Rattus norvegicus

18 known processes

Ptpn11

protein tyrosine phosphatase, non-receptor type 11

(Aliases: Shp2)

Ptpn11 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 289 0.312
organic acid metabolic process GO:0006082 292 0.281
regulation of cellular protein metabolic process GO:0032268 267 0.269
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 116 0.251
Human Mouse Fly
cellular response to endogenous stimulus GO:0071495 377 0.240
Human Mouse Fly
oxoacid metabolic process GO:0043436 290 0.207
cellular response to oxygen containing compound GO:1901701 386 0.202
Human
regulation of cellular component organization GO:0051128 368 0.197
regulation of cellular localization GO:0060341 263 0.196
Mouse
positive regulation of cellular component organization GO:0051130 200 0.190
response to tumor necrosis factor GO:0034612 56 0.182
apoptotic process GO:0006915 381 0.153
Fly
regulation of secretion GO:0051046 224 0.147
Mouse
regulation of transcription dna templated GO:0006355 374 0.144
Fly
neuron projection development GO:0031175 273 0.136
Mouse
programmed cell death GO:0012501 392 0.131
Fly
regulation of rna biosynthetic process GO:2001141 381 0.129
Fly
intracellular signal transduction GO:0035556 314 0.126
Mouse
positive regulation of multicellular organismal process GO:0051240 387 0.121
anatomical structure morphogenesis GO:0009653 298 0.119
Human Zebrafish Mouse Fly
signal transduction by phosphorylation GO:0023014 144 0.113
Mouse
neuron differentiation GO:0030182 368 0.112
Mouse Fly
positive regulation of cell proliferation GO:0008284 249 0.106
cellular response to hormone stimulus GO:0032870 247 0.106
Human Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 85 0.105
Human Mouse Fly
regulation of signal transduction GO:0009966 318 0.104
Human Mouse
nucleic acid templated transcription GO:0097659 379 0.103
Fly
cellular component biogenesis GO:0044085 368 0.102
cellular amine metabolic process GO:0044106 38 0.101
cellular ketone metabolic process GO:0042180 51 0.100
organelle organization GO:0006996 266 0.097
regulation of multicellular organismal development GO:2000026 376 0.096
Fly
cellular amino acid metabolic process GO:0006520 107 0.095
neuron development GO:0048666 286 0.095
Mouse Fly
protein localization GO:0008104 191 0.095
Mouse
negative regulation of apoptotic process GO:0043066 181 0.095
Fly
regulation of protein phosphorylation GO:0001932 183 0.093
Mouse
rna biosynthetic process GO:0032774 380 0.092
Fly
positive regulation of response to stimulus GO:0048584 285 0.092
Human Mouse
rna metabolic process GO:0016070 406 0.091
Fly
positive regulation of signaling GO:0023056 270 0.090
Human Mouse
transcription dna templated GO:0006351 377 0.090
Fly
regulation of nervous system development GO:0051960 264 0.089
Fly
single organism organelle organization GO:1902589 180 0.089
amine metabolic process GO:0009308 38 0.088
negative regulation of cell death GO:0060548 229 0.087
Zebrafish Fly
signal release GO:0023061 145 0.086
Mouse
aging GO:0007568 241 0.084
nitrogen compound transport GO:0071705 229 0.084
Mouse
negative regulation of multicellular organismal process GO:0051241 203 0.084
Mouse
regulation of phosphorus metabolic process GO:0051174 349 0.082
Mouse
regulation of cellular amino acid metabolic process GO:0006521 2 0.082
neurological system process GO:0050877 219 0.079
cellular component assembly GO:0022607 360 0.079
regulation of cellular ketone metabolic process GO:0010565 27 0.079
secretion by cell GO:0032940 248 0.078
Mouse
regulation of intracellular signal transduction GO:1902531 218 0.077
Mouse
lipid metabolic process GO:0006629 283 0.077
Mouse
response to peptide hormone GO:0043434 278 0.076
Human
positive regulation of protein metabolic process GO:0051247 178 0.075
Mouse
negative regulation of gene expression GO:0010629 199 0.073
positive regulation of cell communication GO:0010647 271 0.072
Human Mouse
regulation of cell proliferation GO:0042127 359 0.071
