Rattus norvegicus

0 known processes

Psap

prosaposin

(Aliases: SGP1A,SGP-1)

Psap biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
autophagic cell death GO:0048102 4 0.286
catabolic process GO:0009056 351 0.246
regulation of angiotensin metabolic process GO:0060177 3 0.233
single organism catabolic process GO:0044712 283 0.198
cell growth GO:0016049 104 0.175
cellular catabolic process GO:0044248 295 0.161
organic substance catabolic process GO:1901575 316 0.145
regulation of protein metabolic process GO:0051246 289 0.140
positive regulation of multicellular organismal process GO:0051240 387 0.135
response to cgmp GO:0070305 3 0.133
cellular component biogenesis GO:0044085 368 0.132
organophosphate metabolic process GO:0019637 370 0.129
negative regulation of nervous system development GO:0051961 79 0.124
positive regulation of gene expression GO:0010628 244 0.113
cell type specific apoptotic process GO:0097285 134 0.111
cellular response to external stimulus GO:0071496 118 0.100
Rat
reproductive process GO:0022414 372 0.100
cellular ketone metabolic process GO:0042180 51 0.100
lipid metabolic process GO:0006629 283 0.099
programmed cell death GO:0012501 392 0.097
oxoacid metabolic process GO:0043436 290 0.097
negative regulation of cell development GO:0010721 82 0.097
negative regulation of cell death GO:0060548 229 0.092
response to extracellular stimulus GO:0009991 380 0.089
Rat
response to mechanical stimulus GO:0009612 134 0.089
Rat
proteolysis GO:0006508 175 0.089
regulation of cell differentiation GO:0045595 320 0.087
carboxylic acid metabolic process GO:0019752 289 0.085
angiotensin maturation GO:0002003 2 0.085
translation GO:0006412 35 0.084
neuron projection development GO:0031175 273 0.083
negative regulation of neuron differentiation GO:0045665 62 0.082
growth GO:0040007 165 0.081
multi organism reproductive process GO:0044703 262 0.080
apoptotic process GO:0006915 381 0.079
hormone metabolic process GO:0042445 69 0.079
organic acid metabolic process GO:0006082 292 0.079
blood circulation GO:0008015 183 0.078
axon choice point recognition GO:0016198 2 0.076
regulation of cell development GO:0060284 263 0.075
regulation of blood pressure GO:0008217 83 0.073
cell projection morphogenesis GO:0048858 123 0.072
antigen processing and presentation GO:0019882 2 0.072
regulation of nervous system development GO:0051960 264 0.071
regulation of hormone levels GO:0010817 187 0.070
cellular component assembly GO:0022607 360 0.066
regulation of growth GO:0040008 105 0.062
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.062
ribose phosphate metabolic process GO:0019693 235 0.062
positive regulation of nervous system development GO:0051962 178 0.059
regulation of cellular amine metabolic process GO:0033238 8 0.058
multicellular organismal reproductive process GO:0048609 233 0.058
response to nutrient levels GO:0031667 370 0.057
Rat
response to peptide GO:1901652 292 0.057
regulation of multicellular organismal development GO:2000026 376 0.057
protein phosphorylation GO:0006468 345 0.057
developmental growth GO:0048589 100 0.056
response to hexose GO:0009746 144 0.055
Rat
negative regulation of neurogenesis GO:0050768 78 0.055
cellular lipid metabolic process GO:0044255 208 0.055
retina development in camera type eye GO:0060041 27 0.055
negative regulation of developmental process GO:0051093 125 0.054
regulation of neuron differentiation GO:0045664 208 0.054
nucleobase containing small molecule metabolic process GO:0055086 316 0.053
regulation of nucleic acid templated transcription GO:1903506 380 0.053
carboxylic acid biosynthetic process GO:0046394 83 0.052
regulation of cellular amino acid metabolic process GO:0006521 2 0.051
