Rattus norvegicus

0 known processes

Ptpn5

protein tyrosine phosphatase, non-receptor type 5

(Aliases: STEP)

Ptpn5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic acid transport GO:0015849 116 0.184
synaptic transmission GO:0007268 235 0.184
cell cell signaling GO:0007267 335 0.131
neuron differentiation GO:0030182 368 0.116
Rat Fly
anion transport GO:0006820 178 0.108
transmembrane transport GO:0055085 412 0.103
nucleobase containing small molecule metabolic process GO:0055086 316 0.090
ion transmembrane transport GO:0034220 365 0.088
glutamate receptor signaling pathway GO:0007215 43 0.088
ion homeostasis GO:0050801 212 0.086
protein complex subunit organization GO:0071822 302 0.086
regulation of cellular component organization GO:0051128 368 0.085
inorganic cation transmembrane transport GO:0098662 202 0.081
cellular component assembly GO:0022607 360 0.081
response to alkaloid GO:0043279 132 0.079
carboxylic acid transport GO:0046942 115 0.079
lipid metabolic process GO:0006629 283 0.077
response to temperature stimulus GO:0009266 94 0.077
ionotropic glutamate receptor signaling pathway GO:0035235 34 0.073
amino acid transport GO:0006865 70 0.070
response to estrogen GO:0043627 232 0.069
cation homeostasis GO:0055080 195 0.069
blood circulation GO:0008015 183 0.068
cellular chemical homeostasis GO:0055082 247 0.067
regulation of saliva secretion GO:0046877 3 0.066
organic anion transport GO:0015711 132 0.066
g protein coupled receptor signaling pathway GO:0007186 242 0.066
regulation of ion transport GO:0043269 245 0.064
cellular component biogenesis GO:0044085 368 0.062
rna metabolic process GO:0016070 406 0.061
single organism behavior GO:0044708 130 0.061
cellular calcium ion homeostasis GO:0006874 160 0.060
cellular response to hormone stimulus GO:0032870 247 0.058
macromolecular complex subunit organization GO:0043933 339 0.056
response to corticosteroid GO:0031960 235 0.056
organophosphate metabolic process GO:0019637 370 0.056
metal ion transport GO:0030001 289 0.056
cellular response to steroid hormone stimulus GO:0071383 93 0.055
anatomical structure morphogenesis GO:0009653 298 0.055
Fly
response to toxic substance GO:0009636 133 0.053
transcription dna templated GO:0006351 377 0.052
organelle organization GO:0006996 266 0.052
cellular response to stress GO:0033554 269 0.052
response to amine GO:0014075 46 0.052
secretion GO:0046903 307 0.051
chemical homeostasis GO:0048878 292 0.051
cation transport GO:0006812 382 0.050
organonitrogen compound catabolic process GO:1901565 179 0.050
circulatory system process GO:0003013 183 0.049
membrane organization GO:0061024 94 0.049
response to peptide GO:1901652 292 0.049
cellular catabolic process GO:0044248 295 0.049
response to extracellular stimulus GO:0009991 380 0.049
response to ketone GO:1901654 182 0.046
response to oxygen levels GO:0070482 265 0.046
intracellular signal transduction GO:0035556 314 0.045
Fly
nucleic acid templated transcription GO:0097659 379 0.045
divalent metal ion transport GO:0070838 132 0.045
regulation of blood circulation GO:1903522 110 0.045
catabolic process GO:0009056 351 0.044
response to glucocorticoid GO:0051384 223 0.043
negative regulation of cell communication GO:0010648 158 0.043
Fly
ribonucleotide metabolic process GO:0009259 231 0.043
cellular response to endogenous stimulus GO:0071495 377 0.043
adult locomotory behavior GO:0008344 4 0.042
calcium ion homeostasis GO:0055074 162 0.042
synaptic growth at neuromuscular junction GO:0051124 1 0.041
cellular ion homeostasis GO:0006873 184 0.041
cellular divalent inorganic cation homeostasis GO:0072503 162 0.041
response to inorganic substance GO:0010035 377 0.041
regulation of postsynaptic membrane potential GO:0060078 25 0.040
response to nutrient levels GO:0031667 370 0.040
telencephalon development GO:0021537 62 0.040
