Rattus norvegicus

34 known processes

Ppia

peptidylprolyl isomerase A (cyclophilin A)

(Aliases: MGC72881,CYCA)

Ppia biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of nitric oxide synthase activity GO:0050999 8 0.588
response to ketone GO:1901654 182 0.548
regulation of high voltage gated calcium channel activity GO:1901841 3 0.476
positive regulation of camp metabolic process GO:0030816 31 0.457
porphyrin containing compound biosynthetic process GO:0006779 6 0.437
l glutamate import GO:0051938 2 0.402
regulation of monooxygenase activity GO:0032768 8 0.395
regulation of nucleotide biosynthetic process GO:0030808 47 0.371
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.356
adenine nucleotide transport GO:0051503 2 0.345
regulation of transporter activity GO:0032409 50 0.342
regulation of molecular function GO:0065009 398 0.342
positive regulation of phosphate metabolic process GO:0045937 262 0.329
synaptic growth at neuromuscular junction GO:0051124 1 0.305
cellular ketone metabolic process GO:0042180 51 0.288
positive regulation of phosphorus metabolic process GO:0010562 262 0.287
positive regulation of purine nucleotide biosynthetic process GO:1900373 36 0.279
regulation of transmembrane transport GO:0034762 122 0.250
rna metabolic process GO:0016070 406 0.248
positive regulation of molecular function GO:0044093 230 0.246
response to corticosterone GO:0051412 40 0.239
regulation of atp biosynthetic process GO:2001169 2 0.232
positive regulation of monooxygenase activity GO:0032770 5 0.227
regulation of ryanodine sensitive calcium release channel activity GO:0060314 5 0.213
tetrapyrrole biosynthetic process GO:0033014 7 0.211
positive regulation of nucleotide metabolic process GO:0045981 91 0.210
regulation of phosphate metabolic process GO:0019220 349 0.187
nucleoside phosphate biosynthetic process GO:1901293 102 0.179
neurotransmitter uptake GO:0001504 3 0.165
camp biosynthetic process GO:0006171 47 0.156
homeostatic process GO:0042592 331 0.153
cellular response to oxidative stress GO:0034599 76 0.153
regulation of cation channel activity GO:2001257 23 0.152
inorganic cation transmembrane transport GO:0098662 202 0.148
transmembrane transport GO:0055085 412 0.148
regulation of purine nucleotide biosynthetic process GO:1900371 46 0.130
macromolecular complex subunit organization GO:0043933 339 0.130
cation transport GO:0006812 382 0.128
positive regulation of mitochondrial membrane permeability GO:0035794 1 0.127
ribose phosphate metabolic process GO:0019693 235 0.126
peptidyl amino acid modification GO:0018193 126 0.124
Human
nucleic acid templated transcription GO:0097659 379 0.123
ribose phosphate biosynthetic process GO:0046390 87 0.121
regulation of rna metabolic process GO:0051252 391 0.120
positive regulation of nucleotide biosynthetic process GO:0030810 36 0.120
response to oxidative stress GO:0006979 186 0.119
developmental growth GO:0048589 100 0.118
regulation of nucleotide metabolic process GO:0006140 117 0.115
response to corticosteroid GO:0031960 235 0.112
organophosphate biosynthetic process GO:0090407 143 0.106
positive regulation of cyclase activity GO:0031281 15 0.105
pigment biosynthetic process GO:0046148 4 0.103
response to glucocorticoid GO:0051384 223 0.102
ribonucleoside metabolic process GO:0009119 174 0.100
response to amine GO:0014075 46 0.099
organonitrogen compound biosynthetic process GO:1901566 167 0.098
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.092
regulation of cellular ketone metabolic process GO:0010565 27 0.091
protein phosphorylation GO:0006468 345 0.091
response to peptide GO:1901652 292 0.091
response to mineralocorticoid GO:0051385 49 0.086
response to acid chemical GO:0001101 222 0.085
positive regulation of cellular biosynthetic process GO:0031328 295 0.084
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.082