cellular response to growth factor stimulus GO:0071363 162 0.071
Mouse Fly
cellular component morphogenesis GO:0032989 155 0.071
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.071
regulation of nucleic acid templated transcription GO:1903506 380 0.070
Fly
protein phosphorylation GO:0006468 345 0.070
Mouse
regulation of phosphorylation GO:0042325 248 0.069
Mouse
regulation of apoptotic process GO:0042981 335 0.069
Fly
regulation of secretion by cell GO:1903530 208 0.068
Mouse
regulation of protein modification process GO:0031399 194 0.068
Mouse
regulation of catalytic activity GO:0050790 304 0.068
Mouse
protein complex biogenesis GO:0070271 263 0.067
regulation of phosphate metabolic process GO:0019220 349 0.067
Mouse
protein complex subunit organization GO:0071822 302 0.067
response to extracellular stimulus GO:0009991 380 0.066
protein autophosphorylation GO:0046777 66 0.066
cellular response to cytokine stimulus GO:0071345 127 0.064
response to growth factor GO:0070848 189 0.063
Mouse Fly
negative regulation of metabolic process GO:0009892 331 0.061
circulatory system development GO:0072359 134 0.061
Human Zebrafish
defense response GO:0006952 194 0.060
positive regulation of phosphorus metabolic process GO:0010562 262 0.060
Mouse
cellular response to stress GO:0033554 269 0.060
Mouse
secretion GO:0046903 307 0.059
Mouse
regulation of molecular function GO:0065009 398 0.059
Mouse
negative regulation of macromolecule metabolic process GO:0010605 260 0.059
establishment of protein localization GO:0045184 141 0.058
Mouse
negative regulation of cellular metabolic process GO:0031324 281 0.057
regulation of neurogenesis GO:0050767 247 0.056
Fly
macromolecular complex subunit organization GO:0043933 339 0.056
cellular catabolic process GO:0044248 295 0.055
regulation of protein metabolic process GO:0051246 289 0.054
Mouse
localization of cell GO:0051674 202 0.054
Fly
cell type specific apoptotic process GO:0097285 134 0.054
regulation of kinase activity GO:0043549 117 0.054
Mouse
cellular response to tumor necrosis factor GO:0071356 46 0.054
protein complex assembly GO:0006461 263 0.053
response to peptide GO:1901652 292 0.053
Human
cellular response to nitrogen compound GO:1901699 210 0.053
Human
rhythmic process GO:0048511 156 0.053
positive regulation of phosphate metabolic process GO:0045937 262 0.052
Mouse
ribonucleotide metabolic process GO:0009259 231 0.052
nucleobase containing small molecule metabolic process GO:0055086 316 0.052
regulation of cellular amine metabolic process GO:0033238 8 0.052
behavior GO:0007610 205 0.052
positive regulation of developmental process GO:0051094 283 0.051
developmental process involved in reproduction GO:0003006 159 0.050
Human Fly
locomotion GO:0040011 237 0.050
Fly
cellular macromolecule localization GO:0070727 122 0.050
Mouse
regulation of rna metabolic process GO:0051252 391 0.049
Fly
regulation of neuron death GO:1901214 115 0.049
regulation of cell morphogenesis GO:0022604 77 0.048
regulation of anatomical structure morphogenesis GO:0022603 141 0.047
Fly
macromolecule localization GO:0033036 252 0.047
Mouse
response to radiation GO:0009314 137 0.047
response to nutrient levels GO:0031667 370 0.046
positive regulation of biosynthetic process GO:0009891 319 0.046
regulation of programmed cell death GO:0043067 341 0.046
Fly
positive regulation of neurogenesis GO:0050769 165 0.046
response to biotic stimulus GO:0009607 226 0.046
positive regulation of cell differentiation GO:0045597 217 0.045
taxis GO:0042330 67 0.045
cell migration GO:0016477 197 0.045
Fly
cardiovascular system development GO:0072358 134 0.045
Human Zebrafish
cell projection organization GO:0030030 302 0.045
Mouse
negative regulation of signaling GO:0023057 157 0.045
Mouse
organic substance catabolic process GO:1901575 316 0.044
circadian rhythm GO:0007623 88 0.043
cellular response to peptide GO:1901653 133 0.043
Human
protein transport GO:0015031 132 0.043
Mouse
