Rattus norvegicus

0 known processes

Psmb9

proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

(Aliases: Lmp2)

Psmb9 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of natural killer cell mediated immunity GO:0002716 4 0.966
cellular response to iron ion starvation GO:0010106 1 0.957
negative regulation of cell killing GO:0031342 5 0.939
positive regulation of leukocyte mediated cytotoxicity GO:0001912 7 0.930
regulation of tolerance induction to nonself antigen GO:0002655 1 0.926
natural killer cell mediated cytotoxicity GO:0042267 6 0.891
antigen processing and presentation of endogenous peptide antigen via mhc class i GO:0019885 1 0.839
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.821
leukocyte mediated cytotoxicity GO:0001909 10 0.810
positive regulation of t cell mediated cytotoxicity GO:0001916 4 0.742
negative regulation of innate immune response GO:0045824 4 0.655
regulation of natural killer cell mediated immunity GO:0002715 6 0.603
immune response GO:0006955 104 0.588
positive regulation of tolerance induction GO:0002645 1 0.575
cell killing GO:0001906 13 0.564
antigen processing and presentation GO:0019882 2 0.562
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 4 0.561
positive regulation of tolerance induction dependent upon immune response GO:0002654 1 0.558
regulation of natural killer cell mediated cytotoxicity GO:0042269 6 0.539
t cell tolerance induction GO:0002517 3 0.535
negative regulation of lymphocyte mediated immunity GO:0002707 5 0.439
immune system process GO:0002376 204 0.433
negative regulation of leukocyte mediated immunity GO:0002704 6 0.428
antigen processing and presentation of endogenous antigen GO:0019883 1 0.387
response to other organism GO:0051707 220 0.373
positive regulation of tolerance induction to nonself antigen GO:0002657 1 0.347
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 1 0.308
positive regulation of cell killing GO:0031343 9 0.298
regulation of cell killing GO:0031341 12 0.287
tolerance induction dependent upon immune response GO:0002461 2 0.273
regulation of multicellular organismal development GO:2000026 376 0.260
cellular component assembly GO:0022607 360 0.259
cellular response to peptide hormone stimulus GO:0071375 120 0.253
natural killer cell mediated immunity GO:0002228 6 0.237
cellular response to stress GO:0033554 269 0.226
Fly
protein complex assembly GO:0006461 263 0.212
carbohydrate derivative metabolic process GO:1901135 346 0.209
protein complex biogenesis GO:0070271 263 0.193
positive regulation of immune system process GO:0002684 90 0.182
hepaticobiliary system development GO:0061008 90 0.174
modification dependent protein catabolic process GO:0019941 14 0.171
Yeast
innate immune response GO:0045087 35 0.170
regulation of cell proliferation GO:0042127 359 0.169
immune effector process GO:0002252 53 0.163
macromolecular complex assembly GO:0065003 273 0.162
cellular response to organic cyclic compound GO:0071407 202 0.154
arp2 3 complex mediated actin nucleation GO:0034314 2 0.148
negative regulation of response to stimulus GO:0048585 155 0.147
catabolic process GO:0009056 351 0.145
Yeast
negative regulation of immune system process GO:0002683 39 0.144
defense response GO:0006952 194 0.138
programmed cell death GO:0012501 392 0.132
cellular catabolic process GO:0044248 295 0.127
Yeast
nucleoside triphosphate metabolic process GO:0009141 144 0.125
regulation of protein metabolic process GO:0051246 289 0.123
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 7 0.123
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 55 0.120
chemical homeostasis GO:0048878 292 0.120
regulation of phosphorus metabolic process GO:0051174 349 0.119
lymphocyte homeostasis GO:0002260 2 0.119
nucleoside monophosphate metabolic process GO:0009123 93 0.112
response to estradiol GO:0032355 164 0.109
leukocyte proliferation GO:0070661 29 0.104