positive regulation of catalytic activity GO:0043085 184 0.082
metal ion transport GO:0030001 289 0.080
regulation of calcium ion transmembrane transport GO:1903169 18 0.080
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.079
single organism organelle organization GO:1902589 180 0.076
regulation of rna biosynthetic process GO:2001141 381 0.076
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.074
cation transmembrane transport GO:0098655 263 0.073
organelle organization GO:0006996 266 0.073
Human
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.072
ribonucleotide metabolic process GO:0009259 231 0.071
cellular component assembly GO:0022607 360 0.071
positive regulation of biosynthetic process GO:0009891 319 0.071
cellular component biogenesis GO:0044085 368 0.069
nucleotide metabolic process GO:0009117 279 0.069
carbohydrate derivative biosynthetic process GO:1901137 124 0.069
negative regulation of metabolic process GO:0009892 331 0.064
negative regulation of rna biosynthetic process GO:1902679 118 0.062
cellular response to oxygen containing compound GO:1901701 386 0.062
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.062
regulation of cellular amine metabolic process GO:0033238 8 0.062
positive regulation of camp biosynthetic process GO:0030819 28 0.062
positive regulation of developmental process GO:0051094 283 0.062
regulation of catalytic activity GO:0050790 304 0.061
adult locomotory behavior GO:0008344 4 0.061
organophosphate metabolic process GO:0019637 370 0.057
positive regulation of kinase activity GO:0033674 77 0.057
dna metabolic process GO:0006259 96 0.057
negative regulation of cellular biosynthetic process GO:0031327 161 0.057
positive regulation of multicellular organismal process GO:0051240 387 0.057
ion transmembrane transport GO:0034220 365 0.056
catabolic process GO:0009056 351 0.056
cyclic purine nucleotide metabolic process GO:0052652 62 0.055
regulation of transmembrane transporter activity GO:0022898 49 0.055
amino acid transport GO:0006865 70 0.055
nucleotide biosynthetic process GO:0009165 98 0.054
cellular chemical homeostasis GO:0055082 247 0.053
immune system process GO:0002376 204 0.053
ribonucleoside triphosphate metabolic process GO:0009199 141 0.052
regulation of nucleic acid templated transcription GO:1903506 380 0.050
multi organism reproductive process GO:0044703 262 0.050
regulation of neuron apoptotic process GO:0043523 83 0.050
regulation of phosphorus metabolic process GO:0051174 349 0.050
purine ribonucleotide metabolic process GO:0009150 227 0.049
positive regulation of protein phosphorylation GO:0001934 135 0.049
positive regulation of atp biosynthetic process GO:2001171 2 0.049
regulation of cellular amino acid metabolic process GO:0006521 2 0.048
regulation of cellular component organization GO:0051128 368 0.048
neuron apoptotic process GO:0051402 88 0.048
positive regulation of cellular amine metabolic process GO:0033240 3 0.048
cyclic nucleotide metabolic process GO:0009187 80 0.048
positive regulation of nitric oxide synthase activity GO:0051000 5 0.047
camp metabolic process GO:0046058 63 0.047
negative regulation of biosynthetic process GO:0009890 168 0.047
organic acid transport GO:0015849 116 0.047
positive regulation of transferase activity GO:0051347 81 0.047
inorganic ion transmembrane transport GO:0098660 229 0.046
rna biosynthetic process GO:0032774 380 0.046
purine ribonucleotide biosynthetic process GO:0009152 81 0.045
regulation of transcription dna templated GO:0006355 374 0.045
negative regulation of macromolecule metabolic process GO:0010605 260 0.045
intracellular signal transduction GO:0035556 314 0.045
response to peptide hormone GO:0043434 278 0.045
neuron projection development GO:0031175 273 0.044
membrane organization GO:0061024 94 0.044
chemical homeostasis GO:0048878 292 0.044
