Rattus norvegicus

85 known processes

Ppp1ca

protein phosphatase 1, catalytic subunit, alpha isoform

Ppp1ca biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macromolecular complex subunit organization GO:0043933 339 0.303
positive regulation of cell death GO:0010942 184 0.301
Mouse
positive regulation of programmed cell death GO:0043068 157 0.234
Mouse
intracellular signal transduction GO:0035556 314 0.185
cell cycle checkpoint GO:0000075 2 0.183
positive regulation of response to stimulus GO:0048584 285 0.173
Mouse
regulation of programmed cell death GO:0043067 341 0.162
Mouse
cell growth GO:0016049 104 0.157
regulation of signal transduction GO:0009966 318 0.153
Mouse
protein localization GO:0008104 191 0.144
regulation of apoptotic process GO:0042981 335 0.133
Mouse
intracellular transport GO:0046907 185 0.122
macromolecule localization GO:0033036 252 0.121
regulation of catalytic activity GO:0050790 304 0.121
regulation of intracellular signal transduction GO:1902531 218 0.119
sorbitol biosynthetic process GO:0006061 1 0.118
apoptotic process GO:0006915 381 0.116
Mouse
cellular response to endogenous stimulus GO:0071495 377 0.113
positive regulation of apoptotic process GO:0043065 154 0.113
Mouse
phenol containing compound metabolic process GO:0018958 30 0.110
programmed cell death GO:0012501 392 0.109
Mouse
regulation of neuron death GO:1901214 115 0.108
positive regulation of cell communication GO:0010647 271 0.107
Mouse
response to ketone GO:1901654 182 0.102
cell type specific apoptotic process GO:0097285 134 0.101
cellular component biogenesis GO:0044085 368 0.100
negative regulation of cellular metabolic process GO:0031324 281 0.099
positive regulation of signaling GO:0023056 270 0.097
Mouse
cell cycle GO:0007049 101 0.093
organic substance catabolic process GO:1901575 316 0.092
multi organism reproductive process GO:0044703 262 0.090
developmental growth GO:0048589 100 0.088
positive regulation of cell proliferation GO:0008284 249 0.085
macromolecular complex assembly GO:0065003 273 0.082
cell migration GO:0016477 197 0.081
homeostatic process GO:0042592 331 0.081
regulation of cell proliferation GO:0042127 359 0.081
organophosphate metabolic process GO:0019637 370 0.080
immune response GO:0006955 104 0.080
positive regulation of developmental process GO:0051094 283 0.080
multicellular organismal reproductive process GO:0048609 233 0.079
positive regulation of protein phosphorylation GO:0001934 135 0.077
dna metabolic process GO:0006259 96 0.076
multicellular organism reproduction GO:0032504 233 0.073
locomotion GO:0040011 237 0.071
regulation of neuron apoptotic process GO:0043523 83 0.071
cellular response to oxygen containing compound GO:1901701 386 0.071
neuron projection development GO:0031175 273 0.070
nucleic acid templated transcription GO:0097659 379 0.069
regulation of transcription dna templated GO:0006355 374 0.068
taxis GO:0042330 67 0.068
carbohydrate metabolic process GO:0005975 130 0.067
regulation of protein localization GO:0032880 81 0.066
organophosphate biosynthetic process GO:0090407 143 0.065
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.063
regulation of nucleic acid templated transcription GO:1903506 380 0.063
regulation of cardiac muscle tissue growth GO:0055021 12 0.063
cytoskeleton organization GO:0007010 111 0.062
positive regulation of protein metabolic process GO:0051247 178 0.062
positive regulation of neuron death GO:1901216 43 0.062
cellular amino acid metabolic process GO:0006520 107 0.062
reproduction GO:0000003 245 0.061
cellular protein localization GO:0034613 122 0.061
muscle system process GO:0003012 115 0.061
regulation of cell differentiation GO:0045595 320 0.061
cellular response to stress GO:0033554 269 0.057
nucleotide metabolic process GO:0009117 279 0.057
positive regulation of transcription dna templated GO:0045893 197 0.057
protein transport GO:0015031 132 0.056
protein complex subunit organization GO:0071822 302 0.056
regulation of phosphorylation GO:0042325 248 0.055
regulation of growth GO:0040008 105 0.055
positive regulation of rna biosynthetic process GO:1902680 197 0.054
negative regulation of neuron death GO:1901215 69 0.053