nucleoside phosphate metabolic process GO:0006753 283 0.102
nucleoside metabolic process GO:0009116 179 0.101
tolerance induction to nonself antigen GO:0002462 2 0.100
ribonucleoside metabolic process GO:0009119 174 0.097
t cell mediated cytotoxicity GO:0001913 5 0.097
ribonucleotide metabolic process GO:0009259 231 0.096
gland development GO:0048732 155 0.094
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 8 0.092
response to biotic stimulus GO:0009607 226 0.092
atp catabolic process GO:0006200 54 0.092
negative regulation of defense response GO:0031348 19 0.090
regulation of immune response GO:0050776 55 0.088
cellular component biogenesis GO:0044085 368 0.088
regulation of arp2 3 complex mediated actin nucleation GO:0034315 2 0.086
purine nucleoside monophosphate metabolic process GO:0009126 84 0.086
liver development GO:0001889 90 0.085
negative regulation of jak stat cascade GO:0046426 3 0.085
antigen processing and presentation of peptide antigen GO:0048002 2 0.084
cellular macromolecule catabolic process GO:0044265 29 0.082
Yeast
purine nucleoside triphosphate metabolic process GO:0009144 141 0.078
aromatic compound catabolic process GO:0019439 168 0.077
ribonucleoside catabolic process GO:0042454 126 0.076
regulation of programmed cell death GO:0043067 341 0.076
regulation of immune system process GO:0002682 123 0.076
ribose phosphate metabolic process GO:0019693 235 0.074
positive regulation of response to stimulus GO:0048584 285 0.074
response to external biotic stimulus GO:0043207 221 0.074
glycosyl compound metabolic process GO:1901657 182 0.073
mitotic spindle organization GO:0007052 2 0.071
organ regeneration GO:0031100 101 0.071
negative regulation of metanephric nephron tubule epithelial cell differentiation GO:0072308 1 0.071
regulation of phosphate metabolic process GO:0019220 349 0.069
microtubule organizing center organization GO:0031023 1 0.069
atp metabolic process GO:0046034 72 0.068
nucleoside phosphate catabolic process GO:1901292 140 0.067
response to cytokine GO:0034097 215 0.067
regulation of hydrolase activity GO:0051336 143 0.067
reproductive process GO:0022414 372 0.066
nucleoside catabolic process GO:0009164 126 0.065
positive regulation of multicellular organismal process GO:0051240 387 0.064
regulation of adaptive immune response GO:0002819 8 0.063
positive regulation of cell proliferation GO:0008284 249 0.062
regulation of tolerance induction GO:0002643 2 0.061
regulation of cellular protein metabolic process GO:0032268 267 0.060
organelle organization GO:0006996 266 0.059
nucleobase containing small molecule metabolic process GO:0055086 316 0.058
apoptotic process GO:0006915 381 0.058
spindle organization GO:0007051 2 0.058
purine ribonucleotide metabolic process GO:0009150 227 0.057
positive regulation of protein polymerization GO:0032273 10 0.056
extracellular transport GO:0006858 1 0.056
lymphocyte activation GO:0046649 43 0.055
cellular protein complex assembly GO:0043623 44 0.055
t cell mediated immunity GO:0002456 7 0.055
cellular macromolecular complex assembly GO:0034622 58 0.055
positive regulation of biosynthetic process GO:0009891 319 0.055
purine nucleoside catabolic process GO:0006152 124 0.053
ribonucleoside triphosphate metabolic process GO:0009199 141 0.053
positive regulation of satellite cell proliferation GO:1902724 1 0.052
nucleotide metabolic process GO:0009117 279 0.052
purine nucleoside triphosphate catabolic process GO:0009146 122 0.052
negative regulation of macromolecule metabolic process GO:0010605 260 0.050
single organism organelle organization GO:1902589 180 0.050
negative regulation of metabolic process GO:0009892 331 0.050
single organism biosynthetic process GO:0044711 342 0.050
response to metal ion GO:0010038 253 0.049
positive regulation of immune effector process GO:0002699 19 0.049
