Rattus norvegicus

34 known processes

Prnp

prion protein

(Aliases: Prn,PrP)

Prnp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of multicellular organismal process GO:0051241 203 0.198
histamine secretion involved in inflammatory response GO:0002441 3 0.188
nitrogen compound transport GO:0071705 229 0.176
secretion GO:0046903 307 0.157
regulation of cellular component organization GO:0051128 368 0.128
cation transport GO:0006812 382 0.125
response to metal ion GO:0010038 253 0.120
positive regulation of signaling GO:0023056 270 0.119
catabolic process GO:0009056 351 0.116
response to peptide GO:1901652 292 0.106
secretion by cell GO:0032940 248 0.105
regulation of transcription dna templated GO:0006355 374 0.105
regulation of hormone levels GO:0010817 187 0.097
single organism cellular localization GO:1902580 102 0.097
regulation of phosphorus metabolic process GO:0051174 349 0.092
vesicle mediated transport GO:0016192 181 0.090
ion transmembrane transport GO:0034220 365 0.090
cellular macromolecule localization GO:0070727 122 0.088
metal ion transport GO:0030001 289 0.081
response to inorganic substance GO:0010035 377 0.081
carbohydrate derivative metabolic process GO:1901135 346 0.081
protein complex assembly GO:0006461 263 0.079
regulation of cellular localization GO:0060341 263 0.077
nucleic acid templated transcription GO:0097659 379 0.075
ras protein signal transduction GO:0007265 29 0.072
single organism intracellular transport GO:1902582 166 0.070
macromolecule localization GO:0033036 252 0.066
negative regulation of gene expression GO:0010629 199 0.063
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.062
positive regulation of signal transduction GO:0009967 175 0.061
negative regulation of nervous system development GO:0051961 79 0.061
inorganic ion transmembrane transport GO:0098660 229 0.061
protein phosphorylation GO:0006468 345 0.060
cell projection organization GO:0030030 302 0.060
cellular component biogenesis GO:0044085 368 0.059
intracellular transport GO:0046907 185 0.058
regulation of programmed cell death GO:0043067 341 0.058
positive regulation of catalytic activity GO:0043085 184 0.056
regulation of molecular function GO:0065009 398 0.056
regulation of ion transport GO:0043269 245 0.056
positive regulation of phosphate metabolic process GO:0045937 262 0.056
negative regulation of developmental process GO:0051093 125 0.056
response to camp GO:0051591 91 0.055
reproductive process GO:0022414 372 0.054
peptide metabolic process GO:0006518 32 0.053
establishment of protein localization GO:0045184 141 0.053
inorganic cation transmembrane transport GO:0098662 202 0.052
negative regulation of neurogenesis GO:0050768 78 0.052
protein complex subunit organization GO:0071822 302 0.052
positive regulation of protein phosphorylation GO:0001934 135 0.050
negative regulation of cell development GO:0010721 82 0.049
neuron differentiation GO:0030182 368 0.048
regulation of nucleic acid templated transcription GO:1903506 380 0.048
positive regulation of phosphorus metabolic process GO:0010562 262 0.047
positive regulation of cell communication GO:0010647 271 0.047
anion transport GO:0006820 178 0.046
carbohydrate metabolic process GO:0005975 130 0.046
cellular response to hormone stimulus GO:0032870 247 0.045
anatomical structure morphogenesis GO:0009653 298 0.045
cellular response to insulin stimulus GO:0032869 81 0.045
carboxylic acid metabolic process GO:0019752 289 0.045
regulation of nervous system development GO:0051960 264 0.044
positive regulation of response to stimulus GO:0048584 285 0.044
cellular protein localization GO:0034613 122 0.043
cardiac chamber development GO:0003205 1 0.043
regulation of rna biosynthetic process GO:2001141 381 0.042
response to calcium ion GO:0051592 59 0.042
head development GO:0060322 247 0.042
cellular amide metabolic process GO:0043603 44 0.042
regulation of signal transduction GO:0009966 318 0.041
positive regulation of biosynthetic process GO:0009891 319 0.041
regulation of multicellular organismal development GO:2000026 376 0.041
response to insulin GO:0032868 133 0.041
cellular response to nitrogen compound GO:1901699 210 0.040
response to amine GO:0014075 46 0.040
positive regulation of phosphorylation GO:0042327 177 0.040
regulation of catalytic activity GO:0050790 304 0.040
macromolecular complex assembly GO:0065003 273 0.040
neuron projection development GO:0031175 273 0.040