hematopoietic progenitor cell differentiation GO:0002244 2 0.053
regulation of multicellular organismal development GO:2000026 376 0.053
rna biosynthetic process GO:0032774 380 0.051
cellular macromolecular complex assembly GO:0034622 58 0.051
cellular process involved in reproduction in multicellular organism GO:0022412 35 0.051
response to hydrogen peroxide GO:0042542 89 0.050
regulation of molecular function GO:0065009 398 0.050
cellular component assembly GO:0022607 360 0.049
single organism organelle organization GO:1902589 180 0.048
positive regulation of molecular function GO:0044093 230 0.047
transcription from rna polymerase ii promoter GO:0006366 252 0.047
regulation of phosphate metabolic process GO:0019220 349 0.047
reproductive process GO:0022414 372 0.046
norepinephrine metabolic process GO:0042415 3 0.045
response to peptide GO:1901652 292 0.044
neuron death GO:0070997 127 0.044
purine containing compound metabolic process GO:0072521 253 0.044
regulation of organelle organization GO:0033043 80 0.043
positive regulation of protein modification process GO:0031401 142 0.043
cellular catabolic process GO:0044248 295 0.043
sorbitol metabolic process GO:0006060 1 0.042
jak stat cascade GO:0007259 26 0.041
positive regulation of intracellular signal transduction GO:1902533 138 0.041
amine metabolic process GO:0009308 38 0.040
cell cycle process GO:0022402 57 0.040
negative regulation of cell death GO:0060548 229 0.040
behavior GO:0007610 205 0.040
urogenital system development GO:0001655 78 0.039
response to reactive oxygen species GO:0000302 120 0.038
regulation of cellular localization GO:0060341 263 0.038
catabolic process GO:0009056 351 0.038
regulation of cellular protein metabolic process GO:0032268 267 0.038
positive regulation of transport GO:0051050 245 0.038
rna metabolic process GO:0016070 406 0.037
head development GO:0060322 247 0.037
transcription dna templated GO:0006351 377 0.037
response to oxidative stress GO:0006979 186 0.037
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.037
neurological system process GO:0050877 219 0.036
oxoacid metabolic process GO:0043436 290 0.036
regulation of phosphorus metabolic process GO:0051174 349 0.036
cellular ketone metabolic process GO:0042180 51 0.036
purine nucleoside triphosphate metabolic process GO:0009144 141 0.036
cellular chemical homeostasis GO:0055082 247 0.035
regulation of developmental growth GO:0048638 45 0.035
negative regulation of mitotic cell cycle phase transition GO:1901991 3 0.035
cellular response to peptide GO:1901653 133 0.034
neuron differentiation GO:0030182 368 0.033
ribonucleotide metabolic process GO:0009259 231 0.033
central nervous system development GO:0007417 311 0.033
regulation of cellular component organization GO:0051128 368 0.033
regulation of cell growth GO:0001558 85 0.032
positive regulation of phosphate metabolic process GO:0045937 262 0.032
positive regulation of phosphorus metabolic process GO:0010562 262 0.032
negative regulation of macromolecule metabolic process GO:0010605 260 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.032
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.031
negative regulation of cell cycle phase transition GO:1901988 4 0.031
localization of cell GO:0051674 202 0.031
neuron apoptotic process GO:0051402 88 0.031
organelle organization GO:0006996 266 0.031
cellular response to growth factor stimulus GO:0071363 162 0.031
microtubule cytoskeleton organization GO:0000226 25 0.031
collecting duct development GO:0072044 1 0.030
tissue development GO:0009888 252 0.030
Mouse
cellular homeostasis GO:0019725 252 0.030
response to estrogen GO:0043627 232 0.030
single organism behavior GO:0044708 130 0.030
single organism reproductive process GO:0044702 297 0.030
response to estradiol GO:0032355 164 0.030
purine nucleoside metabolic process GO:0042278 169 0.030
cellular amine metabolic process GO:0044106 38 0.030
carbohydrate derivative metabolic process GO:1901135 346 0.029
protein phosphorylation GO:0006468 345 0.029
single organism carbohydrate metabolic process GO:0044723 118 0.029
heart development GO:0007507 72 0.028