regulation of rna biosynthetic process GO:2001141 381 0.048
regulation of innate immune response GO:0045088 15 0.048
cellular response to endogenous stimulus GO:0071495 377 0.047
response to decreased oxygen levels GO:0036293 237 0.047
regulation of leukocyte mediated cytotoxicity GO:0001910 10 0.047
positive regulation of developmental process GO:0051094 283 0.047
response to transition metal nanoparticle GO:1990267 122 0.046
regulation of apoptotic process GO:0042981 335 0.046
leukocyte activation GO:0045321 76 0.046
response to peptide hormone GO:0043434 278 0.046
purine ribonucleoside metabolic process GO:0046128 168 0.046
response to molecule of bacterial origin GO:0002237 194 0.045
protein complex subunit organization GO:0071822 302 0.045
purine nucleoside metabolic process GO:0042278 169 0.045
intracellular signal transduction GO:0035556 314 0.045
adaptive immune response GO:0002250 14 0.045
positive regulation of nucleoside metabolic process GO:0045979 55 0.044
actin filament based process GO:0030029 86 0.043
positive regulation of cellular component movement GO:0051272 102 0.043
positive regulation of lymphocyte mediated immunity GO:0002708 7 0.043
regulation of satellite cell proliferation GO:0014842 1 0.043
purine containing compound metabolic process GO:0072521 253 0.043
cell cycle GO:0007049 101 0.043
regulation of body fluid levels GO:0050878 90 0.043
carbohydrate derivative catabolic process GO:1901136 147 0.042
macromolecular complex subunit organization GO:0043933 339 0.041
cytoskeleton organization GO:0007010 111 0.041
cation homeostasis GO:0055080 195 0.041
negative regulation of immune effector process GO:0002698 12 0.041
nucleoside triphosphate catabolic process GO:0009143 123 0.040
cellular response to dna damage stimulus GO:0006974 19 0.040
Fly
metal ion homeostasis GO:0055065 186 0.040
ribonucleoside triphosphate catabolic process GO:0009203 122 0.040
carboxylic acid metabolic process GO:0019752 289 0.039
protein catabolic process GO:0030163 30 0.039
Yeast
cellular protein catabolic process GO:0044257 19 0.039
Yeast
glycosyl compound catabolic process GO:1901658 126 0.039
cellular response to organonitrogen compound GO:0071417 197 0.039
regulation of defense response GO:0031347 68 0.038
response to purine containing compound GO:0014074 126 0.038
regulation of leukocyte mediated immunity GO:0002703 19 0.038
t cell proliferation GO:0042098 19 0.038
nucleoside monophosphate catabolic process GO:0009125 56 0.038
response to wounding GO:0009611 254 0.038
amide transport GO:0042886 105 0.038
regulation of antigen processing and presentation GO:0002577 1 0.038
reactive oxygen species biosynthetic process GO:1903409 8 0.038
positive regulation of programmed cell death GO:0043068 157 0.036
mononuclear cell proliferation GO:0032943 29 0.036
regulation of mononuclear cell proliferation GO:0032944 26 0.036
positive regulation of t cell mediated immunity GO:0002711 4 0.036
organophosphate metabolic process GO:0019637 370 0.035
homeostatic process GO:0042592 331 0.035
jak stat cascade GO:0007259 26 0.035
cellular amino acid metabolic process GO:0006520 107 0.035
heterocycle catabolic process GO:0046700 167 0.035
nucleotide catabolic process GO:0009166 139 0.035
regulation of immune effector process GO:0002697 32 0.034
metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 1 0.034
aging GO:0007568 241 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.033
purine nucleoside monophosphate catabolic process GO:0009128 55 0.033
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 6 0.033
response to hydrogen peroxide GO:0042542 89 0.033
proteolysis GO:0006508 175 0.033
Yeast
purine ribonucleotide catabolic process GO:0009154 136 0.033
cellular response to insulin stimulus GO:0032869 81 0.032
sensory organ development GO:0007423 74 0.032
negative regulation of gene expression GO:0010629 199 0.032