regulation of calcium ion transmembrane transporter activity GO:1901019 17 0.044
heme biosynthetic process GO:0006783 4 0.043
cell part morphogenesis GO:0032990 123 0.043
regulation of programmed cell death GO:0043067 341 0.043
cellular response to endogenous stimulus GO:0071495 377 0.043
negative regulation of cell death GO:0060548 229 0.043
cell redox homeostasis GO:0045454 1 0.042
synaptic transmission GO:0007268 235 0.042
hair follicle development GO:0001942 2 0.041
calcium ion transport GO:0006816 131 0.041
regulation of purine nucleotide metabolic process GO:1900542 115 0.041
regulation of cellular localization GO:0060341 263 0.041
Human
neuron development GO:0048666 286 0.040
transcription dna templated GO:0006351 377 0.040
single organism biosynthetic process GO:0044711 342 0.040
regulation of membrane potential GO:0042391 110 0.040
positive regulation of transport GO:0051050 245 0.040
Human
macromolecular complex assembly GO:0065003 273 0.039
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.039
circulatory system process GO:0003013 183 0.038
regulation of intracellular transport GO:0032386 65 0.038
response to thyroxine GO:0097068 3 0.038
retinal metabolic process GO:0042574 3 0.036
purine nucleotide transport GO:0015865 3 0.036
regulation of cyclic nucleotide biosynthetic process GO:0030802 45 0.036
positive regulation of cyclic nucleotide metabolic process GO:0030801 37 0.035
multicellular organismal homeostasis GO:0048871 49 0.034
positive regulation of phosphorylation GO:0042327 177 0.034
nuclear transport GO:0051169 49 0.034
hippocampus development GO:0021766 30 0.034
negative regulation of cellular metabolic process GO:0031324 281 0.034
ion homeostasis GO:0050801 212 0.033
cellular homeostasis GO:0019725 252 0.033
nucleoside phosphate metabolic process GO:0006753 283 0.033
regulation of neuron death GO:1901214 115 0.033
neuron projection morphogenesis GO:0048812 122 0.033
negative regulation of gene expression GO:0010629 199 0.033
carboxylic acid transport GO:0046942 115 0.033
divalent metal ion transport GO:0070838 132 0.033
negative regulation of transcription dna templated GO:0045892 116 0.033
anatomical structure homeostasis GO:0060249 29 0.032
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.032
defense response GO:0006952 194 0.031
regulation of cell development GO:0060284 263 0.031
peptidyl serine phosphorylation GO:0018105 33 0.031
organic substance catabolic process GO:1901575 316 0.031
growth GO:0040007 165 0.030
dicarboxylic acid transport GO:0006835 34 0.030
cellular lipid metabolic process GO:0044255 208 0.030
norepinephrine metabolic process GO:0042415 3 0.030
cofactor transport GO:0051181 5 0.030
positive regulation of transporter activity GO:0032411 14 0.030
positive regulation of ion transport GO:0043270 94 0.029
positive regulation of cell differentiation GO:0045597 217 0.029
purine containing compound metabolic process GO:0072521 253 0.029
regulation of camp biosynthetic process GO:0030817 38 0.029
protein import into nucleus GO:0006606 35 0.029
ribonucleoside triphosphate biosynthetic process GO:0009201 7 0.028
regulation of mitochondrial membrane permeability GO:0046902 5 0.028
regulation of cell proliferation GO:0042127 359 0.028
regulation of phosphorylation GO:0042325 248 0.028
positive regulation of cell proliferation GO:0008284 249 0.028
glycosyl compound biosynthetic process GO:1901659 25 0.027
inflammatory response GO:0006954 150 0.027
response to monosaccharide GO:0034284 159 0.027
striated muscle contraction GO:0006941 44 0.027
multicellular organism reproduction GO:0032504 233 0.027
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.027
nucleoside transport GO:0015858 8 0.027
neuron differentiation GO:0030182 368 0.027
cellular calcium ion homeostasis GO:0006874 160 0.027
salivary gland development GO:0007431 3 0.026
purine nucleotide biosynthetic process GO:0006164 83 0.026
