Rattus norvegicus

144 known processes

Ppat

phosphoribosyl pyrophosphate amidotransferase

(Aliases: Atase,MGC93251)

Ppat biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic substance catabolic process GO:1901575 316 0.244
protein complex subunit organization GO:0071822 302 0.214
macromolecular complex subunit organization GO:0043933 339 0.213
protein oligomerization GO:0051259 191 0.151
protein targeting GO:0006605 61 0.142
cellular component assembly GO:0022607 360 0.139
positive regulation of cell communication GO:0010647 271 0.137
regulation of protein metabolic process GO:0051246 289 0.133
nucleic acid templated transcription GO:0097659 379 0.120
negative regulation of cellular metabolic process GO:0031324 281 0.117
rna biosynthetic process GO:0032774 380 0.113
negative regulation of metabolic process GO:0009892 331 0.112
aging GO:0007568 241 0.108
Fly
positive regulation of response to stimulus GO:0048584 285 0.106
macromolecular complex assembly GO:0065003 273 0.103
transcription dna templated GO:0006351 377 0.101
regulation of protein transport GO:0051223 68 0.099
cellular response to endogenous stimulus GO:0071495 377 0.095
dna metabolic process GO:0006259 96 0.092
response to temperature stimulus GO:0009266 94 0.092
response to cytokine GO:0034097 215 0.091
cellular component biogenesis GO:0044085 368 0.090
carbohydrate derivative biosynthetic process GO:1901137 124 0.089
negative regulation of macromolecule metabolic process GO:0010605 260 0.088
response to oxygen levels GO:0070482 265 0.086
protein localization GO:0008104 191 0.085
single organism organelle organization GO:1902589 180 0.085
positive regulation of biosynthetic process GO:0009891 319 0.081
oxoacid metabolic process GO:0043436 290 0.081
response to inorganic substance GO:0010035 377 0.078
macromolecule localization GO:0033036 252 0.078
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.077
dephosphorylation GO:0016311 98 0.074
cellular protein localization GO:0034613 122 0.069
single organism reproductive process GO:0044702 297 0.069
regulation of nucleic acid templated transcription GO:1903506 380 0.068
response to metal ion GO:0010038 253 0.067
organelle organization GO:0006996 266 0.067
regulation of cellular component organization GO:0051128 368 0.065
protein dephosphorylation GO:0006470 38 0.065
protein import GO:0017038 37 0.065
regulation of cellular localization GO:0060341 263 0.063
single organism intracellular transport GO:1902582 166 0.062
nuclear import GO:0051170 35 0.062
intracellular transport GO:0046907 185 0.061
response to decreased oxygen levels GO:0036293 237 0.061
response to wounding GO:0009611 254 0.061
rna metabolic process GO:0016070 406 0.061
protein transport GO:0015031 132 0.061
response to nutrient levels GO:0031667 370 0.060
protein complex biogenesis GO:0070271 263 0.059
organic acid metabolic process GO:0006082 292 0.059
protein phosphorylation GO:0006468 345 0.057
response to acid chemical GO:0001101 222 0.055
response to hypoxia GO:0001666 231 0.054
regulation of cell proliferation GO:0042127 359 0.053
multicellular organism reproduction GO:0032504 233 0.053
negative regulation of response to stimulus GO:0048585 155 0.053
amine metabolic process GO:0009308 38 0.052
negative regulation of rna metabolic process GO:0051253 123 0.052
regulation of molecular function GO:0065009 398 0.052
cellular catabolic process GO:0044248 295 0.052
nuclear transport GO:0051169 49 0.050
inflammatory response GO:0006954 150 0.050
positive regulation of gene expression GO:0010628 244 0.049
positive regulation of signaling GO:0023056 270 0.049
positive regulation of multicellular organismal process GO:0051240 387 0.048
nucleoside phosphate biosynthetic process GO:1901293 102 0.048
response to carbohydrate GO:0009743 183 0.048
response to peptide hormone GO:0043434 278 0.048
cellular response to oxygen containing compound GO:1901701 386 0.048
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.048
reproductive process GO:0022414 372 0.048
ribonucleotide metabolic process GO:0009259 231 0.048
cellular response to stress GO:0033554 269 0.048
single organism cellular localization GO:1902580 102 0.048
organonitrogen compound biosynthetic process GO:1901566 167 0.047
Fly
protein complex assembly GO:0006461 263 0.046
response to peptide GO:1901652 292 0.046
defense response GO:0006952 194 0.045
protein localization to organelle GO:0033365 57 0.045
regulation of rna metabolic process GO:0051252 391 0.043
