Rattus norvegicus

0 known processes

Psmd4

proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

Psmd4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
dna templated transcriptional preinitiation complex assembly GO:0070897 3 0.565
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 3 0.560
cellular catabolic process GO:0044248 295 0.437
transcription initiation from rna polymerase ii promoter GO:0006367 3 0.390
regulation of protein complex assembly GO:0043254 33 0.357
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 3 0.333
positive regulation of rna biosynthetic process GO:1902680 197 0.299
single organism catabolic process GO:0044712 283 0.285
cellular response to stress GO:0033554 269 0.266
dna templated transcription initiation GO:0006352 4 0.264
organophosphate catabolic process GO:0046434 148 0.232
positive regulation of dna templated transcription initiation GO:2000144 3 0.217
regulation of programmed cell death GO:0043067 341 0.216
regulation of cellular component biogenesis GO:0044087 86 0.207
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.195
purine nucleoside catabolic process GO:0006152 124 0.195
locomotion GO:0040011 237 0.188
ubiquitin dependent protein catabolic process GO:0006511 14 0.187
ribonucleoside triphosphate metabolic process GO:0009199 141 0.182
rna biosynthetic process GO:0032774 380 0.173
chromosome segregation GO:0007059 2 0.173
organelle organization GO:0006996 266 0.173
regulation of cellular component organization GO:0051128 368 0.163
ribonucleoside monophosphate metabolic process GO:0009161 88 0.163
cellular protein catabolic process GO:0044257 19 0.156
nucleoside phosphate metabolic process GO:0006753 283 0.153
apoptotic process GO:0006915 381 0.152
organic substance catabolic process GO:1901575 316 0.150
positive regulation of rna metabolic process GO:0051254 203 0.142
purine nucleoside triphosphate metabolic process GO:0009144 141 0.140
proteolysis GO:0006508 175 0.139
programmed cell death GO:0012501 392 0.137
carbohydrate derivative catabolic process GO:1901136 147 0.134
sex differentiation GO:0007548 113 0.132
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 3 0.131
carbohydrate derivative metabolic process GO:1901135 346 0.129
cellular macromolecule catabolic process GO:0044265 29 0.128
purine containing compound metabolic process GO:0072521 253 0.123
nucleoside triphosphate metabolic process GO:0009141 144 0.123
catabolic process GO:0009056 351 0.122
cellular protein complex assembly GO:0043623 44 0.121
purine nucleoside metabolic process GO:0042278 169 0.121
purine nucleotide metabolic process GO:0006163 229 0.121
cellular component biogenesis GO:0044085 368 0.119
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.119
protein complex biogenesis GO:0070271 263 0.118
protein catabolic process GO:0030163 30 0.114
spindle organization GO:0007051 2 0.113
positive regulation of apoptotic process GO:0043065 154 0.111
cell cycle GO:0007049 101 0.111
macromolecular complex subunit organization GO:0043933 339 0.110
aging GO:0007568 241 0.109
positive regulation of gene expression GO:0010628 244 0.108
regulation of phosphate metabolic process GO:0019220 349 0.106
reproductive process GO:0022414 372 0.105
proteolysis involved in cellular protein catabolic process GO:0051603 19 0.103
rna metabolic process GO:0016070 406 0.100
development of primary sexual characteristics GO:0045137 107 0.096
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.095
negative regulation of cell death GO:0060548 229 0.094
nucleoside metabolic process GO:0009116 179 0.093
mitotic spindle organization GO:0007052 2 0.093
purine containing compound catabolic process GO:0072523 138 0.093
defense response GO:0006952 194 0.092
nucleoside phosphate catabolic process GO:1901292 140 0.091
endomembrane system organization GO:0010256 48 0.089
modification dependent macromolecule catabolic process GO:0043632 14 0.089
purine ribonucleoside metabolic process GO:0046128 168 0.088
positive regulation of cellular component organization GO:0051130 200 0.087