positive regulation of protein metabolic process GO:0051247 178 0.026
regulation of multicellular organismal development GO:2000026 376 0.026
aging GO:0007568 241 0.026
negative regulation of response to stimulus GO:0048585 155 0.025
single organism behavior GO:0044708 130 0.025
cell projection organization GO:0030030 302 0.025
regulation of ion transmembrane transporter activity GO:0032412 48 0.025
organelle localization GO:0051640 55 0.025
regulation of mitochondrion organization GO:0010821 7 0.025
positive regulation of cellular protein metabolic process GO:0032270 167 0.025
amine metabolic process GO:0009308 38 0.025
cellular response to stress GO:0033554 269 0.024
nucleobase containing small molecule metabolic process GO:0055086 316 0.024
reproduction GO:0000003 245 0.024
negative regulation of rna metabolic process GO:0051253 123 0.024
cellular response to peptide GO:1901653 133 0.024
jak stat cascade GO:0007259 26 0.024
divalent inorganic cation transport GO:0072511 134 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
nitrogen compound transport GO:0071705 229 0.023
second messenger mediated signaling GO:0019932 51 0.023
blood circulation GO:0008015 183 0.023
collecting duct development GO:0072044 1 0.023
response to inorganic substance GO:0010035 377 0.022
taxis GO:0042330 67 0.022
immune response GO:0006955 104 0.022
mitochondrial calcium ion homeostasis GO:0051560 3 0.022
calcium ion transmembrane transport GO:0070588 70 0.021
positive regulation of protein modification process GO:0031401 142 0.021
regulation of camp metabolic process GO:0030814 43 0.021
response to mechanical stimulus GO:0009612 134 0.021
negative regulation of neuron apoptotic process GO:0043524 45 0.021
anion transport GO:0006820 178 0.021
purine ribonucleoside metabolic process GO:0046128 168 0.021
regulation of protein modification process GO:0031399 194 0.020
carbohydrate derivative metabolic process GO:1901135 346 0.020
purine nucleoside metabolic process GO:0042278 169 0.020
organic anion transport GO:0015711 132 0.020
terpenoid metabolic process GO:0006721 37 0.020
multicellular organismal reproductive process GO:0048609 233 0.020
negative regulation of transport GO:0051051 136 0.019
purine nucleotide metabolic process GO:0006163 229 0.019
adp transport GO:0015866 1 0.019
cell morphogenesis GO:0000902 142 0.019
neuron death GO:0070997 127 0.019
l amino acid import GO:0043092 5 0.019
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
cell activation GO:0001775 97 0.018
peptidyl serine modification GO:0018209 34 0.018
neurotransmitter transport GO:0006836 42 0.018
programmed cell death GO:0012501 392 0.018
cell cell signaling GO:0007267 335 0.018
tetrapyrrole metabolic process GO:0033013 11 0.018
cellular amino acid metabolic process GO:0006520 107 0.018
axon development GO:0061564 96 0.017
response to hexose GO:0009746 144 0.017
ribonucleotide biosynthetic process GO:0009260 85 0.017
regulation of protein kinase activity GO:0045859 105 0.017
protein import into nucleus translocation GO:0000060 9 0.016
head development GO:0060322 247 0.016
ctp biosynthetic process GO:0006241 1 0.016
nucleoside metabolic process GO:0009116 179 0.016
positive regulation of lyase activity GO:0051349 15 0.016
organic acid metabolic process GO:0006082 292 0.016
cyclic nucleotide biosynthetic process GO:0009190 63 0.016
response to glucose GO:0009749 136 0.016
regulation of ion transmembrane transport GO:0034765 121 0.016
regulation of immune system process GO:0002682 123 0.016
establishment of neuroblast polarity GO:0045200 1 0.016
purine ribonucleoside biosynthetic process GO:0046129 21 0.015
rho protein signal transduction GO:0007266 11 0.015
regulation of ion transport GO:0043269 245 0.015
central nervous system development GO:0007417 311 0.015
protein complex subunit organization GO:0071822 302 0.015
