulation of purine nucleotide metabolic process GO:1900542 115 0.011
cellular response to lipid GO:0071396 201 0.011
response to biotic stimulus GO:0009607 226 0.010
rhythmic process GO:0048511 156 0.010
morphogenesis of embryonic epithelium GO:0016331 3 0.010
carbohydrate metabolic process GO:0005975 130 0.010
sexual reproduction GO:0019953 148 0.010
gland development GO:0048732 155 0.010
hair cycle GO:0042633 3 0.010
embryonic skeletal system development GO:0048706 3 0.010
reactive oxygen species metabolic process GO:0072593 37 0.010
regulation of growth GO:0040008 105 0.010
gamete generation GO:0007276 124 0.010
mechanoreceptor differentiation GO:0042490 2 0.010
organic acid transport GO:0015849 116 0.010
negative regulation of programmed cell death GO:0043069 183 0.010
bmp signaling pathway GO:0030509 4 0.010
negative regulation of cell death GO:0060548 229 0.010
appendage morphogenesis GO:0035107 4 0.010
response to bacterium GO:0009617 200 0.010
regulation of cell migration GO:0030334 128 0.010
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
amide transport GO:0042886 105 0.010
negative regulation of rna metabolic process GO:0051253 123 0.010
erk1 and erk2 cascade GO:0070371 48 0.010
non canonical wnt signaling pathway GO:0035567 3 0.010
rho protein signal transduction GO:0007266 11 0.010
divalent inorganic cation transport GO:0072511 134 0.010
cellular response to nutrient levels GO:0031669 60 0.010
negative regulation of apoptotic process GO:0043066 181 0.010

Plekhg3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.034
sensory system disease DOID:0050155 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
cancer DOID:162 0 0.018
organ system cancer DOID:0050686 0 0.016
disease of metabolism DOID:0014667 0 0.013
musculoskeletal system disease DOID:17 0 0.013
gastrointestinal system cancer DOID:3119 0 0.012