cellular homeostasis GO:0019725 252 0.039
action potential GO:0001508 54 0.039
negative regulation of cellular metabolic process GO:0031324 281 0.039
Fly
regulation of synaptic transmission GO:0050804 141 0.038
cellular lipid metabolic process GO:0044255 208 0.038
multicellular organism reproduction GO:0032504 233 0.038
metal ion homeostasis GO:0055065 186 0.037
nucleoside phosphate metabolic process GO:0006753 283 0.037
calcium ion transport GO:0006816 131 0.037
negative regulation of signaling GO:0023057 157 0.036
Fly
respiratory gaseous exchange GO:0007585 4 0.036
regulation of vesicle mediated transport GO:0060627 81 0.035
sensory perception GO:0007600 101 0.035
positive regulation of cytosolic calcium ion concentration GO:0007204 122 0.034
protein complex biogenesis GO:0070271 263 0.034
glycerolipid metabolic process GO:0046486 67 0.034
positive regulation of signal transduction GO:0009967 175 0.034
vesicle mediated transport GO:0016192 181 0.034
regeneration GO:0031099 163 0.033
somatostatin signaling pathway GO:0038170 4 0.033
macromolecule localization GO:0033036 252 0.033
rna biosynthetic process GO:0032774 380 0.032
multi organism reproductive process GO:0044703 262 0.032
intracellular transport GO:0046907 185 0.032
regulation of cellular localization GO:0060341 263 0.032
response to estradiol GO:0032355 164 0.032
cellular response to organic cyclic compound GO:0071407 202 0.032
regulation of transcription dna templated GO:0006355 374 0.032
negative regulation of response to stimulus GO:0048585 155 0.031
Fly
response to hypoxia GO:0001666 231 0.031
regulation of multicellular organismal development GO:2000026 376 0.031
divalent inorganic cation homeostasis GO:0072507 165 0.031
negative regulation of metabolic process GO:0009892 331 0.030
Fly
response to insulin GO:0032868 133 0.030
vesicle localization GO:0051648 33 0.030
regulation of membrane potential GO:0042391 110 0.029
sexual reproduction GO:0019953 148 0.029
dicarboxylic acid transport GO:0006835 34 0.029
neuron apoptotic process GO:0051402 88 0.029
organic substance catabolic process GO:1901575 316 0.029
neuron projection development GO:0031175 273 0.029
neuromuscular process GO:0050905 2 0.029
response to metal ion GO:0010038 253 0.028
cation transmembrane transport GO:0098655 263 0.028
positive regulation of nucleotide metabolic process GO:0045981 91 0.028
regulation of hydrolase activity GO:0051336 143 0.028
forebrain development GO:0030900 98 0.028
response to radiation GO:0009314 137 0.028
regulation of molecular function GO:0065009 398 0.027
regulation of blood pressure GO:0008217 83 0.027
cellular cation homeostasis GO:0030003 180 0.027
peptide hormone secretion GO:0030072 84 0.027
response to mechanical stimulus GO:0009612 134 0.027
nucleotide metabolic process GO:0009117 279 0.027
regulation of respiratory gaseous exchange GO:0043576 2 0.027
regulation of synaptic vesicle recycling GO:1903421 1 0.027
cellular response to estradiol stimulus GO:0071392 16 0.027
protein complex assembly GO:0006461 263 0.027
positive regulation of macromolecule biosynthetic process GO:0010557 247 0.026
regulation of apoptotic process GO:0042981 335 0.026
oxoacid metabolic process GO:0043436 290 0.026
positive regulation of protein serine threonine kinase activity GO:0071902 52 0.026
protein oligomerization GO:0051259 191 0.026
response to decreased oxygen levels GO:0036293 237 0.026
positive regulation of apoptotic process GO:0043065 154 0.025
macromolecular complex assembly GO:0065003 273 0.025
cellular nitrogen compound catabolic process GO:0044270 163 0.025
negative regulation of cellular biosynthetic process GO:0031327 161 0.025
response to monosaccharide GO:0034284 159 0.025
homeostatic process GO:0042592 331 0.025
transcription from rna polymerase ii promoter GO:0006366 252 0.025
cardiac chamber development GO:0003205 1 0.025