positive regulation of cell development GO:0010720 176 0.050
reproduction GO:0000003 245 0.050
endocytosis GO:0006897 84 0.050
lipid biosynthetic process GO:0008610 128 0.050
synaptic growth at neuromuscular junction GO:0051124 1 0.050
single organism reproductive process GO:0044702 297 0.049
sexual reproduction GO:0019953 148 0.049
nucleotide metabolic process GO:0009117 279 0.049
regulation of neurogenesis GO:0050767 247 0.049
behavior GO:0007610 205 0.049
negative regulation of cell differentiation GO:0045596 99 0.048
regulation of cellular component organization GO:0051128 368 0.047
regulation of cellular ketone metabolic process GO:0010565 27 0.047
positive regulation of neurogenesis GO:0050769 165 0.047
regulation of developmental growth GO:0048638 45 0.047
negative regulation of multicellular organismal process GO:0051241 203 0.046
neuromuscular process GO:0050905 2 0.045
response to camp GO:0051591 91 0.045
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 1 0.045
cellular calcium ion homeostasis GO:0006874 160 0.045
multicellular organism reproduction GO:0032504 233 0.045
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.045
response to organophosphorus GO:0046683 102 0.043
ribonucleotide metabolic process GO:0009259 231 0.042
cellular macromolecule catabolic process GO:0044265 29 0.042
neuron differentiation GO:0030182 368 0.042
organic hydroxy compound metabolic process GO:1901615 115 0.041
cellular response to hormone stimulus GO:0032870 247 0.041
alcohol metabolic process GO:0006066 77 0.040
macromolecule catabolic process GO:0009057 58 0.039
nitrogen compound transport GO:0071705 229 0.039
glial cell differentiation GO:0010001 65 0.038
homeostatic process GO:0042592 331 0.038
rna biosynthetic process GO:0032774 380 0.038
transcription from rna polymerase ii promoter GO:0006366 252 0.037
transcription dna templated GO:0006351 377 0.037
response to oxygen levels GO:0070482 265 0.037
Rat
multicellular organismal catabolic process GO:0044243 2 0.037
single organism biosynthetic process GO:0044711 342 0.037
adult locomotory behavior GO:0008344 4 0.037
neuron development GO:0048666 286 0.036
cell projection organization GO:0030030 302 0.036
regulation of apoptotic process GO:0042981 335 0.036
axon cargo transport GO:0008088 1 0.035
protein maturation GO:0051604 68 0.035
anatomical structure morphogenesis GO:0009653 298 0.035
response to cytokine GO:0034097 215 0.035
Rat
cellular chemical homeostasis GO:0055082 247 0.034
positive regulation of rna metabolic process GO:0051254 203 0.034
negative regulation of cellular component organization GO:0051129 83 0.034
regulation of cell growth GO:0001558 85 0.034
positive regulation of developmental process GO:0051094 283 0.033
response to glucose GO:0009749 136 0.033
Rat
response to starvation GO:0042594 59 0.033
regulation of systemic arterial blood pressure GO:0003073 30 0.033
steroid metabolic process GO:0008202 73 0.033
response to external biotic stimulus GO:0043207 221 0.033
Rat
protein catabolic process GO:0030163 30 0.032
carbohydrate derivative catabolic process GO:1901136 147 0.032
positive regulation of biosynthetic process GO:0009891 319 0.032
cellular amide metabolic process GO:0043603 44 0.031
regulation of signal transduction GO:0009966 318 0.031
purine containing compound metabolic process GO:0072521 253 0.031
cellular amine metabolic process GO:0044106 38 0.031
amine metabolic process GO:0009308 38 0.031
organelle assembly GO:0070925 22 0.031
nucleoside phosphate metabolic process GO:0006753 283 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.030
cation transport GO:0006812 382 0.030
multicellular organism growth GO:0035264 1 0.030