cellular response to organonitrogen compound GO:0071417 197 0.043
Human
chemotaxis GO:0006935 66 0.042
regulation of cell differentiation GO:0045595 320 0.042
Fly
response to ethanol GO:0045471 162 0.042
membrane organization GO:0061024 94 0.042
Fly
cell morphogenesis GO:0000902 142 0.042
Mouse
homeostatic process GO:0042592 331 0.041
Mouse
regulation of neuron differentiation GO:0045664 208 0.041
Fly
reproductive process GO:0022414 372 0.041
Human Mouse Fly
catabolic process GO:0009056 351 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 1 0.041
regulation of cell development GO:0060284 263 0.041
Fly
regulation of neuron projection development GO:0010975 161 0.041
positive regulation of cell development GO:0010720 176 0.040
regulation of response to external stimulus GO:0032101 106 0.040
neuron apoptotic process GO:0051402 88 0.040
heart morphogenesis GO:0003007 3 0.040
Zebrafish
organonitrogen compound catabolic process GO:1901565 179 0.040
learning or memory GO:0007611 90 0.039
positive regulation of locomotion GO:0040017 102 0.039
positive regulation of transport GO:0051050 245 0.039
Human Mouse
cellular response to lipid GO:0071396 201 0.039
positive regulation of cell migration GO:0030335 96 0.038
response to nutrient GO:0007584 248 0.038
regulation of hormone secretion GO:0046883 106 0.038
Mouse
organophosphate metabolic process GO:0019637 370 0.038
cellular component movement GO:0006928 248 0.038
Fly
vesicle mediated transport GO:0016192 181 0.038
Fly
neuron death GO:0070997 127 0.037
cytoskeleton organization GO:0007010 111 0.037
intracellular protein transport GO:0006886 79 0.037
Mouse
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.037
transcription from rna polymerase ii promoter GO:0006366 252 0.036
Fly
cell morphogenesis involved in differentiation GO:0000904 119 0.035
Mouse
cognition GO:0050890 92 0.035
negative regulation of cell communication GO:0010648 158 0.035
Mouse
positive regulation of intracellular signal transduction GO:1902533 138 0.035
Mouse
hormone secretion GO:0046879 115 0.035
Mouse
response to hexose GO:0009746 144 0.034
carbohydrate derivative metabolic process GO:1901135 346 0.034
purine ribonucleotide metabolic process GO:0009150 227 0.034
cellular lipid metabolic process GO:0044255 208 0.034
Mouse
axon development GO:0061564 96 0.034
Mouse
protein oligomerization GO:0051259 191 0.034
response to corticosteroid GO:0031960 235 0.034
cation transport GO:0006812 382 0.034
regulation of lipid metabolic process GO:0019216 68 0.033
monocarboxylic acid metabolic process GO:0032787 152 0.033
cell motility GO:0048870 202 0.033
Fly
response to external biotic stimulus GO:0043207 221 0.033
response to lipopolysaccharide GO:0032496 191 0.033
purine containing compound metabolic process GO:0072521 253 0.033
mapk cascade GO:0000165 140 0.033
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 153 0.033
nucleotide metabolic process GO:0009117 279 0.032
positive regulation of cellular biosynthetic process GO:0031328 295 0.032
positive regulation of protein phosphorylation GO:0001934 135 0.032
Mouse
positive regulation of cellular amine metabolic process GO:0033240 3 0.032
regulation of cell projection organization GO:0031344 175 0.032
peptidyl tyrosine modification GO:0018212 72 0.032
response to insulin GO:0032868 133 0.032
Human
positive regulation of neuron projection development GO:0010976 99 0.032
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.032
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.032
Fly
positive regulation of nervous system development GO:0051962 178 0.031
ras protein signal transduction GO:0007265 29 0.031
negative regulation of developmental process GO:0051093 125 0.031
positive regulation of cellular protein metabolic process GO:0032270 167 0.031
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 117 0.031
mechanoreceptor differentiation GO:0042490 2 0.031
hormone transport GO:0009914 121 0.031
Mouse