regulation of rna biosynthetic process GO:2001141 381 0.028
regulation of cellular amino acid metabolic process GO:0006521 2 0.028
response to peptide hormone GO:0043434 278 0.028
dna integrity checkpoint GO:0031570 2 0.028
regulation of protein phosphorylation GO:0001932 183 0.028
single organism biosynthetic process GO:0044711 342 0.027
cellular macromolecule localization GO:0070727 122 0.027
regulation of cellular amine metabolic process GO:0033238 8 0.027
negative regulation of metabolic process GO:0009892 331 0.027
cation transport GO:0006812 382 0.027
chemotaxis GO:0006935 66 0.027
mitotic spindle organization GO:0007052 2 0.027
cellular response to ketone GO:1901655 51 0.027
purine nucleotide metabolic process GO:0006163 229 0.027
negative regulation of programmed cell death GO:0043069 183 0.026
cellular lipid metabolic process GO:0044255 208 0.026
isoprenoid metabolic process GO:0006720 45 0.026
positive regulation of signal transduction GO:0009967 175 0.026
Mouse
negative regulation of neuron apoptotic process GO:0043524 45 0.026
cellular response to nitrogen compound GO:1901699 210 0.026
alditol metabolic process GO:0019400 4 0.025
response to cytokine GO:0034097 215 0.025
regulation of cellular ketone metabolic process GO:0010565 27 0.025
regulation of anatomical structure size GO:0090066 135 0.025
regulation of rna metabolic process GO:0051252 391 0.025
small molecule biosynthetic process GO:0044283 124 0.025
mitotic cell cycle checkpoint GO:0007093 1 0.025
positive regulation of growth GO:0045927 55 0.025
regulation of protein modification process GO:0031399 194 0.024
cardiovascular system development GO:0072358 134 0.024
Zebrafish
renal system development GO:0072001 67 0.024
sexual reproduction GO:0019953 148 0.024
cellular component movement GO:0006928 248 0.024
regulation of homeostatic process GO:0032844 101 0.024
organonitrogen compound biosynthetic process GO:1901566 167 0.024
cellular ion homeostasis GO:0006873 184 0.024
organic hydroxy compound metabolic process GO:1901615 115 0.024
purine ribonucleotide metabolic process GO:0009150 227 0.024
response to wounding GO:0009611 254 0.024
negative regulation of molecular function GO:0044092 133 0.024
positive regulation of nucleic acid templated transcription GO:1903508 197 0.024
regulation of cell migration GO:0030334 128 0.024
positive regulation of cellular component organization GO:0051130 200 0.023
microtubule based process GO:0007017 36 0.023
cation homeostasis GO:0055080 195 0.023
response to growth factor GO:0070848 189 0.023
cardiac muscle cell development GO:0055013 16 0.023
response to glucocorticoid GO:0051384 223 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.023
protein import into nucleus GO:0006606 35 0.023
response to radiation GO:0009314 137 0.023
Mouse
positive regulation of cell growth GO:0030307 44 0.023
negative regulation of apoptotic process GO:0043066 181 0.022
dephosphorylation GO:0016311 98 0.022
response to metal ion GO:0010038 253 0.022
somatic stem cell division GO:0048103 2 0.022
cellular protein complex assembly GO:0043623 44 0.022
carbohydrate derivative catabolic process GO:1901136 147 0.022
brain development GO:0007420 247 0.022
mitotic cell cycle GO:0000278 49 0.022
response to alkaloid GO:0043279 132 0.022
organonitrogen compound catabolic process GO:1901565 179 0.022
positive regulation of phosphorylation GO:0042327 177 0.022
guanosine containing compound catabolic process GO:1901069 71 0.022
cell motility GO:0048870 202 0.022
positive regulation of multicellular organismal process GO:0051240 387 0.022
negative regulation of signaling GO:0023057 157 0.022
carbohydrate derivative biosynthetic process GO:1901137 124 0.021
negative regulation of phosphorus metabolic process GO:0010563 80 0.021
positive regulation of cellular protein metabolic process GO:0032270 167 0.021
synaptic growth at neuromuscular junction GO:0051124 1 0.021
vesicle localization GO:0051648 33 0.021
inner medullary collecting duct development GO:0072061 1 0.021
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.021
positive regulation of developmental growth GO:0048639 29 0.021
proteolysis GO:0006508 175 0.021