negative regulation of growth GO:0045926 37 0.030
protein processing GO:0016485 68 0.030
glycosyl compound catabolic process GO:1901658 126 0.029
protein complex assembly GO:0006461 263 0.029
vesicle mediated transport GO:0016192 181 0.029
head development GO:0060322 247 0.029
protein complex subunit organization GO:0071822 302 0.029
purine nucleoside triphosphate metabolic process GO:0009144 141 0.028
glycosyl compound metabolic process GO:1901657 182 0.027
reproductive system development GO:0061458 128 0.027
cellular ion homeostasis GO:0006873 184 0.027
response to acid chemical GO:0001101 222 0.027
regulation of proteasomal protein catabolic process GO:0061136 4 0.027
cellular cation homeostasis GO:0030003 180 0.027
cell morphogenesis involved in differentiation GO:0000904 119 0.027
positive regulation of neuron differentiation GO:0045666 126 0.027
neuron apoptotic process GO:0051402 88 0.026
response to purine containing compound GO:0014074 126 0.026
regulation of cell projection organization GO:0031344 175 0.026
cellular response to endogenous stimulus GO:0071495 377 0.026
developmental process involved in reproduction GO:0003006 159 0.026
central nervous system development GO:0007417 311 0.026
carbohydrate derivative metabolic process GO:1901135 346 0.025
synaptic vesicle endocytosis GO:0048488 4 0.025
cellular response to nutrient levels GO:0031669 60 0.025
cellular response to extracellular stimulus GO:0031668 73 0.025
defense response GO:0006952 194 0.025
tissue remodeling GO:0048771 40 0.025
positive regulation of molecular function GO:0044093 230 0.025
purine ribonucleotide metabolic process GO:0009150 227 0.025
response to oxidative stress GO:0006979 186 0.025
Rat
enzyme linked receptor protein signaling pathway GO:0007167 116 0.024
positive regulation of cell differentiation GO:0045597 217 0.024
regulation of protein phosphorylation GO:0001932 183 0.023
purine nucleotide metabolic process GO:0006163 229 0.023
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 1 0.023
regulation of rna biosynthetic process GO:2001141 381 0.023
response to decreased oxygen levels GO:0036293 237 0.023
Rat
oxidation reduction process GO:0055114 304 0.023
gamete generation GO:0007276 124 0.023
antigen processing and presentation of exogenous antigen GO:0019884 1 0.023
organophosphate biosynthetic process GO:0090407 143 0.023
negative regulation of neuron projection development GO:0010977 46 0.023
positive regulation of protein metabolic process GO:0051247 178 0.022
single organism carbohydrate metabolic process GO:0044723 118 0.022
epithelial cell proliferation GO:0050673 54 0.022
negative regulation of innate immune response GO:0045824 4 0.022
single organism carbohydrate catabolic process GO:0044724 40 0.022
response to hypoxia GO:0001666 231 0.022
Rat
epithelium development GO:0060429 96 0.022
neuron death GO:0070997 127 0.022
response to carbohydrate GO:0009743 183 0.022
Rat
ion homeostasis GO:0050801 212 0.022
regulation of neuron projection development GO:0010975 161 0.022
immune response GO:0006955 104 0.022
neuron projection extension GO:1990138 26 0.022
single organism intracellular transport GO:1902582 166 0.022
positive regulation of cellular protein metabolic process GO:0032270 167 0.022
axon midline choice point recognition GO:0016199 2 0.022
regulation of transcription dna templated GO:0006355 374 0.022
positive regulation of programmed cell death GO:0043068 157 0.021
calcium ion transport GO:0006816 131 0.021
muscle contraction GO:0006936 88 0.021
metal ion transport GO:0030001 289 0.021
autophagy GO:0006914 19 0.021
glycogen metabolic process GO:0005977 23 0.021
organic acid biosynthetic process GO:0016053 83 0.021