cell part morphogenesis GO:0032990 123 0.043
negative regulation of signaling GO:0023057 157 0.043
nucleotide biosynthetic process GO:0009165 98 0.043
Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.043
purine containing compound biosynthetic process GO:0072522 85 0.043
Fly
positive regulation of protein metabolic process GO:0051247 178 0.043
positive regulation of cell migration GO:0030335 96 0.042
nucleocytoplasmic transport GO:0006913 48 0.042
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.042
negative regulation of gene expression GO:0010629 199 0.041
intracellular protein transport GO:0006886 79 0.041
single organism biosynthetic process GO:0044711 342 0.040
proteolysis GO:0006508 175 0.040
response to extracellular stimulus GO:0009991 380 0.040
cellular amino acid metabolic process GO:0006520 107 0.040
multi organism reproductive process GO:0044703 262 0.040
negative regulation of cell communication GO:0010648 158 0.040
single organism nuclear import GO:1902593 35 0.039
carbohydrate derivative metabolic process GO:1901135 346 0.039
transcription from rna polymerase ii promoter GO:0006366 252 0.038
nucleoside phosphate metabolic process GO:0006753 283 0.038
regulation of rna biosynthetic process GO:2001141 381 0.037
divalent metal ion transport GO:0070838 132 0.036
response to nutrient GO:0007584 248 0.036
cellular macromolecule localization GO:0070727 122 0.036
cardiovascular system development GO:0072358 134 0.035
response to heat GO:0009408 60 0.035
regulation of hormone levels GO:0010817 187 0.035
actin filament based process GO:0030029 86 0.034
negative regulation of nucleic acid templated transcription GO:1903507 117 0.034
positive regulation of signal transduction GO:0009967 175 0.033
response to transition metal nanoparticle GO:1990267 122 0.033
ribose phosphate metabolic process GO:0019693 235 0.033
regulation of cell cycle GO:0051726 73 0.032
catabolic process GO:0009056 351 0.031
cellular homeostasis GO:0019725 252 0.031
homeostatic process GO:0042592 331 0.031
organophosphate biosynthetic process GO:0090407 143 0.031
positive regulation of cellular amine metabolic process GO:0033240 3 0.031
tube development GO:0035295 89 0.031
cation transport GO:0006812 382 0.031
response to monosaccharide GO:0034284 159 0.031
response to reactive oxygen species GO:0000302 120 0.030
negative regulation of transcription dna templated GO:0045892 116 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.030
central nervous system development GO:0007417 311 0.030
purine ribonucleoside metabolic process GO:0046128 168 0.030
regulation of secretion GO:0051046 224 0.030
nucleoside monophosphate metabolic process GO:0009123 93 0.030
organic cyclic compound catabolic process GO:1901361 175 0.029
regulation of anatomical structure size GO:0090066 135 0.029
reproduction GO:0000003 245 0.029
growth GO:0040007 165 0.029
purine containing compound metabolic process GO:0072521 253 0.029
Fly
response to electrical stimulus involved in regulation of muscle adaptation GO:0014878 4 0.028
negative regulation of molecular function GO:0044092 133 0.028
positive regulation of homeostatic process GO:0032846 49 0.028
gland development GO:0048732 155 0.028
negative regulation of biosynthetic process GO:0009890 168 0.028
nucleotide metabolic process GO:0009117 279 0.028
Fly
transmembrane transport GO:0055085 412 0.028
positive regulation of secretion by cell GO:1903532 128 0.028
secretion GO:0046903 307 0.028
negative regulation of apoptotic process GO:0043066 181 0.028
tissue development GO:0009888 252 0.028
regulation of secretion by cell GO:1903530 208 0.028
cell cell signaling GO:0007267 335 0.028
anatomical structure morphogenesis GO:0009653 298 0.027
regulation of establishment of protein localization GO:0070201 69 0.027
positive regulation of intracellular signal transduction GO:1902533 138 0.027
purine nucleotide metabolic process GO:0006163 229 0.027
Fly
response to amino acid GO:0043200 75 0.026
cellular carbohydrate metabolic process GO:0044262 72 0.026
regulation of protein localization GO:0032880 81 0.026
nucleobase containing small molecule metabolic process GO:0055086 316 0.026
establishment of protein localization to organelle GO:0072594 44 0.025
response to ethanol GO:0045471 162 0.025
response to camp GO:0051591 91 0.025
cellular amine metabolic process GO:0044106 38 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.024
monocarboxylic acid transport GO:0015718 52 0.024