negative regulation of cell proliferation GO:0008285 119 0.040
oxoacid metabolic process GO:0043436 290 0.039
protein localization GO:0008104 191 0.039
multi organism reproductive process GO:0044703 262 0.039
neurological system process GO:0050877 219 0.038
macromolecular complex subunit organization GO:0043933 339 0.038
divalent inorganic cation transport GO:0072511 134 0.038
positive regulation of multicellular organismal process GO:0051240 387 0.037
response to glucocorticoid GO:0051384 223 0.037
response to peptide hormone GO:0043434 278 0.037
regulation of hydrolase activity GO:0051336 143 0.036
defense response GO:0006952 194 0.036
response to carbohydrate GO:0009743 183 0.036
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.036
divalent metal ion transport GO:0070838 132 0.035
localization of cell GO:0051674 202 0.035
transcription dna templated GO:0006351 377 0.034
regulation of cell differentiation GO:0045595 320 0.034
protein oligomerization GO:0051259 191 0.034
regulation of neurogenesis GO:0050767 247 0.033
cellular amine metabolic process GO:0044106 38 0.033
response to nutrient levels GO:0031667 370 0.033
intracellular signal transduction GO:0035556 314 0.032
cellular response to peptide hormone stimulus GO:0071375 120 0.032
rna biosynthetic process GO:0032774 380 0.032
regulation of phosphate metabolic process GO:0019220 349 0.031
homeostatic process GO:0042592 331 0.031
cellular response to peptide GO:1901653 133 0.031
cellular response to stress GO:0033554 269 0.031
positive regulation of programmed cell death GO:0043068 157 0.031
carbohydrate derivative catabolic process GO:1901136 147 0.031
organic substance catabolic process GO:1901575 316 0.031
response to molecule of bacterial origin GO:0002237 194 0.031
regulation of cell proliferation GO:0042127 359 0.031
protein complex biogenesis GO:0070271 263 0.030
transmembrane transport GO:0055085 412 0.030
cellular component assembly GO:0022607 360 0.030
regulation of protein modification process GO:0031399 194 0.030
transcription from rna polymerase ii promoter GO:0006366 252 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
positive regulation of gene expression GO:0010628 244 0.029
positive regulation of transcription dna templated GO:0045893 197 0.029
protein heterooligomerization GO:0051291 89 0.029
protein transport GO:0015031 132 0.029
negative regulation of cellular metabolic process GO:0031324 281 0.029
intracellular protein transport GO:0006886 79 0.029
cellular response to oxygen containing compound GO:1901701 386 0.029
positive regulation of transport GO:0051050 245 0.028
multicellular organismal reproductive process GO:0048609 233 0.028
protein processing GO:0016485 68 0.028
cellular component movement GO:0006928 248 0.028
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.028
cellular response to organonitrogen compound GO:0071417 197 0.028
regulation of neuron differentiation GO:0045664 208 0.028
chemical homeostasis GO:0048878 292 0.027
positive regulation of secretion GO:0051047 140 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.027
establishment of protein localization to organelle GO:0072594 44 0.027
monocarboxylic acid transport GO:0015718 52 0.027
regulation of high voltage gated calcium channel activity GO:1901841 3 0.027
organophosphate catabolic process GO:0046434 148 0.027
positive regulation of developmental process GO:0051094 283 0.027
negative regulation of transport GO:0051051 136 0.027
regulation of calcium ion transmembrane transporter activity GO:1901019 17 0.026
protein targeting GO:0006605 61 0.026
positive regulation of neurogenesis GO:0050769 165 0.026
regulation of cell development GO:0060284 263 0.026
cellular chemical homeostasis GO:0055082 247 0.026
organonitrogen compound catabolic process GO:1901565 179 0.026
anion transmembrane transport GO:0098656 77 0.026
cellular catabolic process GO:0044248 295 0.026
positive regulation of protein metabolic process GO:0051247 178 0.025
regulation of cellular protein metabolic process GO:0032268 267 0.025
signal release GO:0023061 145 0.025
cell motility GO:0048870 202 0.025
response to corticosteroid GO:0031960 235 0.025
multicellular organism reproduction GO:0032504 233 0.025
positive regulation of cell differentiation GO:0045597 217 0.025
positive regulation of cell development GO:0010720 176 0.024
neuron development GO:0048666 286 0.024
regulation of ion transmembrane transport GO:0034765 121 0.024
cellular homeostasis GO:0019725 252 0.024