regulation of protein modification process GO:0031399 194 0.020
positive regulation of cellular biosynthetic process GO:0031328 295 0.020
monocarboxylic acid metabolic process GO:0032787 152 0.020
cell cycle phase transition GO:0044770 21 0.020
early endosome to late endosome transport GO:0045022 2 0.020
cell cycle GO:0007049 101 0.020
chemical homeostasis GO:0048878 292 0.020
cation homeostasis GO:0055080 195 0.019
positive regulation of catalytic activity GO:0043085 184 0.019
developmental programmed cell death GO:0010623 2 0.019
regulation of programmed cell death GO:0043067 341 0.019
cellular homeostasis GO:0019725 252 0.019
nucleoside triphosphate catabolic process GO:0009143 123 0.019
positive regulation of cell projection organization GO:0031346 111 0.019
cellular response to stress GO:0033554 269 0.019
Rat
positive regulation of cellular amine metabolic process GO:0033240 3 0.019
cellular amino acid biosynthetic process GO:0008652 32 0.019
regulation of cell size GO:0008361 37 0.019
antigen processing and presentation of exogenous peptide antigen GO:0002478 1 0.019
reproductive behavior GO:0019098 10 0.019
positive regulation of cell cycle g2 m phase transition GO:1902751 1 0.019
regulation of system process GO:0044057 208 0.018
respiratory system development GO:0060541 45 0.018
cell part morphogenesis GO:0032990 123 0.018
organophosphate catabolic process GO:0046434 148 0.018
positive regulation of neuron projection development GO:0010976 99 0.018
cellular metal ion homeostasis GO:0006875 172 0.018
regulation of cell cycle g2 m phase transition GO:1902749 4 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.018
cellular nitrogen compound catabolic process GO:0044270 163 0.018
organelle organization GO:0006996 266 0.018
regulation of phosphorus metabolic process GO:0051174 349 0.018
organonitrogen compound biosynthetic process GO:1901566 167 0.018
wound healing GO:0042060 122 0.018
transmembrane transport GO:0055085 412 0.018
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.017
regulation of g2 m transition of mitotic cell cycle GO:0010389 4 0.017
positive regulation of rna biosynthetic process GO:1902680 197 0.017
regulation of protein kinase activity GO:0045859 105 0.017
cellular protein catabolic process GO:0044257 19 0.017
neuron projection morphogenesis GO:0048812 122 0.017
gliogenesis GO:0042063 93 0.017
nucleotide biosynthetic process GO:0009165 98 0.017
cellular amino acid metabolic process GO:0006520 107 0.017
protein complex biogenesis GO:0070271 263 0.017
organonitrogen compound catabolic process GO:1901565 179 0.017
response to amine GO:0014075 46 0.017
intracellular transport GO:0046907 185 0.017
mitotic spindle organization GO:0007052 2 0.017
nucleobase containing compound catabolic process GO:0034655 152 0.017
regeneration GO:0031099 163 0.017
response to cadmium ion GO:0046686 35 0.016
regulation of fat cell differentiation GO:0045598 3 0.016
cell morphogenesis GO:0000902 142 0.016
response to amino acid GO:0043200 75 0.016
rna metabolic process GO:0016070 406 0.016
posttranscriptional regulation of gene expression GO:0010608 37 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
reproductive structure development GO:0048608 128 0.016
regulation of cell proliferation GO:0042127 359 0.016
regulation of transferase activity GO:0051338 123 0.016
peptide metabolic process GO:0006518 32 0.016
positive regulation of growth GO:0045927 55 0.016
collagen catabolic process GO:0030574 2 0.016
mrna 3 end processing GO:0031124 1 0.016
axonogenesis GO:0007409 71 0.016
synaptic transmission GO:0007268 235 0.016
organelle inheritance GO:0048308 2 0.015
purine nucleoside metabolic process GO:0042278 169 0.015