regulation of mapk cascade GO:0043408 116 0.031
Mouse
reactive oxygen species metabolic process GO:0072593 37 0.031
response to ketone GO:1901654 182 0.031
response to glucocorticoid GO:0051384 223 0.030
neuron projection morphogenesis GO:0048812 122 0.030
Mouse
lipid biosynthetic process GO:0008610 128 0.030
regulation of transferase activity GO:0051338 123 0.030
Mouse
synaptic growth at neuromuscular junction GO:0051124 1 0.030
regulation of ion transport GO:0043269 245 0.030
single organism behavior GO:0044708 130 0.030
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.030
single organism reproductive process GO:0044702 297 0.030
Human Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.030
negative regulation of cellular protein metabolic process GO:0032269 106 0.029
alpha amino acid metabolic process GO:1901605 71 0.029
cellular response to peptide hormone stimulus GO:0071375 120 0.029
Human
purine nucleotide metabolic process GO:0006163 229 0.029
growth GO:0040007 165 0.029
Zebrafish Mouse
positive regulation of gene expression GO:0010628 244 0.028
positive regulation of protein modification process GO:0031401 142 0.028
Mouse
positive regulation of molecular function GO:0044093 230 0.028
Mouse
single organism catabolic process GO:0044712 283 0.028
negative regulation of biosynthetic process GO:0009890 168 0.028
intracellular transport GO:0046907 185 0.028
Mouse
head development GO:0060322 247 0.028
Human
regulation of cellular component biogenesis GO:0044087 86 0.028
negative regulation of rna metabolic process GO:0051253 123 0.028
negative regulation of programmed cell death GO:0043069 183 0.028
Fly
positive regulation of cellular component movement GO:0051272 102 0.027
regulation of hormone levels GO:0010817 187 0.027
Mouse
proteolysis GO:0006508 175 0.027
macromolecular complex assembly GO:0065003 273 0.027
regulation of nucleotide metabolic process GO:0006140 117 0.027
regulation of protein localization GO:0032880 81 0.027
Mouse
ribose phosphate metabolic process GO:0019693 235 0.027
inflammatory response GO:0006954 150 0.027
positive regulation of cell motility GO:2000147 97 0.026
response to wounding GO:0009611 254 0.026
Rat
negative regulation of cell development GO:0010721 82 0.026
asymmetric stem cell division GO:0098722 2 0.026
response to temperature stimulus GO:0009266 94 0.026
negative regulation of rna biosynthetic process GO:1902679 118 0.026
ribonucleoside metabolic process GO:0009119 174 0.025
response to decreased oxygen levels GO:0036293 237 0.025
chromosome segregation GO:0007059 2 0.025
regulation of cell migration GO:0030334 128 0.025
positive regulation of signal transduction GO:0009967 175 0.025
Human Mouse
purine nucleoside metabolic process GO:0042278 169 0.025
organic acid transport GO:0015849 116 0.025
central nervous system development GO:0007417 311 0.025
Human Fly
negative regulation of phosphate metabolic process GO:0045936 80 0.025
regulation of response to stress GO:0080134 126 0.025
blood circulation GO:0008015 183 0.025
single organism cellular localization GO:1902580 102 0.025
amide transport GO:0042886 105 0.024
Mouse
negative regulation of protein metabolic process GO:0051248 114 0.024
small gtpase mediated signal transduction GO:0007264 36 0.024
calcium ion transport GO:0006816 131 0.024
glycosyl compound metabolic process GO:1901657 182 0.024
memory GO:0007613 54 0.024
actin filament based process GO:0030029 86 0.024
biological adhesion GO:0022610 110 0.024
Human Mouse
response to other organism GO:0051707 220 0.024
response to alkaloid GO:0043279 132 0.024
negative regulation of response to stimulus GO:0048585 155 0.024
organonitrogen compound biosynthetic process GO:1901566 167 0.024
negative regulation of transport GO:0051051 136 0.023
Mouse
nucleoside phosphate metabolic process GO:0006753 283 0.023
developmental growth GO:0048589 100 0.023
Zebrafish Mouse
anion transport GO:0006820 178 0.023
response to axon injury GO:0048678 59 0.023