regulation of cellular amino acid metabolic process GO:0006521 2 0.024
carboxylic acid metabolic process GO:0019752 289 0.024
regulation of locomotion GO:0040012 148 0.024
macromolecule catabolic process GO:0009057 58 0.024
cellular component morphogenesis GO:0032989 155 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
nitrogen compound transport GO:0071705 229 0.024
protein homooligomerization GO:0051260 91 0.023
response to toxic substance GO:0009636 133 0.023
regulation of cellular amine metabolic process GO:0033238 8 0.023
nucleoside metabolic process GO:0009116 179 0.023
regulation of protein targeting GO:1903533 28 0.023
regulation of cellular ketone metabolic process GO:0010565 27 0.023
ribonucleoside catabolic process GO:0042454 126 0.023
regulation of cellular protein metabolic process GO:0032268 267 0.023
organ regeneration GO:0031100 101 0.023
intracellular signal transduction GO:0035556 314 0.023
response to hexose GO:0009746 144 0.023
regulation of hormone secretion GO:0046883 106 0.022
response to growth factor GO:0070848 189 0.022
embryo development GO:0009790 49 0.022
Fly
cellular response to hormone stimulus GO:0032870 247 0.022
brain development GO:0007420 247 0.022
anion transport GO:0006820 178 0.022
single organism carbohydrate metabolic process GO:0044723 118 0.022
positive regulation of cellular biosynthetic process GO:0031328 295 0.022
secretion by cell GO:0032940 248 0.022
organic anion transport GO:0015711 132 0.022
rhythmic process GO:0048511 156 0.022
cellular response to lipid GO:0071396 201 0.022
response to ketone GO:1901654 182 0.021
response to biotic stimulus GO:0009607 226 0.021
positive regulation of cell proliferation GO:0008284 249 0.021
embryonic axis specification GO:0000578 1 0.021
response to bacterium GO:0009617 200 0.021
anterior posterior pattern specification GO:0009952 1 0.021
response to external biotic stimulus GO:0043207 221 0.021
actin filament organization GO:0007015 42 0.021
regulation of transcription dna templated GO:0006355 374 0.021
signal transduction by phosphorylation GO:0023014 144 0.021
organonitrogen compound catabolic process GO:1901565 179 0.021
protein modification by small protein conjugation or removal GO:0070647 35 0.021
regulation of organelle organization GO:0033043 80 0.021
cytoskeleton organization GO:0007010 111 0.021
cell projection organization GO:0030030 302 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.021
ion transmembrane transport GO:0034220 365 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
carboxylic acid biosynthetic process GO:0046394 83 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
carbohydrate metabolic process GO:0005975 130 0.020
positive regulation of cellular component movement GO:0051272 102 0.020
response to glucocorticoid GO:0051384 223 0.020
purine ribonucleoside biosynthetic process GO:0046129 21 0.019
positive regulation of rna biosynthetic process GO:1902680 197 0.019
negative regulation of phosphorus metabolic process GO:0010563 80 0.019
regeneration GO:0031099 163 0.019
positive regulation of transport GO:0051050 245 0.019
translation GO:0006412 35 0.019
purine ribonucleotide metabolic process GO:0009150 227 0.019
aromatic compound catabolic process GO:0019439 168 0.019
regulation of skeletal muscle tissue growth GO:0048631 3 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
reproductive structure development GO:0048608 128 0.019
p38mapk cascade GO:0038066 1 0.019
positive regulation of neurogenesis GO:0050769 165 0.019
regulation of homeostatic process GO:0032844 101 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.019
localization of cell GO:0051674 202 0.019
regulation of cell differentiation GO:0045595 320 0.019
cytoplasmic transport GO:0016482 115 0.018
developmental process involved in reproduction GO:0003006 159 0.018
Fly
regulation of signal transduction GO:0009966 318 0.018
lipid metabolic process GO:0006629 283 0.018
purine nucleoside metabolic process GO:0042278 169 0.018
regulation of peptide transport GO:0090087 87 0.018
pyrimidine nucleobase metabolic process GO:0006206 8 0.018
multicellular organism growth GO:0035264 1 0.018
hormone transport GO:0009914 121 0.018
positive regulation of cellular protein metabolic process GO:0032270 167 0.018
negative regulation of immune system process GO:0002683 39 0.018
positive regulation of release of cytochrome c from mitochondria GO:0090200 3 0.018