negative regulation of leukocyte mediated cytotoxicity GO:0001911 5 0.032
cellular protein localization GO:0034613 122 0.032
regulation of phosphorylation GO:0042325 248 0.032
ribonucleotide catabolic process GO:0009261 136 0.031
regulation of lymphocyte mediated immunity GO:0002706 11 0.031
cellular amine metabolic process GO:0044106 38 0.031
positive regulation of cellular component organization GO:0051130 200 0.031
multicellular organismal reproductive process GO:0048609 233 0.031
purine nucleotide metabolic process GO:0006163 229 0.031
purine nucleotide catabolic process GO:0006195 136 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.030
organic cyclic compound catabolic process GO:1901361 175 0.030
regulation of cellular ketone metabolic process GO:0010565 27 0.030
positive regulation of cellular biosynthetic process GO:0031328 295 0.030
regulation of intracellular signal transduction GO:1902531 218 0.029
nucleobase containing compound catabolic process GO:0034655 152 0.029
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.029
negative regulation of phosphate metabolic process GO:0045936 80 0.029
intracellular transport GO:0046907 185 0.028
cellular response to hormone stimulus GO:0032870 247 0.028
membrane organization GO:0061024 94 0.028
regulation of metanephros development GO:0072215 4 0.028
rna biosynthetic process GO:0032774 380 0.027
negative regulation of cell death GO:0060548 229 0.027
leukocyte mediated immunity GO:0002443 28 0.027
response to bacterium GO:0009617 200 0.027
multi organism reproductive process GO:0044703 262 0.026
regulation of cellular amine metabolic process GO:0033238 8 0.026
organonitrogen compound catabolic process GO:1901565 179 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.026
microtubule cytoskeleton organization GO:0000226 25 0.026
regulation of protein phosphorylation GO:0001932 183 0.026
regulation of response to stress GO:0080134 126 0.025
anatomical structure morphogenesis GO:0009653 298 0.025
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.025
negative regulation of protein modification process GO:0031400 52 0.025
cellular nitrogen compound catabolic process GO:0044270 163 0.025
regulation of t cell mediated cytotoxicity GO:0001914 5 0.025
organophosphate catabolic process GO:0046434 148 0.024
negative regulation of phosphorus metabolic process GO:0010563 80 0.024
proteasomal protein catabolic process GO:0010498 8 0.024
Yeast
response to carbohydrate GO:0009743 183 0.024
brain development GO:0007420 247 0.024
centrosome organization GO:0051297 1 0.024
tissue development GO:0009888 252 0.024
cell morphogenesis GO:0000902 142 0.023
negative regulation of cellular metabolic process GO:0031324 281 0.023
organic acid biosynthetic process GO:0016053 83 0.023
single organism intracellular transport GO:1902582 166 0.023
response to peptide GO:1901652 292 0.023
positive regulation of antigen processing and presentation GO:0002579 1 0.023
reproduction GO:0000003 245 0.022
regulation of protein modification process GO:0031399 194 0.022
cellular ketone metabolic process GO:0042180 51 0.022
circadian rhythm GO:0007623 88 0.022
regulation of purine nucleotide metabolic process GO:1900542 115 0.022
ribonucleoside monophosphate metabolic process GO:0009161 88 0.022
cellular response to nitrogen compound GO:1901699 210 0.021
antigen processing and presentation of exogenous antigen GO:0019884 1 0.021
gtp catabolic process GO:0006184 71 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
reactive nitrogen species metabolic process GO:2001057 1 0.021
rhythmic process GO:0048511 156 0.021
purine containing compound catabolic process GO:0072523 138 0.021
regulation of cell differentiation GO:0045595 320 0.021
negative regulation of cell communication GO:0010648 158 0.021
response to inorganic substance GO:0010035 377 0.021
regulation of catalytic activity GO:0050790 304 0.021