purine ribonucleoside catabolic process GO:0046130 124 0.087
atp metabolic process GO:0046034 72 0.086
positive regulation of cellular biosynthetic process GO:0031328 295 0.086
reproductive system development GO:0061458 128 0.086
nucleoside monophosphate metabolic process GO:0009123 93 0.083
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.082
regulation of nucleic acid templated transcription GO:1903506 380 0.082
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.081
gonad development GO:0008406 104 0.081
nucleic acid templated transcription GO:0097659 379 0.080
purine nucleoside triphosphate catabolic process GO:0009146 122 0.080
ribonucleoside catabolic process GO:0042454 126 0.079
reproduction GO:0000003 245 0.079
positive regulation of nucleic acid templated transcription GO:1903508 197 0.079
ribonucleotide metabolic process GO:0009259 231 0.078
positive regulation of molecular function GO:0044093 230 0.078
protein complex assembly GO:0006461 263 0.076
ribonucleotide catabolic process GO:0009261 136 0.076
cellular component movement GO:0006928 248 0.075
growth GO:0040007 165 0.075
nucleotide metabolic process GO:0009117 279 0.074
regulation of apoptotic process GO:0042981 335 0.073
reproductive structure development GO:0048608 128 0.072
membrane fusion GO:0061025 26 0.072
macromolecular complex assembly GO:0065003 273 0.072
cation transport GO:0006812 382 0.071
positive regulation of transcription dna templated GO:0045893 197 0.071
purine nucleoside monophosphate metabolic process GO:0009126 84 0.069
ribonucleoside triphosphate catabolic process GO:0009203 122 0.069
purine nucleotide catabolic process GO:0006195 136 0.068
nucleobase containing small molecule metabolic process GO:0055086 316 0.068
ribose phosphate metabolic process GO:0019693 235 0.068
intracellular signal transduction GO:0035556 314 0.067
nucleotide catabolic process GO:0009166 139 0.066
purine ribonucleotide catabolic process GO:0009154 136 0.065
cell migration GO:0016477 197 0.065
response to wounding GO:0009611 254 0.064
positive regulation of phosphate metabolic process GO:0045937 262 0.064
ribonucleoside metabolic process GO:0009119 174 0.063
membrane organization GO:0061024 94 0.062
nucleoside monophosphate catabolic process GO:0009125 56 0.062
regulation of rna biosynthetic process GO:2001141 381 0.060
transcription from rna polymerase ii promoter GO:0006366 252 0.060
cellular macromolecular complex assembly GO:0034622 58 0.059
organonitrogen compound catabolic process GO:1901565 179 0.058
heterocycle catabolic process GO:0046700 167 0.057
positive regulation of signal transduction GO:0009967 175 0.057
regulation of transcription dna templated GO:0006355 374 0.056
aromatic compound catabolic process GO:0019439 168 0.056
modification dependent protein catabolic process GO:0019941 14 0.056
cytoskeleton organization GO:0007010 111 0.055
purine ribonucleoside monophosphate metabolic process GO:0009167 84 0.054
regulation of rna metabolic process GO:0051252 391 0.053
ribonucleoside monophosphate catabolic process GO:0009158 55 0.053
single organism reproductive process GO:0044702 297 0.052
nucleoside catabolic process GO:0009164 126 0.052
regulation of cellular catabolic process GO:0031329 101 0.052
positive regulation of cellular component biogenesis GO:0044089 55 0.051
cell growth GO:0016049 104 0.051
single organism organelle organization GO:1902589 180 0.051
regulation of nucleotide metabolic process GO:0006140 117 0.051
positive regulation of biosynthetic process GO:0009891 319 0.050
regulation of system process GO:0044057 208 0.050
regulation of protein modification process GO:0031399 194 0.049
multicellular organism reproduction GO:0032504 233 0.049
regulation of cell proliferation GO:0042127 359 0.049
single organism biosynthetic process GO:0044711 342 0.049
mitotic cell cycle GO:0000278 49 0.048
regulation of ion transport GO:0043269 245 0.048
regulation of cellular protein metabolic process GO:0032268 267 0.047
multicellular organismal reproductive process GO:0048609 233 0.047