aging GO:0007568 241 0.021
regulation of vesicle mediated transport GO:0060627 81 0.021
developmental process involved in reproduction GO:0003006 159 0.021
multicellular organism growth GO:0035264 1 0.021
response to inorganic substance GO:0010035 377 0.020
nucleoside triphosphate metabolic process GO:0009141 144 0.020
nucleocytoplasmic transport GO:0006913 48 0.020
circulatory system development GO:0072359 134 0.020
Zebrafish
membrane organization GO:0061024 94 0.020
protein ubiquitination GO:0016567 28 0.020
nucleobase containing small molecule metabolic process GO:0055086 316 0.019
secretion GO:0046903 307 0.019
negative regulation of nucleic acid templated transcription GO:1903507 117 0.019
regulation of secretion GO:0051046 224 0.019
growth GO:0040007 165 0.019
regulation of hormone levels GO:0010817 187 0.019
cellular response to organonitrogen compound GO:0071417 197 0.018
regulation of hydrolase activity GO:0051336 143 0.018
protein modification by small protein conjugation or removal GO:0070647 35 0.018
camp metabolic process GO:0046058 63 0.018
striated muscle tissue development GO:0014706 58 0.018
lipid metabolic process GO:0006629 283 0.018
cellular metal ion homeostasis GO:0006875 172 0.017
retinal metabolic process GO:0042574 3 0.017
negative regulation of catalytic activity GO:0043086 103 0.017
carboxylic acid metabolic process GO:0019752 289 0.017
hormone metabolic process GO:0042445 69 0.017
regulation of system process GO:0044057 208 0.017
response to corticosteroid GO:0031960 235 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
cardiac cell development GO:0055006 16 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
ion transmembrane transport GO:0034220 365 0.017
cytoplasmic transport GO:0016482 115 0.017
cellular response to dna damage stimulus GO:0006974 19 0.016
dna damage checkpoint GO:0000077 2 0.016
positive regulation of biosynthetic process GO:0009891 319 0.016
axon development GO:0061564 96 0.016
phospholipid metabolic process GO:0006644 61 0.016
atp metabolic process GO:0046034 72 0.016
regulation of heart growth GO:0060420 12 0.016
heart morphogenesis GO:0003007 3 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
organic hydroxy compound biosynthetic process GO:1901617 51 0.016
ion homeostasis GO:0050801 212 0.016
regulation of muscle system process GO:0090257 79 0.016
muscle structure development GO:0061061 87 0.016
ribonucleoside triphosphate metabolic process GO:0009199 141 0.016
regulation of ion transport GO:0043269 245 0.016
response to acid chemical GO:0001101 222 0.016
axis specification GO:0009798 4 0.016
chromosome segregation GO:0007059 2 0.016
carbohydrate biosynthetic process GO:0016051 42 0.016
regulation of response to external stimulus GO:0032101 106 0.016
cell projection morphogenesis GO:0048858 123 0.016
sequestering of calcium ion GO:0051208 8 0.015
regulation of muscle tissue development GO:1901861 25 0.015
metal ion transport GO:0030001 289 0.015
regulation of smooth muscle cell proliferation GO:0048660 75 0.015
spermatogenesis GO:0007283 99 0.015
nucleoside metabolic process GO:0009116 179 0.015
hippocampus development GO:0021766 30 0.015
anatomical structure formation involved in morphogenesis GO:0048646 83 0.015
Zebrafish
purine ribonucleoside metabolic process GO:0046128 168 0.015
positive regulation of cellular biosynthetic process GO:0031328 295 0.015
gamete generation GO:0007276 124 0.015
tube development GO:0035295 89 0.014
Mouse
organic acid metabolic process GO:0006082 292 0.014
establishment of protein localization GO:0045184 141 0.014
negative regulation of cellular component organization GO:0051129 83 0.014
positive regulation of muscle organ development GO:0048636 13 0.014
lipid storage GO:0019915 1 0.014
chemical homeostasis GO:0048878 292 0.014
galactose metabolic process GO:0006012 4 0.014
regulation of kinase activity GO:0043549 117 0.014
cellular component morphogenesis GO:0032989 155 0.014
protein autophosphorylation GO:0046777 66 0.014
response to oxygen levels GO:0070482 265 0.014
negative regulation of signal transduction GO:0009968 83 0.014
regulation of lipid metabolic process GO:0019216 68 0.014