multicellular organismal reproductive process GO:0048609 233 0.023
Mouse Fly
ribonucleotide catabolic process GO:0009261 136 0.023
sex differentiation GO:0007548 113 0.023
Human
regulation of peptide secretion GO:0002791 82 0.023
Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.023
regulation of organelle organization GO:0033043 80 0.022
peptide transport GO:0015833 97 0.022
Mouse
single organism biosynthetic process GO:0044711 342 0.022
regulation of peptide transport GO:0090087 87 0.022
Mouse
cell cell signaling GO:0007267 335 0.022
Mouse
positive regulation of secretion by cell GO:1903532 128 0.022
Mouse
positive regulation of neuron differentiation GO:0045666 126 0.022
regulation of growth GO:0040008 105 0.022
Mouse
circulatory system process GO:0003013 183 0.022
regulation of cellular catabolic process GO:0031329 101 0.021
vasculogenesis GO:0001570 3 0.021
cell cycle GO:0007049 101 0.021
Mouse Fly
endocytosis GO:0006897 84 0.021
Fly
axon guidance GO:0007411 24 0.021
positive regulation of phosphorylation GO:0042327 177 0.021
Mouse
positive regulation of apoptotic process GO:0043065 154 0.021
cellular ion homeostasis GO:0006873 184 0.021
response to inorganic substance GO:0010035 377 0.021
response to carbohydrate GO:0009743 183 0.021
positive regulation of programmed cell death GO:0043068 157 0.021
regulation of locomotion GO:0040012 148 0.021
organophosphate catabolic process GO:0046434 148 0.021
nucleoside metabolic process GO:0009116 179 0.021
purine ribonucleotide catabolic process GO:0009154 136 0.021
tissue development GO:0009888 252 0.020
Zebrafish Fly
reactive oxygen species biosynthetic process GO:1903409 8 0.020
negative regulation of molecular function GO:0044092 133 0.020
positive regulation of cell projection organization GO:0031346 111 0.020
aromatic compound catabolic process GO:0019439 168 0.020
organic cyclic compound catabolic process GO:1901361 175 0.020
regulation of reactive oxygen species metabolic process GO:2000377 26 0.020
single organism intracellular transport GO:1902582 166 0.020
Mouse
nucleotide catabolic process GO:0009166 139 0.020
cytoplasmic transport GO:0016482 115 0.020
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 5 0.020
gastrulation GO:0007369 2 0.020
Zebrafish
neuron fate commitment GO:0048663 4 0.020
Fly
positive regulation of growth GO:0045927 55 0.020
dendrite development GO:0016358 72 0.020
reactive nitrogen species metabolic process GO:2001057 1 0.020
response to metal ion GO:0010038 253 0.020
response to glucose GO:0009749 136 0.020
regulation of nucleocytoplasmic transport GO:0046822 28 0.020
Mouse
regulation of catabolic process GO:0009894 113 0.020
positive regulation of rna metabolic process GO:0051254 203 0.020
cell cycle process GO:0022402 57 0.020
Mouse
response to oxygen levels GO:0070482 265 0.019
g protein coupled receptor signaling pathway GO:0007186 242 0.019
neuron projection guidance GO:0097485 24 0.019
cellular chemical homeostasis GO:0055082 247 0.019
insulin receptor signaling pathway GO:0008286 24 0.019
positive regulation of cell death GO:0010942 184 0.019
cellular homeostasis GO:0019725 252 0.019
chemosensory behavior GO:0007635 2 0.019
response to cytokine GO:0034097 215 0.019
regulation of cell cycle GO:0051726 73 0.019
Mouse
positive regulation of immune response GO:0050778 42 0.019
peptidyl tyrosine phosphorylation GO:0018108 72 0.019
negative regulation of neurogenesis GO:0050768 78 0.019
embryonic pattern specification GO:0009880 1 0.019
Fly
metal ion transport GO:0030001 289 0.019
response to acid chemical GO:0001101 222 0.019
response to fibroblast growth factor GO:0071774 29 0.019
Fly
blood vessel morphogenesis GO:0048514 58 0.019
regeneration GO:0031099 163 0.018
carbohydrate derivative catabolic process GO:1901136 147 0.018
regulation of anatomical structure size GO:0090066 135 0.018
cellular protein localization GO:0034613 122 0.018
Mouse
protein heterooligomerization GO:0051291 89 0.018