positive regulation of nervous system development GO:0051962 178 0.024
cellular ketone metabolic process GO:0042180 51 0.024
response to ethanol GO:0045471 162 0.024
positive regulation of neuron differentiation GO:0045666 126 0.024
regulation of protein metabolic process GO:0051246 289 0.023
organelle organization GO:0006996 266 0.023
regulation of metal ion transport GO:0010959 118 0.023
calcium ion transport GO:0006816 131 0.023
cell cell signaling GO:0007267 335 0.023
small gtpase mediated signal transduction GO:0007264 36 0.023
cardiac ventricle development GO:0003231 1 0.023
central nervous system development GO:0007417 311 0.023
negative regulation of protein metabolic process GO:0051248 114 0.023
cellular amino acid metabolic process GO:0006520 107 0.023
mitochondrion organization GO:0007005 35 0.023
organic anion transport GO:0015711 132 0.023
regulation of secretion GO:0051046 224 0.023
carbohydrate derivative biosynthetic process GO:1901137 124 0.022
regulation of rna metabolic process GO:0051252 391 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
negative regulation of cell differentiation GO:0045596 99 0.022
response to growth factor GO:0070848 189 0.022
organic acid metabolic process GO:0006082 292 0.022
negative regulation of nucleic acid templated transcription GO:1903507 117 0.022
hormone transport GO:0009914 121 0.022
apoptotic process GO:0006915 381 0.022
ion homeostasis GO:0050801 212 0.022
regulation of apoptotic process GO:0042981 335 0.022
single organism catabolic process GO:0044712 283 0.022
rna metabolic process GO:0016070 406 0.021
calcium ion transmembrane transport GO:0070588 70 0.021
regulation of calcium ion transport GO:0051924 77 0.021
response to extracellular stimulus GO:0009991 380 0.021
cellular response to endogenous stimulus GO:0071495 377 0.021
protein localization to organelle GO:0033365 57 0.021
positive regulation of apoptotic process GO:0043065 154 0.021
response to wounding GO:0009611 254 0.021
negative regulation of protein transport GO:0051224 17 0.021
regulation of cellular amine metabolic process GO:0033238 8 0.021
regeneration GO:0031099 163 0.021
negative regulation of metabolic process GO:0009892 331 0.020
positive regulation of molecular function GO:0044093 230 0.020
carboxylic acid transport GO:0046942 115 0.020
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
positive regulation of cell projection organization GO:0031346 111 0.020
cation transmembrane transport GO:0098655 263 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
inflammatory response GO:0006954 150 0.020
regulation of calcium ion transmembrane transport GO:1903169 18 0.019
organic hydroxy compound transport GO:0015850 77 0.019
response to hypoxia GO:0001666 231 0.019
reproduction GO:0000003 245 0.019
organophosphate metabolic process GO:0019637 370 0.019
regulation of synaptic plasticity GO:0048167 70 0.019
cellular response to organic cyclic compound GO:0071407 202 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.019
purine ribonucleotide catabolic process GO:0009154 136 0.019
single organism biosynthetic process GO:0044711 342 0.019
regulation of cell migration GO:0030334 128 0.018
protein maturation GO:0051604 68 0.018
centrosome organization GO:0051297 1 0.018
regulation of ryanodine sensitive calcium release channel activity GO:0060314 5 0.018
hormone metabolic process GO:0042445 69 0.018
response to cytokine GO:0034097 215 0.018
cation homeostasis GO:0055080 195 0.018
purine containing compound metabolic process GO:0072521 253 0.018
lipid metabolic process GO:0006629 283 0.018
female pregnancy GO:0007565 122 0.018
positive regulation of cellular component organization GO:0051130 200 0.018
negative regulation of transcription dna templated GO:0045892 116 0.018
positive regulation of nucleic acid templated transcription GO:1903508 197 0.018
mast cell activation GO:0045576 15 0.018
regulation of cell projection organization GO:0031344 175 0.018
cell adhesion GO:0007155 110 0.018
hormone secretion GO:0046879 115 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
response to organophosphorus GO:0046683 102 0.017
single organism reproductive process GO:0044702 297 0.017
regulation of neuron projection development GO:0010975 161 0.017
positive regulation of protein modification process GO:0031401 142 0.017
reproductive system development GO:0061458 128 0.017
regulation of ion transmembrane transporter activity GO:0032412 48 0.017