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.046
stress activated protein kinase signaling cascade GO:0031098 37 0.045
purine nucleoside monophosphate catabolic process GO:0009128 55 0.045
muscle system process GO:0003012 115 0.044
secretion by cell GO:0032940 248 0.043
rhythmic process GO:0048511 156 0.043
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.043
single organism membrane organization GO:0044802 74 0.043
regulation of phosphorus metabolic process GO:0051174 349 0.042
transcription dna templated GO:0006351 377 0.042
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.042
macromolecule localization GO:0033036 252 0.042
purine ribonucleotide metabolic process GO:0009150 227 0.041
atp catabolic process GO:0006200 54 0.040
nucleobase containing compound catabolic process GO:0034655 152 0.040
neurological system process GO:0050877 219 0.040
immune system process GO:0002376 204 0.040
cellular nitrogen compound catabolic process GO:0044270 163 0.039
regulation of intracellular signal transduction GO:1902531 218 0.039
double strand break repair GO:0006302 1 0.038
nucleoside triphosphate catabolic process GO:0009143 123 0.038
negative regulation of apoptotic process GO:0043066 181 0.038
negative regulation of biosynthetic process GO:0009890 168 0.037
positive regulation of catalytic activity GO:0043085 184 0.037
protein complex subunit organization GO:0071822 302 0.036
localization of cell GO:0051674 202 0.036
purine nucleotide biosynthetic process GO:0006164 83 0.036
multi organism reproductive process GO:0044703 262 0.036
protein dna complex subunit organization GO:0071824 7 0.035
regulation of catabolic process GO:0009894 113 0.034
hexitol metabolic process GO:0006059 1 0.034
retinal metabolic process GO:0042574 3 0.034
positive regulation of phosphorus metabolic process GO:0010562 262 0.034
negative regulation of macromolecule metabolic process GO:0010605 260 0.033
regulation of purine nucleotide metabolic process GO:1900542 115 0.033
organophosphate metabolic process GO:0019637 370 0.033
organic cyclic compound catabolic process GO:1901361 175 0.031
regulation of signal transduction GO:0009966 318 0.031
positive regulation of protein modification process GO:0031401 142 0.031
positive regulation of nucleotide metabolic process GO:0045981 91 0.031
secretion GO:0046903 307 0.031
developmental process involved in reproduction GO:0003006 159 0.031
intracellular transport GO:0046907 185 0.031
microtubule based process GO:0007017 36 0.030
regulation of cell development GO:0060284 263 0.030
regulation of growth GO:0040008 105 0.030
response to peptide GO:1901652 292 0.030
transmembrane transport GO:0055085 412 0.030
purine ribonucleoside monophosphate catabolic process GO:0009169 55 0.030
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 4 0.029
glycosyl compound metabolic process GO:1901657 182 0.029
chromatin remodeling GO:0006338 3 0.029
regulation of protein metabolic process GO:0051246 289 0.028
regulation of neuron death GO:1901214 115 0.028
positive regulation of response to stimulus GO:0048584 285 0.028
blood vessel morphogenesis GO:0048514 58 0.028
regulation of muscle system process GO:0090257 79 0.027
positive regulation of developmental process GO:0051094 283 0.027
regulation of cell differentiation GO:0045595 320 0.027
microtubule cytoskeleton organization GO:0000226 25 0.027
golgi organization GO:0007030 17 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.026
establishment of organelle localization GO:0051656 37 0.026
response to peptide hormone GO:0043434 278 0.026
positive regulation of cellular catabolic process GO:0031331 71 0.026
establishment of chromosome localization GO:0051303 1 0.026
dna metabolic process GO:0006259 96 0.025
divalent metal ion transport GO:0070838 132 0.025
ras protein signal transduction GO:0007265 29 0.025
protein localization GO:0008104 191 0.024
developmental growth GO:0048589 100 0.023
negative regulation of metabolic process GO:0009892 331 0.023
positive regulation of protein metabolic process GO:0051247 178 0.023
protein folding GO:0006457 12 0.023