calcium ion transmembrane transport GO:0070588 70 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 319 0.025
negative regulation of transport GO:0051051 136 0.025
reproductive process GO:0022414 372 0.025
nitrogen compound transport GO:0071705 229 0.025
regulation of response to external stimulus GO:0032101 106 0.025
single organism reproductive process GO:0044702 297 0.024
response to peptide hormone GO:0043434 278 0.024
associative learning GO:0008306 19 0.024
somatostatin receptor signaling pathway GO:0038169 4 0.024
head development GO:0060322 247 0.024
regulation of system process GO:0044057 208 0.024
proteolysis GO:0006508 175 0.024
muscle system process GO:0003012 115 0.024
nucleoside phosphate biosynthetic process GO:1901293 102 0.024
central nervous system development GO:0007417 311 0.023
carbohydrate derivative metabolic process GO:1901135 346 0.023
secretion by cell GO:0032940 248 0.023
neuron death GO:0070997 127 0.023
positive regulation of response to stimulus GO:0048584 285 0.023
positive regulation of catalytic activity GO:0043085 184 0.023
regulation of cell differentiation GO:0045595 320 0.023
rhythmic process GO:0048511 156 0.023
cellular response to extracellular stimulus GO:0031668 73 0.023
positive regulation of multicellular organismal process GO:0051240 387 0.023
cell cycle GO:0007049 101 0.023
Fly
cell morphogenesis GO:0000902 142 0.022
glycosyl compound catabolic process GO:1901658 126 0.022
positive regulation of nucleic acid templated transcription GO:1903508 197 0.022
gtp metabolic process GO:0046039 72 0.022
phasic smooth muscle contraction GO:0014821 3 0.022
response to transition metal nanoparticle GO:1990267 122 0.022
protein transport GO:0015031 132 0.022
carboxylic acid metabolic process GO:0019752 289 0.022
response to osmotic stress GO:0006970 42 0.022
neurological system process GO:0050877 219 0.022
response to heat GO:0009408 60 0.022
cellular response to oxygen containing compound GO:1901701 386 0.021
positive regulation of biosynthetic process GO:0009891 319 0.021
regulation of locomotion GO:0040012 148 0.021
detection of calcium ion GO:0005513 1 0.021
regulation of cell projection organization GO:0031344 175 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 334 0.021
organophosphate catabolic process GO:0046434 148 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.021
regulation of ion transmembrane transporter activity GO:0032412 48 0.021
ribose phosphate metabolic process GO:0019693 235 0.021
regulation of neurogenesis GO:0050767 247 0.021
lipid modification GO:0030258 52 0.021
regulation of intracellular signal transduction GO:1902531 218 0.021
Fly
single organism biosynthetic process GO:0044711 342 0.021
regulation of rna metabolic process GO:0051252 391 0.021
cellular metal ion homeostasis GO:0006875 172 0.021
learning GO:0007612 33 0.021
monovalent inorganic cation transport GO:0015672 172 0.021
negative regulation of macromolecule metabolic process GO:0010605 260 0.020
regulation of neuronal synaptic plasticity GO:0048168 31 0.020
regulation of neuron projection development GO:0010975 161 0.020
regulation of organic acid transport GO:0032890 35 0.020
inorganic ion transmembrane transport GO:0098660 229 0.020
circulatory system development GO:0072359 134 0.020
regulation of cell morphogenesis involved in differentiation GO:0010769 72 0.020
cyclic nucleotide metabolic process GO:0009187 80 0.020
purine containing compound metabolic process GO:0072521 253 0.020
regulation of anion transport GO:0044070 43 0.020
regulation of cellular protein metabolic process GO:0032268 267 0.020
organic acid metabolic process GO:0006082 292 0.019
regulation of catalytic activity GO:0050790 304 0.019
response to ethanol GO:0045471 162 0.019
positive regulation of programmed cell death GO:0043068 157 0.019
protein homooligomerization GO:0051260 91 0.019