single organism nuclear import GO:1902593 35 0.017
negative regulation of rna biosynthetic process GO:1902679 118 0.017
proteolysis GO:0006508 175 0.017
single organism carbohydrate metabolic process GO:0044723 118 0.017
regulation of locomotion GO:0040012 148 0.017
ribose phosphate metabolic process GO:0019693 235 0.017
cellular response to growth factor stimulus GO:0071363 162 0.017
amine metabolic process GO:0009308 38 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.017
gland development GO:0048732 155 0.016
regulation of protein transport GO:0051223 68 0.016
negative regulation of biosynthetic process GO:0009890 168 0.016
response to glucose GO:0009749 136 0.016
somatic stem cell division GO:0048103 2 0.016
positive regulation of secretion by cell GO:1903532 128 0.016
regulation of transmembrane transport GO:0034762 122 0.016
negative regulation of neuron differentiation GO:0045665 62 0.016
response to hexose GO:0009746 144 0.016
regulation of cellular amino acid metabolic process GO:0006521 2 0.016
positive regulation of cell death GO:0010942 184 0.016
regulation of intracellular signal transduction GO:1902531 218 0.016
negative regulation of molecular function GO:0044092 133 0.016
cell activation GO:0001775 97 0.016
response to ketone GO:1901654 182 0.016
regulation of transporter activity GO:0032409 50 0.015
nuclear transport GO:0051169 49 0.015
positive regulation of cellular amine metabolic process GO:0033240 3 0.015
synaptic transmission GO:0007268 235 0.015
negative regulation of cellular protein metabolic process GO:0032269 106 0.015
response to bacterium GO:0009617 200 0.015
immune response GO:0006955 104 0.015
developmental process involved in reproduction GO:0003006 159 0.015
exocytosis GO:0006887 60 0.015
response to purine containing compound GO:0014074 126 0.015
gliogenesis GO:0042063 93 0.015
locomotion GO:0040011 237 0.015
regulation of nitric oxide synthase activity GO:0050999 8 0.015
nucleoside phosphate metabolic process GO:0006753 283 0.015
regulation of smoothened signaling pathway GO:0008589 2 0.014
multicellular organism growth GO:0035264 1 0.014
histamine secretion by mast cell GO:0002553 3 0.014
nucleocytoplasmic transport GO:0006913 48 0.014
reproductive structure development GO:0048608 128 0.014
protein targeting to nucleus GO:0044744 35 0.014
brain development GO:0007420 247 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
positive regulation of hydrolase activity GO:0051345 86 0.014
ribonucleoside catabolic process GO:0042454 126 0.014
regulation of establishment of protein localization GO:0070201 69 0.014
tissue development GO:0009888 252 0.014
protein localization to nucleus GO:0034504 39 0.014
glial cell differentiation GO:0010001 65 0.014
camp biosynthetic process GO:0006171 47 0.014
multi multicellular organism process GO:0044706 138 0.014
regulation of system process GO:0044057 208 0.014
regulation of cell motility GO:2000145 131 0.014
histamine production involved in inflammatory response GO:0002349 3 0.014
aromatic compound catabolic process GO:0019439 168 0.014
purine containing compound catabolic process GO:0072523 138 0.013
protein import into nucleus GO:0006606 35 0.013
regulation of cyclic nucleotide metabolic process GO:0030799 51 0.013
organic hydroxy compound metabolic process GO:1901615 115 0.013
regulation of anatomical structure size GO:0090066 135 0.013
chemosensory behavior GO:0007635 2 0.013
cellular cation homeostasis GO:0030003 180 0.013
multicellular organismal signaling GO:0035637 44 0.013
response to acid chemical GO:0001101 222 0.013
action potential GO:0001508 54 0.013
divalent inorganic cation homeostasis GO:0072507 165 0.013
mesoderm development GO:0007498 2 0.013
purine nucleotide metabolic process GO:0006163 229 0.013
regulation of small gtpase mediated signal transduction GO:0051056 48 0.013
cardiovascular system development GO:0072358 134 0.013
microtubule organizing center organization GO:0031023 1 0.013
axis specification GO:0009798 4 0.013
leukocyte activation GO:0045321 76 0.013
regulation of voltage gated calcium channel activity GO:1901385 6 0.013
protein homooligomerization GO:0051260 91 0.013
purine nucleoside catabolic process GO:0006152 124 0.013
behavior GO:0007610 205 0.013
response to oxygen levels GO:0070482 265 0.013
response to biotic stimulus GO:0009607 226 0.013
response to amphetamine GO:0001975 25 0.013
cellular divalent inorganic cation homeostasis GO:0072503 162 0.013