protein modification by small protein conjugation or removal GO:0070647 35 0.023
sexual reproduction GO:0019953 148 0.022
response to biotic stimulus GO:0009607 226 0.022
cell motility GO:0048870 202 0.022
defense response to other organism GO:0098542 17 0.022
cellular protein localization GO:0034613 122 0.021
positive regulation of multicellular organismal process GO:0051240 387 0.021
positive regulation of cell communication GO:0010647 271 0.021
regulation of response to stress GO:0080134 126 0.021
metal ion transport GO:0030001 289 0.021
regulation of metal ion transport GO:0010959 118 0.021
response to inorganic substance GO:0010035 377 0.021
divalent inorganic cation transport GO:0072511 134 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 7 0.020
regeneration GO:0031099 163 0.020
negative regulation of cellular metabolic process GO:0031324 281 0.020
microtubule anchoring GO:0034453 1 0.020
hematopoietic progenitor cell differentiation GO:0002244 2 0.020
negative regulation of nucleic acid templated transcription GO:1903507 117 0.020
chordate embryonic development GO:0043009 18 0.020
action potential GO:0001508 54 0.020
negative regulation of programmed cell death GO:0043069 183 0.020
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.020
vascular process in circulatory system GO:0003018 96 0.020
multicellular organism growth GO:0035264 1 0.019
metal ion homeostasis GO:0055065 186 0.019
chemotaxis GO:0006935 66 0.019
regulation of protein phosphorylation GO:0001932 183 0.019
regulation of protein kinase activity GO:0045859 105 0.019
behavior GO:0007610 205 0.019
sorbitol metabolic process GO:0006060 1 0.019
norepinephrine metabolic process GO:0042415 3 0.019
macromolecule catabolic process GO:0009057 58 0.019
neuron apoptotic process GO:0051402 88 0.019
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.019
negative regulation of cellular biosynthetic process GO:0031327 161 0.018
embryo development GO:0009790 49 0.018
response to endoplasmic reticulum stress GO:0034976 10 0.018
circulatory system development GO:0072359 134 0.018
regulation of cell cycle GO:0051726 73 0.018
homeostatic process GO:0042592 331 0.018
ovulation cycle GO:0042698 67 0.017
regulation of calcium ion transport GO:0051924 77 0.017
positive regulation of protein phosphorylation GO:0001934 135 0.017
female sex differentiation GO:0046660 59 0.017
positive regulation of cell differentiation GO:0045597 217 0.017
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 3 0.017
cation transmembrane transport GO:0098655 263 0.017
regulation of molecular function GO:0065009 398 0.017
male sex differentiation GO:0046661 64 0.017
blood circulation GO:0008015 183 0.016
negative regulation of cell cycle phase transition GO:1901988 4 0.016
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 2 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.016
cellular response to oxidative stress GO:0034599 76 0.016
gamete generation GO:0007276 124 0.016
small gtpase mediated signal transduction GO:0007264 36 0.016
gliogenesis GO:0042063 93 0.016
response to nutrient levels GO:0031667 370 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
regulation of response to external stimulus GO:0032101 106 0.016
cell cycle process GO:0022402 57 0.016
regulation of nucleotide catabolic process GO:0030811 65 0.016
positive regulation of phosphorylation GO:0042327 177 0.015
sensory perception of light stimulus GO:0050953 3 0.015
circulatory system process GO:0003013 183 0.015
calcium ion transport GO:0006816 131 0.015
regulation of hydrolase activity GO:0051336 143 0.015
regulation of phosphorylation GO:0042325 248 0.015
central nervous system development GO:0007417 311 0.015
regulation of nucleoside metabolic process GO:0009118 66 0.015
embryonic pattern specification GO:0009880 1 0.015
positive regulation of catabolic process GO:0009896 78 0.015
muscle tissue development GO:0060537 58 0.015
response to oxidative stress GO:0006979 186 0.015
response to reactive oxygen species GO:0000302 120 0.015