acid secretion GO:0046717 48 0.019
programmed cell death GO:0012501 392 0.019
actin filament organization GO:0007015 42 0.019
regulation of signal transduction GO:0009966 318 0.019
Fly
phospholipid metabolic process GO:0006644 61 0.019
heart morphogenesis GO:0003007 3 0.019
response to wounding GO:0009611 254 0.019
smooth muscle contraction GO:0006939 37 0.019
positive regulation of secretion GO:0051047 140 0.019
regulation of tube size GO:0035150 89 0.019
response to starvation GO:0042594 59 0.019
regulation of catabolic process GO:0009894 113 0.019
response to growth factor GO:0070848 189 0.019
response to amphetamine GO:0001975 25 0.019
negative regulation of cellular component organization GO:0051129 83 0.019
peristalsis GO:0030432 2 0.019
positive regulation of phosphorus metabolic process GO:0010562 262 0.018
amine transport GO:0015837 57 0.018
response to external biotic stimulus GO:0043207 221 0.018
positive regulation of developmental process GO:0051094 283 0.018
regulation of organelle organization GO:0033043 80 0.018
reproduction GO:0000003 245 0.018
organic cyclic compound catabolic process GO:1901361 175 0.018
small molecule biosynthetic process GO:0044283 124 0.018
regulation of programmed cell death GO:0043067 341 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 161 0.018
nucleobase containing compound catabolic process GO:0034655 152 0.018
organophosphate biosynthetic process GO:0090407 143 0.017
anatomical structure formation involved in morphogenesis GO:0048646 83 0.017
positive regulation of synaptic vesicle recycling GO:1903423 1 0.017
ribonucleotide biosynthetic process GO:0009260 85 0.017
brain development GO:0007420 247 0.017
cell projection morphogenesis GO:0048858 123 0.017
cellular response to nitrogen compound GO:1901699 210 0.017
cellular response to peptide GO:1901653 133 0.017
synaptic vesicle amine transport GO:0015842 3 0.017
cellular component movement GO:0006928 248 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 141 0.017
single organism organelle organization GO:1902589 180 0.017
cellular response to corticosteroid stimulus GO:0071384 69 0.017
regulation of purine nucleotide metabolic process GO:1900542 115 0.017
muscle contraction GO:0006936 88 0.017
regulation of secretion by cell GO:1903530 208 0.016
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 51 0.016
actin filament based process GO:0030029 86 0.016
dendrite development GO:0016358 72 0.016
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 2 0.016
cytosolic calcium ion homeostasis GO:0051480 140 0.016
purine nucleotide metabolic process GO:0006163 229 0.016
cyclic purine nucleotide metabolic process GO:0052652 62 0.016
purine nucleoside catabolic process GO:0006152 124 0.016
regulation of nucleic acid templated transcription GO:1903506 380 0.016
regulation of rna biosynthetic process GO:2001141 381 0.016
nucleoside triphosphate metabolic process GO:0009141 144 0.016
establishment of vesicle localization GO:0051650 31 0.016
cellular response to alcohol GO:0097306 87 0.016
cellular response to growth factor stimulus GO:0071363 162 0.016
positive regulation of cell death GO:0010942 184 0.015
multi multicellular organism process GO:0044706 138 0.015
regulation of amino acid transport GO:0051955 25 0.015
cell part morphogenesis GO:0032990 123 0.015
signal transduction by phosphorylation GO:0023014 144 0.015
Fly
defecation GO:0030421 1 0.015
chemosensory behavior GO:0007635 2 0.015
regulation of transcription from rna polymerase ii promoter GO:0006357 234 0.015
phosphatidylinositol dephosphorylation GO:0046856 4 0.015
carbohydrate derivative biosynthetic process GO:1901137 124 0.015
ribose phosphate biosynthetic process GO:0046390 87 0.015
response to calcium ion GO:0051592 59 0.015
positive regulation of transcription dna templated GO:0045893 197 0.015