nucleobase containing small molecule metabolic process GO:0055086 316 0.013
ribonucleotide catabolic process GO:0009261 136 0.013
circulatory system development GO:0072359 134 0.013
sexual reproduction GO:0019953 148 0.013
cell cycle GO:0007049 101 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.012
positive regulation of hormone secretion GO:0046887 65 0.012
response to decreased oxygen levels GO:0036293 237 0.012
ribonucleoside metabolic process GO:0009119 174 0.012
purine ribonucleoside catabolic process GO:0046130 124 0.012
regulation of cellular component movement GO:0051270 150 0.012
nucleotide metabolic process GO:0009117 279 0.012
response to reactive oxygen species GO:0000302 120 0.012
glucose homeostasis GO:0042593 75 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
centrosome cycle GO:0007098 1 0.012
protein localization to membrane GO:0072657 36 0.012
response to monosaccharide GO:0034284 159 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.012
protein import GO:0017038 37 0.012
regulation of catabolic process GO:0009894 113 0.012
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 34 0.012
cytoplasmic transport GO:0016482 115 0.012
cell activation involved in immune response GO:0002263 16 0.012
salivary gland development GO:0007431 3 0.012
negative regulation of neuron projection development GO:0010977 46 0.012
neuron projection regeneration GO:0031102 35 0.012
gamete generation GO:0007276 124 0.011
embryonic pattern specification GO:0009880 1 0.011
protein targeting to plasma membrane GO:0072661 4 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.011
organic acid transport GO:0015849 116 0.011
regulation of secretion by cell GO:1903530 208 0.011
positive regulation of protein kinase activity GO:0045860 73 0.011
spindle organization GO:0007051 2 0.011
regulation of cellular ketone metabolic process GO:0010565 27 0.011
negative regulation of rna metabolic process GO:0051253 123 0.011
monosaccharide metabolic process GO:0005996 61 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.011
cell morphogenesis GO:0000902 142 0.011
response to nutrient GO:0007584 248 0.011
regulation of proteolysis GO:0030162 66 0.011
odontogenesis GO:0042476 32 0.011
positive regulation of cell proliferation GO:0008284 249 0.011
response to axon injury GO:0048678 59 0.011
camp metabolic process GO:0046058 63 0.011
regulation of anatomical structure morphogenesis GO:0022603 141 0.011
regulation of nucleocytoplasmic transport GO:0046822 28 0.011
regulation of long term neuronal synaptic plasticity GO:0048169 15 0.011
regulation of ras protein signal transduction GO:0046578 45 0.011
cellular response to carbohydrate stimulus GO:0071322 72 0.011
circulatory system process GO:0003013 183 0.011
response to other organism GO:0051707 220 0.011
response to radiation GO:0009314 137 0.011
regulation of protein phosphorylation GO:0001932 183 0.011
negative regulation of secretion GO:0051048 82 0.011
peptide hormone secretion GO:0030072 84 0.011
embryo implantation GO:0007566 15 0.011
cellular component morphogenesis GO:0032989 155 0.011
regulation of monooxygenase activity GO:0032768 8 0.011
gtp metabolic process GO:0046039 72 0.011
cellular response to glucose stimulus GO:0071333 65 0.011
insulin secretion GO:0030073 69 0.011
heterocycle catabolic process GO:0046700 167 0.011
purine nucleotide catabolic process GO:0006195 136 0.010
regulation of kinase activity GO:0043549 117 0.010
regulation of transferase activity GO:0051338 123 0.010
rho protein signal transduction GO:0007266 11 0.010
guanosine containing compound metabolic process GO:1901068 74 0.010
regulation of growth GO:0040008 105 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
cellular nitrogen compound catabolic process GO:0044270 163 0.010
response to alkaloid GO:0043279 132 0.010
peptide catabolic process GO:0043171 5 0.010
regulation of hormone secretion GO:0046883 106 0.010
regulation of response to wounding GO:1903034 69 0.010
regulation of phosphorylation GO:0042325 248 0.010
signal transduction by phosphorylation GO:0023014 144 0.010

Prnp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
sensory system disease DOID:0050155 0 0.022
eye and adnexa disease DOID:1492 0 0.022
eye disease DOID:5614 0 0.022
disease of metabolism DOID:0014667 0 0.014
acquired metabolic disease DOID:0060158 0 0.010
blood protein disease DOID:620 0 0.010
immune system disease DOID:2914 0 0.010
hematopoietic system disease DOID:74 0 0.010