positive regulation of catalytic activity GO:0043085 184 0.021
gonad development GO:0008406 104 0.020
regulation of cellular component organization GO:0051128 368 0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 31 0.020
cellular response to external stimulus GO:0071496 118 0.020
negative regulation of molecular function GO:0044092 133 0.020
single organism reproductive process GO:0044702 297 0.020
tolerance induction GO:0002507 5 0.020
lymphocyte mediated immunity GO:0002449 14 0.020
regulation of actin nucleation GO:0051125 2 0.020
nucleic acid templated transcription GO:0097659 379 0.019
negative regulation of rna metabolic process GO:0051253 123 0.019
regulation of reactive oxygen species metabolic process GO:2000377 26 0.019
intracellular protein transport GO:0006886 79 0.019
multicellular organism reproduction GO:0032504 233 0.019
actin polymerization or depolymerization GO:0008154 14 0.019
ras protein signal transduction GO:0007265 29 0.019
protein phosphorylation GO:0006468 345 0.019
nitrogen compound transport GO:0071705 229 0.019
calcium ion transport GO:0006816 131 0.019
regeneration GO:0031099 163 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.019
Yeast
cellular response to growth factor stimulus GO:0071363 162 0.019
regulation of circadian sleep wake cycle sleep GO:0045187 18 0.018
regulation of cellular amino acid metabolic process GO:0006521 2 0.018
response to extracellular stimulus GO:0009991 380 0.018
embryonic pattern specification GO:0009880 1 0.018
negative regulation of protein phosphorylation GO:0001933 44 0.018
mitotic cell cycle process GO:1903047 35 0.018
carbohydrate derivative biosynthetic process GO:1901137 124 0.018
immune system development GO:0002520 41 0.018
regulation of signal transduction GO:0009966 318 0.018
positive regulation of gene expression GO:0010628 244 0.017
negative regulation of vesicle fusion GO:0031339 2 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.017
developmental process involved in reproduction GO:0003006 159 0.017
response to organophosphorus GO:0046683 102 0.017
response to virus GO:0009615 17 0.017
rna metabolic process GO:0016070 406 0.016
macromolecule catabolic process GO:0009057 58 0.016
Yeast
female pregnancy GO:0007565 122 0.016
regulation of nucleoside metabolic process GO:0009118 66 0.016
cell proliferation involved in heart morphogenesis GO:0061323 2 0.016
anterior posterior pattern specification GO:0009952 1 0.016
eye morphogenesis GO:0048592 4 0.016
cellular response to cytokine stimulus GO:0071345 127 0.016
cellular response to acid chemical GO:0071229 75 0.016
negative regulation of apoptotic process GO:0043066 181 0.016
ion homeostasis GO:0050801 212 0.016
negative regulation of developmental process GO:0051093 125 0.016
mitotic cell cycle GO:0000278 49 0.016
purine containing compound biosynthetic process GO:0072522 85 0.015
negative regulation of arp2 3 complex mediated actin nucleation GO:0034316 1 0.015
negative regulation of actin nucleation GO:0051126 1 0.015
regulation of molecular function GO:0065009 398 0.015
negative regulation of programmed cell death GO:0043069 183 0.015
positive regulation of nucleic acid templated transcription GO:1903508 197 0.015
response to insulin GO:0032868 133 0.015
cellular response to peptide GO:1901653 133 0.015
negative regulation of signal transduction GO:0009968 83 0.015
kidney mesenchyme development GO:0072074 2 0.015
single organism catabolic process GO:0044712 283 0.015
actin cytoskeleton organization GO:0030036 73 0.015
muscle structure development GO:0061061 87 0.015
protein localization GO:0008104 191 0.014
protein transport GO:0015031 132 0.014
purine ribonucleoside catabolic process GO:0046130 124 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.014
negative regulation of cellular amine metabolic process GO:0033239 3 0.014
cellular component movement GO:0006928 248 0.014