peptidyl amino acid modification GO:0018193 126 0.018
regulation of dendrite development GO:0050773 59 0.018
multicellular organism reproduction GO:0032504 233 0.018
Mouse Fly
peptide hormone secretion GO:0030072 84 0.018
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 75 0.018
vasculature development GO:0001944 70 0.018
stem cell division GO:0017145 4 0.018
positive regulation of transcription dna templated GO:0045893 197 0.018
multicellular organism growth GO:0035264 1 0.018
Mouse
olfactory learning GO:0008355 1 0.018
negative regulation of neuron apoptotic process GO:0043524 45 0.018
carboxylic acid transport GO:0046942 115 0.018
eye morphogenesis GO:0048592 4 0.017
Fly
peptide secretion GO:0002790 86 0.017
Mouse
immune response GO:0006955 104 0.017
regulation of cell activation GO:0050865 50 0.017
development of primary sexual characteristics GO:0045137 107 0.017
sensory perception GO:0007600 101 0.017
regulation of protein targeting GO:1903533 28 0.017
heterocycle catabolic process GO:0046700 167 0.017
negative regulation of neuron death GO:1901215 69 0.017
gonad development GO:0008406 104 0.017
nucleoside triphosphate metabolic process GO:0009141 144 0.017
gamete generation GO:0007276 124 0.017
Fly
cell adhesion GO:0007155 110 0.017
Human Mouse
positive regulation of immune system process GO:0002684 90 0.017
regulation of proteasomal protein catabolic process GO:0061136 4 0.017
regulation of peptide hormone secretion GO:0090276 80 0.016
Mouse
response to monosaccharide GO:0034284 159 0.016
response to molecule of bacterial origin GO:0002237 194 0.016
t cell activation GO:0042110 29 0.016
glycosyl compound catabolic process GO:1901658 126 0.016
cellular response to insulin stimulus GO:0032869 81 0.016
Human
response to estradiol GO:0032355 164 0.016
divalent inorganic cation homeostasis GO:0072507 165 0.016
cell activation GO:0001775 97 0.016
regulation of cell motility GO:2000145 131 0.016
negative regulation of hormone secretion GO:0046888 46 0.016
Mouse
regulation of cellular component movement GO:0051270 150 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 148 0.016
regulation of metal ion transport GO:0010959 118 0.016
nucleoside phosphate catabolic process GO:1901292 140 0.016
calcium mediated signaling using intracellular calcium source GO:0035584 1 0.016
regulation of protein kinase activity GO:0045859 105 0.016
Mouse
fatty acid metabolic process GO:0006631 99 0.016
regulation of purine nucleotide metabolic process GO:1900542 115 0.016
cellular response to lipopolysaccharide GO:0071222 55 0.015
chemical homeostasis GO:0048878 292 0.015
Mouse
positive regulation of cellular component biogenesis GO:0044089 55 0.015
organophosphate biosynthetic process GO:0090407 143 0.015
axonogenesis GO:0007409 71 0.015
Mouse
hormone metabolic process GO:0042445 69 0.015
Mouse
cellular response to organic cyclic compound GO:0071407 202 0.015
heart development GO:0007507 72 0.015
Human Zebrafish
purine containing compound catabolic process GO:0072523 138 0.015
dephosphorylation GO:0016311 98 0.015
nucleoside catabolic process GO:0009164 126 0.015
regulation of hydrolase activity GO:0051336 143 0.015
cellular nitrogen compound catabolic process GO:0044270 163 0.015
olfactory behavior GO:0042048 2 0.015
nucleobase containing compound catabolic process GO:0034655 152 0.015
purine ribonucleoside metabolic process GO:0046128 168 0.015
urogenital system development GO:0001655 78 0.015
sensory perception of pain GO:0019233 73 0.015
reproduction GO:0000003 245 0.014
Mouse Fly
response to hypoxia GO:0001666 231 0.014
response to estrogen GO:0043627 232 0.014
negative regulation of phosphorus metabolic process GO:0010563 80 0.014
intracellular receptor signaling pathway GO:0030522 35 0.014
sexual reproduction GO:0019953 148 0.014
Fly
positive regulation of nucleic acid templated transcription GO:1903508 197 0.014
cell growth GO:0016049 104 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 140 0.014