carbohydrate metabolic process GO:0005975 130 0.015
dendrite development GO:0016358 72 0.015
calcium ion homeostasis GO:0055074 162 0.015
peptidyl amino acid modification GO:0018193 126 0.015
positive regulation of cell proliferation GO:0008284 249 0.015
camera type eye development GO:0043010 48 0.015
gastrulation GO:0007369 2 0.015
regulation of ion transport GO:0043269 245 0.015
regulation of kinase activity GO:0043549 117 0.015
regulation of phosphorylation GO:0042325 248 0.015
purine containing compound catabolic process GO:0072523 138 0.015
nucleotide catabolic process GO:0009166 139 0.015
response to radiation GO:0009314 137 0.015
multi multicellular organism process GO:0044706 138 0.015
endocrine process GO:0050886 32 0.015
synapse organization GO:0050808 46 0.015
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 1 0.014
regulation of transcription regulatory region dna binding GO:2000677 4 0.014
muscle system process GO:0003012 115 0.014
female pregnancy GO:0007565 122 0.014
purine nucleoside catabolic process GO:0006152 124 0.014
positive regulation of cellular component organization GO:0051130 200 0.014
sterol metabolic process GO:0016125 18 0.014
chromatin organization GO:0006325 34 0.014
striated muscle tissue development GO:0014706 58 0.014
cellular divalent inorganic cation homeostasis GO:0072503 162 0.014
developmental induction GO:0031128 2 0.014
negative regulation of response to stimulus GO:0048585 155 0.014
ribonucleotide biosynthetic process GO:0009260 85 0.014
protection from natural killer cell mediated cytotoxicity GO:0042270 2 0.014
response to glucocorticoid GO:0051384 223 0.014
Rat
cellular response to organonitrogen compound GO:0071417 197 0.014
aging GO:0007568 241 0.014
axon development GO:0061564 96 0.014
cellular response to drug GO:0035690 30 0.013
nucleoside catabolic process GO:0009164 126 0.013
purine ribonucleoside catabolic process GO:0046130 124 0.013
negative regulation of cell cycle phase transition GO:1901988 4 0.013
neurological system process GO:0050877 219 0.013
regulation of axonogenesis GO:0050770 37 0.013
positive regulation of hydrolase activity GO:0051345 86 0.013
nucleoside phosphate biosynthetic process GO:1901293 102 0.013
metal ion homeostasis GO:0055065 186 0.013
purine nucleoside triphosphate catabolic process GO:0009146 122 0.013
antigen processing and presentation of peptide or polysaccharide antigen via mhc class ii GO:0002504 1 0.013
sex differentiation GO:0007548 113 0.013
negative regulation of apoptotic process GO:0043066 181 0.013
secretion by cell GO:0032940 248 0.013
response to light stimulus GO:0009416 52 0.013
transmission of nerve impulse GO:0019226 42 0.013
male mating behavior GO:0060179 3 0.013
aromatic compound catabolic process GO:0019439 168 0.013
multicellular organismal homeostasis GO:0048871 49 0.013
regulation of rna metabolic process GO:0051252 391 0.013
ionotropic glutamate receptor signaling pathway GO:0035235 34 0.013
response to biotic stimulus GO:0009607 226 0.013
Rat
regulation of blood circulation GO:1903522 110 0.013
response to growth factor GO:0070848 189 0.013
Rat
nucleoside metabolic process GO:0009116 179 0.013
polysaccharide metabolic process GO:0005976 25 0.013
regulation of organelle organization GO:0033043 80 0.013
germ cell migration GO:0008354 1 0.013
synaptic vesicle localization GO:0097479 24 0.013
autophagic vacuole assembly GO:0000045 4 0.013
cellular response to mechanical stimulus GO:0071260 48 0.013
Rat
epithelial cell differentiation GO:0030855 71 0.012
membrane organization GO:0061024 94 0.012
insulin like growth factor receptor signaling pathway GO:0048009 3 0.012
regulation of immunoglobulin production GO:0002637 4 0.012