dna integrity checkpoint GO:0031570 2 0.014
peptidyl tyrosine phosphorylation GO:0018108 72 0.014
positive regulation of adaptive immune response GO:0002821 6 0.014
head development GO:0060322 247 0.014
response to hexose GO:0009746 144 0.014
cytoplasmic transport GO:0016482 115 0.013
macromolecule localization GO:0033036 252 0.013
regulation of nucleotide metabolic process GO:0006140 117 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.013
regulation of rna metabolic process GO:0051252 391 0.013
mitochondrion organization GO:0007005 35 0.013
peptide transport GO:0015833 97 0.013
regulation of t cell mediated immunity GO:0002709 6 0.013
response to monosaccharide GO:0034284 159 0.013
response to heat GO:0009408 60 0.013
negative regulation of cellular protein metabolic process GO:0032269 106 0.013
response to nutrient levels GO:0031667 370 0.013
negative regulation of viral entry into host cell GO:0046597 3 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.013
negative regulation of protein metabolic process GO:0051248 114 0.012
response to glucose GO:0009749 136 0.012
negative regulation of catalytic activity GO:0043086 103 0.012
regulation of smooth muscle cell proliferation GO:0048660 75 0.012
ubiquitin dependent protein catabolic process GO:0006511 14 0.012
Yeast
metanephric mesenchymal cell differentiation GO:0072162 1 0.012
microtubule based process GO:0007017 36 0.012
response to temperature stimulus GO:0009266 94 0.012
viral gene expression GO:0019080 2 0.012
viral transcription GO:0019083 2 0.012
antigen processing and presentation of exogenous peptide antigen GO:0002478 1 0.012
regulation of nucleic acid templated transcription GO:1903506 380 0.012
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003339 2 0.012
positive regulation of cellular component biogenesis GO:0044089 55 0.012
multi multicellular organism process GO:0044706 138 0.012
positive regulation of immune response GO:0050778 42 0.012
response to interleukin 1 GO:0070555 55 0.012
positive regulation of leukocyte mediated immunity GO:0002705 13 0.011
transcription dna templated GO:0006351 377 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
regulation of neuron death GO:1901214 115 0.011
positive regulation of signaling GO:0023056 270 0.011
regulation of actin cytoskeleton organization GO:0032956 30 0.011
amine metabolic process GO:0009308 38 0.011
skeletal muscle satellite cell proliferation GO:0014841 1 0.011
secretion GO:0046903 307 0.011
mammary gland epithelium development GO:0061180 1 0.011
positive regulation of cell communication GO:0010647 271 0.011
response to cadmium ion GO:0046686 35 0.011
cell cycle checkpoint GO:0000075 2 0.011
single organism cell adhesion GO:0098602 46 0.011
response to estrogen GO:0043627 232 0.011
development of primary sexual characteristics GO:0045137 107 0.011
regulation of actin filament depolymerization GO:0030834 2 0.011
positive regulation of rna metabolic process GO:0051254 203 0.011
cellular response to oxygen containing compound GO:1901701 386 0.011
ovulation cycle GO:0042698 67 0.011
regulation of cell migration GO:0030334 128 0.011
regulation of cell development GO:0060284 263 0.011
cell migration GO:0016477 197 0.011
negative regulation of nf kappab transcription factor activity GO:0032088 4 0.011
cellular macromolecule localization GO:0070727 122 0.011
regulation of actin filament based process GO:0032970 42 0.011
regulation of cellular component movement GO:0051270 150 0.010
regulation of cell morphogenesis GO:0022604 77 0.010
cellular response to dsrna GO:0071359 8 0.010
positive regulation of apoptotic process GO:0043065 154 0.010
triglyceride homeostasis GO:0070328 2 0.010
positive regulation of phosphorus metabolic process GO:0010562 262 0.010
negative regulation of phosphorylation GO:0042326 57 0.010

Psmb9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org