regulation of cellular component movement GO:0051270 150 0.018
positive regulation of transcription factor import into nucleus GO:0042993 4 0.017
peptide transport GO:0015833 97 0.017
muscle system process GO:0003012 115 0.017
chemical homeostasis GO:0048878 292 0.017
cellular chemical homeostasis GO:0055082 247 0.017
negative regulation of programmed cell death GO:0043069 183 0.017
protein import into nucleus GO:0006606 35 0.017
single organism catabolic process GO:0044712 283 0.017
positive regulation of transcription dna templated GO:0045893 197 0.017
cellular ketone metabolic process GO:0042180 51 0.017
positive regulation of protein localization to nucleus GO:1900182 15 0.017
response to manganese ion GO:0010042 13 0.017
positive regulation of protein transport GO:0051222 41 0.017
carboxylic acid transport GO:0046942 115 0.017
positive regulation of cell motility GO:2000147 97 0.017
negative regulation of cellular biosynthetic process GO:0031327 161 0.017
nucleotide catabolic process GO:0009166 139 0.017
positive regulation of secretion GO:0051047 140 0.017
regulation of cell motility GO:2000145 131 0.016
negative regulation of protein metabolic process GO:0051248 114 0.016
cellular ion homeostasis GO:0006873 184 0.016
positive regulation of cellular component organization GO:0051130 200 0.016
ion homeostasis GO:0050801 212 0.016
immune system process GO:0002376 204 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
cytosolic calcium ion homeostasis GO:0051480 140 0.016
regulation of cytoskeleton organization GO:0051493 49 0.016
response to corticosteroid GO:0031960 235 0.016
organic acid transport GO:0015849 116 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.016
cellular cation homeostasis GO:0030003 180 0.016
heterocycle catabolic process GO:0046700 167 0.016
ribose phosphate biosynthetic process GO:0046390 87 0.016
organ morphogenesis GO:0009887 75 0.016
regulation of hydrolase activity GO:0051336 143 0.016
regulation of p38mapk cascade GO:1900744 1 0.016
cellular component movement GO:0006928 248 0.016
regulation of peptide hormone secretion GO:0090276 80 0.016
purine nucleotide catabolic process GO:0006195 136 0.015
regulation of intracellular transport GO:0032386 65 0.015
ribonucleoside metabolic process GO:0009119 174 0.015
reactive oxygen species biosynthetic process GO:1903409 8 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
circulatory system development GO:0072359 134 0.015
regulation of cellular response to stress GO:0080135 49 0.015
renal system development GO:0072001 67 0.015
axis specification GO:0009798 4 0.015
negative regulation of rna biosynthetic process GO:1902679 118 0.015
cellular response to peptide GO:1901653 133 0.015
purine containing compound catabolic process GO:0072523 138 0.015
cell motility GO:0048870 202 0.014
positive regulation of neuron differentiation GO:0045666 126 0.014
reproductive system development GO:0061458 128 0.014
positive regulation of smooth muscle cell migration GO:0014911 27 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.014
cellular response to organonitrogen compound GO:0071417 197 0.014
negative regulation of transport GO:0051051 136 0.014
protein localization to nucleus GO:0034504 39 0.014
cofactor metabolic process GO:0051186 95 0.014
memory GO:0007613 54 0.014
response to estrogen GO:0043627 232 0.014
amide transport GO:0042886 105 0.014
response to retinoic acid GO:0032526 63 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.014
regulation of phosphorylation GO:0042325 248 0.014
purine ribonucleotide biosynthetic process GO:0009152 81 0.014
protein refolding GO:0042026 3 0.014
cellular response to interleukin 1 GO:0071347 37 0.014
regulation of programmed cell death GO:0043067 341 0.014
cellular response to cytokine stimulus GO:0071345 127 0.014
fatty acid derivative metabolic process GO:1901568 38 0.014
establishment of protein localization GO:0045184 141 0.014
response to organophosphorus GO:0046683 102 0.014
calcium ion transport GO:0006816 131 0.013
programmed cell death GO:0012501 392 0.013
embryonic pattern specification GO:0009880 1 0.013
regulation of membrane potential GO:0042391 110 0.013
regulation of system process GO:0044057 208 0.013
calcium ion homeostasis GO:0055074 162 0.013
response to molecule of bacterial origin GO:0002237 194 0.013
ribonucleotide biosynthetic process GO:0009260 85 0.013
positive regulation of cell death GO:0010942 184 0.013
protein homotetramerization GO:0051289 25 0.013