metal ion homeostasis GO:0055065 186 0.014
reproductive structure development GO:0048608 128 0.014
Human
response to activity GO:0014823 73 0.014
organic anion transport GO:0015711 132 0.014
response to light stimulus GO:0009416 52 0.014
synaptic transmission GO:0007268 235 0.014
regulation of leukocyte activation GO:0002694 45 0.014
purine ribonucleoside catabolic process GO:0046130 124 0.014
positive regulation of catalytic activity GO:0043085 184 0.014
Mouse
reproductive system development GO:0061458 128 0.014
Human
protein maturation GO:0051604 68 0.014
generation of precursor metabolites and energy GO:0006091 62 0.014
gliogenesis GO:0042063 93 0.014
cellular protein complex assembly GO:0043623 44 0.014
ribonucleoside triphosphate metabolic process GO:0009199 141 0.013
ribonucleoside catabolic process GO:0042454 126 0.013
inorganic cation transmembrane transport GO:0098662 202 0.013
cellular response to external stimulus GO:0071496 118 0.013
carbohydrate derivative biosynthetic process GO:1901137 124 0.013
multi organism reproductive process GO:0044703 262 0.013
Fly
cell morphogenesis involved in neuron differentiation GO:0048667 106 0.013
Mouse
regulation of protein transport GO:0051223 68 0.013
Mouse
regulation of cell growth GO:0001558 85 0.013
somatic stem cell division GO:0048103 2 0.013
negative regulation of secretion GO:0051048 82 0.013
Mouse
forebrain development GO:0030900 98 0.013
response to bacterium GO:0009617 200 0.013
regulation of establishment of protein localization GO:0070201 69 0.013
Mouse
actin cytoskeleton organization GO:0030036 73 0.013
response to mechanical stimulus GO:0009612 134 0.013
positive regulation of ion transport GO:0043270 94 0.013
immune system process GO:0002376 204 0.013
Mouse
gtp catabolic process GO:0006184 71 0.013
negative regulation of cellular biosynthetic process GO:0031327 161 0.013
steroid metabolic process GO:0008202 73 0.013
feeding behavior GO:0007631 53 0.013
glial cell differentiation GO:0010001 65 0.013
lymphocyte activation GO:0046649 43 0.013
oxidation reduction process GO:0055114 304 0.013
regulation of nucleoside metabolic process GO:0009118 66 0.013
regulation of immune system process GO:0002682 123 0.013
protein localization to organelle GO:0033365 57 0.013
phosphatidylinositol 3 kinase signaling GO:0014065 14 0.012
negative regulation of signal transduction GO:0009968 83 0.012
negative regulation of protein phosphorylation GO:0001933 44 0.012
negative regulation of cellular component organization GO:0051129 83 0.012
purine nucleoside triphosphate catabolic process GO:0009146 122 0.012
regulation of insulin secretion GO:0050796 65 0.012
Mouse
positive regulation of organelle organization GO:0010638 48 0.012
positive regulation of secretion GO:0051047 140 0.012
Mouse
amino acid transport GO:0006865 70 0.012
regulation of embryonic development GO:0045995 2 0.012
lipid storage GO:0019915 1 0.012
purine nucleoside catabolic process GO:0006152 124 0.012
calcium ion homeostasis GO:0055074 162 0.012
protein targeting GO:0006605 61 0.012
cellular cation homeostasis GO:0030003 180 0.012
regulation of membrane potential GO:0042391 110 0.012
cellular calcium ion homeostasis GO:0006874 160 0.012
hematopoietic progenitor cell differentiation GO:0002244 2 0.012
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 41 0.012
b cell differentiation GO:0030183 2 0.012
axis specification GO:0009798 4 0.012
Fly
negative regulation of cell differentiation GO:0045596 99 0.012
spindle organization GO:0007051 2 0.012
regulation of synaptic transmission glutamatergic GO:0051966 26 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.012

Ptpn11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.028
inherited metabolic disorder DOID:655 0 0.020
disease of metabolism DOID:0014667 0 0.020
cancer DOID:162 0 0.014
Human
organ system cancer DOID:0050686 0 0.014
Human
disease of cellular proliferation DOID:14566 0 0.014
Human