alditol metabolic process GO:0019400 4 0.015
cation homeostasis GO:0055080 195 0.015
cellular carbohydrate metabolic process GO:0044262 72 0.015
dna replication GO:0006260 37 0.015
regulation of transferase activity GO:0051338 123 0.015
apoptotic process GO:0006915 381 0.014
action potential GO:0001508 54 0.014
regulation of metal ion transport GO:0010959 118 0.014
acidic amino acid transport GO:0015800 10 0.014
regulation of signal transduction GO:0009966 318 0.014
response to wounding GO:0009611 254 0.014
calcium mediated signaling GO:0019722 23 0.014
positive regulation of lipid kinase activity GO:0090218 2 0.014
molting cycle GO:0042303 3 0.014
positive regulation of pseudopodium assembly GO:0031274 1 0.013
tube development GO:0035295 89 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
regulation of anatomical structure size GO:0090066 135 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
positive regulation of response to stimulus GO:0048584 285 0.013
gastrulation GO:0007369 2 0.013
sorbitol biosynthetic process GO:0006061 1 0.013
telencephalon development GO:0021537 62 0.013
mitochondrial transport GO:0006839 19 0.013
innate immune response GO:0045087 35 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.013
cellular response to insulin stimulus GO:0032869 81 0.013
l amino acid transport GO:0015807 21 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
multicellular organism growth GO:0035264 1 0.013
negative regulation of mitochondrion organization GO:0010823 2 0.013
endocytosis GO:0006897 84 0.013
single organism catabolic process GO:0044712 283 0.013
positive regulation of nucleoside metabolic process GO:0045979 55 0.013
negative regulation of neuron death GO:1901215 69 0.012
metal ion homeostasis GO:0055065 186 0.012
monovalent inorganic cation transport GO:0015672 172 0.012
regulation of protein phosphorylation GO:0001932 183 0.012
cell growth GO:0016049 104 0.012
regulation of neurotransmitter levels GO:0001505 42 0.012
mitochondrion organization GO:0007005 35 0.012
positive regulation of lamellipodium assembly GO:0010592 4 0.012
cellular component movement GO:0006928 248 0.012
isoprenoid metabolic process GO:0006720 45 0.012
regulation of cellular catabolic process GO:0031329 101 0.012
carboxylic acid metabolic process GO:0019752 289 0.012
spliceosomal complex assembly GO:0000245 2 0.011
single organism intracellular transport GO:1902582 166 0.011
protein oligomerization GO:0051259 191 0.011
regulation of protein metabolic process GO:0051246 289 0.011
purine nucleoside triphosphate biosynthetic process GO:0009145 6 0.011
negative regulation of protein modification by small protein conjugation or removal GO:1903321 4 0.011
regulation of developmental growth GO:0048638 45 0.011
cellular response to organonitrogen compound GO:0071417 197 0.011
single organism membrane organization GO:0044802 74 0.011
regulation of kinase activity GO:0043549 117 0.011
positive regulation of cell communication GO:0010647 271 0.011
anion transmembrane transport GO:0098656 77 0.011
nucleocytoplasmic transport GO:0006913 48 0.011
regulation of blood circulation GO:1903522 110 0.010
response to hydrogen peroxide GO:0042542 89 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.010
vesicle mediated transport GO:0016192 181 0.010
cellular component morphogenesis GO:0032989 155 0.010
carbohydrate homeostasis GO:0033500 75 0.010
regulation of cyclase activity GO:0031279 21 0.010
heart contraction GO:0060047 57 0.010
pseudopodium assembly GO:0031269 3 0.010
regulation of body fluid levels GO:0050878 90 0.010

Ppia disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.016
osteochondrodysplasia DOID:2256 0 0.016
bone disease DOID:0080001 0 0.016
musculoskeletal system disease DOID:17 0 0.016
connective tissue disease DOID:65 0 0.016
disease of anatomical entity DOID:7 0 0.016