enzyme linked receptor protein signaling pathway GO:0007167 116 0.015
response to ammonium ion GO:0060359 71 0.015
glycerophospholipid metabolic process GO:0006650 47 0.015
positive regulation of cellular biosynthetic process GO:0031328 295 0.015
positive regulation of secretion by cell GO:1903532 128 0.015
organelle localization GO:0051640 55 0.015
endocytosis GO:0006897 84 0.015
regulation of phosphate metabolic process GO:0019220 349 0.015
Fly
amine metabolic process GO:0009308 38 0.015
regulation of ion transmembrane transport GO:0034765 121 0.015
aging GO:0007568 241 0.015
wound healing GO:0042060 122 0.015
limb morphogenesis GO:0035108 4 0.014
regulation of transmembrane transport GO:0034762 122 0.014
response to morphine GO:0043278 27 0.014
regulation of cellular component biogenesis GO:0044087 86 0.014
regulation of cellular catabolic process GO:0031329 101 0.014
saliva secretion GO:0046541 3 0.014
regulation of cell proliferation GO:0042127 359 0.014
mapk cascade GO:0000165 140 0.014
Fly
single organism catabolic process GO:0044712 283 0.014
gamete generation GO:0007276 124 0.014
positive regulation of rna biosynthetic process GO:1902680 197 0.014
embryonic appendage morphogenesis GO:0035113 4 0.014
regulation of nucleotide metabolic process GO:0006140 117 0.014
heterocycle catabolic process GO:0046700 167 0.014
response to oxidative stress GO:0006979 186 0.014
neuron development GO:0048666 286 0.014
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 3 0.014
smooth muscle cell proliferation GO:0048659 77 0.014
cellular response to glucocorticoid stimulus GO:0071385 68 0.014
purine containing compound biosynthetic process GO:0072522 85 0.013
cellular response to external stimulus GO:0071496 118 0.013
multicellular organismal reproductive process GO:0048609 233 0.013
presynaptic membrane assembly GO:0097105 3 0.013
developmental growth GO:0048589 100 0.013
cyclic nucleotide biosynthetic process GO:0009190 63 0.013
negative regulation of biosynthetic process GO:0009890 168 0.013
negative regulation of phosphorus metabolic process GO:0010563 80 0.013
Fly
positive regulation of molecular function GO:0044093 230 0.013
positive regulation of cell proliferation GO:0008284 249 0.013
regulation of excitatory postsynaptic membrane potential GO:0060079 18 0.013
activation of cysteine type endopeptidase activity GO:0097202 4 0.013
male mating behavior GO:0060179 3 0.013
growth GO:0040007 165 0.013
response to carbohydrate GO:0009743 183 0.013
olfactory learning GO:0008355 1 0.013
regulation of smooth muscle cell proliferation GO:0048660 75 0.013
single organism intracellular transport GO:1902582 166 0.013
purine containing compound catabolic process GO:0072523 138 0.013
regulation of cell cycle GO:0051726 73 0.013
divalent inorganic cation transport GO:0072511 134 0.013
positive regulation of intracellular signal transduction GO:1902533 138 0.013
cytoskeleton organization GO:0007010 111 0.013
detection of stimulus GO:0051606 24 0.013
developmental process involved in reproduction GO:0003006 159 0.013
positive regulation of dendritic spine development GO:0060999 9 0.013
startle response GO:0001964 2 0.013
response to cold GO:0009409 29 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 27 0.013
negative regulation of molecular function GO:0044092 133 0.012
gliogenesis GO:0042063 93 0.012
positive regulation of signaling GO:0023056 270 0.012
cellular response to metal ion GO:0071248 55 0.012
apoptotic process GO:0006915 381 0.012
cellular component morphogenesis GO:0032989 155 0.012
positive regulation of saliva secretion GO:0046878 3 0.012
defense response GO:0006952 194 0.012
response to manganese ion GO:0010042 13 0.012
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 19 0.012
regulation of heart contraction GO:0008016 48 0.012
regulation of homeostatic process GO:0032844 101 0.012