glutamine family amino acid biosynthetic process GO:0009084 2 0.012
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
purine nucleotide biosynthetic process GO:0006164 83 0.012
positive regulation of transcription dna templated GO:0045893 197 0.012
bmp signaling pathway GO:0030509 4 0.012
spermatogenesis GO:0007283 99 0.012
positive regulation of nucleic acid templated transcription GO:1903508 197 0.012
response to nutrient GO:0007584 248 0.012
Rat
macromolecular complex subunit organization GO:0043933 339 0.012
regulation of blood vessel size GO:0050880 89 0.012
salivary gland development GO:0007431 3 0.012
regulation of molecular function GO:0065009 398 0.012
biological adhesion GO:0022610 110 0.012
cellular component morphogenesis GO:0032989 155 0.012
positive regulation of blood circulation GO:1903524 65 0.012
positive regulation of apoptotic process GO:0043065 154 0.012
epidermal growth factor receptor signaling pathway GO:0007173 23 0.012
dephosphorylation GO:0016311 98 0.012
small molecule biosynthetic process GO:0044283 124 0.012
cellular response to oxygen containing compound GO:1901701 386 0.012
Rat
intracellular signal transduction GO:0035556 314 0.012
positive regulation of cell growth GO:0030307 44 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.012
carbohydrate biosynthetic process GO:0016051 42 0.012
positive regulation of cell death GO:0010942 184 0.011
mapk cascade GO:0000165 140 0.011
response to insulin GO:0032868 133 0.011
chemotaxis GO:0006935 66 0.011
single organism organelle organization GO:1902589 180 0.011
regulation of response to stress GO:0080134 126 0.011
negative regulation of protein phosphorylation GO:0001933 44 0.011
secretion GO:0046903 307 0.011
coagulation GO:0050817 28 0.011
peptidyl serine modification GO:0018209 34 0.011
multicellular organismal signaling GO:0035637 44 0.011
protein homooligomerization GO:0051260 91 0.011
chemosensory behavior GO:0007635 2 0.011
anion transmembrane transport GO:0098656 77 0.011
glucose metabolic process GO:0006006 52 0.011
regulation of protein complex assembly GO:0043254 33 0.011
protein oligomerization GO:0051259 191 0.011
positive regulation of muscle contraction GO:0045933 22 0.011
cellular component movement GO:0006928 248 0.011
response to vitamin GO:0033273 131 0.011
Rat
cellular protein localization GO:0034613 122 0.011
organ induction GO:0001759 1 0.011
regulation of organ formation GO:0003156 2 0.011
male gamete generation GO:0048232 99 0.011
regulation of muscle system process GO:0090257 79 0.011
protein transport GO:0015031 132 0.010
peptidyl tyrosine modification GO:0018212 72 0.010
negative regulation of peptidase activity GO:0010466 38 0.010
cellular response to cytokine stimulus GO:0071345 127 0.010
ras protein signal transduction GO:0007265 29 0.010
regulation of peptidase activity GO:0052547 55 0.010
hormone secretion GO:0046879 115 0.010
response to wounding GO:0009611 254 0.010

Psap disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
lysosomal storage disease DOID:3211 0 0.381
lipid storage disease DOID:9455 0 0.381
disease of metabolism DOID:0014667 0 0.381
inherited metabolic disorder DOID:655 0 0.381
nervous system disease DOID:863 0 0.061
disease of anatomical entity DOID:7 0 0.061
central nervous system disease DOID:331 0 0.029
combined t cell and b cell immunodeficiency DOID:628 0 0.028
immune system disease DOID:2914 0 0.028
severe combined immunodeficiency DOID:627 0 0.028
primary immunodeficiency disease DOID:612 0 0.028
musculoskeletal system disease DOID:17 0 0.017
acquired metabolic disease DOID:0060158 0 0.014
bone disease DOID:0080001 0 0.012
connective tissue disease DOID:65 0 0.012