divalent inorganic cation transport GO:0072511 134 0.013
cellular response to peptide hormone stimulus GO:0071375 120 0.013
acute inflammatory response GO:0002526 58 0.013
regulation of canonical wnt signaling pathway GO:0060828 4 0.013
cellular response to growth factor stimulus GO:0071363 162 0.013
response to lipopolysaccharide GO:0032496 191 0.013
actin cytoskeleton organization GO:0030036 73 0.013
positive regulation of cell differentiation GO:0045597 217 0.013
fatty acid metabolic process GO:0006631 99 0.013
regulation of catabolic process GO:0009894 113 0.013
mapk cascade GO:0000165 140 0.013
regulation of muscle system process GO:0090257 79 0.012
male gamete generation GO:0048232 99 0.012
urogenital system development GO:0001655 78 0.012
positive regulation of dna metabolic process GO:0051054 39 0.012
cellular response to metal ion GO:0071248 55 0.012
regulation of cell migration GO:0030334 128 0.012
chromosome organization GO:0051276 36 0.012
regulation of apoptotic process GO:0042981 335 0.012
peroxisome organization GO:0007031 6 0.012
cellular response to organic cyclic compound GO:0071407 202 0.012
metal ion homeostasis GO:0055065 186 0.012
regulation of nucleocytoplasmic transport GO:0046822 28 0.012
positive regulation of phosphorylation GO:0042327 177 0.012
regulation of peptide secretion GO:0002791 82 0.012
response to testosterone GO:0033574 55 0.012
behavioral response to ethanol GO:0048149 1 0.012
regulation of response to stress GO:0080134 126 0.012
cellular nitrogen compound catabolic process GO:0044270 163 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
positive regulation of mitochondrion organization GO:0010822 4 0.012
cellular protein complex assembly GO:0043623 44 0.012
neuron projection development GO:0031175 273 0.012
response to other organism GO:0051707 220 0.012
regulation of immune system process GO:0002682 123 0.012
wound healing GO:0042060 122 0.012
cell cycle GO:0007049 101 0.012
cofactor biosynthetic process GO:0051188 28 0.011
neuron differentiation GO:0030182 368 0.011
cellular calcium ion homeostasis GO:0006874 160 0.011
cellular response to alcohol GO:0097306 87 0.011
release of cytochrome c from mitochondria GO:0001836 8 0.011
negative regulation of secretion by cell GO:1903531 72 0.011
neurological system process GO:0050877 219 0.011
positive regulation of membrane potential GO:0045838 16 0.011
sulfur compound metabolic process GO:0006790 70 0.011
response to purine containing compound GO:0014074 126 0.011
response to interleukin 1 GO:0070555 55 0.011
cellular response to oxygen levels GO:0071453 60 0.011
hormone secretion GO:0046879 115 0.011
gonad development GO:0008406 104 0.011
regulation of apoptotic signaling pathway GO:2001233 13 0.011
cell morphogenesis GO:0000902 142 0.011
positive regulation of protein modification process GO:0031401 142 0.011
posttranscriptional regulation of gene expression GO:0010608 37 0.011
lymphocyte homeostasis GO:0002260 2 0.011
regulation of transferase activity GO:0051338 123 0.011
positive regulation of immune system process GO:0002684 90 0.011
protein tetramerization GO:0051262 38 0.011
regulation of cellular component biogenesis GO:0044087 86 0.011
negative regulation of signal transduction GO:0009968 83 0.011
positive regulation of neuron projection development GO:0010976 99 0.011
positive regulation of developmental process GO:0051094 283 0.011
cell activation GO:0001775 97 0.010
regulation of mrna stability GO:0043488 3 0.010
leukocyte activation GO:0045321 76 0.010
multi multicellular organism process GO:0044706 138 0.010
regulation of dna metabolic process GO:0051052 60 0.010
regulation of anatomical structure morphogenesis GO:0022603 141 0.010
positive regulation of hormone secretion GO:0046887 65 0.010
protein targeting to nucleus GO:0044744 35 0.010
apoptotic process GO:0006915 381 0.010
syncytium formation by plasma membrane fusion GO:0000768 3 0.010
positive regulation of programmed cell death GO:0043068 157 0.010
chromosome segregation GO:0007059 2 0.010
double strand break repair GO:0006302 1 0.010
immune response GO:0006955 104 0.010
development of primary sexual characteristics GO:0045137 107 0.010
regulation of intracellular protein transport GO:0033157 34 0.010
nucleobase containing compound catabolic process GO:0034655 152 0.010
kidney development GO:0001822 67 0.010

Ppat disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.010
nervous system disease DOID:863 0 0.010