organonitrogen compound biosynthetic process GO:1901566 167 0.012
single organism cellular localization GO:1902580 102 0.012
regulation of nervous system development GO:0051960 264 0.012
cellular amino acid metabolic process GO:0006520 107 0.012
lipid biosynthetic process GO:0008610 128 0.012
limbic system development GO:0021761 38 0.012
steroid hormone mediated signaling pathway GO:0043401 8 0.012
feeding behavior GO:0007631 53 0.012
cardiac muscle cell contraction GO:0086003 10 0.012
purine ribonucleotide biosynthetic process GO:0009152 81 0.012
response to fluoride GO:1902617 3 0.012
regulation of neurotransmitter levels GO:0001505 42 0.012
regulation of cellular component movement GO:0051270 150 0.012
heart process GO:0003015 57 0.012
response to food GO:0032094 27 0.012
cell cycle checkpoint GO:0000075 2 0.011
cellular response to nutrient levels GO:0031669 60 0.011
regulation of developmental growth GO:0048638 45 0.011
positive regulation of transport GO:0051050 245 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 91 0.011
regulation of protein localization GO:0032880 81 0.011
gastrulation GO:0007369 2 0.011
cellular response to alkaloid GO:0071312 25 0.011
ribonucleoside metabolic process GO:0009119 174 0.011
lipid transport GO:0006869 61 0.011
response to electrical stimulus GO:0051602 56 0.011
renin secretion into blood stream GO:0002001 1 0.011
cardiovascular system development GO:0072358 134 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 148 0.011
response to fungicide GO:0060992 20 0.011
response to antibiotic GO:0046677 39 0.011
embryonic axis specification GO:0000578 1 0.011
vascular process in circulatory system GO:0003018 96 0.011
positive regulation of cell differentiation GO:0045597 217 0.011
regulation of g protein coupled receptor protein signaling pathway GO:0008277 28 0.011
axis specification GO:0009798 4 0.011
negative regulation of signal transduction GO:0009968 83 0.011
Fly
nucleotide catabolic process GO:0009166 139 0.011
actin cytoskeleton organization GO:0030036 73 0.011
neurotransmitter gated ion channel clustering GO:0072578 3 0.011
nucleotide biosynthetic process GO:0009165 98 0.011
positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway GO:0010579 2 0.011
tissue remodeling GO:0048771 40 0.011
organelle fission GO:0048285 25 0.011
protein phosphorylation GO:0006468 345 0.011
response to light stimulus GO:0009416 52 0.011
sensory perception of light stimulus GO:0050953 3 0.011
response to activity GO:0014823 73 0.011
glutamate secretion GO:0014047 19 0.011
response to glucose GO:0009749 136 0.010
response to biotic stimulus GO:0009607 226 0.010
establishment of protein localization GO:0045184 141 0.010
rhythmic behavior GO:0007622 24 0.010
behavior GO:0007610 205 0.010
spindle organization GO:0007051 2 0.010
circadian rhythm GO:0007623 88 0.010
positive regulation of cell communication GO:0010647 271 0.010
pallium development GO:0021543 42 0.010
purine nucleoside metabolic process GO:0042278 169 0.010
heart contraction GO:0060047 57 0.010
positive regulation of long term synaptic potentiation GO:1900273 4 0.010
regulation of phosphorus metabolic process GO:0051174 349 0.010
Fly
regulation of purine nucleotide catabolic process GO:0033121 65 0.010
acute inflammatory response GO:0002526 58 0.010
chromosome segregation GO:0007059 2 0.010
endoplasmic reticulum organization GO:0007029 1 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 122 0.010
cellular amine metabolic process GO:0044106 38 0.010
signal release GO:0023061 145 0.010
positive regulation of dendritic spine morphogenesis GO:0061003 3 0.010

Ptpn5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.053
musculoskeletal system disease DOID:17 0 0.053
cardiovascular system disease DOID:1287 0 0.042
myopathy DOID:423 0 0.020
muscular disease DOID:0080000 0 0.020
muscle tissue disease DOID:66 0 0.020