response to amino acid GO:0043200 75 0.014
cardiac muscle tissue growth GO:0055017 20 0.014
cell projection organization GO:0030030 302 0.014
response to nutrient levels GO:0031667 370 0.013
peptidyl amino acid modification GO:0018193 126 0.013
positive regulation of cell development GO:0010720 176 0.013
gtp metabolic process GO:0046039 72 0.013
negative regulation of protein metabolic process GO:0051248 114 0.013
regulation of cell development GO:0060284 263 0.013
ribonucleoside metabolic process GO:0009119 174 0.013
cell cell signaling GO:0007267 335 0.013
glucose homeostasis GO:0042593 75 0.013
alcohol metabolic process GO:0006066 77 0.013
cell part morphogenesis GO:0032990 123 0.013
phospholipid biosynthetic process GO:0008654 29 0.013
positive regulation of cellular component biogenesis GO:0044089 55 0.013
positive regulation of cell differentiation GO:0045597 217 0.013
regulation of meiotic cell cycle GO:0051445 3 0.013
single organism intracellular transport GO:1902582 166 0.013
regulation of cellular component size GO:0032535 51 0.013
cellular response to cytokine stimulus GO:0071345 127 0.013
positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 5 0.013
regulation of organ growth GO:0046620 13 0.013
positive regulation of catalytic activity GO:0043085 184 0.012
heart growth GO:0060419 20 0.012
cation transmembrane transport GO:0098655 263 0.012
g protein coupled receptor signaling pathway GO:0007186 242 0.012
cellular response to lipid GO:0071396 201 0.012
regulation of immune system process GO:0002682 123 0.012
regulation of locomotion GO:0040012 148 0.012
positive regulation of gene expression GO:0010628 244 0.012
regulation of cellular component biogenesis GO:0044087 86 0.012
nitrogen compound transport GO:0071705 229 0.012
neuron development GO:0048666 286 0.012
organ growth GO:0035265 24 0.012
protein localization to endoplasmic reticulum GO:0070972 1 0.012
negative regulation of rna metabolic process GO:0051253 123 0.012
ribonucleoprotein complex subunit organization GO:0071826 8 0.012
regulation of cell projection organization GO:0031344 175 0.012
gastrulation GO:0007369 2 0.012
regulation of nucleotide metabolic process GO:0006140 117 0.012
protein homooligomerization GO:0051260 91 0.012
hexose metabolic process GO:0019318 58 0.012
axon guidance GO:0007411 24 0.012
single organism cellular localization GO:1902580 102 0.012
protein complex biogenesis GO:0070271 263 0.012
locomotory behavior GO:0007626 15 0.011
protein complex assembly GO:0006461 263 0.011
cellular response to external stimulus GO:0071496 118 0.011
male sex differentiation GO:0046661 64 0.011
heterocycle catabolic process GO:0046700 167 0.011
inorganic ion transmembrane transport GO:0098660 229 0.011
spindle organization GO:0007051 2 0.011
aromatic compound catabolic process GO:0019439 168 0.011
response to extracellular stimulus GO:0009991 380 0.011
establishment of vesicle localization GO:0051650 31 0.011
purine nucleoside triphosphate catabolic process GO:0009146 122 0.011
positive regulation of jak stat cascade GO:0046427 19 0.011
neuron projection guidance GO:0097485 24 0.011
regulation of neurogenesis GO:0050767 247 0.011
cardiac muscle tissue development GO:0048738 26 0.011
organic cyclic compound catabolic process GO:1901361 175 0.010
regulation of cell motility GO:2000145 131 0.010
cellular aldehyde metabolic process GO:0006081 11 0.010
muscle cell proliferation GO:0033002 84 0.010
regulation of neuron differentiation GO:0045664 208 0.010
regulation of nervous system development GO:0051960 264 0.010
kidney development GO:0001822 67 0.010
regulation of cell size GO:0008361 37 0.010
intracellular protein transport GO:0006886 79 0.010
regulation of cell cycle process GO:0010564 31 0.010
transmembrane transport GO:0055085 412 0.010
nucleoside catabolic process GO:0009164 126 0.010
sensory organ development GO:0007423 74 0.010
naphthalene metabolic process GO:0018931 2 0.010

Ppp1ca disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.018
disease of anatomical entity DOID:7 0 0.018
connective tissue disease DOID:65 0 0.018
disease of cellular proliferation DOID:14566 0 0.016
benign neoplasm DOID:0060072 0 0.016