response to external biotic stimulus GO:0043207 221 0.015
regulation of cell growth GO:0001558 85 0.015
oxidation reduction process GO:0055114 304 0.015
cellular response to ketone GO:1901655 51 0.015
cell projection organization GO:0030030 302 0.015
regulation of kinase activity GO:0043549 117 0.015
ncrna metabolic process GO:0034660 8 0.015
monovalent inorganic cation transport GO:0015672 172 0.014
neuron differentiation GO:0030182 368 0.014
positive regulation of cell death GO:0010942 184 0.014
positive regulation of nucleoside metabolic process GO:0045979 55 0.014
single organism membrane fusion GO:0044801 17 0.014
positive regulation of transferase activity GO:0051347 81 0.014
telencephalon development GO:0021537 62 0.014
cellular component assembly GO:0022607 360 0.014
response to decreased oxygen levels GO:0036293 237 0.014
regulation of cell migration GO:0030334 128 0.014
negative regulation of molecular function GO:0044092 133 0.014
naphthalene metabolic process GO:0018931 2 0.014
maintenance of protein location in cell GO:0032507 7 0.014
regulation of catalytic activity GO:0050790 304 0.014
purine ribonucleotide biosynthetic process GO:0009152 81 0.013
axis specification GO:0009798 4 0.013
response to estrogen GO:0043627 232 0.013
cytoplasmic sequestering of protein GO:0051220 3 0.013
glial cell differentiation GO:0010001 65 0.013
eye morphogenesis GO:0048592 4 0.013
collecting duct development GO:0072044 1 0.013
immune effector process GO:0002252 53 0.013
response to light stimulus GO:0009416 52 0.013
urogenital system development GO:0001655 78 0.013
cellular response to dna damage stimulus GO:0006974 19 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
neuron death GO:0070997 127 0.012
ion transmembrane transport GO:0034220 365 0.012
proteasomal protein catabolic process GO:0010498 8 0.012
cellular amine metabolic process GO:0044106 38 0.012
cell type specific apoptotic process GO:0097285 134 0.012
cell cell signaling GO:0007267 335 0.012
blood vessel development GO:0001568 69 0.012
single organism carbohydrate catabolic process GO:0044724 40 0.012
positive regulation of developmental growth GO:0048639 29 0.012
positive regulation of signaling GO:0023056 270 0.012
regulation of membrane potential GO:0042391 110 0.012
positive regulation of cell proliferation GO:0008284 249 0.012
guanosine containing compound metabolic process GO:1901068 74 0.011
female gonad development GO:0008585 53 0.011
microtubule polymerization or depolymerization GO:0031109 13 0.011
development of primary female sexual characteristics GO:0046545 56 0.011
phenol containing compound metabolic process GO:0018958 30 0.011
anatomical structure morphogenesis GO:0009653 298 0.011
chromosome organization GO:0051276 36 0.011
g protein coupled receptor signaling pathway GO:0007186 242 0.011
cell cell signaling involved in cell fate commitment GO:0045168 2 0.011
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 5 0.011
intermediate filament based process GO:0045103 3 0.011
regulation of cellular amino acid metabolic process GO:0006521 2 0.011
positive regulation of cellular protein metabolic process GO:0032270 167 0.011
neuronal action potential GO:0019228 35 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 53 0.011
gtp catabolic process GO:0006184 71 0.011
cardiovascular system development GO:0072358 134 0.010
positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 5 0.010
guanosine containing compound catabolic process GO:1901069 71 0.010
response to metal ion GO:0010038 253 0.010
vesicle mediated transport GO:0016192 181 0.010
regulation of proteasomal protein catabolic process GO:0061136 4 0.010
organonitrogen compound biosynthetic process GO:1901566 167 0.010
transmission of nerve impulse GO:0019226 42 0.010
response to other organism GO:0051707 220 0.010
positive regulation of mapk cascade GO:0043410 92 0.010
positive regulation of growth GO:0045927 55 0.010

Psmd4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.011
cardiovascular system disease DOID:1287 0 0.011
nervous system disease DOID:863 0 0.011